The range of application of polyurethanes has been limited by their poor hemocompatibility and inability to resist non‐specific binding of biomolecules and cells. In this work, a non‐adhesive PU‐based material was synthesized via the copolymerization of PU with dermatan sulfate. Incorporation of DS into the PU backbone dramatically increased material hydrophilicity and decreased protein adsorption. The in vitro adhesion of several cell types, including platelets, also significantly decreased with increasing DS content. Both the physical and biological properties of the DS contributed to the anti‐adhesive properties of the PU/DS copolymer, and this anti‐adhesive nature of PU/DS renders this new biomaterial attractive for blood‐contacting or non‐fouling applications.
A combined nanomaterials‐based approach for simultaneous therapy and molecular imaging has powerful potential for efficient treatment and monitoring the prognosis of incurable diseases such as malignant tumors or degenerative diseases. Recent developments of hybrid polymeric nanomaterials for siRNA delivery and imaging are highlighted. A particular focus is on various conjugation and formulation strategies of how to incorporate siRNA and imaging agents onto the surface of functionally active polymer‐coated inorganic nanomaterials such as iron oxide, gold, and quantum‐dot nanoparticles for theranostic applications. These multifunctional nanocarriers may allow real‐time tracking of siRNA as well as visualization of its therapeutic effects in vitro and in vivo.
