Novel Synthetic Routes of 3-Methoxypropanal from Glycerol

A new synthesis of 3-methoxypropanal from glycerol was presented. With this new approach, the conversion of glycerol to 3-methoxypropanal can be effected in moderate yield using catalysts of copper sulfate and polyethylene glycol (PEG).

Deoxygenation of Aromatic Ketones Using Transfer Hydrogenolysis with Raney Nickel in 2-Propanol

Aryl ketones are readily deoxygenated to their corresponding aryl alkanes upon treatment with Raney nickel catalyst in boiling 2-propanol.

Simple and Efficient One-Pot Synthesis of Nitriles from Amides and Oximes Using in Situ–Generated Burgess-Type Reagent

The dehydration of aldoximes and amides, and oxidation of benzoin are accomplished in one-pot using in situ–generated Burgess-type reagent.

Improved Synthesis of Monoprotected 5- and 6-Amino-2-azanorbornanes

An improved synthesis of Boc-monoprotected 5- and 6-amino-2-azanorbornanes is reported. The synthetic scheme consists of five steps and allows multigram quantities of the title compounds to be obtained. The regio- and stereochemistries of the products are established by two-dimensional NMR experiments.

Palladium-Catalyzed N-Arylation of 3-Functionalized 2-Amino-4,5-dimethylpyrroles

A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladium-catalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.

Facile and Efficient Method for the Synthesis of 14-Substituted-14-H-dibenzo[a,j]xanthenes Catalyzed by Ruthenium Chloride Hydrate as a Homogeneous Catalyst

Synthesis of dibenzoxanthenes through condensation of β-naphthol with various aromatic and aliphatic aldehydes in ethanol as an ecofriendly solvent using Ru^III as catalyst is reported.

Stereoselective Synthesis of Dialkyl 2-(Arylsulfonylamino)-3-(dialkoxyphosphoryl) Succinates by Reaction of Trialkyl(aryl) Phosphites,Dialkyl Acetylenedicarboxylates,and Arylsulfonamides

A three-component reaction of trialkyl(aryl) phosphites, dialkyl acetylenedicarboxylates, and arylsulfonamides is described as a simple and efficient route for the synthesis of dialkyl 2-(arylsulfonylamino)-3-(dialkoxyphosphoryl)-succinates in good yields.

Use of Magnesium (Turnings) as a Powerful Catalyst for the O-Acylative Cleavage of Tetrahydrofuran

In a short reaction time, acyl chlorides and dry tetrahydrofuran react in the presence of a catalytic amount of magnesium turnings (Mg) at 25 °C to give 4-chlorobutyl esters in excellent yields.

Novel One-Pot Synthesis for 2,5-Diaryl and 5-Aryl-pyridazin-3(2H)-ones

A novel method for the synthesis of 2-phenyl-5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones and 5-(o-hydroxyphenyl)-pyridazin-3(2H)-ones has been found during the reaction of 4-bromomethylcoumarins with phenylhydrazine and hydrazinehydrate, respectively, under controlled alkaline conditions.

Highly Efficient One-Pot Synthesis of 2-Aminobenzoxazoles Using Triflic Acid as a Cyclodesulfurizing Reagent

An efficient one-pot synthetic strategy for 2-aminobenzoxazoles was developed from isothiocyanates and 2-aminophenol using triflic acid as a cyclodesulfurizing reagent.

Solvent-Free Amination of Secondary Benzylic Alcohols with N-Nucleophiles Catalyzed by FeCl3

A general, simple, and environmentally friendly method for the direct amination of secondary benzyl alcohols with amides or 4-nitroaniline is described. This method has been applied to a variety of substrates, and the reaction proceeded smoothly at room temperature under solvent-free conditions. CbzNH₂ was proved to be very useful in the direct preparation of the benzylic amines from corresponding alcohols.

Acetic Anhydride/Et3N/DMAP: An Effective Acetylating System for Hemiacetals

The selective and efficient acetylation of the hemiacetal hydroxyl in the equilibrium mixture between RCl₂C(OAll)OH and AllOH/RCl₂CHO was achieved using the acylating system Ac₂O/Et₃N/dimethylaminopyridine (DMAP).

Synthesis of 4-Methylene-1,3-naphthoxazines by the Reaction of Imines with Triphosgene

Reaction of 2-acetyl-1-naphthol with aliphatic amines under microwave irradiation gave the corresponding imines (Schiff bases), which were treated with triphosgene to give 4-methylene-1,3-naphthoxazines in good yields.

Copper(I)-Catalyzed Cycloaddition of Methyl O-Propargylpodocarpate and Azides at Room Temperature

Copper iodide was employed as an efficient catalyst for the synthesis of 1,2,3-triazole derivatives of podocarpic acid at room temperature through “click” chemistry cycloaddition reactions of methyl O-propargylpodocarpate and propargyl O-propargylpodocarpate with azides.

Three-Component,One-Pot Synthesis of 2,4,5-Trisubstituted Imidazoles Catalyzed by TiCl4-SiO2 Under Conventional Heating Conditions or Microwave Irradiation

In this study, silica-supported titanium tetrachloride was prepared and used as a novel catalyst for rapid and efficient synthesis of 2,4,5-trisubstituted imidazoles by a three-component, one-pot condensation of 1,2-diketones and aryl aldehydes in excellent yield under solvent-free conditions using conventional heating or microwave irradiation.

Recyclable Siloxy Serine Organocatalyst for the Direct Asymmetric Mannich Reactions in Ionic Liquids

A recyclable siloxy-L-serine organocatalyst has been developed to catalyze the asymmetric direct three-component Mannich reactions in ionic liquid hmim[PF₆], furnishing the β-amino carbonyl scaffold in high enantio- and diastereoselectivities. The direct Mannich reaction between a selection of aromatic aldehydes and ketones resulted in good yields and high enantioselectivities.

Efficient and Selective Demethylation of Heteroaryl Methyl Ethers in the Presence of Aryl Methyl Ethers

A new and efficient method for the demethylation of 6-membered aza-heterocyclic methyl ethers is described using lithium chloride and para-toluenesulfonic acid. This process is chemoselective for aza-heterocyclic methyl ethers in the presence of aryl methyl ethers.

Amberlyst-15–Catalyzed Facile Synthesis of α-Amino Phosphonates

A simple and efficient method has been developed for the synthesis of sulfonamide phosphonates from N-tosyl aldimines and dimethyl trimethylsilyl phosphite at 0 °C in the presence of Amberlyst-15 as a heterogeneous catalyst.

Mg-Al Hydrotalcite as a First Heterogeneous Basic Catalyst for the Synthesis of 4H-Pyrano[2,3-c]pyrazoles Through a Four-Component Reaction

Mg/Al hydrotalcite acts as an efficient heterogeneous basic catalyst for the synthesis of 4H-pyrano[2,3-c]pyrazoles via a multicomponent reaction of aromatic hydrazine hydrate, ethyl acetoacetate, aldehydes, and malononitrile in ethanol at ambient temperature. The hydrotalcite catalyst was easily separated from the reaction mixture and can be reused.

Ammonium Chloride–Catalyzed One-Pot Synthesis of Tetrahydrobenzo[α]xanthen-11-one Derivatives Under Solvent-Free Conditions

A one-pot, multicomponent reaction of aldehydes, dimedone, and β-naphthols is described for the preparation of 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[α]xanthen-11-one derivatives using ammonium chloride as a mild, inexpensive, and environmentally benign catalyst under solvent-free conditions. Different types of aldehyde and β-naphthol derivatives are used in the reaction, and in all cases the products were synthesized successfully.