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MeiHuaXIE LuLingWU XianHUANG 《中国化学快报》2003,14(9):887-888
Phenylseleno and sulfonyl substituted allyl alcohols were synthesized stereoselectively by the three-componem reaction of acetylenic sulfone, phenylselenomagnesium bromide and ketones in one-pot. 相似文献
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综述了近年来手性烯丙基胺的合成进展, 重点介绍了催化剂配体对化学选择性和对映选择性的影响, 并阐述了各种类型的反应机理.手性; 烯丙基胺; 催化 相似文献
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David Grassi Dr. Chrysanthi Dolka Dr. Olivier Jackowski Prof. Alexandre Alexakis 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(4):1466-1475
The Cu‐free asymmetric allylic alkylation, catalysed by NHC, with Grignard reagents is reported on allyl bromide derivatives with good results. The enantioselectivity was quite homogeneous (around 85 % ee) on large and various substrates, regardless of the nature of the Grignard reagent. The formation of stereogenic quaternary centres was highly regioselective for both aliphatic and aromatic derivatives with good enantiomeric excess (up to 92 % ee). The methodology developed was found to be complementary with the Cu‐catalysed version. Several new NHCs were tested with improved efficiency. In addition, mechanistic studies, using NMR spectroscopy, led to the discovery of the catalytically active species. 相似文献
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Meunier 等曾研究了 Cp_2TiCl_2催化下,格氏试剂对卤代烷和羰基化合物的还原反应,并报道了与芳环或碳-碳双键或碳-碳三键共轭的羰基化合物不被格氏试剂还原。我们却发现,在较低温度下,这些芳醛或与碳-碳重键共轭的羰基化合物也会被还原,特别是在芳环上有吸电子取代基时,还原产物的产率很高。 相似文献
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l-α-biaomo-2,3,4,6-tetra-O-acetyl-D-giucopyranose reacts with Grignard eagents prepared frorn the acnvated magnesium under very mild condition to ellord C- glucosides in a very high yield compared with Grignard Reagent prepared from usual method.β-anomer predominates in the reaction, mixture The configuration of anomers was assigned by 13C NMR spectra. 相似文献
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Dr. Valentín Hornillos Dr. Manuel Pérez Dr. Martín Fañanás‐Mastral Prof. Dr. Ben L. Feringa 《Chemistry (Weinheim an der Bergstrasse, Germany)》2013,19(17):5432-5441
An efficient and highly enantioselective copper‐catalyzed allylic alkylation of phosphonates and phosphine oxides with Grignard reagents and Taniaphos or phosphoramidites as chiral ligands is reported. Transformation of these products leads to a variety of new phosphorus‐containing chiral intermediates. 相似文献
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Alkyl sulfoxides were synthesized in good yields from the reaction of alkanesulfinyl chloride with Grignard reagents in the presence of zinc chloride. 相似文献
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Meihua Xie Chengyou Feng Jitan Zhang Changqing Liu Kuang Fang Guanying Shu Wansheng Zuo 《Journal of organometallic chemistry》2011,696(21):3397-3401
Highly functionalized tetrasubstituted allylic alcohols were prepared conveniently by CuI-catalyzed tandem carbomagnesiation/carbonyl addition of Grignard reagents with acetylenic ketones. The obtained allylic alcohols can be further transformed to polysubstituted indenes by intramolecular cyclization. 相似文献
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Hydrozirconation of propargyl selenides afford(E)-3-selanyl vinylzirconocenes chlorides 2.Intermediates 2 reacted with aldehydes to obtain δ-selanyl allylic alcohols. 相似文献
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Mohamed Ali Ayedi Yves Le Bigot Souhir Abid Rachid El Gharbi Michel Delmas 《合成通讯》2013,43(16):2127-2133
We report here a novel, one-pot, two-step reductive amination of aldehydes for the atom-economical synthesis of primary amines. The amination step has been carried out with hydroxylammonium chloride and does not require the use of a base. In the subsequent reduction step, a metal zinc/hydrochloride acid system has been used. This method is applicable to both aliphatic and aromatic aldehydes. The operational simplicity, the short reaction times, and the mild reaction conditions add to the value of this method as a practical alternative to the reductive amination of aldehydes. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. 相似文献
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Hossein Anaraki-Ardakani Shirin Sadeghian Foroghossadat Rastegari Alireza Hassanabadi 《合成通讯》2013,43(12):1990-1999
The three-component reaction between dialkyl acetylenedicarboxylates and triphenylphosphine in the presence of arylsulfonyl hydrazides or aryl hydrazines produces highly functionalized, salt-free phosphorus ylides in excellent yields. 相似文献
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Meihua Xie Gaofeng Lin Jinhua Zhang Ming Li Chengyou Feng 《Journal of organometallic chemistry》2010,695(6):882-9965
(Z)-Tetrasubstituted allylic alcohols bearing sulfonyl group were synthesized regio- and stereoselectively by alkylzincation of acetylenic sulfone followed by addition to aldehyde. 相似文献
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Tobias Kaper Dennis Geik Felix Fornfeist Dr. Marc Schmidtmann Prof. Dr. Sven Doye 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(10):e202103931
Intermolecular hydroaminoalkylation reactions of symmetrical and unsymmetrical alkynes with tertiary amines take place in the presence of catalytic amounts of TiBn4, Ph3C[B(C6F5)4], and a sterically demanding aminopyridinato ligand precursor. The resulting products, synthetically and pharmaceutically useful tertiary β,γ-disubstituted allylic amines, are formed in convincing yields and with excellent stereoselectivity. Particularly promising for future applications is the fact that even the industrial side product trimethylamine can be used as a substrate. 相似文献
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Meihua Xie 《Journal of organometallic chemistry》2005,690(17):4058-4062
Carbomagnesiation of acetylenic sulfone in the presence of catalytic amount of CuCN gave α-sulfonyl vinyl magnesium reagent, which further reacted with aldehydes to afford polysubstituted vinyl sulfones in moderate to good yields. 相似文献