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Wang Rendong Li Jian Li Chunju Liu Jun Li Dafeng Jia Xueshun Zhai Hongbin 《中国化学》2010,28(7):1253-1256
The environmentally benign, regio‐ and stereoselective synthesis of functionalized tertiary amine 3 from acetates of Baylis‐Hillman adducts with the aliphatic primary amines in the absence of any solvent and catalysts was reported. 相似文献
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TCBiswellknownasnacceptorwhichcanformCTcomplexeswithmanydonormolecules"',andalsocanbeusedintheanalysisandqualitycontrolofdrugsindifferentpharmaceuticaldosageforms3.AlthoughspectrophotometricalmethodisoftenusedtostudythecharacterofCTcomplexes,verylittleresearchonCTcomplexesformedbyTCBandsimpletertiaryaminehavebeenfound.Recently,weemploythespectrophotometricalmethodtoStudytheCTcomplexesusingtheTCBasnacceptorandtertiaryamineasdonors.Inthispaper,wereporttheaboveresultsandexplainsomephenomen… 相似文献
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综述了近年来手性烯丙基胺的合成进展, 重点介绍了催化剂配体对化学选择性和对映选择性的影响, 并阐述了各种类型的反应机理.手性; 烯丙基胺; 催化 相似文献
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Tobias Kaper Dennis Geik Felix Fornfeist Dr. Marc Schmidtmann Prof. Dr. Sven Doye 《Chemistry (Weinheim an der Bergstrasse, Germany)》2022,28(10):e202103931
Intermolecular hydroaminoalkylation reactions of symmetrical and unsymmetrical alkynes with tertiary amines take place in the presence of catalytic amounts of TiBn4, Ph3C[B(C6F5)4], and a sterically demanding aminopyridinato ligand precursor. The resulting products, synthetically and pharmaceutically useful tertiary β,γ-disubstituted allylic amines, are formed in convincing yields and with excellent stereoselectivity. Particularly promising for future applications is the fact that even the industrial side product trimethylamine can be used as a substrate. 相似文献
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通过氮α-位碳自由基构造氮α-位碳-碳键是合成含氮有机化合物的重要方法. 近期, 利用可见光催化氧化芳香叔胺—氮α-位去质子化形成氮α-位碳自由基的原理发展了一系列新颖的自由基加成(偶联)反应, 成为氮α-位碳自由基化学发展的重要方向. 本文应用Ir-催化剂, 实现了光催化氧化还原体系中硝酮与芳香叔胺的自由基偶联反应, 高效地合成β-氨基羟胺化合物. 该反应条件温和、操作简单, 具有较高的原子经济性, 且对于各种链状、环状以及手性硝酮都具有良好的适用性, 产物可方便地转化为重要的邻二胺化合物. 相似文献
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Dr. Shuya Liu Zhiguo Zhao Prof. Dr. Yao Wang 《Chemistry (Weinheim an der Bergstrasse, Germany)》2019,25(10):2423-2441
N-Heterocycles have been found in a large number of natural products, drug molecules, and bioactive compounds, and they thereby play a vital role in diverse research disciplines including drug discovery, organic synthesis, chemical biology, and material science. To this end, the development of new methods and strategies for the construction of N-heterocyclic frameworks is arguably one of the most dynamic and significant research areas in organic synthesis. One of these powerful approaches to the synthesis of N-heterocycles is to establish cyclization reactions based on the transformation of tertiary amines, which has emerged as an attractive research topic. In this Minireview, the significant achievements in the construction of N-heterocycles through cyclization of tertiary amines are highlighted and a comprehensive overview of the rational design, development, and application of these synthetic methods is presented. 相似文献
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Dmitry L. Lipilin Alexander E. Frumkin Alexey Y. Tyurin Vitalij V. Levin Alexander D. Dilman 《Molecules (Basel, Switzerland)》2021,26(11)
A reaction of aromatic halides bearing electron-withdrawing groups with tertiary amines in the presence of an iridium catalyst under blue light irradiation is described. Products of the aromatic substitution of the halide by the dialkylamino fragment are obtained. The interaction of aryl radicals with tertiary amines to generate zwitterionic radical species is believed to be the key factor responsible for the reaction efficiency. 相似文献
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《Analytical letters》2012,45(8):699-707
Abstract A gas chromatographic method for the determination of tertiary amines in micro- and nanogram amounts is presented. The tertiary amine is reacted with ethyl chloroformate to form a urethan, which is cleaved to a secondary amine. This is transformed to heptafluoro-butyramide, which makes quantitative determination with electron capture detection possible. The yields of the secondary amines for two tertiary amines were 60 and 75%. By use of internal standard technique in the entire reaction recoveries of 97.6 ± 2.2% at the 100 μg level and 100 ± 4% at the 200 ng level were obtained. 相似文献
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以环氧氯丙烷为桥接, 将具有较强给电子能力的芳叔胺(ATA)结构引入香豆素衍生物C分子中, 通过芳叔胺结构的光化学促进作用加速香豆素基元的光二聚反应. 用紫外(UV)和荧光(FL)光谱等手段对该香豆素衍生物进行表征. 结果表明, 芳叔胺结构的引入可有效增强香豆素基元在260-400 nm之间的吸收. 紫外点光源光二聚反应实验表明, 芳叔胺结构的引入使香豆素基元的光响应性能得以大幅增强, 在相同光照条件下, 其在匀速反应区间内对光照时间的依赖性的斜率高达6.47, 光二聚反应程度达到80%时所需光照时间仅为29 s. 相似文献
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N-Acyloxyammonium salts were isolated in reactions of diacyl peroxides with trialkylamines in the presence of sodium tetraphenylborate at low temperature. These salts are intermediates in reactions of organic peroxides with trialkylamines, which follow the nucleophilic substitution pattern. 相似文献
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Savelova V. A. Popov A. A. Petrova T. D. Platonov V. E. Mikhailov V. A. 《Theoretical and Experimental Chemistry》2003,39(1):25-29
A mechanism is proposed for the substitution of the first halogen atom in N-pentafluorophenylcarbonimidoyl dihalides (ArFN=CX2, X = Cl, Br) by aliphatic amines and includes a tetrahedral intermediate (T
E
). In the case of the reactions of primary and secondary amines the rate-limiting stage is the formation of the intermediate, and in the case of tertiary amines it is stereomutation of the intermediate (T
E
) to the thermodynamically more stable configuration (T
Z
). In the case of all the amines the final product (the Z isomer) is formed from the configuration (T
Z
). 相似文献
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Kiyoshi Matsumoto Shiro Hashimoto Masao Hashimoto Mitsuo Toda Sinichi Otani 《合成通讯》2013,43(5):787-792
Consecutive SNAr-dealkylation reactions of chlorodiazines such as 2-chloropyrimidine and 3, 6-dichloropyridazine with tertiary amines took place in a highly selective fashion. 相似文献
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(45):14352-14356
Described herein is a selective way to control the reaction of allylic amines with metalorganic bases depending on the amine handle as well as the metalorganic base is used. Depending on the number of coordinating groups within the amine handle either a selective carbometalation or deprotonation reaction can be performed. By changing the alkali metal within the base from lithium to either sodium or potassium, a change of chemoselectivity takes place and the reaction of piperidinoallylamine can be controlled. 相似文献
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Aditya Kherudkar Angana Bhattacharjee Akash Nawkhare Soumi Mukherjee Sukhendu Pramanick Dr. Joydev K. Laha 《Chemical record (New York, N.Y.)》2023,23(10):e202300063
Aldehydes serve as the key functional group in organic synthesis and are valuable intermediates. The various advanced methods of direct formylation reactions have been reviewed in this article. Overcoming the drawbacks of the traditional methods of formylation, newer methods involving homo and heterogenous catalysts, one pot reactions, solvent free techniques are elaborated, which can be performed under mild conditions and using inexpensive resources. 相似文献
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The reactions of 3,7-dinitrodibenzobromolium salt with some amines were studied. A reaction mechanism based on the structure of the major product 6 and the minor product 7 was proposed. The reaction was considered to proceed via a substituted benzyene intermediate. 相似文献
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以不对称长链叔胺为中性载体的PVC膜PH电极的研究 总被引:2,自引:0,他引:2
合成了一系列不对称长链叔胺类化合物作中性载体,研制成PVC膜pH电极。其中(2-羟基苄基)二正癸胺、(β-氰乙基)LA-2、(2-羟基苄基)LA-2的电极线性范围分别为pH2.5~12.5、pH2.5~12.5、pH3.0~12.5,斜率分别为56.6±0.4mV/pH、56.3±0.7mV/pH、55.9±0.3mV/pH(30℃)。这些pH电极内阻低,响应速度快,性能较稳定,可用于血清样中的pH值测量。此外,以(2-羟基辛基)LA-2为载体可制成流通式PVC膜pH内电极型氨气敏电极。 相似文献