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This review is a literature survey of antipyrine, considered as one of the most valuable compounds in the fields of organic and medicinal chemistry. The biological importance, synthetic procedures, and reactions are discussed. Generally, the preparation of antipyrine was reported through the methylation of the corresponding 1H-pyrazolone following different reaction conditions. The reactions, in general, are electrophilic substitutions at C4-position of pyrazolone. The mechanistic pathways of the reactions are surveyed. 相似文献
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This review describes the chemistry of 2,3-dihydroxynaphthalene and the related analogues. The synthetic routes reported to obtain the investigated structures are discussed. In addition, the reactivity and the synthesis of fused heterocyclic systems containing one or two heteroatoms are discussed. The compounds derived from 2,3-dihydroxynaphthalene are located in the basic skeleton of several natural drugs. The products were applied in the fields of polymer chemistry, physical chemistry, and medicinal chemistry. The different sections cover: methods of preparation, reactions, heterocyclic systems, macrocycles, organosilicon derivatives, coordination chemistry, and biological importance. The assessment relates to the recent reports and contains a short, targeted survey of the title compound for the past 15 years. 相似文献
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本文总结了近十年来多核苷酸合成化学的进展,重点论述了核苷和核苷酸的区域选择酰化反应,亲核性催化的保护基和新近发展的核苷酸间键合的形成方法。 相似文献
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Etify Abdel-Ghafar Bakhite 《Phosphorus, sulfur, and silicon and the related elements》2013,188(5):929-992
The nomenclature, synthesis, and reactions of various isomeric thienopyridines as well as their applications are reviewed. 相似文献
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本文着重对最近几年来有机硒和碲化合物在有机合成中的应用进行了简要的综述。现在就硒和碲化合物作为反应试剂、在有机分子中引入硒和碲的方法以及从有机分中除去硒和碲的方法三个方面进行了讨论。由此也可见,有机硒和缔化合物在有机合成中的重要性。 相似文献
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The focus of this review is on the structure, methods of syntheses, chemical reactivity, and biological activity of 2,4-azepandione and some derivatives. Some important fused-ring systems containing 2,4-azepandione moiety were also reviewed. 相似文献
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The focus of our review is on the methods of synthesis and chemical reactivity of 2-pyridone and some derivatives as 2-chloro-3-nicotinonitrile in addition to the biological activity of the 2-pyridone moiety. 相似文献
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The chemistry of boron clusters has been dominated by icosahedral carboranes for over half a century. Only in recent years has significant progress been made in the chemistry of supercarboranes (carboranes with more than 12 vertices). A number of CAd (carbon‐atoms‐adjacent) 13‐ and 14‐vertex carboranes, and CAp (carbon‐atoms‐apart) 13‐vertex carboranes as well as their corresponding 14‐ and 15‐vertex metallacarboranes have been successfully prepared and structurally characterized. This breakthrough relied on the use of CAd nido‐carborane dianions as starting materials. These supercarboranes can undergo single‐electron reduction to give stable supercarborane radical monoanions with [2n+3] framework electrons, and electrophilic substitution reaction to afford hexasubstituted supercarboranes. They can react with nucleophiles to offer monocarba‐closo‐dodecaborate monoanions from cage‐carbon extrusion reactions. Their unique chemical properties make the chemistry of supercarboranes distinct from that of their 12‐vertex analogues. These studies open up new possibilities for the development of polyhedral clusters of extraordinary size. This focus review offers an overview of recent advances in this growing research field. 相似文献
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Risto S. Laitinen 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3-4):777-782
Recent progress in imidoselenium chemistry is reviewed. Selenium diimides are thermally unstable and decompose forming a number of cyclic selenium imide derivatives Se3(NR)2, Se3(NR)3, Se6(NR)2, Se9(NR)6, OSe(μ-NR)2SeO, RNSe(μ-NR)2SeO, and RNSe(μ-NR)2SO2 (R = t Bu or adamantyl). All species have been structurally characterized. The experimental and theoretical evidence for the possibility of [2 + 2] cyclodimerization of selenium diimides is discussed. 相似文献
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This review highlights the methods used for the synthesis of 3-oxo-N-(pyridin-2-yl)butanamide compounds. The reactivity and synthetic importance are investigated. In this context, recent progress in the synthesis and use of 3-oxo-N-(pyridin-2-yl)butanamide as precursors for heterocyclic compounds is reviewed. The synthetic routes for preparation of 3-oxo-N-(pyridin-2-yl)butanamide are based on the reaction of diketene with aromatic primary amine and reaction of 2-aminopyridine with β-keto-t-butylthioester or ethylacetoacetate. The bibliography includes 73 references. 相似文献
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本文简要介绍了2005年至今有机合成领域的进展,第一部份有机合成方法学的一些新进展中突出介绍了金属参与的有机合成反应、自由基介导的合成反应、"一个反应瓶"内的多步反应以及不对称反应四个方面;第二部份复杂天然产物全合成则以10个分子的为例介绍这方面的进展。 相似文献