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Abbas Shockravi Hashem Shargi Hassan Valizadeh Majid M. Heravi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(11):2555-2559
An efficient synthesis of 3-substituted coumarins under solventless system is described. 相似文献
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Harish R. Talele Firasat Hussain Ashutosh V. Bedekar 《Journal of heterocyclic chemistry》2015,52(3):914-918
The phenomenon of peri interaction of 1,8‐disubstituted naphthalene has been utilized to construct small molecules with internal twist resulting in helical isomers. A series of new naphthalene‐attached coumarins have been synthesized and characterized. The helical conformational twist in thiophene–coumarin capped naphthalene was established by H‐NMR and single crystal X‐ray diffraction analysis. 相似文献
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3-Alkyl coumarins are reported to have anthelmintic, hypnotic and insecticidal properties1–3. Here we report a novel general method for the synthesis of 3-alkylated coumarins. This involves direct C-alkylatioa at the C-3 position of 3-carbethoxy-3,4-dihydrocoumarin followed by hydrolysis, decarboxylation and dehydrogenation of the resulting dihydrocoumarin. 3-Methyl-, 3-ethyl-, 3-n-pro-pyl-, and 3-benzylcoumarins have been synthesised in good yields following the same procedure depicted in the Scheme-1. 相似文献
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Synthesis and Antimicrobial Activities of Some Triazole,Thiadiazole, and Oxadiazole Substituted Coumarins
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K. Rajasekhar Reddy R. Mamatha M. S. Surendra Babu K. Shiva Kumar K. N. Jayaveera G. Narayanaswamy 《Journal of heterocyclic chemistry》2014,51(1):132-137
Ethyl‐2‐(4‐methyl‐2‐oxo‐2‐coumarin‐7‐yloxy)acetate 1 has been prepared from 7‐hydroxy‐4‐methyl‐2‐coumarin, which on further treatment with hydrazine hydrate in boiling ethanol gave the hydrazide compound 2 . The resulting hydrazide was reacted with substituted aryl isothiocyanates to form thiosemicarbazides compounds 3a , 3b , 3c , 3d , 3e . 1‐(2‐(4‐Methyl‐2‐oxo‐2‐coumarin‐7‐yloxy)acetyl)‐4‐aryl thiosemicarbazides 3 underwent cyclization with different reagents under different reaction conditions to furnish coumarin derivatives possessing triazoles 4a , 4b , 4c , 4d , 4e , thiadiazoles 5a , 5b , 5c , 5d , 5e , and oxadiazoles 6a , 6b , 6c , 6d , 6e , respectively. The structures of all the compounds have been assigned by elemental analysis and spectral studies. The synthesized compounds were screened for their antimicrobial analgesic activities. The nonconventional controlled microwave irradiation synthesis is carried out at (200 W) at 70°C. This approach offers a number of advantages in terms of methodology, high‐product yield, short reaction time, mild reaction conditions, environmentally benign, and easy workup. 相似文献
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Zakharov D. O. Lipeeva A. V. Gatilov Yu. V. Makarov A. G. Shults E. E. 《Russian Journal of Organic Chemistry》2019,55(10):1518-1526
Russian Journal of Organic Chemistry - Umbelliferone-6-carbonyl chloride reacted with amines and α-, β-, and ω-amino acid methyl esters to afford the corresponding N-substituted... 相似文献
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M. M. Garazd Ya. L. Garazd S. V. Shilin V. P. Khilya 《Chemistry of Natural Compounds》2000,36(5):478-484
5-Phenyl-7H-furo[2,3-g]chromen-7-ones and 9-phenyl-7H-furo-[2,3-f]chromen-7-ones, new analogs of psoralen and allopsoralen, are synthesized from 7-hydroxy- and 5-hydroxy-4-phenylcoumarins 相似文献
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香豆素是一类苯并六元含氧杂环类化合物,具有抗氧化、抗菌、抗炎等多种生理活性,受到人们的广泛关注。近年来不断有香豆素的新合成方法报道,特别是高效的过渡金属钯催化合成反应。本文综述了近20年来钯络合物催化合成香豆素骨架的研究进展,主要包括羰基化反应、炔烃芳基化反应、烯烃芳基化反应和偶联反应,以期为合成新型香豆素提供参考。 相似文献
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K. Shivashankar Manohar V. Kulkarni Lokesh A. Shastri Vijaykumar P. Rasal Sandur V. Rajendra 《Phosphorus, sulfur, and silicon and the related elements》2013,188(9):2187-2200
Various 4-aryloxymethylcoumarins have been obtained by the r.t. allylic substitution with formylphenols. These have been further reacted with o-aminothiophenol resulting in the formation of a benzothiazole skeleton. These compounds have been synthesised with a view to study their potential as microbial growth inhibitors. Comparative studies on the spectral and antimicrobial activities have also been carried out. 相似文献
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Chui Lin RONG Xin Cheng LIAO Jian Chen ZHANG Shu Xia CAO Lun LIU Yu Fen ZHAO 《中国化学快报》2005,16(9):1140-1142
Different hydroxy substituted coumarins were successfully phosphorylated with diisopropylphophite (DIPPH) by the Atherton-Todd reaction in 76-89% yields. Moreover, the reaction activities of different hydroxys of the coumarins in the Atherton-Todd reaction were studied. 相似文献
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Two coumarins isolated from Aster praealtus were synthesized via a direct coupling of the corresponding cyclohexyl carbinol with a coumarin‐derived aryl bromide or iodide, a very difficult etherification due to the excess steric congestion around the carbinol and the low reactivity of the aryl halide that frustrated many seemingly feasible protocols. Unequivocal 1H and 13C NMR data for these compounds were thus made available for the first time. Uncertainty and errors in 1H and 13C NMR data in previous reports are also eliminated and revealed, respectively. 相似文献
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Summary. The 1:1:1 adduct which originates from the reaction of triphenylphosphine, dialkyl acetylenedicarboxylate, and 3-formyl-4-hydroxycoumarin undergoes an intramolecular Wittig reaction to provide a series of unique 2H,5H-pyrano[3,2-c][1]benzopyran-5-ones (pyranocoumarins). 相似文献
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Abbas Shockravi Hassan Valizadeh Majid M. Heravi 《Phosphorus, sulfur, and silicon and the related elements》2013,188(3):501-504
An efficient and facile preparation of simple coumarins via in situ Wittig reaction of salicylaldehydes, triphenylphosphine, and chloroethylacetate supported on MgO in satisfactory yields in solvent-free condition. 相似文献
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Prabhjot Kaur Rupinder Kaur Gill Gagandip Singh Jitender Bariwal 《Journal of heterocyclic chemistry》2016,53(5):1519-1527
Two series of coumarins possessing the aniline‐ and heterocyclic ring at 4th position have been synthesized and evaluated for their in vitro cytotoxic activity against MCF‐7 cancer cell line in MTT assay. Structure activity relationship (SAR) studies reveal that the electron donor group at position‐8 of coumarin played an important role in cytotoxic activity. Compound VIId showed the potent cytotoxic activity followed by compound Xa with IC50 = 6.25 and 6.50 μM, respectively. A docking study has also been carried out for the most potent compound to get an insight into molecular interactions with p50 subunit of NF‐κB protein. 相似文献