Ammonium Chloride–Catalyzed One-Pot Synthesis of Tetrahydrobenzo[α]xanthen-11-one Derivatives Under Solvent-Free Conditions

A one-pot, multicomponent reaction of aldehydes, dimedone, and β-naphthols is described for the preparation of 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[α]xanthen-11-one derivatives using ammonium chloride as a mild, inexpensive, and environmentally benign catalyst under solvent-free conditions. Different types of aldehyde and β-naphthol derivatives are used in the reaction, and in all cases the products were synthesized successfully.

One-Pot Synthesis of β-Phosphonomalonates Catalyzed by Molecular Iodine

A one-pot procedure has been developed for the synthesis of β-phosphonomalonates via P-C bond formation through tandem Knoevenagel–phospha–Michael reaction catalyzed by iodine as a new, inexpensive, nonmetallic, and commercially available catalyst.

[Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications® for the following free supplemental resource(s): Full experimental and spectral details.]     

Molecular Iodine–Catalyzed Synthesis of 1,2,3,6-Tetrahydropyrimidines

A short and simple synthesis of tetrahydropyrimidine derivatives were accomplished in good to excellect yields at room temperature by the reaction of dimethylacetalynedicarboxylate, aniline, and formaldehyde in the presence of 5 mol% of molecular iodine at room temperature in ethanol for 5 min.     

Caro's Acid–Silica Gel: An Efficient and Versatile Catalyst for the One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives

An efficient one-pot synthesis of tetrahydrobenzo[b]pyran is described. This involved the three-component reaction of aromatic aldehydes, molononitrile, and dimedone in the presence of a catalytic amount of Caro's acid supported on silica gel in ethanol/water under reflux.     

Sulfamic Acid–Catalyzed,Three-Component,One-Pot Synthesis of [1,2,4]Triazolo/Benzimidazolo Quinazolinone Derivatives

An efficient and convenient approach is reported for three-component, one-pot synthesis of the [1,2,4]triazolo/benzimidazolo quinazolinones by condensation of 2-amino benzimidazole or 3-amino-1,2,4-triazole as amine sources with dimedone and different aldehydes in the presence of sulfamic acid as a reusable, green catalyst in acetonitrile and under heating conditions.     

One-Pot Synthesis of Tetrahydrobenzo-[b]-pyran Derivatives in Aqueous Media

In modem organic chemical research, 4H-benzo-[b]-pyran and their derivatives have attracted strong interest due to their useful biological and pharmacological properties. Herein, we report a clean one-pot synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydro-benzo-[b]-pyrans from aromatic aldehyde, malononitrile and 5,5-dimethyl-1,3-cyclohexadione using hexadecyl trimethyl ammonium bromide (HTMAB) as the catalyst. This method provides several advantages such as high yield, simple work-up procedure and environmental friendliness. All the products were characterized by 1H NMR and IR analyses.     

Synthesis and Crystal Structure of Calix[4]arene Bearing a 1,8-Bis（propoxy）anthracene-9,10-dione

The title complex （C50H44C14O8） was synthesized and structurally determined by single-crystal X-ray diffraction method. It crystallizes in monoclinic, space group P21/n with a = 19.7768（4）, b =10.2085（2）, c = 21.2721（4）A,β= 97.153（1）°, V = 4261.23（14）A^3, Z = 4, Mr = 914.65, F（000） = 1904, Dc = 1.426 g/cm^3,μ = 0.336, the final R = 0.0550 and wR = 0.1647. The compound was structurally characterized by IR and ^1H NMR. The molecules are stacked through C-H...π interactions and intermolecular C-H...O hydrogen bonds.     

Ionic Liquid–Catalyzed One-Pot Synthesis of 1H-Pyrano[2,3-d]pyrimidin-2(8aH)-one Derivatives via Three-Component Reaction under Solvent-Free Conditions

A series of 1H-pyrano[2,3-d]pyrimidin-2(8aH)-one derivatives were synthesized via one-pot, three-component reaction of aromatic aldehydes, urea or thiourea, and 3,4-dihydro-2H-pyran using the green and inexpensive Brønsted acidic ionic liquid 1-methyl-2-pyrrolidinone hydrosulfate ([Hnmp]HSO₄) as catalyst under solvent-free conditions. The method has several advantages such as mild conditions, shorter reaction time, good yields, and environmentally benign procedure. Moreover, the catalyst could be recovered conveniently and reused at least four times without evident loss of activity.     

Fe3O4–SiO2–Bi2O3-catalyzed One-Pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives Under Solvent-Free Conditions

Russian Journal of Organic Chemistry - A Fe3O4–SiO2–Bi2O3 magnetic nanocatalyst was used to synthesize tetrahydrobenzo[b]pyran derivatives from malononitrile, cyclohexane-1,3-dione, and...     

Tungstophosphoric Acid–Catalyzed Imino-Diels–Alder Reaction: An Efficient One-Pot Synthesis of Pyrano- and Furanoquinoline Derivatives

Tungstophosphoric acid has been found to be an efficient catalyst for the synthesis of pyranos- and furanoquinolines through the Imino-Diels–Alder reaction involving one-pot coupling of benzaldehydes, anilines, and 3,4-dihydro-2 H-pyran or 2,3-dihydrofuran. The products are formed at room temperature in excellent yields in a short period of time.     

Phase Transfer–Catalyzed,One-Pot Synthesis of Some Novel N-Pyrimidinyl-N′-nicotinyl Thiourea Derivatives

Abstract

A new series of acyl thiourea derivatives were synthesized in one-pot using PEG-600 as the phase transfer catalyst (PTC). The structures of title compounds were characterized by ¹H NMR, IR, MS, and elemental analysis. In addition, the fungicidal activity of the acyl thiourea derivatives were tested, which showed that most of them exhibit moderate activity.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

GRAPHICAL ABSTRACT      

Solvent-Free One-Pot Synthesis of Spiro[indoline-3,4′(1H′)-pyrano[2,3-c]pyrazol]-2-one Derivatives by Grinding

The solvent-free one pot synthesis of spiropyranyl-oxindole in the presence of NaHCO₃ under grinding has been achieved. This process is simple, fast, efficient and environmentally benign.      

H6P2W18O62·18H2O–Catalyzed,Three-Component,One-Pot Synthesis of Indeno[1,2-b]quinoline-7-one Derivatives

In this work, a rapid and efficient one-pot method for the synthesis of indeno[1,2-b]quinoline-7-one derivatives by condensation of 1-naphthylamine, 1,3-indanedione, and different aldehydes in the presence of H₆P₂W₁₈O₆₂·18H₂O as a green and reusable catalyst in refluxing acetic acid is described.     

Fluoroboric Acid Adsorbed on Silica-Gel–Catalyzed Synthesis of 14-Aryl-14H-dibenzo[a,j]xanthene Derivatives

A simple and efficient procedure has been developed for the preparation of 14-aryl-14H-dibenzo[a,j]xanthene derivatives using fluoroboric acid adsorbed on silica gel as a heterogeneous catalyst. The methodology involves the one-pot condensation reaction of β-naphthol and aryl aldehydes under solvent-free conventional heating conditions. The present approach offers several advantages such as shorter reaction times, simple work-up, excellent yields, low cost, and mild reaction conditions. The catalyst is easily recoverable and reusable without loss of its catalytic activity.     

Synthesis of Bicyclo[3.2.1]-octanone Derivatives by Metal Catalyzed Decomposition of α-Diazomethylketones

Highly functionalized bicyclo[3.2.1]-octanone derivatives have been prepared by metal catalyzed decompostion of diazoketones through a net retention of configuration at the benzylic center.

     

Nickel‐Catalyzed Electrochemical Synthesis of Dihydro‐Benzo[b]thiophene Derivatives

Abstract

The intramolecular electrochemical reductive cyclization of ortho‐haloaryl allyl thioethers catalyzed by Ni(II) complexes associated to cyclam ligands affords dihydro‐benzo[b]thiophene derivatives in moderate to good yields.     

One-Pot Synthesis of Thieno[2,3-b]pyridine and Pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine Derivatives

Russian Journal of Organic Chemistry - 2-Acyl-4,5,6-trialkyl-3-aminothieno[2,3-b]pyridines,...