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1.
Daniel R. Zuidema Sarah L. Williams Katherine J. Wert Karin J. Bosma Abigail L. Smith Robert C. Mebane 《合成通讯》2013,43(19):2927-2931
Aryl ketones are readily deoxygenated to their corresponding aryl alkanes upon treatment with Raney nickel catalyst in boiling 2-propanol.
2.
The dehydration of aldoximes and amides, and oxidation of benzoin are accomplished in one-pot using in situ–generated Burgess-type reagent.
Keywords: Amide, benzil, benzoin, Burgess reagent, Burgess-type reagent, dehydration, nitrile, oxidation, oxime
3.
Oleksandr P. Dacenko Olga V. Manoylenko Pavel K. Mykhailiuk Dmitriy M. Volochnyuk Oleg V. Shishkin 《合成通讯》2013,43(7):981-992
An improved synthesis of Boc-monoprotected 5- and 6-amino-2-azanorbornanes is reported. The synthetic scheme consists of five steps and allows multigram quantities of the title compounds to be obtained. The regio- and stereochemistries of the products are established by two-dimensional NMR experiments.
4.
A new synthesis of 3-methoxypropanal from glycerol was presented. With this new approach, the conversion of glycerol to 3-methoxypropanal can be effected in moderate yield using catalysts of copper sulfate and polyethylene glycol (PEG).
5.
Synthesis of dibenzoxanthenes through condensation of β-naphthol with various aromatic and aliphatic aldehydes in ethanol as an ecofriendly solvent using RuIII as catalyst is reported.
6.
Selective reduction of the nitro group in methyl 1-(2-nitrophenyl)-4-oxo-cyclohex-2-enecarboxylates with zinc-acetic acid forms hexahydrocarbazoles. The reaction is applicable to the corresponding pyridyl analogs to generate azahexahydrocarbazoles. This provides an efficient method for the generation of tricyclic framework.
7.
An efficient, safe, and viable process has been developed for large-scale preparation of salidroside, a natural product. The process consists of two chemical steps, which produce the salidroside on a multikilogram scale with 72% overall yield and >98% purity. A series of novel salidroside analogs were prepared according to the same method.
8.
In a short reaction time, acyl chlorides and dry tetrahydrofuran react in the presence of a catalytic amount of magnesium turnings (Mg) at 25 °C to give 4-chlorobutyl esters in excellent yields.
9.
An efficient one-pot synthetic strategy for 2-aminobenzoxazoles was developed from isothiocyanates and 2-aminophenol using triflic acid as a cyclodesulfurizing reagent.
10.
Dao M. Nguyen 《合成通讯》2013,43(12):1759-1771
Copper iodide was employed as an efficient catalyst for the synthesis of 1,2,3-triazole derivatives of podocarpic acid at room temperature through “click” chemistry cycloaddition reactions of methyl O-propargylpodocarpate and propargyl O-propargylpodocarpate with azides.
11.
Abdullah Saad Al-Bogami 《合成通讯》2013,43(19):2952-2958
Reaction of 2-acetyl-1-naphthol with aliphatic amines under microwave irradiation gave the corresponding imines (Schiff bases), which were treated with triphosgene to give 4-methylene-1,3-naphthoxazines in good yields.
12.
A three-component reaction of trialkyl(aryl) phosphites, dialkyl acetylenedicarboxylates, and arylsulfonamides is described as a simple and efficient route for the synthesis of dialkyl 2-(arylsulfonylamino)-3-(dialkoxyphosphoryl)-succinates in good yields.
13.
In this study, silica-supported titanium tetrachloride was prepared and used as a novel catalyst for rapid and efficient synthesis of 2,4,5-trisubstituted imidazoles by a three-component, one-pot condensation of 1,2-diketones and aryl aldehydes in excellent yield under solvent-free conditions using conventional heating or microwave irradiation.
14.
A simple and efficient method has been developed for the synthesis of sulfonamide phosphonates from N-tosyl aldimines and dimethyl trimethylsilyl phosphite at 0 °C in the presence of Amberlyst-15 as a heterogeneous catalyst.
15.
Recyclable Siloxy Serine Organocatalyst for the Direct Asymmetric Mannich Reactions in Ionic Liquids
Fui-Fong Yong 《合成通讯》2013,43(9):1293-1300
A recyclable siloxy-L-serine organocatalyst has been developed to catalyze the asymmetric direct three-component Mannich reactions in ionic liquid hmim[PF6], furnishing the β-amino carbonyl scaffold in high enantio- and diastereoselectivities. The direct Mannich reaction between a selection of aromatic aldehydes and ketones resulted in good yields and high enantioselectivities.
16.
A new and efficient method for the demethylation of 6-membered aza-heterocyclic methyl ethers is described using lithium chloride and para-toluenesulfonic acid. This process is chemoselective for aza-heterocyclic methyl ethers in the presence of aryl methyl ethers.
17.
Naser Foroughifar Akbar Mobinikhaledi Hassan Moghanian Reza Mozafari Hamid R. M. Esfahani 《合成通讯》2013,43(18):2663-2673
A one-pot, multicomponent reaction of aldehydes, dimedone, and β-naphthols is described for the preparation of 12-aryl- or 12-alkyl-8,9,10,12-tetrahydrobenzo[α]xanthen-11-one derivatives using ammonium chloride as a mild, inexpensive, and environmentally benign catalyst under solvent-free conditions. Different types of aldehyde and β-naphthol derivatives are used in the reaction, and in all cases the products were synthesized successfully.
18.
The one-pot synthesis of spirooxindoles via three-component reaction of urea, isatin, and 1,3-dicarbonyl compounds in the presence of a catalytic amount of p-toluenesulfonic acid in acetonitrile has been carried out.
19.
A versatile class of 2-aminopyrroles containing various electron-withdrawing substituents at the 3-position have been N-arylated on the amine using a palladium-catalyzed cross-coupling reaction. Using this methodology, a pyrimidone-based tricyclic system has been prepared in just one step from a starting 2-aminopyrrole.
20.
Formation of 1-aryl-4-oxo-cyclohexa(e)nonecarboxylates from the Diels–Alder cycloaddition of 2-trimethylsilyloxy-1,3-butadiene and Danishefsky diene with aryl- and pyridylacrylates and further conversion thereof to spirocycles is described. This provides an efficient method for spiro oxindoles, azaoxindoles, and dihydroisoquinolones.