Synthesis and biological activity of 5'-aminobenzoxazinorifamycin derivatives.

Benzoxazinorifamycin reacted with various secondary amines to yield various 5'-substituted aminobenzoxazinorifamycin derivatives. The derivatives exhibited potent activities against gram-positive bacteria and mycobacteria. The antimicrobial activities of these compounds against Mycobacterium tuberculosis and Mycobacterium intracellulare were superior to those of rifampicin. Some of these compounds showed good plasma levels after oral administration in rats.     

海洋珊瑚中抗肿瘤活性物质及其提取、分离方法

珊瑚主要生长在热带、亚热带海洋中，资源非常丰富且具有显著的生物多样性。研究表明，海洋珊瑚中含有许多结构多样、生理活性独特的次生代谢产物。本文概要地介绍了从珊瑚中发现的具有抗肿瘤活性的各种萜类和甾类化合物的来源、结构、抗肿瘤活性和提取、分离方法，同时展望了海洋药物的研究与开发前景。     

A Review on the Extraction,Bioactivity, and Application of Tea Polysaccharides

Tea is a non-alcoholic drink containing various active ingredients, including tea polysaccharides (TPSs). TPSs have various biological activities, such as antioxidant, anti-tumor, hypoglycemic, and anti-cancer activities. However, TPSs have a complex composition, which significantly limits the extraction and isolation methods, thus limiting their application. This paper provides insight into the composition, methodological techniques for isolation and extraction of the components, biological activities, and functions of TPSs, as well as their application prospects.     

Updates on synthesis and biological activities of 1,3,4-oxadiazole: A review

The new era of heterocyclic moieties which are developed in the decades plays a very important role in the treatment of various diseases. Among them are 1,3,4-oxadiazoles, a heterocyclic five-membered ring which plays an vital role in the development of newer medicinal compounds for treating various biological activities, such as proliferation of cells, tuberculosis, allergy, viral diseases, etc. The present review will summarize the various synthetic approaches which will be correlated with the biological activities so that the information in future may be used by many researches to give a path breaking lead in the field of medicinal chemistry.     

Current perspectives on quinazolines with potent biological activities: A review

Quinazoline is a heterocyclic compound having biological activities. It is aromatic in nature having bicyclic structure containing benzene ring and pyrimidine ring. Quinazoline and its derivatives are found to have wide range of biological activities that is anticancer, analgesic, antimicrobial, antihypertensive, anticonvulsant, antimalarial, antitumor, and anti-tubercular activities. The purpose of this review is to highlight the recent researches made by researchers on various biological activities of quinazoline derivatives on different targets.     

A Review of Diterpenes from Marine-Derived Fungi: 2009–2021

Marine-derived fungi are important sources of novel compounds and pharmacologically active metabolites. As an important class of natural products, diterpenes show various biological activities, such as antiviral, antibacterial, anti-inflammatory, antimalarial, and cytotoxic activities. Developments of equipment for the deep-sea sample collection allow discoveries of more marine-derived fungi with increasing diversity, and much progress has been made in the identification of diterpenes with novel structures and bioactivities from marine fungi in the past decade. The present review article summarized the chemical structures, producing organisms and biological activities of 237 diterpenes which were isolated from various marine-derived fungi over the period from 2009 to 2021. This review is beneficial for the exploration of marine-derived fungi as promising sources of bioactive diterpenes.     

Synthesis of 3-aryl pyrrolidines: A highlights

Pyrrolidine derivatives are very important families of heterocyclic compounds that show diverse biological activity. The substitution pattern and functionalization on these derivatives show different biological activities. Different substituted pyrrolidines shown to have different antibacterial effects. They are also used as scaffolds in the synthesis of unnatural oligomers which have various biological applications in the field of antidiabetic, anticancer, antimalarial, antiviral, antimicrobial, anti-inflammatory, and antibacterial activities . Numerous groups have synthesized substituted pyrrolidines and they constructed the pyrrolidine ring by the formation of various different bonds from acyclic precursors. Some of the groups have synthesized that derivatives only by reduction.     

Total synthesis of naturally occurring chiral cyclopropane fatty acids and related compounds

Cyclopropane fatty acids (CFAs) and related compounds containing CFAs commonly occur in various natural sources, including plants or microorganisms. Some CFAs exhibit intriguing biological activities such as antifungal or immunosuppressive activities. Due to their biological importance and structural features, a number of synthetic studies have been conducted to date. These total syntheses have helped to elucidate their structural determinants or biological activities. Herein the total syntheses of naturally occurring CFAs and related compounds are summarized.     

Coumarin–triazole Hybrids and Their Biological Activities

Hybridization is emerged as a promising strategy in the discovery of new drugs, especially these with complimentary activities and multiple pharmacological targets that are the potential weapons to prevent the drug resistance. Currently, several hybrids are under different stages of clinical trial, and may be introduced into clinical practice to treat various diseases in the near future. Triazoles including 1,2,3‐triazole and 1,2,4‐triazole as well as coumarins occupy an important position in medicinal chemistry attribute to their various biological activities, and some of them have been used in clinical practice. Obviously, hybridization of these two pharmacophores may lead to novel candidates with broader spectrum, more effective, lower toxicity, and multiple mechanisms of action. This review aims to outline the biological activities of coumarin–triazole hybrids, and discuss their structure–activity relationship to pave the way for the further rational development of this kind of hybrids.     

Solid-phase synthesis of isoquinolinones using Bischler-Napieralski cyclization

Isoquinolinone is a structural unit found in many natural products having various important biological activities. A traceless solid-phase synthetic approach has been developed to prepare isoquinolinone derivatives. This approach enables one to synthesize isoquinolinones having various moieties on benzene nuclei and also can produce derivatives with a proton on the amide nitrogen.     

Biological Potential of Thiazole Derivatives of Synthetic Origin

Thiazole and related nucleus are one of the most important potential entities in the largely growing chemical world of heterocyclic compounds exhibiting remarkable pharmacological activities. The knowledge of various synthetic pathways and diverse physicochemical parameters of such compounds draw the especial attention of medicinal chemists to produce combinatorial library and carry out exhaustive efforts in the search of lead molecules. The similar compounds synthesized through different routes bear variable magnitudes of biological activities. The present review highlights a broad view on biological activities of compounds having thiazole nucleus.     

Effect of the acidity of a zeolite and its modification with cerium and zirconium on the activity and thermal stability of Pd/beta in the reaction of deep toluene oxidation

Acidities of beta zeolites with various moduli and the catalytic activities of Pd/beta in the reaction of deep toluene oxidation were compared.     

强酸阳离子交换树脂催化性能的研究

通过叔丁醇脱水生成异丁烯的反应研究对比了国内外常见种类的凝胶型和大孔型强酸阳离子交换树脂的催化性能，并对树脂的性质，预处理方法，以及其用量和再生程度等因素对树脂催化活性的影响进行了研究。在此基础上，合成了具有较高催化活性的新型大孔强酸阳离子交换树脂。     

Synthesis and platelet aggregation inhibitory activities of 3-(2-oxopropylidene)azetidin-2-one derivatives. II.

A series of 3-acylidene-4-methylazetidin-2-one derivatives bearing various substituents at the 1-position of the azetidin-2-one ring was synthesized. These compounds were evaluated for platelet aggregation inhibitory activities. Most of the compounds synthesized showed potent inhibitory activities against rabbit platelet aggregation induced by adenosine diphosphate or collagen in vitro. Structure-activity relationships are also discussed.     

Condensation of benzyl chloride catalyzed by group II metals

The polymerization of benzyl chloride in the presence of various group II metal salts has been investigated. The extent of reaction and the relative activities of various salts were determined by measurement of the evolved HCl as a function of time. Formation, in situ, of an active catalyst is proposed.     

The Pro-Apoptotic Activity of Tamarixetin on Liver Cancer Cells Via Regulation Mitochondrial Apoptotic Pathway

Applied Biochemistry and Biotechnology - Based on the various pharmacological activities of tamarixetin, the present study investigated the cytotoxicity property of tamarixetin in human liver...     

Highly Sensitive to Methane Sensor Materials Based on Nano-Pd/SnO2

Theoretical and Experimental Chemistry - Catalytic activities of nanomaterials based on tin dioxide with various palladium contents in the oxidation of CH4 and sensitivities of adsorption...     

黄烷酮化合物的合成研究进展

黄烷酮化合物是自然界中广泛存在的一类具诸多生理活性的重要化合物，本文对近20年来黄烷酮化合物的合成研究进展进行了综述。     

Comparative superoxide dismutase activity studies

Our results indicate that the various methods for measurement of superoxide dismutase (SOD) activity differ considerably as regards sensitivity. The activity difference may be particularly striking in the determination of the SOD activities of crude homogenates, because of the large number of disturbing factors. We consider the epinephrine-adrenochrome method to be the most suitable for measurement of the SOD activities of crude homogenates and purified enzyme preparations.     

Planar catechin analogues with alkyl side chains: a potent antioxidant and an alpha-glucosidase inhibitor

Planar catechin analogues having various alkyl side chain lengths were synthesized, and their remarkable antioxidative abilities and alpha-glucosidase inhibitory activities are shown.