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1.
A facile and efficient method for synthesis of 3-arylthiazol-2(3H)-one through the reaction of acyl azide and 1,4-dithiane-2,5-diol was reported. This reaction proceeded at 80?°C at first and then in acidic condition at room temperature, to afford products in good yields for a wide range of substrates and a possible mechanism has also been proposed. 相似文献
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Yong Sun Bo-Qiao Fu Ming-Wu Ding 《Phosphorus, sulfur, and silicon and the related elements》2013,188(6):1437-1443
The isothiocyanates 2, obtained from aza-Wittig reactions of vinyliminophosphoranes 1 with CS 2 , reacted with hydrazine to give 3-amino-2-thioxo-4-imidazolidinones 4. One-pot reactions of 4, aromatic isocyanates, Ph 3 P, C 2 Cl 6 , and Et 3 N generated imidazo[2,1-b]-1,3,4-thiadiazol-5(6H)-ones 7. Compound 7 exhibited good fungicidal activities, especially against Sclerotinia sclerotiorum de Bary and Botrytis Cinerea Pers. 相似文献
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Anthranilonitrile reacting with formic acid at room temperature for three days gave 64% of 3-(2-cyanophenyl)quinazolin-4(3H)-one. Under similar conditions anthranilic acid. 4-nitroaniline, and 2,5-dichloroaniline were N-formylated in good yields.Institute of Organic Chemistry and Technology, Silesian Technical University, Krzywoustego, 4, 44–100 Gliwice, Poland; e-mail: wojtex@zeus.polsl.gliwice.pl. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 922–924, July, 2000. 相似文献
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S. Sh. Shukurov M. T. Karimova I. M. Nasyrov K. S. Zakharov R. A. Karakhanov 《Russian Chemical Bulletin》1994,43(4):702-704
A new type of dithiocarbamic acid derivatives,S-(2-X-ethyI) ethers ofN-(5R-1,3,4-thiadiazol-2-yl)-dithiocarbamic acids (X = CN, COOMe), has been synthesized by the reaction of sodiumN-(1,3,4-thiadiazol-2-yl) dithiocarbamates with acrylonitrile and methylacrylate.Deceased.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 4, pp. 749–750, April, 1994. 相似文献
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The reactions of some 5-aryl-1,3,4-oxadiazoline-2(3H)-thiones (aryl = phenyl, 4-bromophenyl, 4-methylphenyl, 2,4-dichlorophenyl) with N-alkyl- and N-arylchloroacetamides has been studied. The nature of the substituents in the molecules of the thiones and the chloroacetamides does not affect the direction of the reaction but does affect the yield of the desired products. 相似文献
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Ali Souldozi Samad Karami 《Phosphorus, sulfur, and silicon and the related elements》2016,191(6):867-870
(N-isocyanimino)triphenylphosphorane, 2-pyridinecarbaldehyde, and aromatic carboxylic acids (benzoic acid, 3-methylbenzoic acid, 4-methylbenzoic acid, 3-methoxybenzoic acid, 1-naphthoic acid, and 2-naphthoic acid) undergo a 1:1:1 addition reaction under mild conditions in a one-pot reaction to afford novel series of fully substituted 1,3,4-oxadiazole derivatives in good yields. 相似文献
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《Green Chemistry Letters and Reviews》2013,6(4):603-607
Abstract An efficient and convenient method for the preparation of 3-benzylquinazolin-4(1H)-one derivatives under solvent-free and catalyst-free conditions by the reaction of isatoic anhydride, benzylamine, and aromatic aldehydes was reported. In reported papers, ammonia water, ammonium salt, and aromatic amine were often used to synthesize quinazolin-4(1H)-one derivative, but benzylamine was seldom used in this synthesis. This article offers a green method for the synthesis of 3-benzylquinazolin-4(1H)-one derivative used benzylamine as starting material. This methodology has the advantages of short reaction time, mild reaction conditions, easy work-up, and environmental friendliness. 相似文献
8.
The Synthesis of 3-(2'-Hydroxybutyl) isobenzofuran-1 (3H)-one 总被引:1,自引:0,他引:1
l(3H】.Isobenzoturans(Dhthalldes】werereDortedtoexhibitawiderangeofbiologicalactivities.Forexample,3-n-butylphthallde(NB)exhibitsantlasthmatlc’,antlconvuls-ant“actlvltles.PenEandZhouhavestudiedonthemetabolismofNBPInrats‘.Theyfoundthat... 相似文献
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Vakhid A. Mamedov Vera L. Mamedova Victor V. Syakaev Gulnaz Z. Khikmatova Dmitry E. Korshin Temur A. Kushatov Shamil K. Latypov 《Tetrahedron letters》2018,59(44):3923-3925
The formation of 3-(2-nitrophenyl)pyruvic acid and its amide and ester derivatives – key compounds for the Reissert indole synthesis – was achieved under various reaction conditions via the acid catalyzed hydrolysis of 5-(2-nitrobenzyliden)-2,2-dimethyl-1,3-oxazolidin-4-one, which is readily available from 3-(2-nitrophenyl)oxirane-2-carboxamide. A new and highly efficient method for the synthesis of indole-2-carboxylic acid derivatives via the intramolecular reductive cyclization of o-nitrophenylpyruvic acid and its amide and ester derivatives was developed using Na2S2O4 in dioxane/water at reflux. 相似文献
10.
A practical and straightforward protocol has been developed for the preparation of 2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives from dithiocarbamate chemistry. The method involves the reaction of anthranilic acid derivatives (2-aminobenzoic acid, 2-aminobenzamide and isatoic anhydride) with various dithiocarbamate derivatives using ethanol as solvent. The main advantages of this protocol include practical simplicity, good to high yields, and ease of product isolation, purification and cheapness of the solvent. 相似文献
11.
《Arabian Journal of Chemistry》2019,12(7):1522-1531
A variety of novel 2-methylquinazolin-4(3H)-one derivatives (1–29) bearing urea, thiourea and sulphonamide functionalities at position 3 of biological interest have been synthesized and screened for their anti-inflammatory (TNF-α and IL-6) and antimicrobial activities (antibacterial and antifungal). “Biological evaluation study revealed that the compounds 3, 4, 6, 9, 16 and 18 were found to have promising anti-inflammatory activity (up to 62–84% TNF-α and 73–92% IL-6 inhibitory activity) at concentration of 10 μM with reference to standard dexamethasone (75% TNF-α and 84% IL-6 inhibitory activities at 1 μM) and 7, 10, 12, 23, 25 and 28 have antimicrobial activity at MIC of 10–30 μg/mL against selected pathogenic bacteria and fungi.” 相似文献
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Mahmoud R. Mahmoud 《合成通讯》2013,43(10):1516-1529
The title compound 1 was prepared and allowed to react with a series of nitrogen nucleophiles to afford the quinazoline and quinazolinone derivatives 2–12 and tetrazole derivative 13. The IR, 1H NMR, 13C NMR, and mass spectra of all the synthesized compounds were discussed. 相似文献
14.
A mild, efficient, and environmentally benign one-pot synthesis of functionalized chromeno[4,3-b]pyrrol-4(1H)-ones by a three-component domino reaction of 4-aminocoumarins, arylglyoxal monohydrates, and 1,3-dicarbonyl compounds in refluxing ethanol without the use of catalyst is reported. The present protocol features operational simplicity, short reaction time, good yields, and the absence of aqueous workup procedure and chromatographic separation. 相似文献
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The general synthesis and a novel intramolecular nucleophilic aromatic substitution (SNAr) reaction of 2-carboxamido-3-arylquinazolin-4-ones, a potentially useful scaffold in the field of medicinal chemistry, are described. The synthetic utility of the SNAr reaction as a tool for the synthesis of secondary aryl amines, including diaryl amines, is also demonstrated. 相似文献
17.
Ali Souldozi 《Tetrahedron letters》2007,48(9):1549-1551
The reactions of benzoic acid derivatives with (N-isocyanimino)triphenylphosphorane proceed smoothly at room temperature to afford 2-aryl-1,3,4-oxadiazoles in high yields. 相似文献
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<正>Four novel 5-substituted pyridine-2(1H)-one derivatives were designed and synthesized by using addition-elimination reactions.The structures of these novelly synthesized compounds were verified by ~1H NMR,ESI-MS and single crystal X-ray diffraction.Furthermore,all four compounds(most notably compound 7a) were found to be highly efficient against hepatitis B virus (HBV) in cultured HepG2 2.2.15 cell,making them promising drug candidates for potential bioactive molecule against hepatitis B. 相似文献