共查询到20条相似文献,搜索用时 16 毫秒
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Lin He Kishore Natte Jabor Rabeah Christoph Taeschler Helfried Neumann Angelika Brückner Matthias Beller 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(14):4394-4398
Fluorinated organic compounds are gaining increasing interest for life science applications. The replacement of hydrogen in arenes or heteroarenes by a perfluoroalkyl group has a profound influence on the physical and biological properties of such building blocks. Here, an operationally simple protocol for the direct C H perfluoroalkylation of (hetero)arenes with RfI or RfBr has been developed, using a robust supported platinum catalyst. The ready availability of the starting materials, the excellent substrate tolerance, and the reusability of the catalyst make this method attractive for the synthesis of a variety of perfluoroalkyl‐substituted aromatic compounds. Preliminary mechanistic studies revealed the formation of radicals to be crucial in the reaction system. 相似文献
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Vaibhav P. Mehta Jos‐Antonio García‐Lpez Michael F. Greaney 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2014,126(6):1555-1559
Three orthogonal cascade C H functionalization processes are described, based on ruthenium‐catalyzed C H alkenylation. 1‐Indanones, indeno indenes, and indeno furanones were accessed through cascade pathways by using arylacetophenones as substrates under conditions of catalytic [{Ru(p‐cymene)Cl2}2] and stoichiometric Cu(OAc)2. Each transformation uses C H functionalization methods to form C C bonds sequentially, with the indeno furanone synthesis featuring a C O bond formation as the terminating step. This work demonstrates the power of ruthenium‐catalyzed alkenylation as a platform reaction to develop more complex transformations, with multiple C H functionalization steps taking place in a single operation to access novel carbocyclic structures. 相似文献
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Julien Buendia Benjamin Darses Philippe Dauban 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(19):5789-5793
A new tandem C N and C C bond‐forming reaction has been achieved through RhII/Pd0 catalysis. The sequence first involves an iodine(III) oxidant, then the in situ generated iodine(I) by‐product is used as a coupling partner. The overall process demonstrates the synthetic value of iodoarenes produced in trivalent iodine reagent mediated oxidations. 相似文献
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