Photoglottographic measures in parkinson's disease

This study examines the usefulness of photoglottographic measures in reflecting the phonatory effect of Parkinson's disease. In the first experiment, data obtained by photoglottography were compared between 15 male patients with Parkinson's disease and 15 normal male speakers of similar age. Six photoglottographic parameters, mean open quotient (OQ), mean speed quotient (SQ), perturbation of open quotient (POQ), perturbation of speed quotient (PSQ), frequency perturbation ratio (FPR), and amplitude perturbation ratio (APR), in sustained vowel phonation were investigated. Increased SQ (t = -2.731, df = 28, P = 0.011) and POQ (t = -2.584, df = 28, P = 0.015) were significantly associated with data from patients in comparison to normal speakers. The FPR, APR, and OQ were not significantly different between normal subjects and patients. A follow-up experiment, including 12 female and 19 male patients with Parkinson's disease, was designed to evaluate the sensitivity of SQ and POQ in detecting vocal dysfunction. The sensitivity of SQ was found to be relatively high (93.5%), while that of POQ was low (45.2%). Methodological issues regarding the effects of gender, age, stage of the disease, and treatment on photoglottographic measures in Parkinson's disease were discussed.     

Comparison of Two Inverse Filtering Methods in Parameterization of the Glottal Closing Phase Characteristics in Different Phonation Types

SUMMARY: Inverse filtering (IF) is a common method used to estimate the source of voiced speech, the glottal flow. This investigation aims to compare two IF methods: one manual and the other semiautomatic. Glottal flows were estimated from speech pressure waveforms of six female and seven male subjects producing sustained vole /a/ in breathy, normal, and pressed phonation. The closing phase characteristics of the glottal pulse were parameterized using two time-based parameters: the closing quotient (C1Q) and the normalized amplitude quotient (NAQ). The information given by these two parameters indicates a strong correlation between the two IF methods. The results are encouraging in showing that the parameterization of the voice source in different speech sounds can be performed independently of the technique used for inverse filtering.     

Glottal airflow and electroglottographic measures of vocal function at multiple intensities

Ten normal female subjects produced syllables at 5 dB increments from soft to loud. The differentiated electroglottogram (dEGG) open and speed quotients were compared to similar quotients from the inverse-filtered airflow waveform. The latter were measured according to objective and subjective criteria. The data indicate that the open quotient from the airflow waveform decreased as the intensity increased. The dEGG open quotient did not demonstrate this trend. The speed quotient from airflow increased initially with vocal intensity and decreased again as the intensity ceiling was approached. The ratio of closing to opening slopes calculated from peaks in the dEGG signal followed a similar pattern. While the trends across intensity conditions were found to correspond for several of the measures, the absolute values obtained using the different methodologies were not comparable.     

Verma Modules for Yangians

We study the Verma modules M((μu)) over the Yangian Y associated with a simple Lie algebra . We give necessary and sufficient conditions for irreducibility of M(μ(u)). Moreover, regarding the simple quotient L((μu)) of M((μu)) as an -module, we give necessary and sufficient conditions for finite-dimensionality of the weight subspaces of L((μu)).     

Aerodynamic Measurements: Normative Data for Children Ages 6:0 to 10:11 Years

Normative measures of open quotient, speed quotient, maximum flow declination rate (MFDR), and subglottal pressure were determined for 75 children between the ages of 6 years 0 months and 10 years 11 months. The participants produced a sustained /a/ at low, comfort, and high pitches for a minimum of 5 seconds, and five to seven repetitions of /pa/ at low, comfort, and high pitches. No statistically significant differences were found in the mean measures of any aerodynamic variables (open quotient, speed quotient, maximum flow declination rate, subglottal pressure) between the frequency levels (low, comfort, high pitches). Also, no strong evidence (P > .05) exists that age or sex effect differed between the frequency levels (low, comfort, high) for any of the aerodynamic measures. For /a/ response tasks, mean open quotient measures increased slightly from low to comfort frequency and from comfort to high frequency. Mean speed quotient measures showed minimal differences between low and comfort frequency, with decreased mean measures for high frequency. Mean MFDR measures increased from low to comfort frequency and from comfort to high frequency. Mean subglottal pressure measures increased slightly from low to comfort frequency and from comfort to high frequency.     

Clinical Characteristics and Voice Analysis of Patients With Mutational Dysphonia: Clinical Significance of Diplophonia and Closed Quotients

The aim of this study was to investigate the acoustic and electroglottographic characteristics of patients with mutational dysphonia before and after voice therapy. The clinical records of 15 patients with mutational dysphonia were reviewed, and their voice recordings were analyzed with the help of the Lx Speech Studio program (Laryngograph Ltd, London, UK). After voice therapy combined with the manual compression method, the subjects' voices lowered in pitch and improved in quality. In addition, we classified the mutational dysphonia into four categories according to the presence of diplophonia and closed quotients. The most common type among the categories was characterized by a bimodal distribution of fundamental frequency (diplophonia), accompanied by a low closed quotient (falsetto voice) at high frequencies. However, the results also showed that mutational dysphonia cannot be generalized as always having a falsetto voice, as shown in other types. The effect of therapy was different for each type, and those cases with both diplophonia and a non-trained falsetto voice could be treated more readily. Consequently, the diplophonia and closed quotient, which were easily analyzed using Lx Speech Studio program, are important factors in the classification of mutational dysphonia. Identification of these characteristics may affect treatment choices, facilitate monitoring of the efficacy of therapy, and aid in estimating prognosis.     

Variation of electrolaryngographically derived closed quotient for trained and untrained adult female singers

The derivation of larynx closed quotient (CQ) measures from the electrolarynogograph output is discussed and data are presented for a group of trained and untrained adult female singers (N = 26) for a sung two-octave G major scale. Statistically significant trends are observed between the trained and untrained groups that suggest for the trained group: (a) CQ tends to be lower for pitches below D4 and higher for pitches above B4, and (b) the gradient [CQ/log(F0)] tends to correlate positively with the number of years singing training/experience. These data are compared with those reported previously for an adult male group, and it is suggested that CQ could be a useful parameter to include in a real-time visual display for singing training.     

Measures of vocal function during changes in vocal effort level

The purpose of this article is to present the results of a controlled study of the day-to-day variabilities of three acoustic parameters (jitter, shimmer, and normalized noise energy), and two electroglottographic parameters (contact quotient and contact quotient perturbation) for vowels produced at three vocal efforts (low, normal, high). Data were obtained with use of a sophisticated bilinear interpolation pitch detection method. A repeated measures design required subjects to produce the vowels // and /a/ five times a day over 3 days at each vocal effort level. The jitter, shimmer, and normalized noise energy values from acoustic measures and contact quotient and contact quotient perturbation values varied significantly among the three vocal effort levels. The clinical implication of this finding is that vocal effort must be controlled in order to obtain consistent clinical measures. Furthermore, day-to-day variability must be taken into account if representative measures are to be obtained for clinical use.     

Investigation of vocal fold impact stress in human subjects

The primary purpose of the study was to explore a methodology for measuring vocal fold impact stress (SI) in awake humans, and to provide information about the general magnitude of SIs that may occur at the midpoint of the membranous vocal folds during phonation. A secondary purpose was to examine the potential use of the electroglottographic closed quotient (EGG CQ) to indirectly reflect SI. Seven male and 13 female adults were enrolled as subjects, of whom 18 had normal larynges and normal voices, 1 had nodules, and 1 had vocal fold paresis and bowing. Subjects attempted to produce 3 different voice types (pressed, normal, breathy), at 3 different pitches (low, medium, high) and 3 different loudness levels (quiet, medium, loud). For a first set of trials, only EGG data were collected. For a second set, a sensor was also introduced to the midmembranous glottis for the collection of SI data. The primary findings were that (1) endolaryngeal sensor placement was achieved during phonation trials for 17 of 20 subjects; however, grossly consistent anteroposterior positioning was accomplished, and analyzable data were obtained, for only 7 subjects; (2) SIs ranged from less than 1 kPa to about 3 kPa for those 7 subjects; and (3) no relation was detected between simultaneous CQs and SIs for individual data, although a relation was reported in a prior canine study. One possible reason for the failure to show such a relation in the present study was subtle variations in vertical as well as anteroposterior positioning of the sensor during the trials. Future studies should focus on developing a methodology for ensuring invariant 3-dimensional sensor positioning between the membranous folds, so that the stability of both SI and simultaneous CQ data can be improved.     

Electroglottographic quasi-open quotient and amplitude in crescendo phonation

Crescendo phonation (swelltone) was used to evaluate the laryngeal tensioning behavior of seven normal speakers and of 12 dysphonic patients. EGG quasi-open quotient (qOq), stroboscopic open quotient, and vocal sound pressure level (SPL) were measured, and EGG amplitude and the mucosal wave were assessed qualitatively. For normal speakers, the qOq decreased greatly as vocal intensity increased. The same tendency was observed, but to a lesser extent, among hyperfunctional dysphonics. In contrast, qOq increased with vocal intensity among the hypofunctional dysphonics. The crescendo task combined with EGG assessment appears to offer a valid approach to the classification of laryngeal dysfunctions.     

Laryngeal adduction in resonant voice

The primary question in this study was whether subjects with nodules and subjects with healthy larynges would produce “resonant voice” with a similar laryngeal configuration. A second question regarded whether the electroglottographic closed quotient (EGG CQ) could be used to noninvasively distinguish resonant from other voice types. Twelve adult singers and actors served as subjects, including 6 persons with healthy larynges and 6 persons with nodules. Performers were used as an attempt to maximize token validity and stability. Subjects produced repeated tokens of resonant, pressed, normal, and breathy voice during sustained vowels. Laryngeal adduction was directly estimated using blinded, ordinal, visual-perceptual ratings based on videoscopic views of the larynx. EGG CQs were further calculated based on separate trials. The perceptual ratings indicated that subjects in both groups produced resonant voice with a barely adducted or barely abducted laryngeal configuration that was distinct from configurations for pressed and breathy (but not normal) voice. Previous literature suggests that this configuration may be relevant in many cases of voice therapy (I). Average CQs distinguished resonant from pressed voice, but inconsistently distinguished resonant from breathy voice. Further CQs were reliably different across healthy subjects and subjects with nodules. Thus, the utility of this measure to noninvasively estimate resonant voice may be limited, particularly without ongoing subject-specific calibration procedures.     

中子输运方程源项反演的瑞利商迭代算法

中子输运方程源项反演问题中,有效倍增因子的求解经过球谐函数展开和差分离散后,转化为求解大型矩阵的特征值问题.针对矩阵的特点,利用Gerschgorin圆盘定理,给出反幂法迭代初值的选取方法,并进行相应的扰动分析.针对有效倍增因子是矩阵最大特征值的特点,采用瑞利商迭代算法进行求解.理论和算例表明,该方法不需选取特定初值,达到三阶收敛速度.     

Vocal Intensity Characteristics inNormal and Elderly Speakers

The relationship of lung pressure, fundamental frequency, peak airflow, open quotient, and maximal flow declination rate to vocal intensity for a normal speaking, young male control group and an elderly male group was investigated. The control group consisted of 17 healthy male subjects with a mean age of 30 years and the elderly group consisted of 11 healthy male subjects with a mean age of 77 years. Data were collected at three levels of vocal intensity: soft, comfortable, and loud, corresponding to 25%, 50%, and 75% of dynamic range, respectively. Phonational threshold pressure and lung pressure were obtained using the intraoral technique. The oral airflow waveform was inverse filtered to provide an approximation to the glottal airflow waveform from which measures of fundamental frequency, peak airflow, open quotient, and maximal flow declination rate were determined. Excess lung pressure was calculated as lung pressure minus estimated phonational threshold pressure. The results show for both groups an increase in sound pressure level across the conditions, with corresponding increases in lung pressure, excess lung pressure, fundamental frequency, peak airflow, and maximal flow declination rate. Open quotient decreased with increasing vocal intensity. Lung pressure, sound pressure level, and peak airflow were all found to be significantly greater for the control group than for the elderly group at each condition. Open quotient was found to be significantly lower in the control group than in the elderly group at each condition. No significant difference was observed for excess lung pressure, phonational threshold pressure, fundamental frequency, or maximal flow declination rate between the two groups. These results show that a difference in vocal intensity does exist between young and elderly voices and that this difference is the result of differences in lung pressure, peak airflow, and open quotient.     

A novel method for crack detection in beam-like structures by measurements of natural frequencies

A novel method is proposed for calculating the natural frequencies of a multiple cracked beam and detecting unknown number of multiple cracks from the measured natural frequencies. First, an explicit expression of the natural frequencies through crack parameters is derived as a modification of the Rayleigh quotient for the multiple cracked beams that differ from the earlier ones by including nonlinear terms with respect to crack severity. This expression provides a simple tool for calculating the natural frequencies of the beam with arbitrary number of cracks instead of solving the complicated characteristic equation. The obtained nonlinear expression for natural frequencies in combination with the so-called crack scanning method proposed recently by the authors allowed the development of a novel procedure for consistent identification of unknown amount of cracks in the beam with a limited number of measured natural frequencies. The developed theory has been illustrated and validated by both numerical and experimental results.     

Estimating perceived phonatory pressedness in singing from flow glottograms

The normalized amplitude quotient (NAQ), defined as the ratio between the peak-to-peak amplitude of the flow pulse and the negative peak amplitude of the differentiated flow glottogram and normalized with respect to period time, has been shown to be related to glottal adduction. Glottal adduction, in turn, affects mode of phonation and hence perceived phonatory pressedness. The relationship between NAQ and perceived phonatory pressedness was analyzed in a material collected from a professional female singer and singing teacher who sang a triad pattern in breathy, flow, neutral, and pressed phonation in three different loudness conditions (soft, middle, loud). In addition, she also sang the same triad pattern in four different styles of singing, classical, pop, jazz, and blues, in the same three loudness conditions. A panel of experts rated the degree of perceived phonatory press along visual analogue scales. Comparing the obtained mean rated pressedness ratings with the mean NAQ values for the various triads showed that about 73% of the variation in perceived pressedness could be accounted for by variations of NAQ.     

复合函数算符的微商法则及其在量子物理中的应用

给出了在量子物理学、量子统计学、算符排序理论、矩阵论以及控制理论中有着重要用途的复合函数算符的一般微分法则,利用这一法则研究了Wigner算符和Weyl对应规则中的积分问题,证明了两类典型的算符恒等公式.给出了Wigner算符的有序算符内的微分形式,并得到了一些重要函数的新的微分式.最后,引入了一个参数型的Wigner算符来统一正规序、Weyl编序以及反正规序三种算符排序.