共查询到19条相似文献,搜索用时 609 毫秒
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二芳基碘鎓盐属于有机高价碘化合物,具有无毒、反应条件温和以及良好的选择性等优点,在有机合成中具有重要地位,受到广大化学工作者的关注。近年来,利用二芳基碘鎓盐在金属催化下进行的芳基化反应为一些难以合成的杂环化合物的合成提供了简便、高效的方法;同时,二芳基碘鎓盐在无催化剂下进行的芳基化反应,为C—C偶联反应开辟了新的绿色合成路线。本文综述了近年来二芳基碘鎓盐在有机合成中促进芳基化反应的最新进展,着重介绍了利用二芳基碘鎓盐作为芳基化试剂与有机金属试剂、烯烃和炔烃类以及杂环化合物进行芳基化反应的研究;总结了二芳基碘鎓盐与杂环化合物反应中钯催化和铜催化下芳基化反应的机理,最后对二芳基碘鎓盐在今后有机合成中的应用作出了展望。 相似文献
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Wirth T 《Angewandte Chemie (International ed. in English)》2005,44(24):3656-3665
The impressive development of hypervalent iodine chemistry in recent years is reflected by the number of publications in this area. Although the synthesis of the first hypervalent iodine compound dates back more than 100 years, the investigation of the reactivities of these compounds and their efficient use as metal-free reagents in organic synthesis is still ongoing. This contribution summarizes recent achievements and highlights key findings and developments that will influence future research and lead to novel applications of hypervalent iodine reagents in synthesis. 相似文献
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Site‐selective “cut and sew” transformations employing diazo compounds and hypervalent iodine(III) compounds involve the departure of leaving groups, a “cut” process, followed by a reorganization of the fragments by bond formation, a “sew” process. Bearing controllable cleavage sites, diazo compounds and hypervalent iodine(III) compounds play a critical role as versatile reagents in a wide range of organic transformations because their excellent nucleofugality allows for a large number of unusual reactions to occur. In recent years, the combination of diazo compounds and hypervalent iodine(III) reagents has emerged as a promising tool for developing new and valuable approaches, and has met considerable success. In this Minireview, this combination is systematically illustrated with recent advances in the field, with the aim of elaborating the synthetic utility and potential of this concept as a powerful strategy in organic synthesis. 相似文献
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The anodic oxidation of aryl iodides is a powerful method for synthesis of hypervalent iodine compounds, which have matured to frequently used reagents in organic synthesis. The electrochemical route eliminates the use of expensive or hazardous oxidants for their synthesis. Hypervalent iodine reagents generated at the anode are successfully used as either in-cell or ex-cell mediators for many valuable chemical transformations including fluorinations and oxidative cyclisations. The recent advances in the area of flow electrochemistry are providing additional benefits and allow new synthetic applications. Mechanistic insights and novel technologies enable the development of new concepts for sustainable chemistry. 相似文献
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Through the oxidation of sulfides useful elements of stereocontrol in asymmetric synthesis and important targets of pharmaceutical interest can be obtained. A number of metal-free methods have been developed over recent years for sulfoxidation reactions. The results published after 1998 through the beginning of 2010 have been reviewed with a focus being placed on sulfoxidations with hypervalent iodine compounds; iminium- and oxaziridinium derivatives; organic hydroperoxides and organocatalysts. In addition, autocatalytic and catalyst-free variants are discussed. Although, the asymmetric organocatalytic sulfoxidation is still in its infancy, the reported results show the high potential and versatility of this metal-free methodology. 相似文献
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Hypervalent Iodine‐Catalyzed Oxidative Functionalizations Including Stereoselective Reactions 下载免费PDF全文
Hypervalent iodine chemistry is now a well‐established area of organic chemistry. Novel hypervalent iodine reagents have been introduced in many different transformations owing to their mild reaction conditions and environmentally friendly nature. Recently, these reagents have received particular attention because of their applications in catalysis. Numerous hypervalent iodine‐catalyzed oxidative functionalizations such as oxidations of various alcohols and phenols, α‐functionalizations of carbonyl compounds, cyclizations, and rearrangements have been developed successfully. In these catalytic reactions stoichiometric oxidants such as mCPBA or oxone play a crucial role to generate the iodine(III) or iodine(V) species in situ. In this Focus Review, recent developments of hypervalent iodine‐catalyzed reactions are described including some asymmetric variants. Catalytic reactions using recyclable hypervalent iodine catalysts are also covered. 相似文献
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Samata E. Shetgaonkar Ritu Mamgain Kotaro Kikushima Toshifumi Dohi Fateh V. Singh 《Molecules (Basel, Switzerland)》2022,27(12)
The chemistry of polyvalent iodine compounds has piqued the interest of researchers due to their role as important and flexible reagents in synthetic organic chemistry, resulting in a broad variety of useful organic molecules. These chemicals have potential uses in various functionalization procedures due to their non-toxic and environmentally friendly properties. As they are also strong electrophiles and potent oxidizing agents, the use of hypervalent iodine reagents in palladium-catalyzed transformations has received a lot of attention in recent years. Extensive research has been conducted on the subject of C—H bond functionalization by Pd catalysis with hypervalent iodine reagents as oxidants. Furthermore, the iodine(III) reagent is now often used as an arylating agent in Pd-catalyzed C—H arylation or Heck-type cross-coupling processes. In this article, the recent advances in palladium-catalyzed oxidative cross-coupling reactions employing hypervalent iodine reagents are reviewed in detail. 相似文献
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分子碘催化的有机化学反应 总被引:2,自引:0,他引:2
从有机合成化学的角度,按反应类型综述了分子碘作为催化剂在有机化学中的应用,碘催化的反应主要涉及保护基团的形成和裂解、氧化和还原反应、成环反应、加成反应、取代反应和重排反应等。 相似文献
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分子碘催化的有机化学反应 总被引:5,自引:0,他引:5
从有机合成化学的角度,按反应类型综述了分子碘作为催化剂在有机化学中的应用,碘催化的反应主要涉及保护基团的形成和裂解、氧化和还原反应、成环反应、加成反应、取代反应和重排反应等。 相似文献
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Hypervalent‐Iodine(III)‐Mediated Oxidative Methodology for the Synthesis of Fused Triazoles 下载免费PDF全文
The organic chemistry of hypervalent organoiodine compounds has been an area of unprecedented development. This surge in interest in the use of hypervalent iodine compounds has mainly been owing to their highly selective oxidizing properties, environmentally benign character and commercial availability. Hypervalent iodine reagents have also been used as an alternative to toxic heavy metals, owing to their low toxicity and ease of handling. Hypervalent organoiodine(III) reagents are versatile oxidants that have been successfully employed to extend the scope of selective oxidative transformations of complex organic molecules in synthetic chemistry. This Focus Review concerns the tandem in situ generation and 1,5‐electrocyclization of N‐heteroaryl nitrilimines into fused triazoles. We describe the importance of recently developed hypervalent‐organoiodine(III)‐catalyzed oxidative cyclization reactions, building towards the conclusion that hypervalent iodine chemistry is a promising frontier for oxidative cyclization, in particular of hydrazones, for the synthesis of fused triazoles. 相似文献