A new joint model for longitudinal and survival data with a cure fraction

We develop a new joint cure rate model for longitudinal and survival data. The model allows for multiple longitudinal markers as well as a cure structure for the survival component based on the promotion time cure rate model, as described in Ibrahim et al. (Bayesian Survival Analysis, Springer, New York, 2001). Several characteristics and properties of the new model are discussed and examined. A real dataset from a melanoma clinical trial is given to demonstrate the methodology.     

Finite-sample inference with monotone incomplete multivariate normal data, II

We continue our recent work on inference with two-step, monotone incomplete data from a multivariate normal population with mean and covariance matrix . Under the assumption that is block-diagonal when partitioned according to the two-step pattern, we derive the distributions of the diagonal blocks of and of the estimated regression matrix, . We represent in terms of independent matrices; derive its exact distribution, thereby generalizing the Wishart distribution to the setting of monotone incomplete data; and obtain saddlepoint approximations for the distributions of and its partial Iwasawa coordinates. We prove the unbiasedness of a modified likelihood ratio criterion for testing , where is a given matrix, and obtain the null and non-null distributions of the test statistic. In testing , where and are given, we prove that the likelihood ratio criterion is unbiased and obtain its null and non-null distributions. For the sphericity test, , we obtain the null distribution of the likelihood ratio criterion. In testing we show that a modified locally most powerful invariant statistic has the same distribution as a Bartlett-Pillai-Nanda trace statistic in multivariate analysis of variance.     

Model testing for multivariate censored data

Summary. In the fields like Astronomy and Ecology, the need for proper statistical analysis of data that are censored is being increasingly recognized. Such data occur when, due to noise or other factors, instruments fail to detect low luminosities of celestial objects, or low concentrations of certain pollutants. For multivariate censored data sets there are very few distribution free methods available and researchers in the various fields often impose an assumption on the joint distribution, such as multivariate normality, and carry out parametric inferences. Under censoring, however, such parametric inferences are asymptotically wrong if the imposed assumption is incorrect. In this paper we propose a class of goodness-of-fit procedures for testing assumptions about the multivariate distribution under random censoring. The test procedures generalize Pearson's goodness-of-fit test in the sense that they are based on the concept of observed-minus-expected frequencies. The theory of the test statistic, however, differs from that for the classical Pearson test due to the accommodation of censored data. Received: 24 May 1994 / In revised form: 3 March 1996     

A weighted multivariate signed-rank test for cluster-correlated data

A weighted multivariate signed-rank test is introduced for an analysis of multivariate clustered data. Observations in different clusters may then get different weights. The test provides a robust and efficient alternative to normal theory based methods. Asymptotic theory is developed to find the approximate p-value as well as to calculate the limiting Pitman efficiency of the test. A conditionally distribution-free version of the test is also discussed. The finite-sample behavior of different versions of the test statistic is explored by simulations and the new test is compared to the unweighted and weighted versions of Hotelling’s T² test and the multivariate spatial sign test introduced in [D. Larocque, J. Nevalainen, H. Oja, A weighted multivariate sign test for cluster-correlated data, Biometrika 94 (2007) 267-283]. Finally, a real data example is used to illustrate the theory.     

The Stein phenomenon for monotone incomplete multivariate normal data

We establish the Stein phenomenon in the context of two-step, monotone incomplete data drawn from , a (p+q)-dimensional multivariate normal population with mean and covariance matrix . On the basis of data consisting of n observations on all p+q characteristics and an additional N−n observations on the last q characteristics, where all observations are mutually independent, denote by the maximum likelihood estimator of . We establish criteria which imply that shrinkage estimators of James-Stein type have lower risk than under Euclidean quadratic loss. Further, we show that the corresponding positive-part estimators have lower risk than their unrestricted counterparts, thereby rendering the latter estimators inadmissible. We derive results for the case in which is block-diagonal, the loss function is quadratic and non-spherical, and the shrinkage estimator is constructed by means of a nondecreasing, differentiable function of a quadratic form in . For the problem of shrinking to a vector whose components have a common value constructed from the data, we derive improved shrinkage estimators and again determine conditions under which the positive-part analogs have lower risk than their unrestricted counterparts.     

Diagnostic checking for multivariate regression models

Diagnostic checking for multivariate parametric models is investigated in this article. A nonparametric Monte Carlo Test (NMCT) procedure is proposed. This Monte Carlo approximation is easy to implement and can automatically make any test procedure scale-invariant even when the test statistic is not scale-invariant. With it we do not need plug-in estimation of the asymptotic covariance matrix that is used to normalize test statistic and then the power performance can be enhanced. The consistency of NMCT approximation is proved. For comparison, we also extend the score type test to one-dimensional cases. NMCT can also be applied to diverse problems such as a classical problem for which we test whether or not certain covariables in linear model has significant impact for response. Although the Wilks lambda, a likelihood ratio test, is a proven powerful test, NMCT outperforms it especially in non-normal cases. Simulations are carried out and an application to a real data set is illustrated.     

Asymptotics for testing hypothesis in some multivariate variance components model under non-normality

We consider the problem of deriving the asymptotic distribution of the three commonly used multivariate test statistics, namely likelihood ratio, Lawley-Hotelling and Bartlett-Nanda-Pillai statistics, for testing hypotheses on the various effects (main, nested or interaction) in multivariate mixed models. We derive the distributions of these statistics, both in the null as well as non-null cases, as the number of levels of one of the main effects (random or fixed) goes to infinity. The robustness of these statistics against departure from normality will be assessed.Essentially, in the asymptotic spirit of this paper, both the hypothesis and error degrees of freedom tend to infinity at a fixed rate. It is intuitively appealing to consider asymptotics of this type because, for example, in random or mixed effects models, the levels of the main random factors are assumed to be a random sample from a large population of levels.For the asymptotic results of this paper to hold, we do not require any distributional assumption on the errors. That means the results can be used in real-life applications where normality assumption is not tenable.As it happens, the asymptotic distributions of the three statistics are normal. The statistics have been found to be asymptotically null robust against the departure from normality in the balanced designs. The expressions for the asymptotic means and variances are fairly simple. That makes the results an attractive alternative to the standard asymptotic results. These statements are favorably supported by the numerical results.     

The power of the likelihood ratio test for additional information in a multivariate linear model

Summary This paper deals with the likelihood ratio test for additional information in a multivariate linear model. It is shown that the power of the likelihood ratio test procedure has a monotonicity property. Asymptotic approximations for the power are also obtained.     

A test for the mean vector with fewer observations than the dimension

In this paper, we consider a test for the mean vector of independent and identically distributed multivariate normal random vectors where the dimension p is larger than or equal to the number of observations N. This test is invariant under scalar transformations of each component of the random vector. Theories and simulation results show that the proposed test is superior to other two tests available in the literature. Interest in such significance test for high-dimensional data is motivated by DNA microarrays. However, the methodology is valid for any application which involves high-dimensional data.     

On simultaneous confidence intervals for all contrasts in the means of the intraclass correlation model with missing data

In this paper, we consider simultaneous confidence intervals for all contrasts in the means when the observations are missing at random in the intraclass correlation model. An exact test statistic for the equality of the means and Scheffé, Bonferroni and Tukey types of simultaneous confidence intervals are given by an extension of Bhargava and Srivastava [On Tukey's confidence intervals for the contrasts in the means of the intraclass correlation model, J. Royal Statist. Soc. B35 (1973) 147-152] when the missing observations are of the monotone type. Finally, numerical results of simultaneous confidence intervals are presented.     

A test of location for exchangeable multivariate normal data with unknown correlation

We consider the problem of testing whether the common mean of a single n-vector of multivariate normal random variables with known variance and unknown common correlation ρ is zero. We derive the standardized likelihood ratio test for known ρ and explore different ways of proceeding with ρ unknown. We evaluate the performance of the standardized statistic where ρ is replaced with an estimate of ρ and determine the critical value c_n that controls the type I error rate for the least favorable ρ in [0,1]. The constant c_n increases with n and this procedure has pathological behavior if ρ depends on n and ρ_n converges to zero at a certain rate. As an alternate approach, we replace ρ with the upper limit of a (1−β_n) confidence interval chosen so that c_n=c for all n. We determine β_n so that the type I error rate is exactly controlled for all ρ in [0,1]. We also investigate a simpler approach where we bound the type I error rate. The former method performs well for all n while the less powerful bound method may be a useful in some settings as a simple approach. The proposed tests can be used in different applications, including within-cluster resampling and combining exchangeable p-values.     

A new test for multivariate normality

We propose a new class of rotation invariant and consistent goodness-of-fit tests for multivariate distributions based on Euclidean distance between sample elements. The proposed test applies to any multivariate distribution with finite second moments. In this article we apply the new method for testing multivariate normality when parameters are estimated. The resulting test is affine invariant and consistent against all fixed alternatives. A comparative Monte Carlo study suggests that our test is a powerful competitor to existing tests, and is very sensitive against heavy tailed alternatives.     

Empirical likelihood for semiparametric regression model with missing response data

A bias-corrected technique for constructing the empirical likelihood ratio is used to study a semiparametric regression model with missing response data. We are interested in inference for the regression coefficients, the baseline function and the response mean. A class of empirical likelihood ratio functions for the parameters of interest is defined so that undersmoothing for estimating the baseline function is avoided. The existing data-driven algorithm is also valid for selecting an optimal bandwidth. Our approach is to directly calibrate the empirical log-likelihood ratio so that the resulting ratio is asymptotically chi-squared. Also, a class of estimators for the parameters of interest is constructed, their asymptotic distributions are obtained, and consistent estimators of asymptotic bias and variance are provided. Our results can be used to construct confidence intervals and bands for the parameters of interest. A simulation study is undertaken to compare the empirical likelihood with the normal approximation-based method in terms of coverage accuracies and average lengths of confidence intervals. An example for an AIDS clinical trial data set is used for illustrating our methods.     

Stochastic comparisons in multivariate mixed model of proportional reversed hazard rate with applications

This paper studies the multivariate mixed proportional reversed hazard rate model having dependent mixing variables. Stochastic comparison as well as aging properties in this model are investigated, and stochastic monotone properties of the population vector with respect to the mixing vector are also discussed. Moreover, MTP₂ dependence among the mixing vectors is proved to imply the increasingness of the reversed hazard rate with respect to the baseline one. Finally, some interesting applications are presented as well.     

Weighted-mean trimming of multivariate data

A general notion of trimmed regions for empirical distributions in d-space is introduced. The regions are called weighted-mean trimmed regions. They are continuous in the data as well as in the trimming parameter. Further, these trimmed regions have many other attractive properties. In particular they are subadditive and monotone which makes it possible to construct multivariate measures of risk based on these regions. Special cases include the zonoid trimming and the ECH (expected convex hull) trimming. These regions can be exactly calculated for any dimension. Finally, the notion of weighted-mean trimmed regions extends to probability distributions in d-space, and a law of large numbers applies.     

Third-order power comparisons for a class of tests for multivariate linear hypothesis under general distributions

The purpose of this paper is, in multivariate linear regression model (Part I) and GMANOVA model (Part II), to investigate the effect of nonnormality upon the nonnull distributions of some multivariate test statistics under normality. It is shown that whatever the underlying distributions, the difference of local powers up to order N⁻¹ after either Bartlett’s type adjustment or Cornish-Fisher’s type size adjustment under nonnormality coincides with that in Anderson [An Introduction to Multivariate Statistical Analysis, 2nd ed. and 3rd ed., Wiley, New York, 1984, 2003] under normality. The derivation of asymptotic expansions is based on the differential operator associated with the multivariate linear regression model under general distributions. The performance of higher-order results in finite samples, including monotone Bartlett’s type adjustment and monotone Cornish-Fisher’s type size adjustment, is examined using simulation studies.     

A test for additional information in canonical correlation analysis

Summary In canonical correlation analysis a hypothesis concerning the relevance of a subset of variables from each of the two given variable sets is formulated. The likelihood ratio statistic for the hypothesis and an asymptotic expansion for its null distribution are obtained. In discriminant analysis various alternative forms of a hypothesis concerning the relevance of a specified variable subset are also discussed.     

A multivariate skew normal distribution

In this paper, we define a new class of multivariate skew-normal distributions. Its properties are studied. In particular we derive its density, moment generating function, the first two moments and marginal and conditional distributions. We illustrate the contours of a bivariate density as well as conditional expectations. We also give an extension to construct a general multivariate skew normal distribution.     

Nonparametric likelihood ratio goodness-of-fit tests for survival data

Berk and Jones (Z. Wahrsch. Verw. Gebiete 47 (1979) 47) described a nonparametric likelihood test of uniformity that is more efficient, in Bahadur's sense, than any weighted Kolmogorov-Smirnov test at any alternative. This article shows how to obtain a nonparametric likelihood test of a general parametric family for incomplete survival data. A nonparametric likelihood ratio test process is employed to measure the discrepancy between a parametric family and the observed data. Large sample properties of the likelihood ratio test process are studied under both the null and alternative hypotheses. A Monte Carlo simulation method is proposed to estimate its null distribution. We show how to produce a likelihood ratio graphical check as well as a formal test of a parametric family based on the developed theory. Our method is developed for the right-censorship model, but can be easily extended to some other survival models. Illustrations are given using both real and simulated data.     

Signed-rank tests for location in the symmetric independent component model

The so-called independent component (IC) model states that the observed p-vector X is generated via X=ΛZ+μ, where μ is a p-vector, Λ is a full-rank matrix, and the centered random vector Z has independent marginals. We consider the problem of testing the null hypothesis H₀:μ=0 on the basis of i.i.d. observations X₁,…,X_n generated by the symmetric version of the IC model above (for which all ICs have a symmetric distribution about the origin). In the spirit of [M. Hallin, D. Paindaveine, Optimal tests for multivariate location based on interdirections and pseudo-Mahalanobis ranks, Annals of Statistics, 30 (2002), 1103-1133], we develop nonparametric (signed-rank) tests, which are valid without any moment assumption and are, for adequately chosen scores, locally and asymptotically optimal (in the Le Cam sense) at given densities. Our tests are measurable with respect to the marginal signed ranks computed in the collection of null residuals , where is a suitable estimate of Λ. Provided that is affine-equivariant, the proposed tests, unlike the standard marginal signed-rank tests developed in [M.L. Puri, P.K. Sen, Nonparametric Methods in Multivariate Analysis, Wiley & Sons, New York, 1971] or any of their obvious generalizations, are affine-invariant. Local powers and asymptotic relative efficiencies (AREs) with respect to Hotelling’s T² test are derived. Quite remarkably, when Gaussian scores are used, these AREs are always greater than or equal to one, with equality in the multinormal model only. Finite-sample efficiencies and robustness properties are investigated through a Monte Carlo study.