共查询到20条相似文献,搜索用时 15 毫秒
1.
A. G. Mustafin R. R. Gataullin I. B. Abdrakhmanov L. V. Spirikhin G. A. Tolstikov 《Russian Chemical Bulletin》1998,47(10):2007-2008
A modified synthesis of 3′-azido-3′-deoxythymidine starting fromD-xylose is proposed.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2062–2063, October, 1998. 相似文献
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G. A. Tolstikov A. G. Mustafin R. R. Gataullin L. V. Spirikhin V. S. Sultanova I. B. Abdrakhmanov 《Russian Chemical Bulletin》1993,42(6):1095-1099
-D-Xylofuranosylpyrimidines were obtained by condensation of silyl derivatives of pyrimidines with 1,2-di-O-acetyl-3,5-di-O-benzoyl-D-xylofuranose with subsequent deprotection of the sugar fragment. Refluxing 2-O-tosyl derivatives of nucleosides with NaI results in the formation of 2,2-anhydro-compounds.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1137–1141, June, 1993. 相似文献
4.
α-Dithiophosphates of peracetylated 2-deoxyhexc-pyranoses, 1a, 1b and 2, uhich are easily prepared by addition of organic phosphorodithioic acids to glycais react smoothly with resin-bound 2- and 4-nitrophenoxides to give stereoselectively the respective nitrophenyl 2-deoxy-β-D-hexopyranosides (3, 4, 5 and 6) in high yields. Glycosylation of the 2, 4-dinitro'phenoxide, however, leads with comparable stereoselectivity to 2,4-dinitrophenyl 2-deoxy- α-D-hexopyranosides (7 and 8). Glycosides 3 - 6 are quantitatively deacetylatec by Amberlyst A-26 (OH-), whereas glycosides 7 and 8, under the same reaction conditions undergo splitting of the O-glycosidic bond. 相似文献
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Initial formation of tetrahydrocarboline 3 from tryptophan methyl ester 1 and aldehyde 2 by Pictet–Spengler reaction, followed by treatment with trichlorocyanuric acid, provides a facile and efficient route for a one-pot synthesis of β-carbolines with excellent yields. 相似文献
6.
Ignatovich Zh. V. Ermolinskaya A. L. Petushok V. G. Katok Ya. M. Koroleva E. V. 《Russian Journal of Organic Chemistry》2020,56(12):2092-2097
Russian Journal of Organic Chemistry - New 4,4′-oxydibenzamides and sulfamoyl derivatives of 4,4′-oxydibenzoic acid containing pharmacophoric 2-arylaminopyrimidine fragments in the... 相似文献
7.
Francisco Palacios Ana M. Ochoa de RetanaSergio Pascual Guillermo Fernández de Trocóniz 《Tetrahedron》2011,67(8):1575-1579
A simple and efficient synthesis of fluoroalkylated α-amino nitrile (4) derivatives by regioselective 1,2-addition of trimethylsilyl cyanide to fluoroalkylated α,β-unsaturated imines (1) is described. Fluoroalkylated β-amino nitriles (7) are also prepared by regioselective 1,2-addition of α-carbanions derived from acetonitrile to fluoroalkylated α,β-unsaturated imines (1). Fluoroalkylated α-(4) and β-amino nitriles (7) are also prepared through an ‘one pot’ procedure by reaction of enaminophosphonate 2 with BuLi, addition of aldehydes and subsequent addition of either trimethylsilyl cyanide or α-carbanion derived from acetonitrile. Basic hydrolysis of α-(4) and β-amino nitriles (7) gives fluoroalkylated α-(5) and β-amino acids (8). 相似文献
8.
Dominik A. Megger 《合成通讯》2013,43(17):2524-2529
An improved synthesis of the 2′-deoxyribonucleoside containing 1-deaza-6-methoxypurine as artificial nucleobase is described. By optimizing the conditions for the deprotection of p-toluoyl-protected 1-deaza-6-nitropurine 2′-deoxyribonucleoside, the isolated yield of the title compound could be increased from 15% to 90%. In addition, the synthesis and characterization of the corresponding 5′-(4,4′-dimethoxytrityl) (DMT) protected phosphoramidite, a potentially useful building block for the synthesis of artificial oligonucleotides, is reported. The title compound offers interesting hydrogen bond donor and metal-binding properties for its application in metal-mediated base pairs.
9.
《Tetrahedron letters》1986,27(42):5135-5138
Selective syntheses of α- and gd-damascone, using allylic organoboranes as the key intermediates, are described. 相似文献
10.
Synthesis of 2-oxazolones and α-aminoketones via palladium-catalyzed reaction of β,β-dibromoenamides
β,β-Dibromoenamides show two different interesting reactivities based on the choice of R group under the reaction conditions. On the basis of mechanistic studies, both reactions proceed via an intermolecular Suzuki-Miyaura C-C coupling and an intramolecular C-O coupling. 相似文献
11.
Vasiliy M. Muzalevskiy Aleksey V. Shastin Elizabeth S. Balenkova Günter Haufe Valentine G. Nenajdenko 《Journal of fluorine chemistry》2011,132(12):1247-1253
A novel synthetic approach towards α-trifluoromethyl-phenethylamines was elaborated by reduction of the electron deficient β-aryl-α-trifluoromethyl enamines and imines with sodium cyanoborohydride in the presence of trifluoroacetic acid. The starting imines were prepared by the reaction of primary amines with β-aryl-α-trifluoromethyl enamines or β-chloro-β-(trifluoromethyl)styrenes. 相似文献
12.
JianSONG XiaoLeiWANG YueJunXIANG ChungK.CHU RaymondSCHINAZI KangZHAO 《中国化学快报》2004,15(2):135-137
β-2′,3′-Dideoxy-2′-fluoro-3′-hydroxymethylarabinofuranosylthymine 10 and cytosine 12 were synthesized from L-xylose and were found to be inactive against HIV-1 in acutely infected lymphocytes. 相似文献
13.
This report describes an efficient and practical approach for regioselective synthesis of 1-(3′-substituted quinoxalin-2′-yl)-3-aryl/heteroaryl-5-methylpyrazoles (3a–j). Reaction of 2-chloro-3-substituted quinoxalines (1) with 3(5)-methyl-5(3)-aryl-1H-pyrazoles (2) in the presence of sodium hydride furnished the title compounds in excellent yields with good levels of regioselectivity. The present protocol is superior to the existing method, which yielded a mixture of regioisomeric pyrazoles (I, II) and triazolo[4,3-a]quinoxalines (III). Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. 相似文献
14.
V.V. Nesterov 《Tetrahedron》2007,63(29):6720-6731
An efficient and versatile method for the asymmetric reduction of α- and β-ketophosphonates using chiral reactant derived from sodium borohydride and l-(+)- or d-(−)-tartaric acid is developed. The methodology was used for the preparation of a number of biologically interesting enantiomerically pure products: including 2,3-epoxypropylphosphonate 11, 2-hydroxy-3-aminopropylphosphonic acid 14 (phospho-GABOB), phospho-carnitine 19, and others in multigram scale. 相似文献
15.
A number of steroids containing cyclic amino functions have been prepared and studied for biological activities, and some of them have proved to be clinically useful as a neuromuscular blocking agent, an antitumour agent, and so on.1 As the conventional methods, the reactions of cyclic amines with halides2 or epoxides,3 the reductive amination of ketones,4 and the reduction of enamines5 have been widely used for introducing these amino functions into steroid nucleus. 相似文献
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A. V. Ruseikina L. A. Solov’ev O. V. Andreev 《Russian Journal of Inorganic Chemistry》2013,58(10):1231-1236
The crystal structure of the EuPrCuS3 complex sulfide synthesized for the first time has been solved by X-ray powder diffraction. Crystals are orthorhombic, space group Pnma. EuPrCuS3 has two polymorphs: the high-temperature phase of Ba2MnS3 structural type with unit cell parameters a = 8.0786(1) Å, b = 4.0288(1) Å, and c = 15.8389(2) Å and the low-temperature phase of BaLaCuS3-isostructural with unit cell parameters a = 11.0819(2) Å, b = 4.0710(1) Å, and c = 11.4459(3) Å. 相似文献
17.
《Tetrahedron letters》1987,28(23):2623-2626
2′-5′,3′-5′ Linked triadenylates have been synthesized by direct bisadenylylation of adenosine 2′ and 3′ hydroxyls with an adenosine 5′-phosphorochloridite followed by oxidation. 相似文献
18.
Myong Jung Kim 《合成通讯》2013,43(20):2988-2999
Recently, 2′-C-methyl nucleoside analogues have been reported to exhibit potent anti–hepatitis C virus (HCV) activity through inhibition of HCV RNA replication without significant cytotoxicity. As a part of our continuous efforts of searching for novel antiviral agents, we now report the synthesis of heterobase-modified 2′-C-methyl ribonucleoside analogues. 相似文献
19.
Angel Alberola Celia Andrés Alfonso González Ortega Rafael Pedrosa Martina Vicente 《合成通讯》2013,43(11):1309-1314
β-aminoenones react with cyanamide, molar ratio 1:2, to yield 2-aminopyrimidines in nearly quantitative yields. 相似文献
20.
Summary ,-bis-(p-Benzylphenyl)xylene was synthesized for the first time and its UV and infrared spectra determined. 相似文献