DEM analysis of the effect of electrostatic interaction on particle mixing for carrier-based dry powder inhaler formulations

Particle interactions play a significant role in controlling the performance of dry powder inhalers (DPIs), which mainly arise through van der Waals potentials, electrostatic interactions, and capillary forces. Our aim is to investigate the influence of electrostatic charge on the performance of DPIs as a basis for improving the formulation of the particle ingredients. The mixing process of carrier and active pharmaceutical ingredient (API) particles in a vibrating container is investigated using a discrete element method (DEM). The number of API particles attaching to the carrier particle (i.e., contact number) increases with increasing charge and decreases with increasing container size. The contact number decreases with increasing vibrational velocity amplitude and frequency. Moreover, a mechanism governed by the electrostatic force is proposed for the mixing process. This mechanism is different from that previously proposed for the mixing process governed by van der Waals forces, indicating that long-range and short-range adhesive forces can result in different mixing behaviours.     

Validation of a numerical model for the simulation of an electrostatic powder coating process

Numerical modeling of a complete powder coating process is carried out to understand the gas-particle two-phase flow field inside a powder coating booth and results of the numerical simulations are compared with experimental data to validate the numerical results. The flow inside the coating booth is modeled as a three-dimensional turbulent continuous gas flow with solid powder particles as a discrete phase. The continuous gas flow is predicted by solving Navier–Stokes equations using a standard k–ε turbulence model with non-equilibrium wall functions. The discrete phase is modeled based on a Lagrangian approach. In the calculation of particle propagation, a particle size distribution obtained through experiments is applied. The electrostatic field, including the effect of space charge due to free ions, is calculated with the use of the user defined scalar transport equations and user defined scalar functions in the software package, FLUENT, for the electrostatic potential and charge density.