共查询到19条相似文献,搜索用时 93 毫秒
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2,6-二甲基吡啶经氧化、酯化、Claisen酯缩合后制得新型化合物2-乙酯基-6-乙酰基吡啶(4), 用其作为前驱体, 与一系列小分子脂肪胺: 甲胺、乙胺、乙二胺在微波条件下生成3个吡啶酰胺化合物5, 6, 7. 通过元素分析, 1H NMR, IR和MS对这些化合物进行了表征. 对6-乙酰基-N-甲基吡啶-2-甲酰胺(5)的X射线晶体衍射研究表明: 其属于正交晶系, Pca2(1)空间群, 晶胞参数a=2.2784(2) nm, b=0.4350(4) nm, c=0.9267(3) nm; α=β=γ=90°; Dc=1.288 Mg•m-3, V=0.91856(14) nm3. 实验还发现: 2-乙酯基-6-乙酰基吡啶与脂肪胺及芳香胺缩合时会发生两类不同的反应, 小分子脂肪胺选择与酯基发生胺解反应, 而芳香胺则率先在乙酰基上发生席夫碱缩合. 对这两类有趣的反应机理进行了深入探讨. 相似文献
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合成了三种长链多芳环多胺基客体, 它们分别由三种醛基吡啶异构体与4,4'-二氨基二苯甲烷形成的Schiff碱还原而成, 并得到1H NMR以及质谱分析方法表征证实. 以核磁共振技术、紫外吸收光谱分析方法以及滴定1H NMR方法为研究手段, 对瓜环(cucurbit[n]urils, n=6~8)分别与三种4,4'-二[N-(吡啶甲基)氨基]二苯甲烷盐酸盐相互作用进行了考察. 实验结果表明, 六元瓜环与三种4,4'-二[N-(吡啶甲基)氨基]二苯甲烷盐酸盐相互作用均形成物质的量之比为2∶1的哑铃型包结配合物; 八元瓜环与三种N,N'-二(N-(吡啶甲基)二苯甲烷盐酸盐相互作用形成以类轮烷结构为主的包结配合物; 七元瓜环与三种N,N'-二(N-(吡啶甲基)二苯甲烷盐酸盐相互作用存在多种模式的竞争. 相似文献
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以3,5-二氯吡啶为原料, 通过取代、硝化合成了3-甲氧基-5-氯-2,6-二硝基吡啶, 由X射线单晶衍射, IR, 1H NMR, MS及元素分析对其进行了表征. 晶体结构分析表明, 化合物为单斜晶系, 空间群P21/n, 晶胞参数a=0.66490(13) nm, b=1.0842(2) nm, c=1.2715(3) nm, β=95.55(3)°, V=0.9123(3) nm3; Z=4, Dc=1.701 g•cm-3; F(000)=472; μ=0.426 mm-1. 相似文献
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Dialkyl 4-(3-aminophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates 1 were transformed into alkyl 4-(3-(((2-benzoylamino-2-methoxycarbonyl)ethenyl)amino)phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylates 4 and with 2,2-disubstituted-1-dimethylaminoethenes 7 into dimethyl 4-(3-(((2,2-diacyl- or 2-acyl-2-alkoxycarbonyl)ethenyl)amino)phenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylates 8 and their ethyl methyl analogues 9. 相似文献
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M. Dolores Otero 《Tetrahedron letters》2005,46(50):8681-8683
2,4,6-Trimethylpyridine-3,5-dicarbonitrile has been obtained as the main product after the electrolysis of acetonitrile in the presence of tetrabutylammonium bisulfate as supporting electrolyte using a divided cell with a medium porosity diaphragm. 2,6-Dimethylpyridine-3,5-dicarbonitrile and 2,6-dimethylpyridine-3,4,5-tricarbonitrile have also been obtained in minor quantity. This process, which takes place with participation of both electrodes, is an example of a paired electrosynthesis. 相似文献
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O. U. Nesterova A. S. Pugachova M. V. Voevudsky O. V. Krischik V. I. Musatov 《Chemistry of Heterocyclic Compounds》2011,46(12):1520-1526
Cyclization of the hydrazide of 5-ethoxycarbonyl-2,6-dimethylpyridine-3-carboxylic acid by acylation with aromatic or aliphatic
acid chlorides with subsequent boiling in POCl3 or heating in orthoformic acid gave the corresponding ethyl 2,6-dimethyl-5-(5-R-1,3,4-oxadiazol-2-yl)pyridine-3-carboxylate.
The cyclization of the reaction products with hydrazine hydrate has been studied. Cyclization of the dihydrazide of 2,6-dimethyl-3,5-pyridinedicarboxylic
acid under analogous conditions gave only 3,5-bis-(5-R-1,3,4-oxadiazol-2-yl)-2,6-dimethylpyridines, containing R = 2-FC6H4, H. 相似文献
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N. F. Gol'dshleger A. S. Astakhova A. S. Lobach G. N. Boiko N. N. Denisov V. A. Nadtochenko O. S. Roshchupkina Yu. M. Shul'ga 《Russian Chemical Bulletin》1996,45(10):2402-2404
Heating (100 °C, toluene) or photolysis (Nd3+ : YAG laser, = 532 mil, benzonitrile) of a mixture of ethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (Hantsch ester) (1) and fullerene C60 under anaerobic conditions results in the formation of fullerene hydrogenation products and ethyl 2,6-dimethylpyridine-3,5-dicarboxylate, which is the product of dehydrogenation of1, identified by IR spectroscopy and mass spectrometry. The triplet state of C60 is quenched by the Hantsch ester.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 2531–2534, October, 1996. 相似文献
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以2,6-二甲基吡啶-3,5-二甲酸二乙酯为起始原料,经N-溴代丁二酰亚胺(NBS)溴代、亲电取代反应合成了时间分辨荧光免疫分析双功能螯合剂2,6-{N,N′,N,N′-[二(2,2′-联吡啶-6,6′-二甲基)]二(氨甲基)}-吡啶-3,5-二羧酸二乙酯。经差热分析仪(DTA)、傅里叶变换红外光谱仪(FTIR)、核磁共振波谱仪(1 H NMR)、质谱仪(MS)等技术手段表征确认了化合物结构和性能。对该化合物与铕离子形成螯合物的荧光性质研究表明:激发光谱波长范围较宽,激发峰值为322nm;荧光发射峰为597nm(~5D_0-~7F_1)、618nm(~5D_0-~7F_2);荧光寿命为918μs;量子产率Φ=0.249。 相似文献
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Acylhydrazine and hydrazine are highly reactive chemicals that have a wide spectrum of uses such as in the chemical and pharmaceutical industries and as a fuel and propellant in aircraft, rockets and satellites. And they can react with microelement in the organism, so they were reported to possess different biological and pharmacological activities, such as antiphthistic, antitumour and so on. But, acylhydrazine and hydrazine have free group of NH2, so they usually have some toxicity to the organism. Hydrazones were investigated in view of the possibility of their being less toxic than the parent hydrazides, because of the blocking of the free NH2 group. In order to reduce the toxicity to the organism, people have been interested in the hydrazones compounds in recent years. In this work, 2,6-dimethylpyridine-3,5-diacylhydrazones were synthesized. 相似文献
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Two mononuclear metal-organic complexes, [Co(Hmpdc)2(H2O)4]·4H2O 1 and [Ni(Hfmpdc)2(H2O)4]·6H2O 2, were prepared from 2,6-dimethylpyridine-3,5-dicarboxylic acid (Hzmpdc) and 4-furyl-2,6-dimethylpyridine-3,5-dicarboxylic acid (H2fmpdc) with M(NO3)2 salts, respectively, and characterized by single-crystal X-ray diffraction, elemental analyses, IR spectroscopy, and photoluminescent measurement. Complex 1 crystallizes in triclinic, space group P1 with a = 7.634(5), b = 8.695(5), c = 10.757(6)A, α = 69.647(7), β = 69.957(8), γ = 83.733(7)°, V = 628.9(7)A^3, Dc = 1. 561 g/cm^3,μ(MoKa) = 0.763 mm^-1, F(000) = 309, Z = 1, the final R = 0.0553 and wR = 0.1469 for 1909 observed reflections (Ⅰ 〉 2σ(Ⅰ)). Complex 2 crystallizes in monoclinic, space group P21/n with a = 9.5934(16), b = 12.422(2), c = 14.826(3) A, β = 105.201(2)°, V = 1705.0(5)A3, Dc = 1. 479 g/cm^3,μ(MoKa) = 0.655 mm^-1, F(000) = 796, Z = 2, the final R= 0.0351 and wR = 0.0889 for 2387 obsevved reflections (Ⅰ 〉 2σ(Ⅰ)). In the crystal structures of 1 and 2, diverse supramolecular motifs from 1-D chains/ladders to 3-D networks are constructed from corresponding distinct [M^Ⅱ(H2O)8] ion clusters as the second building units, respectively. The solid state compounds of 1 and 2 show similar photoluminescent spectra with emission maximum at ca. 相似文献
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Two mononuclear metal-organic complexes, [Co(Hmpdc)2(H2O)4]·4H2O 1 and [Ni(Hfmpdc)2(H2O)4]·6H2O 2, were prepared from 2,6-dimethylpyridine-3,5-dicarboxylic acid (H2mpdc) and 4-furyl-2,6-dimethylpyridine-3,5-dicarboxylic acid (H2fmpdc) with M(NO3)2 salts, respectively, and characterized by single-crystal X-ray diffraction, elemental analyses, IR spectroscopy, and photoluminescent measurement. Complex 1 crystallizes in triclinic, space group P with a = 7.634(5), b = 8.695(5), c = 10.757(6)(A), α = 69.647(7), β = 69.957(8), γ = 83.733(7)°, V = 628.9(7)(A)3, Dc = 1. 561 g/cm3, μ(MoKα) = 0.763 mm-1, F(000) = 309, Z = 1, the final R = 0.0553 and wR = 0.1469 for 1909 observed reflections (I > 2σ(I)). Complex 2 crystallizes in monoclinic, space group P21/n with a = 9.5934(16), b = 12.422(2), c = 14.826(3)(A), β = 105.201(2)°, V = 1705.0(5)(A)3, Dc = 1. 479 g/cm3, μ(MoKα) = 0.655 mm-1, F(000) = 796, Z = 2, the final R = 0.0351 and wR = 0.0889 for 2387 observed reflections (I > 2σ(I)). In the crystal structures of 1 and 2, diverse supramolecular motifs from 1-D chains/ladders to 3-D networks are constructed from corresponding distinct [MⅡ(H2O)8] ion clusters as the second building units, respectively. The solid state compounds of 1 and 2 show similar photoluminescent spectra with emission maximum at ca. 466 nm at room temperature. 相似文献
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<正>In the presence of diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate(DHP) and a catalytic amount of potassium iodide,severalα-halo ketones were easily reduced to the corresponding ketones in acetone media.The procedure presented here showed several merits such as short reaction time,practical experimental and isolated procedure,and excellent yields of products. 相似文献