Two New Sesquiterpenes from the Fungus Stereum sp.

Two new sesquiterpenes, stereumin F ( 1 ) and stereumin G ( 2 ), together with two known compounds (3β,5α,22E,24R)‐5,8‐epidioxyergosta‐6,22‐dien‐3‐ol ( 3 ) and 4‐(2‐hydroxyethyl)phenol ( 4 ), were isolated from the AcOEt extract of the culture broth and the MeOH extract of the mycelium of the fungal strain Stereum sp. CCTCC AF 207024. Their structures were established on the basis of spectral analyses.     

Novel Polyketides Isolated from Streptomyces sp.

From the endophytic strain Streptomyces sp. CS of Maytenus hookeri, five novel type III polyketides, compounds 1 – 5 , were isolated. Their structures were elucidated by spectroscopic analyses including 1D‐ and 2D‐NMR experiments, and by HR‐ESI‐MS.     

A New Sesquiterpene Lactone from Ainsliaea bonatii

A new sesquiterpene lactone, Ainsliaolide A, was isolated from Ainsliaea bonatii. The structure was determined on the basis of spectral data.     

A new sesquiterpene from the gorgonian coral Menella sp.

A new sesquiterpene named menecubebane B (1) and a known analogue (2) were isolated from the gorgonian coral Menella sp. Their structures were elucidated by the extensive analyses of spectroscopic data and by the comparison with related literature. Cytotoxic effect against both Eca9706 and HeLa cell lines was evaluated, revealing 1 exhibited moderate cytotoxicity against the two cell lines involved with IC₅₀ values being 20.8 and 30.6 μM, respectively.     

A New Acyclic Sesquiterpene Oligoglycoside from Pericarps of Sapindus mukurossi

A new acyclic sesquiterpene oligoglycoside, named mukurozioside A, was isolated from pericarps of Sapindun mukurossi. On the basis of chemical and spectral evidence, the structure of mukurozioside A has been established as:11(S)-2,6(E,E)-dodecadiene-3,7,11-trimethyl-1,12-diol-1,12-bis-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-6-O-acetyl-β-D-Glucopyranoside(1).     

A Novel Protoilludane Sesquiterpene from the Wood of Xanthoceras sorbifolia

In the course of our searching for anti-HIV agents from natural sources, we have isolated a triterpene and a doubly linked proanthocyanidin dimer as HIV-1 protease inhibitors from the wood of Xanthoceras sorbifolia Bunge (Sapindaceae)1. Further investigation of this plant has led to the isolation of a protoilludane sesquiterpene (1). The present paper describes the isolation and structural determination of this novel sesquiterpene. The EtOH eluate of a MeOH extract of the wood of X. so…     

Two Novel Sesquiterpene Diglycosides from Dictamnus dasycarpus

TherootbarkofDicla));nuscl(I311'c'(I)pllsTurcz.(Chinesename"Bai-Xian-Pi")(Rutaceae)isatraditi0nalChinesemedicineusedtbrtreatment0fjaundice,coughandrheumatism.lthasaIs0beenwidelyusedt0treatsomeskindiseases1.lnourpreviouspapers.werep0rtedtl1eisolati0nandstructuredeterminati0n0fantifungalfuroquinolinealkal0idsandfivenovelsesquiterPeneglycosides=".Inac0ntinuati0n0fourinvestigationofchemicalco11sitituents0fthisplant,weidentifiedan0thertw0novelsesquiterpenediglycosidesnameddictamn0sidesFlandG2f…     

A Novel Sesquiterpene Polyol Ester from Celastrus Angulatus and its Antitumor Activities

Chinesebittersweet(CelaslrusangulalusM.)iswidelydistributedinChina.IthasbeenusedastraditionalplantinsecticideandamedicinalherbformanyyearsinthefolkmedicineofChina'-'.Inpreviousstudies,P-dihydroagarofuransesquiterpenepolyolestersandsesquiterpenealkaloidswerefrequentlyfoundinthecelaslrusfamilyofplants'-',ItwasreportedthatmostofP-dihydroagarofuransesquiterpenepolyolestersfromChinesebit-tersweethaveinhibitoryeffectsonEBVandantitumoractivity'.,'.InourattempttofindnovelbioactivecompoundsintheCh…     

A New Perylenequinone from Hypomyces sp.

Some metabolites of fungi and plants containing perylenequinones have been used as folk medicine for the treatment of many diseases1,2. A filamentous fungus, Ascomy-cetes Hypocreaceae Hypomyces (Fr.) Tul. sp., was found from the northwestern mountains of Yunnan Province, and cultured successfully in the laboratory. A new perylenequinone, named hypomycin A (1), was isolated from its mycelia. In this paper the structure elucidation of 1 was described. Figure 1 The structure of compound 1 Fig…     

Sesquiterpene Lactones from Notoseris Porphyrolepis

Two new sesquiterpene lactones, notoserolides A and B, along with 12 known compounds were isolated from the aerial parts of Notoseris porphyrolepis.By means of spectral methods including MS, NMR (1H NMR, 13C NMR, DEPT, HMQC, HMBC) and X-ray diffraction, as well as chemical reactions, the structures of notoserolides A and B were established as austricin 8-O-β-D-glucopyranoside and 8-O-senecioylaustricin, respectively.     

A New Sesquiterpene from Ligularia Songarica

ThechemicalstudiesofLigulariasongaricahavenotbeenreportedtillnow.Inourpreliminarystudyontherootsofthisplant,anewbisabolanesesquiterpenewasobtainedanditsstructurewasidentifiedasSp-acetoxy-40,8-diangeloyloxy-26,3p,;10,Ildiepoxy-bisabola-7(14)-ene1.,Com...     

New Sesquiterpene Formamides from the Marine Sponge Axinyssa sp.

Chemical investigation of an extract of the marine sponge Axinyssa sp., collected from the South China Sea, led to the isolation and identification of two new sesquiterpene formamides, (4R*,5R*,10R*)‐4‐formamidoeudesm‐7‐ene ( 1 ) and (4R*,5R*,7S*,10R*)‐4‐formamidoeudesman‐11‐ol ( 2 ), together with the known 4α‐formamidogorgon‐11‐ene ( 3 ). Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR spectroscopy, high‐resolution ESI‐TOF mass spectrometry, as well as X‐ray single‐crystal diffraction experiments. Possible biosynthetic pathways for 1 – 3 were also proposed. The human nasopharyngeal cancer cell line CNE‐2, human cervical cancer cell line HeLa, and human normal liver cell line L02 were used to examine the cytotoxic activities of 1 – 3 in vitro. As the results, 1 showed significant cytotoxic activity against CNE‐2, HeLa, and L02 cell lines with the IC₅₀ values of 13.8, 7.5, and 38.0 μg/ml, resp.     

Sesquiterpene Lactones from Notoscris Porphyrolepis

The genus Noloserl's comprising of 14 species is native to China. and Noloserisporphl)rolopis Shin is mainly distributed in southwestern Chinal. So far there are manyreports on sesquiterpenes isolated from Asteraceae=, but nothing is known aboutsecondary metabolites of Notoseris. From the aerial parts of N. porphJ)rolepis. two newguaianolides A and B, named notoserolides A (2) and B (3), along with 12 knowncompounds, austricin (l), artesin'. magnolialide', deoxylactucin', jacquinelin'.cre…     

A New Sesquiterpene from Saussurea parviflora

A new sesquiterpene:11,12,13-trihydroxy-4(15),7(8)-eudesmdien-9-one was isolated from Saussurea parviflora. The structure was elucidated on the basis of spectral evidence.     

Eremophilane sesquiterpenes from the endophytic fungus Xylaria sp. GDG-102

A new eremophilane sesquiterpene, xylareremophil (1), together with five known eremophilanes, 1α,10α-epoxy-3α-hydroxyeremophil-7(11)-en-12,8β-olide (2), 1,10α,13-trihydroxyeremophil-7(11)-en-12,8-olide (3), 1α,10α-epoxy-13-hydroxyeremophil-7(11)-en-12,8β-olide (4), mairetolides B (5) and G (6) were isolated from the endophytic fungus Xylaria sp. GDG-102 cultured from Sophora tonkinensis. Their structures were elucidated on the basis of spectroscopic data analysis. The absolute configurations of 1 was determined by comparing computed electronic circular dichroism (ECD) and optical rotation (OR) with experimental results. Compounds 1, 5 and 6 showed antibacterial activities against Proteus vulgaris, Micrococcus luteus, Micrococcus lysodeikticus and Bacillus subtilis with MIC values of 25–100 μg/mL.     

Four Novel Diterpenoids from Crinipellis sp. 113

Four novel diterpenoids, namely (4β)‐4,4‐O‐dihydrocrinipellin A ( 1 ), (4β,8α)‐4,4‐O,8,8‐O‐tetrahydrocrinipellin B ( 2 ), crinipellin C ( 3 ), and crinipellin D ( 4 ), along with three known ones, (3β,4β)‐3,3‐C,4,4‐O‐tetrahydrocrinipellin A ( 5 ), (4β)‐4,4‐O‐dihydrocrinipellin B ( 6 ), and phlebiakauranol alcohol, were isolated from the fungal strain Crinipellis sp. 113. Their structures were elucidated by spectroscopic analyses, including 1D‐ and 2D‐NMR experiments, and by HR‐Q‐TOF mass spectrometry. Antitumor and antibacterial assays with the novel compounds 1 – 4 were carried out, showing moderate activities against HeLa cells and no effects on the growth of tested bacteria or yeast.     

A new polyoxygenated farnesylcyclohexenone from Fungus Penicillium sp.

A new polyoxygenated farnesylcyclohexenone, peniginsengin A (1), was isolated from the fermentation of Penicillium sp. YIM PH30003, an endophytic fungus associated with Panax notoginseng (Burk.) F. H. Chen. The structure was assigned based on a combination of 1 D and 2 D NMR and mass spectral data. The cytotoxicity and antimicrobial activities of compound 1 were investigated.     

A New Eremophilanoid Sesquiterpene from Senecio oldhamianus

A new Eremophilanoid sesquiterpene(1) was isolated from the whole plant of Senecio oldhaminus. Its structure was elucidated as 7β,11-epoxy-9α,10α-epoxy-8-oxoeremophilane using spectroscopic methords and X-ray analysis.     

A New Sesquiterpene Lactone from Scorzonera austriaca

A new guaianolide was isolated from the roots of Scorzonera austriaca. The structurewas elucidated on the basis of spectral methods including 2D NMR.     

Sinularianins A and B, novel sesquiterpenoids from the Formosan soft coral Sinularia sp.

Two novel sesquiterpenoids, sinularianins A and B (1 and 2), have been isolated from the Formosan coral Sinularia sp. The skeleton of sinularianins A (1), namely sinulariolane, was found to be unprecedented. Sinularianin B (2), with a novel spiro-butenolide moiety, possesses a valerenane skeleton, which had been reported mostly from the plant. The structures of both metabolites were established by extensive analysis of spectroscopic data.