神经系统疾病与认知动力学 (I) : 癫痫发作的动力学与控制

研究表明癫痫发作过程与神经系统本身的非线性动力学行为密切相关. 因此, 开展癫痫发作的非线性网络动力学建模与调控问题的研究, 有助于理解癫痫临床表征的动力学机理和定位致痫灶网络, 进而设计有效的网络调控策略. 本文回顾了癫痫脑神经疾病网络动力学与控制方面的研究进展, 系统总结了本文作者近年来在癫痫发作动力学建模分析及其调控等方面取得的研究成果. 首先, 基于海马齿状回CA3区环路神经元网络模型, 分析了影响颞叶癫痫发作的分子和网络结构因素, 阐释了癫痫发作转迁的动力学机制. 其次, 由于脑神经系统的集群编码特性, 基于神经场模型和平均场模型建模方法完善了皮质?基底节?丘脑环路网络动力学理论框架, 并基于此框架分析了失神癫痫发作转迁的动力学分岔机制, 探讨了不同类型癫痫发作的转迁路径, 发现了失神癫痫发作转迁的多稳态共存现象, 揭示了时滞对失神癫痫同步发作的控制效果, 设计了丰富有效的癫痫深脑刺激调控策略, 给出了电刺激调控失神癫痫发作的动力学解释. 最后, 通过数据驱动的统计建模和神经元群模型动力学建模分析, 提出了局灶癫痫致痫灶定位及寻找有效控制癫痫发作网络关键节点的理论新方法. 这些研究成果为理解难治性癫痫发作动力学本质及在临床诊疗的应用方面提供重要理论支撑. 最后对进一步研究给出若干建议.      

Experimental investigation on the vibro-compacted of RCC

The vibro-compacting process and the structural mechanism of RCC layers are discussed in this paper. In the meantime, some of their dynamic characteristics, such as the effect on the lower layer when rolling on the upper layer, the attenuation pattern of vibro-compacting energy along layer depth, the relationship between rolling parameters of vibro-compactor etc., which were clarified by tests in laboratory and at construction site, are also explained.     

Modeling the Impact of Plant Toxicity on Plant–Herbivore Dynamics

Numerous empirical studies over the past two decades have documented substantial effects of plant toxins on diet choice and feeding behavior of herbivores, but analytical models have failed thus far to incorporate toxin-mediated effects of browsing on plant population dynamics. We study a mathematical model that incorporates plant toxicity in the functional response of plant–herbivore interactions. The model also includes a Lotka–Volterra type competition between plants. The model exhibits a rich variety of complex dynamics including Hopf bifurcation and period-doubling bifurcations. Differences in dynamical behavior stem from interspecific differences in plant biology and strategies for growth and defense as well as variation in responses of herbivores to toxins. Analyses suggest that for realistic parameter values, herbivores are capable of promoting coexistence of plant species by ameliorating competitive effects and hence enhancing biodiversity.     

碾压混凝土振动压实的实验研究

本文通过实验室与现场的实验,对RCC 的振动压实机理进行了研究,初步弄清RCC 层的动态特性及上层碾压对下层的作用,得到:振动压实能沿层深的衰减规律,RCC的各碾压参数之间的关系,振动碾的最佳机械参数,并阐述了RCC 的结构机理与压实过程.     

Modelling and analysis of a multiple delayed exploited ecosystem towards coexistence perspective

This paper describes a multiple delayed modified Leslie–Gower type predator–prey system with a strong Allee effect in prey population growth. Non-selective effort is used to harvest the population. The dynamical characteristics of the delay induced system are rigorously studied using mathematical tools. The existence of coexistence equilibria is ensured, and the dynamic behavior of the system is investigated around coexistence equilibria. Uniform strong persistence and permanence of the system are discussed in order to ensure long-term survival of the species. The stability of the delay preserved system is investigated. Sufficient conditions are derived for local and global stability of the system. The existence of Hopf bifurcation phenomenon is examined around interior equilibria of the system. Subsequently, we use normal form method and center manifold theorem to examine the nature of the Hopf bifurcation. Finally, numerical simulations are carried out to validate the analytical findings.     

Mode change in the dynamics of exploited limited population with age structure

This study focuses on the dynamics of exploited limited population with age structure and compares dynamic modes of population models with and without exploitation while considering age-specific harvesting. Transcritical, period-doubling, and Neimark–Sacker bifurcations occur in the population models. In the case of juvenile harvest, the way of stability loss does not depend on the harvest rate. However, in the case of adult harvest, the hydra effect occurs, which is an increase in harvest rate that subsequently increases the stationary size of the young group. As a rule, harvesting leads to dynamics stabilization. However, the models reveal multistability. Hence, in the case of exploitation, different dynamic modes can occur with their attraction basins at the same population parameter values. Irregular harvesting or a changing harvest rate may also result in fluctuations in exploited population size because the current population size can shift from one attraction basin to another. Controlling exploited population dynamics is sufficient to shift and retain the population number to within the attraction basin of the dynamic mode selected.     

Dynamics of a Periodically Pulsed Bio-Reactor Model With a Hydraulic Storage Zone

In this paper, we investigate a periodically pulsed bio-reactor model of a flowing water habitat with a hydraulic storage zone in which no flow occurs. The full system can be reduced to a limiting system based on a conservation principle. Then we obtain sufficient conditions in terms of principal eigenvalues for the persistence of single population and the coexistence of two competing populations for the limiting system by appealing to the theory of monotone dynamical systems. Finally, we use the theory of chain transitive sets to lift the dynamics of the limiting system to the full system.     

Influence of prey refuge on predator–prey dynamics

A diffusive predator–prey system with Michaelis–Menten type functional response subject to prey refuge is considered. Bifurcation analysis of Hopf and Turing are carried out in detail. In particular, Turing domain is given in the two parameters space. The obtained results show that the refuges used by prey have great influence on the pattern formation of the populations. More specifically, as prey refuge being increased, spotted pattern and coexistence of spotted and stripe-like pattern emerge. It is also proved that the pattern is not dependent on the initial conditions, which means the pattern is controlled by the intrinsic mechanism.     

Dynamics of trains and train-like articulated systems travelling in confined fluid—Part 1: Modelling and basic dynamics

The dynamics and stability of a train of flexibly interconnected rigid cylinders travelling in a confined cylindrical “tunnel” subjected to fluid dynamic forces is studied theoretically. Each cylinder, which is coupled to other cylinders and supported by springs and dampers, has degrees of freedom in the lateral translational and rotational directions. The kinetic, dissipation, and potential energies of the system and the generalized forces associated with the fluid dynamic forces acting on the system, such as inviscid fluid dynamic forces, viscous frictional forces, and form drag, are obtained first. Then the equations of motion are derived in a Lagrangian framework. The principal aim of this study is to investigate the effect of the aerodynamic forces on the dynamics of a high-speed train running in a tunnel, or more generally of a train-like system travelling in a coaxial cylindrical tube. The results of this study show that the system loses stability by flutter and that viscous frictional drag has a considerable effect on stability of the system. In addition, the mechanism of instability of the system is clarified with the aid of a study of the modal shapes and energy considerations.     

A New dynamic model for study of dislocation pattern formation

Based on the principle given in nonlinear diffusion-reaction dynamics, a new dynamic model for dislocation patterning is proposed by introducing a relaxation time to the relation between dislocation density and dislocation flux. The so-called chemical potential like quantities, which appear in the model can be derived from variation principle for free energy functional of dislocated media, where the free energy density function is expessed in terms of not only the dislocation density itself but also their spatial gradients. The linear stability analysis on the governing equations of a simple dislocation density shows that there exists an intrinsic wave number leading to bifurcation of space structure of dislocation density. At the same time, the numerical results also demonstrate the coexistence and transition between different dislocation patterns. The project supported by the National Natural Science Foundation of China, Grant No.19392300     

Nonlinear dynamic characteristic of a face gear drive with effect of modification

Face gear drive is one of the main directions of research for aeronautical transmission for its advantages, but the vibration induced gear noise and dynamic load are rarely involved by researchers. The present work examines the complex, nonlinear dynamic behavior of a 6DOF face gear drive system combining with time varying stiffness, backlash, time varying arm of meshing force and supporting stiffness. The mesh pattern of the face gear drive system is analyzed when the modification strategy is applied and the effect of modification on the dynamics response, the time varying arm of meshing force based on the TCA is deduced. The dynamic responses of the face gear drive system show rich nonlinear phenomena. Nonlinear jumps, chaotic motions, period doubling bifurcation and multiple coexisting stable solutions are detected but different from the spur and bevel gear dynamics, which don’t occur near primary and higher harmonic resonance.     

多体系统动力学中关节效应模型的研究进展

在一般的多体系统动力学研究中认为运动关节是理想运动副. 然而,实际中的运动关节不仅含有间隙与摩擦,还有间隙引起的关节元素之间的接触碰撞、局部变形和磨损. 多体系统动力学中的关节效应不仅引起了系统的振动和噪声,减小了系统的可靠性和寿命,而且损失了系统的精度和稳定性. 为此,对近十几年多体系统动力学中关节效应的研究进行了详细分析,总结了关节效应中间隙运动学模型、接触力模型与磨损模型在多体系统动力学中的建模过程. 其中,着重分析了多体系统动力学中关节磨损效应的研究进展,并对常用的Reye'shypothesis 和Archard 磨损模型进行了比较,详细地分析了Archard 磨损模型的演变形式以及主要磨损参数(接触应力,接触面积和滑移距离),特别分析了关键磨损参数接触应力的建模方法,解释了基于Winkler 弹性基础理论在求解接触应力时遇到的困难. 另外,介绍了4 种间隙运动副(转动副、移动副、圆柱副和球面副) 的运动学模型. 分析了考虑关节磨损多体系统动力学模型的一般建模方法,并以平面五杆机构为例说明了其建模过程.最后,简要地展望了多体系统动力学中关节效应模型的发展趋势以及应用前景.      

大跨度斜拉桥非线性振动模型与理论研究进展

斜拉桥的非线性动力学问题一直都是力学、结构和桥梁领域的研究热点.随着新材料(如碳纤维增强聚合物索)和新施工工艺的发展,斜拉桥的跨越能力不断得到提高,从而在桥梁建设中更具有竞争力.然而,斜拉桥跨度的增大和新材料的应用使结构变得更轻和更柔,使结构的非线性振动问题比以往更为突出,可能危及桥梁安全.基于课题组近年来对斜拉桥非线性动力学的研究,围绕大跨度斜拉桥的非线性建模理论及动力学问题,较为详细地评述近十年来国内外的研究进展情况.主要从斜拉索非线性动力学模型、梁的非线性动力学模型、索-梁组合结构的非线性动力学模型、斜拉桥整体非线性动力学模型与理论、以及斜拉桥的非线性振动实验等几个方面对斜拉桥非线性建模方法、力学模型、数学模型、求解方法及相应研究成果进行评述和讨论.研究结果表明,斜拉桥由于多柔性索和大跨度梁的耦合问题,以及环境载荷的复杂性,导致其具有丰富的非线性动力学行为.同时由于高维非线性系统求解方法的欠缺,整体斜拉桥非线性动力学行为又相当复杂,深入研究面临很大困难.最后,基于未来斜拉桥的发展趋势和可能面临的突出问题,对斜拉桥非线性振动问题今后的发展方向进行了探讨和展望.      

神经系统信息处理和异常功能的复杂动力学

神经系统通过电活动实现信息处理及生物功能,电活动的节律和时空行为是功能的动力学表征.神经电生理实验结合理论模型,借助于分岔揭示了外界激励、参数和噪声调控下的周期、混沌和随机等多样性的节律模式及其节律的复杂转迁规律,揭示了感觉神经对信息(如血压压力信号和痛觉信息)的节律编码机制,揭示了突触噪声扩大脑神经元的信息传递能力并对能力强弱进行了分类,结果可用于提高信息检测能力和指导镇痛;借助于单神经元节律的动力学——如分岔和簇放电节律的快慢动力学——解释了网络功能异常的时空行为,如药物调控脑皮层的螺旋波/癫痫和慢抑制耦合调控的运动网络的同步转迁/运动模式异常,结果给出了调控系统功能的途径;通过大数据分析获得自闭症患者的脑功能网络的时空行为特征——症状相关脑区的同步活动降低,给出了用于诊断的潜在指标.通过新实验发现、新建理论模型、新分析方法和新观点阐释,揭示了神经系统的复杂动力学,认识和解释了神经系统的信息处理机制和异常生物功能/疾病,具有重要科学意义和潜在应用价值.     

Three-dimensional energy channeling in the unit-cell model coupled to a spherical rotator II: unidirectional energy channeling

In order to realize the dynamic response analysis and the chaos identification of flexible spatial parallel mechanism, the nonlinear elastic dynamics model of 4-UPS-UPU flexible parallel mechanism is established under the ideal situation, and the dynamic response, phase diagrams, Poincare map and largest Lyapunov exponent of the spatial parallel mechanism are investigated. Based on the finite element method, the driving limbs of spatial parallel mechanism are divided into elements. The kinetic energy equation and potential energy equation of units are built. Then the nonlinear elastic dynamics model of 4-UPS-UPU parallel mechanism is acquired by Lagrange equation. The dynamic response of kinematic error for 4-UPS-UPU flexible parallel mechanism is analyzed. In addition, the chaos phenomenon contained in the mechanism is identified by phase diagrams, Poincare map and largest Lyapunov exponent, respectively. Subsequently, the relationship between the basic parameters of parallel mechanism and largest Lyapunov exponent is discussed. The results indicate that there exists chaotic phenomena in the 4-UPS-UPU flexible parallel mechanism, and the basic parameters, including the material of driving limbs, diameter of driving limbs, mass of moving platform and the distribution radius of hinges of moving platform all have great effect on chaotic motion of 4-UPS-UPU flexible parallel mechanism. The researches can provide important theoretical for the further nonlinear dynamics behaviors research and optimal design of 4-UPS-UPU flexible spatial parallel mechanism.     

纳米颗粒多相流体动力学研究及应用

纳米颗粒多相流研究是目前多相流研究中新的研究方向及重点发展领域.为探索纳米尺度多相流相间作用机理及内部存在机制,采用理论分析及数值计算手段,对一般动力学方程的封闭处理、颗粒碰撞率宏观模型的有效构建、颗粒凝并系统动力学演变特性的机理分析、非稀相问题碰撞率的求取、双变量问题求解方法的建立以及一些实际应用进行了系统研究,提出了新的针对纳米尺度颗粒动力学演变的一般动力学方程求解方法,并将其应用于实际工业过程问题的研究.该文对上述研究工作进行了综述.     

Biomechanical and dynamic mechanism of locust take-off

The biomimetic locust robot hopping vehicle has promising applications in planet exploration and reconnaissance. This paper explores the bionic dynamics model of locust jumping by using high-speed video and force analysis. This paper applies hybrid rigid-flexible mechanisms to bionic locust hopping and studies its dynamics with emphasis laid on the relationship between force and jumping performance. The hybrid rigid-flexible model is introduced in the analysis of locust mechanism to address the principles of dynamics that govern locust joints and mechanisms during energy storage and take-off. The dynamic response of the biomimetic mechanism is studied by considering the flexi- bility according to the locust jumping dynamics mechanism. A multi-rigid-body dynamics model of locust jumping is established and analyzed based on Lagrange method; elastic knee and tarsus mechanisms that were proposed in previous works are analyzed alongside the original bionic joint configurations and their machinery principles. This work offers primary theories for take-off dynamics and establishes a theoretical basis for future studies and engineering applications.     

基于分子动力学模拟的单晶硅冲击压缩相变研究

晶体硅具有复杂的相变机制,在相图研究中受到广泛关注,其在动载荷下的变形机制是当前研究热点。为揭示晶体硅在强动加载下的变形和相变行为特征,基于分子动力学方法,采用平板冲击加载方式,模拟研究了单晶硅在初始环境温度为300 K时分别沿[001]、[110]和[111]晶向的不同强度下的冲击压缩行为,冲击粒子速度为0.3～3.2 km/s。研究发现,随着冲击粒子速度的增加,单晶硅剪切应力在逐渐增加后由于结构相变发生急剧下降,相变阈值和相变机制均呈现各向异性。其中,沿[001]晶向冲击压缩下观察到多种固-固相变以及固-液相变,并观察到与最新文献的实验高度一致的固-液共存现象。研究结果可为动加载下晶体硅的相变研究提供纳米尺度的结果支撑。     

双臂空间机器人关节空间的补偿学习控制

在载体位置与姿态均不受控制情况下,结合动量(矩)守恒关系对系统进行了运动学、动力学的分析,得到了漂浮基双臂空间机器人的系统动力学方程.采用PD控制的计算力矩法,得到了系统的闭环动态误差方程,在此基础上设计了针对不确定性的自由漂浮空间机器人的控制方案,提出了一种基于遗传算法的补偿学习控制方法.将补偿学习控制与计算力矩法相结合,利用遗传算法的进化学习消除不确定因素的影响,实现机器人轨迹跟踪的良好控制.     

区域稳定动力学研究(一)——理论与方法体系

将区域稳定工程地质学推进到区域稳定动力学的研究层次上, 系统地构建了区域表层稳定动力学、区域浅层稳定动力学、区域深层稳定动力学、区域活动构造动力学、区域地震动力学、区域非稳定动力学过程及机制模式, 以及区域非稳定动力学环境下的地震工程效应、岩体失稳效应、场地失稳效应及建筑物抗断效应的综合研究及分析评价的区域稳定动力学研究的理论体系与方法体系。