共查询到20条相似文献,搜索用时 62 毫秒
1.
O. V. Kushnir N. V. Mel’nichenko M. V. Vovk 《Russian Journal of Organic Chemistry》2011,47(11):1727-1732
Dialkyl 2-oxo-3-allyl-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates obtained by condensation of 1-chlorobenzyl isocyanates
with N-allylfumarates reacted regioselectively with arylhydroxymoyl chlorides with the formation of dialkyl 6-aryl-3-[(3-aryl-4,5-dihydro-5-isoxazolyl)methyl]-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates. 相似文献
2.
V. L. Gein T. M. Zamaraeva E. S. Volkova M. V. Dmitriev 《Russian Journal of Organic Chemistry》2016,52(5):730-733
Reaction of diethyl oxalylacetate sodium salt with aromatic aldehydes and urea led to the formation of diethyl 6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4,5-dicarboxylates. 相似文献
3.
V. L. Gein T. M. Zamaraeva A. Yu. Fedotov A. V. Balandina M. V. Dmitriev 《Russian Journal of General Chemistry》2016,86(11):2437-2441
Reactions of acetoacetic acid N-arylamides with aromatic aldehydes and urea led to the formation of N,6-diaryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined. 相似文献
4.
V. L. Gein N. V. Nosova A. S. Prusakova M. I. Vakhrin A. P. Kriven’ko 《Russian Journal of General Chemistry》2008,78(12):2357-2362
Benzylamine, phenethylamine, and homoveratrylamine reacted with dialkyl 2-aryl-4-hydroxy-4-methyl-6-oxocyclohexane-1,3-dicarboxylates at the endocyclic carbonyl group with conservation of the enolic hydroxy group to give dialkyl 4-alkylamino-2-aryl-6-hydroxy-6-methylcyclohex-3-ene-1,3-dicarboxylates. The reaction of dimethyl 4-hydroxy-4-methyl-6-oxo-2-phenylcyclohexane-1,3-dicarboxylate with tryptamine was accompanied by dehydration with formation of dimethyl 4-[2-(1H-indol-3-yl)ethylamino]-6-methyl-2-phenylcyclohexa-3,5-diene-1,3-dicarboxylate, presumably due to basic properties of the indole nitrogen atom. 相似文献
5.
The highly reactive 1:1 adduct, produced from the reaction between dialkyl acetylenedicarboxylates and alkyl isocyanides, was trapped by strong cyclic CH-acids such as 4-hydroxy-6-methyl-2H-pyran-2-one or 4-hydroxycoumarin to yield dialkyl 2-(alkylamino)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3,4-dicarboxylates or dialkyl 7-methyl-2-(alkylamino)-5-oxo-4H,5H-pyrano[4,3-b]pyran-3,4-dicarboxylates in good yields at room temperature. 相似文献
6.
V. L. Gein I. V. Krylova E. P. Tsypliakova A. R. Gaifullina L. I. Varkentin M. I. Vakhrin 《Chemistry of Heterocyclic Compounds》2009,45(7):829-832
Methyl esters of 5-aroyl-6-aryl-2-oxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acids were synthesized from three component
mixtures of methyl esters of aroylpyruvic acids, urea, and substituted benzaldehydes. 8-Hydroxy-4,5-diphenyl-3,4-dihydropyrimido[4,5-d]pyridazin-2(1H)-one was synthesized by the reaction of 5-benzoyl-2-oxo-6-phenyl-1,2,3,6-tetrahydropyrimidin-4-carboxylate
with hydrazine hydrate. 相似文献
7.
An efficient and one-pot synthesis of 2-(2-oxoindolin-3-ylidene)-1,3-dithiole-4,5-dicarboxylates by a three-component condensation reaction of isatins, carbon disulfide and dialkyl acetylendicarboxylates in the presence of Bu3P is reported. Reaction of carbon disulfide and dialkyl acetylene dicarboxylates with acenaphthylene-1,2-dione, ninhydrine and pyrimidine-tetraone resulted in the formation of 2-(2-oxoacenaphthylen-1(2H)-ylidene)-1,3-dithiole-4,5-dicarboxylates, 2-(1,3-dioxo-1H-inden-2(3H)-ylidene)-1,3-dithiole-4,5-dicarboxylates and 2-(2,4,6-trioxotetrahydropyrimidin-5(6H)-ylidene)-1,3-dithiole-4,5-dicarboxylates, respectively, in the same conditions. 相似文献
8.
Issa Yavari Farough Nasiri Loghman Moradi Hoorieh Djahaniani 《Tetrahedron letters》2004,45(38):7099-7101
Reaction of tert-butyl isocyanide with electron-deficient acetylenic esters in the presence of N1-[(Z)-1-benzoyl-3-oxo-3-phenyl-1-propenyl]-2-(2-furyl)-2-oxoacetamide leads to dialkyl 5-tert-butylamino-[2,2′]bifuranyl-3,4-dicarboxylates in moderate yields. 相似文献
9.
V. V. Shchepin P. S. Silaichev Yu. G. Stepanyan M. I. Vakhrin 《Russian Journal of General Chemistry》2006,76(6):942-945
Organozinc compounds obtained by treatment of dialkyl 2,2-dibromomalonates with zinc reacted with N-substituted 2-oxochromene-3-carboxamides to give dialkyl 1a-R-carbamoyl-2-oxo-1a,7b-dihydro-2H-cyclopropa[c]chromene-1,1-dicarboxylates or alkyl 2-R-1,3,4-trioxo-2,3-dihydro-1H,9bH-chromeno[3′,4′:1,3]-cyclopropa[1,2-c]pyrrole-9c-carboxylates. Reactions of N-substituted 2-oxochromene-3-carboxamides with zinc enolates derived from methyl 4,4-dibromo-3-oxoalkanoates led to the formation of the corresponding 9c-alkyl-2-R-2,3-dihydrochromeno[3′,4′:1,3]cyclopropa[1,2-c]pyrrole-1,3,4-triones. 相似文献
10.
V. L. Gein T. M. Zamaraeva A. V. Balandina M. V. Dmitriev 《Russian Journal of General Chemistry》2016,86(12):2666-2670
Three-component reactions of acetoacetic acid N-arylamides, aromatic aldehydes, and thiourea afforded N,6-diaryl-4-methyl-2-thioxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. Structure and antimicrobial activity of the compounds obtained were examined. 相似文献
11.
Issa Yavari 《Tetrahedron letters》2006,47(17):2953-2956
Benzoyl isothiocyanate reacts with dialkyl acetylenedicarboxylates in the presence of triphenylphosphine in a mechanistically novel reaction to afford highly substituted dialkyl 2-(benzoylimino)-5-phenyl-4H-[1,3]dithiolo[4,5-b]pyrrole-4,6-dicarboxylates with double insertion of the isothiocyanate. The reaction proceeds via a carbon to nitrogen migration of an alkoxycarbonyl group. 相似文献
12.
Reaction of tert-butyl isocyanide with dialkyl acetylenedicarboxylates in the presence of 2-acetylbutyrolactone leads to the formation of dialkyl (E)-2-{(tert-butylamino)[2-oxo-4,5-dihydro-3(2H)-furanylidene]methyl}-2-butenedioates. 相似文献
13.
Pyridines react smoothly with dialkyl acetylenedicarboxylates in the presence of isocyanates to produce dialkyl 2-oxo-1,9a-dihydro-2H-pyrido[1,2-a]pyrimidine 3,4-dicarboxylates in excellent yields. 相似文献
14.
T. M. Zamaraeva T. F. Odegova A. Yu. Fedotov M. V. Tomilov V. L. Gein P. A. Slepukhin 《Russian Journal of General Chemistry》2014,84(10):1950-1952
Three-component reaction of acetoacetanilide, aromatic aldehydes, and N-methylurea afforded 6-aryl-3,4-dimethyl-N-phenyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-carboxamides. IR, 1H NMR spectroscopy, mass spectrometry, and X-ray diffraction analysis data confirmed the structure of the compounds obtained. Antimicrobial activity of these compounds was investigated. 相似文献
15.
E. V. Bayandina E. Yu. Davydova M. N. Dimukhametov A. B. Dobrynin I. A. Litvinov R. Z. Musin V. A. Al'fonsov 《Russian Chemical Bulletin》2005,54(6):1496-1499
Reactions of dialkyl phosphorochloridites with 3-(N-benzylideneamino)propan-1-ol follow two pathways giving rise to linear dialkyl 1-(3-chloropropylamino)benzylphosphonates
and diastereomeric cyclic 2-alkoxy-2-oxo-3-phenyl-1,4,2-oxazaphosphepanes.
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1453–1455, June, 2005. 相似文献
16.
P. S. Silaichev Yu. G. Stepanyan N. V. Kudrevatykh A. N. Maslivets 《Russian Journal of Organic Chemistry》2014,50(6):843-845
1-Aryl-4,5-diaroyl-1H-pyrrole-2,3-diones reacted with 3-aminobut-2-enenitrile to produce 1,6-diaryl-4-aroyl-3-hydroxy-8-methyl-2-oxo-1,7-diazaspiro[4.4]nona-3,6,8-triene-9-carbonitriles. 相似文献
17.
V. L. Gein T. M. Zamaraeva A. A. Kurbatova M. I. Vakhrin 《Chemistry of Heterocyclic Compounds》2010,46(7):856-858
A three-component synthesis using acetoacetanilides and a mixture of an aromatic aldehyde and urea yields 6-aryl-4-methyl-2-oxo-1,2,3,6-tetrahydropyrimidine-5-(N-aryl)carboxamides. 相似文献
18.
Issa Yavari Anvar Mirzaei Loghman Moradi Nargess Hosseini 《Tetrahedron letters》2008,49(15):2355-2358
The 1:1 intermediate generated by the addition of quinoline to dialkyl acetylenedicarboxylates is trapped by 1,3-indanedione to yield dialkyl 3-spiroindanedione-1,2,3,3a-tetrahydropyrrolo[1,2-a]quinoline-1,2-dicarboxylates in good yields. The structures of these products were confirmed by NMR and single-crystal X-ray diffraction studies. 相似文献
19.
Ethyl 4-methyl-2-oxo-7-phenylthio-2,3,6,7-tetrahydro-1H-1,3-diazepine-5-carboxylate and/or ethyl 6-methyl-2-oxo-4-(phenylthiomethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate were obtained in the reaction of ethyl 4-chloromethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate with PhSNa or PhSK with or without PhSH, depending on the reagent ratio, reaction time, or temperature, as a result of ring expansion and/or nucleophilic substitution. The reaction pathway was affected strongly by the basicity-nucleophilicity of the reaction media. The results obtained were confirmed by reactions of 4-mesyloxymethyl-6-methyl-5-tosyltetrahydropyrimidin-2-one with PhSNa/PhSH and ethyl 4-chloromethyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate with NaCN/HCN or NaCH(COOEt)2/CH2(COOEt)2. 相似文献
20.
The domino [2+2+2] cycloaddition reaction of α,β-unsaturated N-arylaldimines, dialkyl acetylenedicarboxylates and 2-arylidene-1,3-indanediones in dry methylene dichloride at room temperature afforded isomeric 2′-styryl-1,2′,3,4′-tetrahydro-1′H-spiro[indene-2,3′-pyridines] in good yields. Under similar conditions, the reaction of α,β-unsaturated N-arylaldimines with two molecules of dialkyl acetylenedicarboxylates resulted in 1-aryl-6-styryl-1,6-dihydropyridine-2,3,4,5-tetracarboxylates. Additionally, the three-component reaction of α,β-unsaturated N-arylaldimines, dimethylacetylenedicarboxylate and benzoyl cyanide also gave isomeric 1,3-oxazine-4,5-dicarboxylates. 相似文献