Quinazoline-2,4(1H,3H)-diones inhibit the growth of multiple human tumor cell lines

Quinazoline-2,4( $1H,3H$ )-diones exhibit a wealth of biological activities including antitumor proliferation. We established an improved method for the synthesis of quinazoline-2,4( $1H,3H$ )-dione derivatives with three points of molecular diversity. Data indicate that compounds 60 (average $\text{ logGI}_{50} \!=\! -6.1$ ), 65 (average $\text{ logGI}_{50} \!=\! -6.13$ ), 69 (average $\text{ logGI}_{50} \!=\! -6.44$ ), 72 (average $\text{ logGI}_{50} \!=\! -6.39$ ), and 86 (average $\text{ logGI}_{50} = -6.45$ ) significantly inhibited the in vitro growth of 60 human tumor cell lines tested. Structure–activity relationship analyses indicate that chlorophenethylureido is the necessary substituent at the $\text{ D}_{3}$ diversity point (7-position of quinazoline-2,4( $1H,3H$ )-dione), in particular, $o$ -chlorophenethylurea (69) achieved optimal activity. $o$ - or $m$ -Chlorophenethyl substitutions (69 and 72) at the $\text{ D}_{2}$ diversity point (3-position of quinazo line-2,4( $1H,3H$ )-dione) gave the most potent compounds. Methoxyl and 4-methylpiperazin-1-yl substitution at the $\text{ D}_{1}$ diversity point (6-position of quinazoline-2,4( $1H,3H$ )-dione skeleton) may yield better activity than other groups. The quinazoline-2,4( $1H,3H$ )-dione scaffold can be effectively replaced by 2 $H$ -benzo[b][1,4]thiazin-3(4 $H$ )-one.     

Extensions of Ordering Sets of States from Effect Algebras onto Their MacNeille Completions

In (Rie?anová and Zajac in Rep. Math. Phys. 70(2):283–290, 2012) it was shown that an effect algebra E with an ordering set $\mathcal{M}$ of states can by embedded into a Hilbert space effect algebra $\mathcal{E}(l_{2}(\mathcal{M}))$ . We consider the problem when its effect algebraic MacNeille completion $\hat{E}$ can be also embedded into the same Hilbert space effect algebra $\mathcal {E}(l_{2}(\mathcal{M}))$ . That is when the ordering set $\mathcal{M}$ of states on E can be extended to an ordering set of states on $\hat{E}$ . We give an answer for all Archimedean MV-effect algebras and Archimedean atomic lattice effect algebras.     

A realistic pattern of lepton mixing and masses from $$S_4$$ and CP

We calculate the combined angular-distribution functions of the polarized photons ( $\gamma _1$ and $\gamma _2$ ) and electron ( $e^-$ ) produced in the cascade process $\bar{p}p\rightarrow {^3{D_3}}\rightarrow {^3{P_2}}+\gamma _1 \rightarrow (\psi +\gamma _2)+\gamma _1\rightarrow (e^++e^-)+\gamma _1+\gamma _2$ , when the colliding $\bar{p}$ and $p$ are unpolarized. Our results are independent of any dynamical models and are expressed in terms of the spherical harmonics whose coefficients are functions of the angular-momentum helicity amplitudes of the individual processes. Once the joint angular distribution of ( $\gamma _1$ , $\gamma _2$ ) and that of ( $\gamma _2$ , $e^-$ ) with the polarization of either one of the two particles are measured, our results will enable one to determine the relative magnitudes as well as the relative phases of all the angular-momentum helicity amplitudes in the radiative decay processes ${^3{D_3}}\rightarrow {^3{P_2}}+\gamma _1$ and ${^3{P_2}}\rightarrow \psi +\gamma _2$ .     

Charmonium rescattering effects in \psi(2S) \rightarrow \gamma \eta_{c}^{} decay

Charmonium rescattering effects in the M1 transition of $ \psi$ (2S) $ \rightarrow$ $ \gamma$ $ \eta_{c}^{}$ are investigated by modeling a $ \chi_{{cJ}}^{}$ or J/ $ \psi$ rescattering into a $ \eta_{c}^{}$ final state. The absorptive and dispersive part of the transition amplitudes for the rescattering loops of $ \eta$ $ \psi$ ( $ \gamma^{{\ast}}_{}$ ) and $ \gamma$ $ \chi$ ( $ \psi$ ) are separately evaluated. The numerical results show that the contribution from the $ \gamma$ $ \chi$ ( $ \psi$ ) rescattering process is negligible. Compared with the virtual D $ \bar{{D}}$ (D ^*) rescattering processes, the $ \eta$ $ \psi$ ( $ \gamma^{{\ast}}_{}$ ) process may be regarded as the next-leading order of the hadronic loop mechanism, which only offers the partial decay width of ～ 0.045 keV to the $ \psi$ (2S) $ \rightarrow$ $ \gamma$ $ \eta_{c}^{}$ .     

Calculation of HELAS amplitudes for QCD processes using graphics processing unit (GPU)

We use a graphics processing unit (GPU) for fast calculations of helicity amplitudes of quark and gluon scattering processes in massless QCD. New HEGET (HELAS Evaluation with GPU Enhanced Technology) codes for gluon self-interactions are introduced, and a C++ program to convert the MadGraph generated FORTRAN codes into HEGET codes in CUDA (a C-platform for general purpose computing on GPU) is created. Because of the proliferation of the number of Feynman diagrams and the number of independent color amplitudes, the maximum number of final state jets we can evaluate on a GPU is limited to 4 for pure gluon processes (gg→4g), or 5 for processes with one or more quark lines such as $q\overline{q}\rightarrow 5g$ and qq→qq+3g. Compared with the usual CPU-based programs, we obtain 60–100 times better performance on the GPU, except for 5-jet production processes and the gg→4g processes for which the GPU gain over the CPU is about 20.     

Self-Dual Noncommutative {\phi^4} -Theory in Four Dimensions is a Non-Perturbatively Solvable and Non-Trivial Quantum Field Theory

We study quartic matrix models with partition function \({\mathcal{Z}[E, J] = \int dM}\) exp(trace \({(JM - EM^{2} - \frac{\lambda}{4} M^4)}\) ). The integral is over the space of Hermitean \({\mathcal{N} \times \mathcal{N}}\) -matrices, the external matrix E encodes the dynamics, \({\lambda > 0}\) is a scalar coupling constant and the matrix J is used to generate correlation functions. For E not a multiple of the identity matrix, we prove a universal algebraic recursion formula which gives all higher correlation functions in terms of the 2-point function and the distinct eigenvalues of E. The 2-point function itself satisfies a closed non-linear equation which must be solved case by case for given E. These results imply that if the 2-point function of a quartic matrix model is renormalisable by mass and wavefunction renormalisation, then the entire model is renormalisable and has vanishing β-function. As the main application we prove that Euclidean \({\phi^4}\) -quantum field theory on four-dimensional Moyal space with harmonic propagation, taken at its self-duality point and in the infinite volume limit, is exactly solvable and non-trivial. This model is a quartic matrix model, where E has for \({\mathcal{N} \to \infty}\) the same spectrum as the Laplace operator in four dimensions. Using the theory of singular integral equations of Carleman type we compute (for \({\mathcal{N} \to \infty}\) and after renormalisation of \({E, \lambda}\) ) the free energy density (1/volume) log \({(\mathcal{Z}[E, J]/\mathcal{Z}[E, 0])}\) exactly in terms of the solution of a non-linear integral equation. Existence of a solution is proved via the Schauder fixed point theorem. The derivation of the non-linear integral equation relies on an assumption which in subsequent work is verified for coupling constants \({\lambda \leq 0}\) .     

Influence of assortativity and degree-preserving rewiring on the spectra of networks

Newman’s measure for (dis)assortativity, the linear degree correlation coefficient $\rho _{D}$ , is reformulated in terms of the total number N _k of walks in the graph with k hops. This reformulation allows us to derive a new formula from which a degree-preserving rewiring algorithm is deduced, that, in each rewiring step, either increases or decreases $\rho _{D}$ conform our desired objective. Spectral metrics (eigenvalues of graph-related matrices), especially, the largest eigenvalue $\lambda _{1}$ of the adjacency matrix and the algebraic connectivity $\mu _{N-1}$ (second-smallest eigenvalue of the Laplacian) are powerful characterizers of dynamic processes on networks such as virus spreading and synchronization processes. We present various lower bounds for the largest eigenvalue $\lambda _{1}$ of the adjacency matrix and we show, apart from some classes of graphs such as regular graphs or bipartite graphs, that the lower bounds for $\lambda _{1}$ increase with $\rho _{D}$ . A new upper bound for the algebraic connectivity $\mu _{N-1}$ decreases with $\rho _{D}$ . Applying the degree-preserving rewiring algorithm to various real-world networks illustrates that (a) assortative degree-preserving rewiring increases $\lambda _{1}$ , but decreases $\mu _{N-1}$ , even leading to disconnectivity of the networks in many disjoint clusters and that (b) disassortative degree-preserving rewiring decreases $\lambda _{1}$ , but increases the algebraic connectivity, at least in the initial rewirings.     

Analysis of the vertexes \Xi_{Q}^{*}′QV , \Sigma_{Q}^{*} \Sigma_{Q}^{}V and radiative decays \Xi_{Q}^{*} \rightarrow ′Q \gamma , \Sigma_{Q}^{*} \rightarrow \Sigma_{Q}^{} \gamma

In this article, we study the vertexes $ \Xi_{Q}^{*}$ ′_Q V and $ \Sigma_{Q}^{*}$ $ \Sigma_{Q}^{}$ V with the light-cone QCD sum rules, then assume the vector meson dominance of the intermediate $ \phi$ (1020) , $ \rho$ (770) and $ \omega$ (782) , and calculate the radiative decays $ \Xi_{Q}^{*}$ $ \rightarrow$ ′_Q $ \gamma$ and $ \Sigma_{Q}^{*}$ $ \rightarrow$ $ \Sigma_{Q}^{}$ $ \gamma$ .     

Reaction pp \rightarrow pp \pi \pi \pi as a background for hadronic decays of the \eta^{{\prime}}_{} meson

Isospin violating hadronic decays of the $ \eta$ and $ \eta{^\prime}$ mesons into 3 $ \pi$ mesons are driven by a term in the QCD Lagrangian proportional to the mass difference of the d and u quarks. The source giving large yield of the mesons for such decay studies are pp interactions close to the respective kinematical thresholds. The most important physics background for $ \eta$ , $ \eta{^\prime}$ $ \rightarrow$ $ \pi$ $ \pi$ $ \pi$ is coming from direct three-pion production reactions. In case of the $ \eta$ meson the background for the decays is relatively low ( $ \approx$ 10% . The purpose of this article is to provide an estimate of the direct pion production background for the $ \eta{^\prime}$ $ \rightarrow$ 3 $ \pi$ decays. Using the inclusive data from the COSY-11 experiment we have extracted the differential cross-section for the pp $ \rightarrow$ pp -multipion production reactions with the invariant mass of the pions equal to the $ \eta{^\prime}$ meson mass and estimated an upper limit for the signal to background ratio for studies of the $ \eta{^\prime}$ $ \rightarrow$ $ \pi^{+}_{}$ $ \pi^{-}_{}$ $ \pi^{0}_{}$ decay.     

Energy dependence of {\bar{K}N} interaction in nuclear medium

When the $\bar{K}N$ system is submerged in nuclear medium the $\bar{K}N$ scattering amplitude and the final state branching ratios exhibit a strong energy dependence when going to energies below the $\bar{K}N$ threshold. A sharp increase of $\bar{K}N$ attraction below the $\bar{K}N$ threshold provides a link between shallow $\bar{K}$ -nuclear potentials based on the chiral $\bar{K}N$ amplitude evaluated at threshold and the deep phenomenological optical potentials obtained in fits to kaonic atoms data. We show the energy dependence of the in-medium K ^??? p amplitude and demonstrate the impact of energy dependent branching ratios on the Λ-hypernuclear production rates.     

Error Analysis on Photonic Qubit Rotations Implemented by Wave Plates

Optical Poincare sphere rotations $e^{-i\theta\sigma_{x}/2}$ , $e^{-i\theta\sigma_{y}/2}$ and $e^{-i\theta\sigma_{z}/2}$ can be realized by wave-plate combinations. Errors due to combinations with non-ideal wave plates are discussed for three specific combinations (θ=π) by trace distance. The result shows that different settings of combinations affect trace distance: (i) trace distance for $e^{-i\pi\sigma_{x}/2}$ equals that for $e^{-i\pi\sigma_{z}/2}$ , but both of them are smaller than that for $e^{-i\pi\sigma_{y}/2}$ , when optics-axis random errors are considered; (ii) trace distance for $e^{-i\pi\sigma_{x}/2}$ also equals that for $e^{-i\pi\sigma_{z}/2}$ , but both of them are larger than that for $e^{-i\pi\sigma_{y}/2}$ , when phase-shift random errors are considered. The method outlined in this paper is general and is useful to analyze other combinations.     

Photoproduction of pions and properties of baryon resonances from a Bonn-Gatchina partial-wave analysis

Masses, widths and photocouplings of baryon resonances are determined in a coupled-channel partial-wave analysis of a large variety of data. The Bonn-Gatchina partial-wave formalism is extended to include a decomposition of t and u exchange amplitudes into individual partial waves. The multipole transition amplitudes for $ \gamma$ p $ \rightarrow$ p $ \pi^{0}_{}$ and $ \gamma$ p $ \rightarrow$ n $ \pi^{+}_{}$ are given and compared to results from other analyses.     

Possible Existence of {(c\bar{c})} –Nucleus Bound States

Charmonium ( \({c \bar{c}}\) ) bound states in few-nucleon systems, ²H, ⁴He and ⁸Be, are studied via Gaussian Expansion Method (GEM). We adopt a Gaussian potential as an effective \({(c \bar{c})}\) –nucleon (N) interaction. The relation between two-body \({(c \bar{c})}\) –N scattering length \({a_{c\bar{c}-N}}\) and the binding energies B of \({(c \bar{c})}\) –nucleus bound states are given. Recent lattice QCD data of \({a_{c\bar{c}-N}}\) corresponds to \({B \simeq 0.5}\) MeV for \({(c \bar{c})-^{4}}\) He and 2 MeV for \({(c \bar{c})-^{8}}\) Be in our results.     

Some Properties of Generalized Quantum Operations

Let $\mathcal{B}(\mathcal{H})$ be the set of all bounded linear operators on the separable Hilbert space  $\mathcal{H}$ . A (generalized) quantum operation is a bounded linear operator defined on  $\mathcal{B}(\mathcal{H})$ , which has the form $\varPhi_{\mathcal{A}}(X)=\sum_{i=1}^{\infty}A_{i}XA_{i}^{*}$ , where $A_{i}\in\mathcal{B}(\mathcal{H})$ (i=1,2,…) satisfy $\sum_{i=1}^{\infty}A_{i}A_{i}^{*}\leq \nobreak I$ in the strong operator topology. In this paper, we establish the relationship between the (generalized) quantum operation $\varPhi_{\mathcal{A}}$ and its dual $\varPhi_{\mathcal {A}}^{\dag}$ with respect to the set of fixed points and the noiseless subspace. In particular, we also partially characterize the extreme points of the set of all (generalized) quantum operations and give some equivalent conditions for the correctable quantum channel.     

Photon Asymmetries in {nd\rightarrow} 3 Hγ Using EFT({/\!\!\!\pi}) Approach

The parity-violating Lagrangian of the weak nucleon-nucleon (NN) interaction in the pionless effective field theory (EFT( \({/\!\!\!\pi}\) )) approach contains five independent unknown low-energy coupling constants (LECs). The photon asymmetry with respect to neutron polarization in \({np\rightarrow d\gamma A_\gamma^{np}}\) , the circular polarization of outgoing photon in \({np\rightarrow d\gamma P_\gamma^{np}}\) , the neutron spin rotation in hydrogen \({\frac{1}{\rho}\frac{d\phi^{np}}{dl}}\) , the neutron spin rotation in deuterium \({\frac{1}{\rho}\frac{d\phi^{nd}}{dl}}\) and the circular polarization of γ-emission in \({nd\rightarrow}\) ³ Hγ \({P^{nd}_\gamma}\) are the parity-violating observables which have been recently calculated in terms of parity-violating LECs in the EFT( \({/\!\!\!\pi}\) ) framework. We obtain the LECs by matching the parity-violating observables to the Desplanques, Donoghue, and Holstein (DDH) best value estimates. Then, we evaluate photon asymmetry with respect to the neutron polarization \({a^{nd}_\gamma}\) and the photon asymmetry in relation to deuteron polarization \({A^{nd}_\gamma}\) in \({nd\rightarrow}\) ³ Hγ process. We finally compare our EFT( \({/\!\!\!\pi}\) ) photon asymmetries results with the experimental values and the previous calculations based on the DDH model.     

Large N approach to Kaon decays and mixing 28 years later: \Delta I=1/2 rule, \hat{B}_K,and \Delta M_K

We review and update our results for $K\rightarrow \pi \pi $ decays and $K^0$ – $\bar{K}^0$ mixing obtained by us in the 1980s within an analytic approximate approach based on the dual representation of QCD as a theory of weakly interacting mesons for large $N$ , where $N$ is the number of colors. In our analytic approach the Standard Model dynamics behind the enhancement of $\hbox {Re}A_0$ and suppression of $\hbox {Re}A_2$ , the so-called $\Delta I=1/2$ rule for $K\rightarrow \pi \pi $ decays, has a simple structure: the usual octet enhancement through the long but slow quark–gluon renormalization group evolution down to the scales $\mathcal{O}(1\, {\hbox { GeV}})$ is continued as a short but fast meson evolution down to zero momentum scales at which the factorization of hadronic matrix elements is at work. The inclusion of lowest-lying vector meson contributions in addition to the pseudoscalar ones and of Wilson coefficients in a momentum scheme improves significantly the matching between quark–gluon and meson evolutions. In particular, the anomalous dimension matrix governing the meson evolution exhibits the structure of the known anomalous dimension matrix in the quark–gluon evolution. While this physical picture did not yet emerge from lattice simulations, the recent results on $\hbox {Re}A_2$ and $\hbox {Re}A_0$ from the RBC-UKQCD collaboration give support for its correctness. In particular, the signs of the two main contractions found numerically by these authors follow uniquely from our analytic approach. Though the current–current operators dominate the $\Delta I=1/2$ rule, working with matching scales $\mathcal{O}(1 \, {\hbox { GeV}})$ we find that the presence of QCD-penguin operator $Q_6$ is required to obtain satisfactory result for $\hbox {Re}A_0$ . At NLO in $1/N$ we obtain $R=\hbox {Re}A_0/\hbox {Re}A_2= 16.0\pm 1.5$ which amounts to an order of magnitude enhancement over the strict large $N$ limit value $\sqrt{2}$ . We also update our results for the parameter $\hat{B}_K$ , finding $\hat{B}_K=0.73\pm 0.02$ . The smallness of $1/N$ corrections to the large $N$ value $\hat{B}_K=3/4$ results within our approach from an approximate cancelation between pseudoscalar and vector meson one-loop contributions. We also summarize the status of $\Delta M_K$ in this approach.     

Analysis of the \frac{1} {2}^ - and \frac{3} {2}^ - heavy and doubly heavy baryon states with QCD sum rules

In this article, we study the $\frac{1} {2}^ -$ and $\frac{3} {2}^ -$ heavy and doubly heavy baryon states $\Sigma _Q \left( {\frac{1} {2}^ - } \right)$ , $\Xi '_Q \left( {\frac{1} {2}^ - } \right)$ , $\Omega _Q \left( {\frac{1} {2}^ - } \right)$ , $\Xi _{QQ} \left( {\frac{1} {2}^ - } \right)$ , $\Omega _{QQ} \left( {\frac{1} {2}^ - } \right)$ , $\Sigma _Q^* \left( {\frac{3} {2}^ - } \right)$ , $\Xi _Q^* \left( {\frac{3} {2}^ - } \right)$ , $\Omega _Q^* \left( {\frac{3} {2}^ - } \right)$ , $\Xi _{QQ}^* \left( {\frac{3} {2}^ - } \right)$ and $\Omega _{QQ}^* \left( {\frac{3} {2}^ - } \right)$ by subtracting the contributions from the corresponding $\frac{1} {2}^ +$ and $\frac{3} {2}^ +$ heavy and doubly heavy baryon states with the QCD sum rules in a systematic way, and make reasonable predictions for their masses.     

Finite W-Superalgebras and Truncated Super Yangians

Let ${Y_{m|n}^{\ell}}$ be the super Yangian of general linear Lie superalgebra for ${\mathfrak{gl}_{m|n}}$ . Let ${e \in \mathfrak{gl}_{m\ell|n\ell}}$ be a “rectangular” nilpotent element and ${\mathcal{W}_e}$ be the finite W-superalgebra associated to e. We show that ${Y_{m|n}^{\ell}}$ is isomorphic to ${\mathcal{W}_e}$ .     

On the Quasi-linear Elliptic PDE {-\nabla \cdot ( \nabla{u}/ \sqrt{1-| \nabla{u} |^2}) = 4 \pi \sum_k a_k \delta_{s_k}} in Physics and Geometry

It is shown that for each finite number N of Dirac measures ${\delta_{s_n}}$ supported at points ${s_n \in {\mathbb R}^3}$ with given amplitudes ${a_n \in {\mathbb R} \backslash\{0\}}$ there exists a unique real-valued function ${u \in C^{0, 1}({\mathbb R}^3)}$ , vanishing at infinity, which distributionally solves the quasi-linear elliptic partial differential equation of divergence form ${-\nabla \cdot ( \nabla{u}/ \sqrt{1-| \nabla{u} |^2}) = 4 \pi \sum_{n=1}^N a_n \delta_{s_n}}$ . Moreover, ${u \in C^{\omega}({\mathbb R}^3\backslash \{s_n\}_{n=1}^N)}$ . The result can be interpreted in at least two ways: (a) for any number N of point charges of arbitrary magnitude and sign at prescribed locations s _n in three-dimensional Euclidean space there exists a unique electrostatic field which satisfies the Maxwell-Born-Infeld field equations smoothly away from the point charges and vanishes as |s| ?? ??; (b) for any number N of integral mean curvatures assigned to locations ${s_n \in {\mathbb R}^3 \subset{\mathbb R}^{1, 3}}$ there exists a unique asymptotically flat, almost everywhere space-like maximal slice with point defects of Minkowski spacetime ${{\mathbb R}^{1, 3}}$ , having lightcone singularities over the s _n but being smooth otherwise, and whose height function vanishes as |s| ?? ??. No struts between the point singularities ever occur.