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1.
I. L. Odinets P. V. Kazakov R. U. Amanov M. Yu. Antipin L. V. Kovalenko Yu. T. Struchkov T. A. Mastryukova 《Russian Chemical Bulletin》1992,41(8):1466-1473
An x-ray structural study of single crystals of 1-diphenylphosphinyl-cyclo-propane- and 1-diphenylphosphinylcyclobutanecarboxylic acids was conducted. 1-Phosphorylated cycloalkanecarboxylic acid amides were obtained from the corresponding acids by the reaction with thionyl chloride with subsequent treatment with primary and secondary amines. It was shown that the reaction of 1-phosphorylated 1-functional substituted cycloalkanes with trimethylbromosilane takes place with preservation of the cyclic structure and yields phosphoric acid silyl esters, and the corresponding cycloalkylphosphonic and cycloalkylphosphinic acids were synthesized by their hydrolysis in soft conditions.A. N. Nesmeyanov Institute of Organoelemental Compounds, Russian Academy of Sciences, 117813 Moscow. Translated from Izvestiya Akademii Nauk, Seriya Khimicheskaya, No. 8, pp. 1879–1888, August, 1992. 相似文献
2.
A series of new aminophosphine oxides, aminophosphonic and aminophosphinic acids derived from thiazole was synthesized by addition of phosphine oxides or silylated phosphorus esters to the corresponding thiazole aldimines. The thiazole aldimines were obtained from 2-thiazole aldehyde and primary amines by a standard procedure. The corresponding phosphine oxides were obtained by alkylation of diethyl phosphite or ethyl phenylphosphinate with the appropriate Grignard reagents. The silylated phosphorus esters were prepared from trimethyl phosphite and from methyl- or phenylphosphinic ethyl ester by treatment with bromotrimethylsilane. The coordination ability towards Cu(II) ions are described for two obtained aminophosphonate ligands. 相似文献
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Reaction of aminoquinolines with maleic acid and its diethyl ester gave N-quinolylaspartic acids or their esters. In aqueous media 4-aminoquinoline formed a maleate or betaine. Hydrazides of aspartic acids were prepared, and N-(3- and 6-quinolyl)aspartic acids were converted into 5-carboxymethyl-l-quinolylimidazolindin-4-one-2-thiones.For Communication 2, see [1].Kaunus Technological University, Kaunas 3028, Lithuania Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 925–931, July, 2000. 相似文献
5.
Synthesis of α,α-disubstituted amino acids based on tandem reaction of dehydroamino acid derivatives
Hideto Miyabe 《Tetrahedron》2005,61(2):385-393
The formation of all-substituted sp3-hybridized carbon-center was investigated via tandem reaction of dehydroamino acid derivatives. The diethylzinc-promoted reaction of dehydroamino acid derivatives with acid anhydride or π-allyl palladium complex proceeded smoothly to afford α,α-disubstituted amino acids via a radical and anionic carbon-carbon bond-forming processes. The tandem reductive reaction of N-phthaloyl dehydroalanine also proceeded effectively by using Bu3SnH and Pd(PPh3)4. 相似文献
6.
D. Zicane Z. Tetere I. Rijkure M. V. Petrova E. Gudriniece U. Kalejs 《Chemistry of Heterocyclic Compounds》2000,36(7):792-795
Monohydrazides of 2-R-4-methyl-4-cyclohexene-1,1-dicarboxylic acids react with trifluoroacetic acid anhydride to give 4-substituted 3,5-dioxopyrazolidines, with phosphorus trichloride to give 4-(2-R-5-chloro-4-methylcyclohexane)-3,5-dioxopyrazolidines, and with acetic anhydride to give 4-(2-R-4-methyl-4-cyclohexene)-3,5-diacetoxypryazoles.For Communication 4, see [1].Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 903–907, July, 2000. 相似文献
7.
A one pot synthesis of α-trifluoromethyl unsaturated acids via a [3,3]-sigmatropic rearrangement of allyl (or propargyl) fluorovinyl ethers is described. By proto- and iodolactonization, these acids lead to the corresponding trifluoromethylated lactones. 相似文献
8.
First nucleoside aminooxy acids were synthesized from furanoid sugar phthalimidooxy acids by N-glycosylation with uracil, thymine, N-benzoylcytosine, 6-N-benzoyladenine and 2-N-acetyl-6-O-diphenylcarbamoylguanine. Boc or Fmoc protected uridine aminooxy acid derivatives have also been prepared. As oxyamine protecting group, the phthalimido group was shown to be instable in MeOH, leading to the imide ring-opening product in a reversible way. This reaction was accelerated under acid or basic conditions. A uridine dimer linked by N-oxy amide has also been prepared by coupling of uridine aminooxy ester with uridine phthalimidooxy acid. These nucleoside aminooxy acids might constitute useful building blocks for the development of novel RNA mimics and conjugates with other biomolecules or reporter compounds. 相似文献
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E. K. Starostin A. A. Mazurchik A. V. Ignatenko G. I. Nikishin 《Russian Chemical Bulletin》1993,42(7):1174-1178
The decomposition of 1,4-dihydroxy-1,4-dihydroperoxycyclohexane under the action of FeSO4 and the decomposition of 1,4-cyclohexanedione monoethyleneketal hydroperoxide under the action of FeII salts in the presence of various ligands or under the action of CuII sulfate have been studied. A preparative method for the synthesis of derivatives of diketodicarboxylic or -functionally substituted ketocarboxylic acids from 1,4-cyclohexanedione monoethyleneketal has been developed.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1231–1235, July, 1993. 相似文献
13.
A. V. Golovchenko R. N. Solomyannyi V. S. Brovarets 《Russian Journal of General Chemistry》2010,80(4):723-727
The available diethyl 5-hydrazino-2-p-tolyl-1,3-oxazol-1-ylphosphonate was readily acylated with chlorides of carboxylic acids of heterocyclic series. On heating
in acetic acid it underwent the oxazole ring cleavage, recyclization and diethylation that was used to prepar the substituted
2-p-toluylaminomethylphosphonic acids containing a series of 2-heteryl-1,3,4-oxadiazol-5-yl residues in the α-position relative
to the phosponyl group. 相似文献
14.
Shah Alam Khan 《中国化学会会志》2004,51(6):1273-1277
Friedel‐Crafts cycloalkylation of biphenyl with 2,3‐dichlorobutyltrichlorosilane(Cl3Si‐CH2CHClCHClCH3) at a temperature of 100°C in the presence of anhydrous aluminum chloride catalyst gave cyclized product, 9‐methyl‐9‐(2‐trichlorosilylethyl)fluorene 1a , in 33% yield. Methylation of 1a with nucleophilic reagent such as methyl magnesium chloride, gave 9‐methyl‐9‐(2‐trimethylsilylethyl)fluorene 2 while bromination of 2 with excess amount of bromine in DMF resulted in 2,7‐dibromo‐9‐methyl‐9‐(2‐trichlorosilyl)fluorene 3 in good yield. All the compounds were structurally identified by GC/MS, 1H and 13C‐NMR spectroscopy. 相似文献
15.
Julio A. Seijas M. Pilar Vázquez-Tato M. Montserrat Mart?&#x;nez Verónica Santiso 《Tetrahedron letters》2004,45(9):1937-1939
A new direct synthesis for anacardic acids based in a nucleophilic substitution of a methoxy group in 2-aryloxazolines by long-chained Grignard reagents is reported. 相似文献
16.
Alex V. ShtelmanJames Y. Becker 《Tetrahedron》2011,67(6):1135-1141
New α-silylacetic acids have been prepared following a general and convenient procedure of a one-pot reaction between trimethylsilylacetate and different chlorosilanes. New derivatives of diphenyl(methyl)silylacetic acid were prepared by a direct alkylation of its dianion with benzyl-, allyl-, and alkyl halides and trimethylchlorogermane to afford new α-silylcarboxylic acids. 相似文献
17.
Agnieszka Wróblewska Egbert Meissner Eugeniusz Milchert 《Journal of fluorine chemistry》2006,127(3):345-350
The influence of technological parameters on the dehydroiodination of perfluoroalkylethene iodides (CF3)2CF(CF2CF2)nCH2CH2I, where n = 1, 2, 3 and 4, has been investigated. The most advantageous conditions for the two-stage oxidation of (CF3)2CF(CF2CF2)nCHCH2, with ozone in the first stage, followed by the oxidation with hydrogen peroxide to the perfluorocarboxylic acids, were determined. The effects of temperature and time on the conversion of perfluoroalkylethenes during the oxidation with ozone were studied. In the second stage, the selectivity of transformation (of each homologue) to the perfluorocarboxylic acid in relation to the theoretical amount resulting from a quantity of perfluoroalkylethene used and the conversion of perfluoroalkylethene in the temperature range of 10-80 °C has been determined. 相似文献
18.
New chiral derivatization reagent for the resolution of amino acids as diastereomers by TLC and HPLC
Summary The applicability of a new chiral reagent to the resolution of amino acid enantiomers has been investigated. The new reagent,
S(-)-N-1-(2-naphthylsulphonyl)-2-pyrrolidinecarbonyl chloride (NSP-C1), was synthesized by the chlorination of S(-)-N-1-(2-naphthylsulphonyl)-2-pyrrolidinecarboxylic
acid which was prepared by the reaction of 2-naphthalene sulphonyl chloride with L-proline. Derivatization of the amino acids
proceeds rapidly at ambient temperature and no racemization takes place during the reaction. The resolution of the diastereomeric
amides was performed by TLC and normal phase HPLC. Complete resolutions were observed for the enantiomers of all amino acids
examined except cysteine, cystine and histidine. The favourable UV absorption of the derivatives enabled the optical antipode
to be determined down to the 0.1% level. 相似文献
19.
Ming-Dong Lu Xiao Zhou Yao-Jun Yu Pi-Hong Li Wei-Jian Sun Cheng-Guang Zhao Zhi-Qiang Zheng Tao You Fei-Hai Wang 《中国化学快报》2013,24(5):415-418
Novel furoxan-based nitric oxide-releasing derivatives 6a-p of hydroxylcinnamic acids were synthesized by coupling the carboxyl group of hydroxylcinnamic acids with furoxan through various alkylol amines. Compounds 6a, e-i and m-p displayed more potent anti-tumor activities superior to control 5-fluorouracil (5-FU) in most cancer cells tested. Furthermore, 6f could selectively inhibit tumor cells, but not non-tumor cell proliferation. This inhibition was attributed to high levels of NO released in cancer cells and potentially synergistic effect of NO donor moieties and the bioactivity of hydroxylcinnamic acids. 相似文献
20.
Prishchenko A. A. Livantsov M. V. Novikova O. P. Livantsova L. I. 《Russian Journal of General Chemistry》2010,80(9):1889-1890
Russian Journal of General Chemistry - 相似文献