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E. J. Llorent-Martínez P. Ortega-Barrales M. L. Fernández de Córdova A. Ruiz-Medina 《Analytical and bioanalytical chemistry》2009,394(3):845-853
This work is aimed at demonstrating the potential of the implementation of automatic flow systems in optosensors using chemiluminescence
detection. With this purpose, two automatic methodologies, multicommutation and sequential injection analysis (SIA), have
been applied to the analysis of 5-aminosalicylic acid (ASA). The analyte is determined for the first time making use of its
chemiluminescence reaction with permanganate anion, previously immobilized on an appropriate solid support in the detection
area. First, the study of the most appropriate commercial flow-through cell and the optimum conditions for the reaction were
performed. Second, the main differences in terms of flow variables and analytical parameters for multicommutation and SIA
approaches were stated. Both methodologies were applied to the determination of the analyte in pharmaceuticals obtaining satisfactory
results. Finally, the advantages and disadvantages of both proposed methods and the recoveries obtained from pharmaceuticals
were statistically compared. 相似文献