共查询到20条相似文献,搜索用时 15 毫秒
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Travis C. McMahonSarah Stanley Edward KazyanskayaDeborah Hung John L. Wood 《Tetrahedron letters》2011,52(17):2262-2264
A formal total synthesis of the epidithiodiketopiperazine natural product, dehydrogliotoxin (2), utilizing an intramolecular ring closure to form key intermediate 5 is described. 相似文献
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Prashant K. Metri 《合成通讯》2020,50(9):1361-1366
AbstractFormal total synthesis of dihydrokawain-5-ol is accomplished starting from tartaric acid. Key reactions include Horner–Wadsworth–Emmons olefination, sodium borohydride mediated stereoselective reduction, orthogonal protection and deprotection of alcohols and ring closing metathesis. 相似文献
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Trost BM Aponick A Stanzl BN 《Chemistry (Weinheim an der Bergstrasse, Germany)》2007,13(34):9547-9560
The use of a mixture of dl- and meso-divinylethylene carbonate as an electrophile in palladium-catalyzed asymmetric allylic alkylation reactions is reported. From the diastereomeric mixture of meso and chiral racemic starting materials, a single product is obtained in high optical purity employing either oxygen or nitrogen nucleophiles. The resulting dienes have proven to be versatile synthetic intermediates as each carbon is functionalized for further transformation and differentiated by virtue of the reaction. A mechanism for this intriguing transformation is proposed and a concise enantioselective total synthesis of (+)-australine hydrochloride is reported as well as a formal synthesis of isoaltholactone. 相似文献
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Tao Li Guangmiao Wu Shangbiao Feng Xiaojun Hu Weiwei Zhang Shouchu Tang Xingang Xie Xuegong She 《Tetrahedron》2019,75(29):3939-3942
A concise enantioselective synthesis of A/B bicyclic segment of naturally occurring α-pyrone meroterpenoid pyripyropene A is achieved in 9 steps (LLS) and 7.5% yield starting from R-(?)-carvone. The significant points of the synthesis include: (1) an intramolecular 1, 3-dipolar cycloaddition reaction to construct the A ring and assemble C4 quaternary carbon stereocenter as well; (2) reductive cleavage of the oxazole motif utilized Raney Ni/B(OCH3)3. 相似文献
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Liu R Zhang M Wyche TP Winston-McPherson GN Bugni TS Tang W 《Angewandte Chemie (International ed. in English)》2012,51(30):7503-7506
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Anserinones A and B are natural products that have been shown to have potential anticancer, antifungal, and antibacterial properties. This work entails the novel synthesis of these natural products. 相似文献
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Nakahata T Fujimura S Kuwahara S 《Chemistry (Weinheim an der Bergstrasse, Germany)》2006,12(17):4584-4593
Pteridic acid A (1) is a spirocyclic octaketide produced by the phytoepiphytic actinomycete Streptomyces hygroscopicus TP-A0451 and possesses potent plant-growth-promoting activity comparable to that of indole-3-acetic acid. The enantioselective total synthesis of this natural product was achieved by employing the Sn(OTf)(2)-mediated Evans aldol reaction and the Fukuyama acetylenic coupling reaction as the key C--C bond-forming steps producing 1 through a 14-step sequence in 22 % overall yield from a known oxazolidinone derivative. MgBr(2)-mediated equilibration of an anomerically favored spirocyclic intermediate used for the synthesis of 1 brought about partial epimerization of the spirocenter to give the corresponding anomerically disfavored epimer, which was converted into pteridic acid B (11-epi-1), another plant-growth promoter of the same microbial origin. 相似文献
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A relay route for the synthesis of azadirachtin 总被引:1,自引:0,他引:1
Veitch GE Beckmann E Burke BJ Boyer A Ayats C Ley SV 《Angewandte Chemie (International ed. in English)》2007,46(40):7633-7635