Carbon-13 nuclear magnetic resonance spectra of fentanyl analogs

Natural abundance carbon-13 chemical shifts are reported for the hydrochloride salts of fentanyl ( 1a ) and fifteen analogs. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, comparisons with model compounds, and thiophene carbon-proton coupling constants. In addition to its forensic value, the data suggest that the solution conformations of the analogs are similar to that of fentanyl hydrochloride.     

Carbon-13 nuclear magnetic resonance spectra of D-homoandrostane derivatives

The ¹³C chemical shift data of a series of ketone, alcohol and ester derivatives of D-homoandrostane are reported. Homologation effects are discussed, as well as substituent effects on the homologated structures.     

Carbon-13 nuclear magnetic resonance spectra of veratrine components

The ¹³C NMR spectra were determined and signals assigned to the various carbons of veratridine and cevadine.     

Carbon-13 nuclear magnetic resonance spectra of methaqualone metabolites

Carbon-13 chemical shifts are reported for methaqualone, seven hydroxylated methaqualone metabolites, and four acetate derivatives. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, and comparisons with model compounds.     

Carbon-13 nuclear magnetic resonance spectra of phenycyclidine analogs

Natural abundance carbon-13 chemical shifts are reported for the hydrochloride salts of phencyclidine ( 1a ) and sixteen analogs. The signals are assigned on the basis of chemical shift theory, SFORD multiplicities, signal intensities, and comparisons with model compounds. In addition to its forensic value, the data suggests that the solution conformations of the analogs are similar to that of phencyclidine hydrochloride.     

Carbon-13 nuclear magnetic resonance spectra of isoquinoline alkaloids

The ¹³C nmr ehemieal shifts of 1,2,3,4-tetrahydroisoquinoline, salsolidine and laudanosine are reported. The various carbon resonances have been assigned on the basis of chemical shift theory, intensity of the signals, multiplicities generated in SFORD spectra and the comparison with model compounds.     

Carbon-13 nuclear magnetic resonance spectra of ceveratrum alkaloids

The ¹³C NMR spectra were determined and signals assigned to the various carbons of the alkamines veracevine, germine and zygacine derived from steroidal alkaloids of the ceveratrum class. Assignment of signals was aided by analysis of the partially relaxed spectrum of cervagenine 9,12,14-orthoacetate-3, 16-diacetate.     

Carbon-13 nuclear magnetic resonance spectra of some aromatic diterpenoids

¹³C n.m.r. studies of a series of tricarbocyclic ring C aromatic diterpenoids using proton-noise and single-frequency off-resonance decoupling, partially relaxed Fourier transform techniques, shift reagents and specifically labelled derivatives have permitted unequivocal assignments of almost all signals. The shieldings caused by oxygenation of C-18 and C-19 and by introduction of various substituents in the aromatic ring are discussed. It is concluded that the ¹³C n.m.r. data are sufficiently characteristic to allow stereochemical assignments. Some effects of deuterium substitution on the carbon resonances are presented.     

Carbon-13 nuclear magnetic resonance spectra of some heterocyclic D-homoandrostanes

The ¹³C chemical shift data of several D-homoandrostanes with heteroatoms (N,O) in the 17a-position are reported. Heteroatom effects on the shieldings of the carbons of rings C and D are discussed.     

Carbon-13 nuclear magnetic resonance spectra of methyl 2-pyronecarboxylates

The ¹³C NMR spectra of methyl 2-pyrone-3-, 4-, 5- and 6-carboxylates were studied and the substituent effects on the 2-pyrone ring were compared with those of some model compounds. ¹H NMR spectra were also recorded and discussed. The long range ¹³C, ¹H coupling constants were obtained, discussed and proved useful in signal assignments.     

Carbon-13 nuclear magnetic resonance spectra of some 2-substituted tetrahydropyrans

Fourier transform carbon-13 nuclear magnetic resonance spectra have been obtained and interpreted for some 2-substituted tetrahydropyrans. The effects of the substituents on α, β, γ and δ-carbon atoms are discussed. Using suitable reference compounds the γ-parameter can be used for quantitative conformational analysis.     

Carbon-13 nuclear magnetic resonance spectra of some mesoionic xanthine analogs

Natural abundance ¹³C NMR chemical shifts have been experimentally determined for a series of mesoionic thiazolo[3,2-a]pyrimidine-5,7-diones. The spectral data are compared with those of related mesoionic dihydrothiazolo[3,2-a]pyrimidine-5,7-diones and mesoionic 1,3,4-thiadiazolo[3,2-a]pyrimidine-5,7-diones. Resonable correlation between the observed ¹³C NMR chemical shifts and CNDO/2 total charge densities have been obtained for the different carbon atoms of 8-methylthiazolo[3,2-a]pyrimidine-5,7-dione.     

Carbon-13 nuclear magnetic resonance spectra of nicotine metabolites and related compounds

The potential of ¹³C NMR techniques for studies of nicotine metabolism has been investigated by acquisition and assignment of ¹³C NMR spectra of nicotine, its metabolites and some related compounds. It is shown that C-2′ of nicotine would be the best site for ¹³C labelling when using the method to gain further insight into the metabolic pathways of nicotine.