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1.
The reaction of pyrroles with diisopropyl azodicarboxylate yields 2- and 2,5-substituted derivatives. 3- and 1,3-substituted indolizines and are formed by the same route. Cycl[3.2.2]azines have been obtained from and with dimethyl acetylenedicarboxylate. 相似文献
2.
E.G. Frandsen 《Tetrahedron》1977,33(8):869-873
The reaction of 4- and 5-aryl-3-methylthio-1,2-dithiolylium iodides with 4-hydroxy-6-methyl-2-pyran-2-one and 4-hydroxycoumarin has been studied. 4-Substituted salts yielded 3-aryl-7-methyl-2-thioxo-2,5-pyrano [3,2-c]pyran-5-ones and 3-aryl-2-thioxo-2H,5H-pyrano[3,2-c]benzo[e]pyran-5-ones, respectively, whereas 5-substituted salts gave rise to 3-(5′-aryl-1′,2′-dithiol-3′-ylidene)-6-methyl-2-pyran-2,4-diones and 3-(5′-aryl-1′,2′-dithiol-3′-ylidene)-2-benzo [b]-pyran-2,4-diones. 相似文献
3.
3-substituted indoles with benzoylperoxide led to the 3-benzoyloxy derivative. The reacton is discussed in terms of homolytic -substitution. 相似文献
4.
Lawrence F. Kelly Peter Dahler Acharan S. Narula Arthur J. Birch 《Tetrahedron letters》1981,22(15):1433-1436
Tricarbonyl-(3-methoxycyclohexa-2,4-dien-1-yl)-iron(1+) PF6(1-) reacts with a variety of nucleophiles to give 5-substituted cyclohex-2-enones. is shown to be a useful precursor for a convergent synthesis of 5-substituted cyclohex-2-enones and to be synthetically equivalent to the 5-cyclohex-2-enone cation . 相似文献
5.
Reduction of the indole-1-carboxaldehydes (-) with borane /THF gives the 1-methylindoles () in 42-91-% yields together with the di(indolylmethyl)ethers (), the indolyl-methyl indolines (), the unsymmetric ether() and the indolenine () as the minor products, except . This appears to be the first report on the formation of symmetric ethers in the borane/THF reduction of an oxygen function. The formation of and from and implies that electrophilic substitution takes place primarily at position 3 of 3-substituted indoles, did not form the corresponding probably because of steric hindrance. These results are discussed in relation to the mechanisms of borane/THF reduction, origin of the different products and electrophilic substitution in 3-substituted indoles. 相似文献
6.
Elimination reactions on isomeric mixtures of and 1,2-dihalo-2,3,3-trifluorocyclobutanes are reported. In zinc-promoted dehalogenations a steady decrease in the relative amount of the isomers compared to the isomers occured, with 2,3,3-trifluorocyclobutene as the sole product. The isomers reacted at a faster rate in potassium hydroxide induced eliminations to yield a slight predominance of 1-halo-2,3,3-trifluorocyclobutenes over 3-halo-3,4,4-trifluorocyclobutenes. However, with triethylamine as the inducing base, an increased rate of elimination from the isomers was noted along with almost exclusive formation of 3-halo-3,4,4-trifluorocyclobutenes. 相似文献
7.
With the help of spiroadamantyl substitution, the first sulfur-substituted 1,2-dioxetanes and , respectively derived from thiophenylmethyleneadamantane () and 2-adamntylidene-1, 3-dithian () were prepared via singlet oxygenation and detected by NMR. 相似文献
8.
One step syntheses of 3-substituted furans by the reactions of a new reagent, lithium di(3-furyl)cuprate , with various substrates and the application of to a total synthesis of dendrolasin are described. 相似文献
9.
The 5-substituted 4-methoxycarbonyloxazole derived from L-serine derivative using diphenyl phosphorazidate (DPPA) has been converted to a 2,4-diaminosugar antibiotic, prumycin. 相似文献
10.
The 4-substituted 1,2,4-triazoline-3,5-diones( ) afford with sulfides( ) having acidic α-hydrogens the 1,4-disubstituted urazoles( ). Reactivity of the triazolinedione shows similarity in possible reaction modes with that of singlet oxygen. 相似文献
11.
Waldemar Adam Klaus Zinner Adolf Krebs Hermann Schmalstieg 《Tetrahedron letters》1981,22(46):4567-4570
The rather stable 1,2-dioxetanes () and (), derived from the sterically stabilized cyclobutadiene (), exhibit distinct enhanced chemiluminescence behavior, namely energy transfer chemiluminescence (ETC) for () and electron exchange chemiluminescence (EEC) for (). 相似文献
12.
The cycloaddition of phenylglyoxylonitrile oxide to the 7-substituted norbornadienes a-c gives predominantly the endo isomers, but that to the 8-substituted 2-azabicyclo[3.2.1]oct-3,6-dienes a,b the exo isomers. 相似文献
13.
The reaction of dichlorocarbene with 1,2-bismethylenecycloheptane yields, besides the 1,2-addition product , the 1,4-addition product in a ration 99:1. 相似文献
14.
The photochemical behavior of -1,2-dihydrophthalide () and its 1,2-trimethylene derivative () was studied. Besides bicyclo[2.2.0]hexene formation in both cases, () transforms into its isomer () whereas () undergoes a 1,2-shift to (). 相似文献
15.
Ester on treatment with sodium salt of sulfone or sulfoxide afforded 2-substituted 1,3-bis(trimethylsily)propene in good yield, from which cyclopentane and cyclohexane derivatives bearing a trimethylsilyl group in the molecules were synthesized. 相似文献
16.
Shun-ichi Hashimoto Hiroshi Kogen Kiyoshi Tomioka Kenji Koga 《Tetrahedron letters》1979,20(32):3009-3012
The 1,4-addition of Grignard reagents to chiral α,β-unsaturated cyclic aldimines (), prepared from the corresponding cycloalkenecarboxaldehydes () and optically active α-amino acid tert-butyl esters (, was found to give, after hydrolysis, trans-2-substituted cycloalkanecarboxaldehydes () in reasonably high enantiomeric purities. 相似文献
17.
N-t-Butyldimethylsilylpyridinium triflate reacted with Grignard reagents at 4-position with almost complete regioselectivity (99%) to afford the corresponding 1,4-dihydropyridine derivatives (), which are easily oxidized by oxygen to give 4-substituted pyridines (: 58 – 70%). 相似文献
18.
By appropriate choice of reaction conditions, the enantiomerically pure ()-(+)-2-(-tolylsulfinyl)cycloalkenone can be converted into an ()-or an ()-3-substituted cycloalkanone in good to excellent enantiomeric purity. 相似文献
19.
Josefina Garcia Robert Greenhouse Joseph M Muchowski Jose Antonio Ruiz 《Tetrahedron letters》1985,26(15):1827-1830
2-Alkyl-3-cyanoindoles are obtained when 1-alkylmethyl-2-chloro-(or 2-phenylsulfonyl)-3-phenylsulfonylindoles are reacted with excess azide ion (90°/DMF). The reaction is considered to occur by a fragmentation recombination process in which the Schiff's base is of central importance. This proposal is supported by the formation of 2-substituted indole-3-carboxylates from aldehydes and the α-phenylsulfonyl--aminophenylacetic acid ester derivative . 相似文献
20.
The synthesis of 3-acetylcyclohexanones , , has been realized by conjugate addition of lithiated cyanohydrin ether to 2-cyclohexenones , , in THF-HMPA, even if 3-substituted. 3-benzoylcyclohexanones , , are obtained from and , , in THF with excellent yields. 相似文献