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1.
Transition metal complex catalyzed cocyclotrimerization of protected alkynylpurine ribonucleosides 1 with various diynes 2 gave rise to a series of 6-arylpurine nucleosides 3 that were further deprotected to free nucleosides 4. Generally, the best yields of cyclotrimerizations were obtained with a catalytic system Ni(cod)2/2PPh(3). On the other hand, CoBr(PPh(3))3 proved to be a superior catalyst for cyclotrimerization of 1 with dipropargyl ether 2g. In addition, Ni catalysis is also suitable for direct cyclotrimerization of unprotected alkynylpurine ribonucleosides 5 to the corresponding 6-arylpurinylribosides 4. 相似文献
2.
An extremely simple method for the selective synthesis of 9-aryl and 9-alkyl 6-alkoxy or 6-alkoxyformimidoylpurines from the corresponding 6-cyanopurines is described. The reaction is carried out with methanol or ethanol in the presence of DBU. At room temperature, nucleophilic attack by the primary alcohol occurs selectively on the cyano carbon atom, leading to 6-alkoxyformimidoylpurines in good yields. Heating the reaction mixture at a temperature greater than or equal to 78 degrees C leads to nucleophilic substitution of the substituent in the 6-position by the alkoxy group, generating the corresponding 6-alkoxypurines, also in excellent yields. The 6-alkoxyformimidoylpurines were used as intermediates in the synthesis of 6-carboxamidinopurines by reaction with methylamine (for 9-methylpurine 5a) or methyl ammonium chloride (for 9-arylpurines and 5b and 5c). 相似文献
3.
[reaction: see text] Cationic rhodium(I)/modified BINAP complexes are effective catalysts for highly regioselective intermolecular cyclotrimerization of terminal alkynes and highly chemo- and regioselective intermolecular cocyclotrimerization of diethyl acetylenedicarboxylate (DEAD) and terminal alkynes. It is a noteworthy example of intermolecular cocyclotrimerization of two different alkynes in terms of catalytic activity, chemo- and regioselectivity, scope of substrates, and ease of operation. The wide applicability of this new cocyclotrimerization procedure is demonstrated in the one-step synthesis of [6]metacyclophane. 相似文献
4.
《Tetrahedron letters》2003,44(4):785-788
A novel approach to 6-arylpurines based on [2+2+2]-co-cyclotrimerization of 6-alkynylpurines with various α,ω-diynes is described. Co-cyclotrimerization is catalyzed by Ni- and Co-phosphine catalysts and their choice depends on the substitution pattern of the both reactants. 相似文献
5.
Niu HY Xia C Qu GR Zhang Q Jiang Y Mao RZ Li DY Guo HM 《Organic & biomolecular chemistry》2011,9(14):5039-5042
CuBr was found to be an efficient catalyst for the C-N cross coupling reaction of purine and diaryliodonium salts. 9-Arylpurines were synthesized in excellent yields with short reaction times (2.5 h). The method represents an alternative to the synthesis of 9-arylpurines via Cu(II) catalyzed C-N coupling reaction with arylboronic acids as arylating agents. 相似文献
6.
Gui-Rong Qu Peng-Yang XinHong-Ying Niu Xin JinXiao-Ting Guo Xi-Ning YangHai-Ming Guo 《Tetrahedron》2011,67(47):9099-9103
An efficient method for the synthesis of 6-arylpurines (nucleosides) was developed via Suzuki-Miyaura cross-coupling reactions of 6-chloropurines (nucleosides) and sodium tetraarylborate in neat water (ethanol). The process gave good to high isolated yields within a short reaction time under microwave irradiated conditions. 相似文献
7.
Purine is utilized as a new directing group for the Pd-catalyzed monoarylation of 6-arylpurines with simple aryl iodides via C-H bond activation in good yields, providing a complementary tool for the modification of 6-arylpurines (nucleosides). Most importantly, purine can be used as a building block for nucleoside derivatives, and the use of purine as a directing group helps avoid additional synthetic steps. 相似文献
8.
A mild method was developed to synthesize 6-amino-2-phenolic-9-alkyl and 9-arylpurines. The new compounds were screened for antibacterial activity against Mycobacterium tuberculosis strain H37Rv. The 9-tolyl derivatives with a dimethylamino or a piperidine substituent in C6 and the 3-hydroxyphenyl or 4-hydroxyphenyl substituent in C2 were highly active against the bacilli. 相似文献
9.
10.
Gnanakumar ES Thushara KS Bhange DS Mathew R Ajithkumar TG Rajamohanan PR Bhaduri S Gopinath CS 《Dalton transactions (Cambridge, England : 2003)》2011,40(41):10936-10944
Benzyl alcohol has been used to prepare a single phase MgCl(2).6BzOH molecular adduct as a support for an ethylene polymerization catalyst (Ziegler catalyst). The structural, spectroscopic and morphological aspects of the MgCl(2).6BzOH molecular adduct and the Ziegler catalyst have been thoroughly studied by various physicochemical characterization techniques. The presence of MgO(6) octahedrons due to the interaction of Mg(2+) with six -OH groups of the benzyl alcohol is confirmed from a Raman feature at 703 cm(-1), and structural studies. The supported catalyst activity has been evaluated for the ethylene polymerization reaction. The lower polymerization activity of the titanated Ziegler-Natta catalyst compared with a standard catalyst is attributed to the strong interaction of titanium chloride with the support and associated electronic factors. 相似文献
11.
An efficient method for the cocyclotrimerization of bicyclic alkenes and benzynes catalyzed by palladium phosphine complexes to give the corresponding norbornane anellated 9,10-dihydrophenanthrene derivatives is described. Bicyclic alkenes 1a-i undergo [2 + 2 + 2] cocyclotrimerization with benzynes generated from precursors 2a-d [2-(trimethylsilyl)phenyl triflate (2a), 4,5-dimethyl-2-(trimethylsilyl)phenyl triflate (2b), 6-(trimethylsilyl)-2,3-dihydro-1H-5-indenyl triflate (2c), 4-methyl-2-(trimethylsilyl)phenyl triflate (2d)] in the presence of PdCl(2)(PPh(3))(2) in acetonitrile at ambient temperature to yield anellated 9,10-dihydrophenanthrene products 3a-r in moderate to excellent yields. The [2 + 2 + 2] cocyclotrimerization products from oxa- and azabicyclic alkenes can be applied for the synthesis of polyaromatics, substituted benzo[b]triphenylenes (8a-f), via a simple Lewis acid mediated deoxyaromatization in good yields. In addition the [2 + 2 + 2] products undergo retro Diels-Alder reaction readily, providing a new method for the synthesis of substituted phenanthrenes and for generating isobenzofurans. A plausible mechanism is proposed to account for the catalytic [2 + 2 + 2] cycloaddition reaction. 相似文献
12.
A facile synthesis of 5-dialkylamino-6-aryl-(2H)-pyridazin-3-one from 5,6-dichloropyridazinone was carried out by using a palladium-catalyzed Suzuki-Miyaura cross coupling of 6-chloro-5-dialkylaminopyridazinone 1 with various arylboronic acids (3 equiv) as the key transformation. The Suzuki-Miyaura cross-coupling reaction proceeded smoothly under microwave irradiation at 135-140 degrees C for 30 min with 5 mol % of Pd catalyst in moderate to good isolated yields. The use of a CombiPhos Pd6 mixture catalyst system and a single Pd-SPhos catalyst system was evaluated. 相似文献
13.
《应用有机金属化学》2017,31(12)
A new bis(N ‐heterocyclic carbene) (NHC) palladium complex supported on silica coated magnetic nanoparticles (MNPs) was prepared using the reaction of synthesized Pd‐NHC complex with MNPs. The Pd‐NHC complex was prepared using the reaction of a hydroxyl‐functionalized bis‐imidazolium ionic liquid. The Pd‐NHC organometallic complex was used as a heterogeneous recyclable and active catalyst in the Suzuki‐Miyaura reaction and various aryl halides were coupled with arylboronic acids in order to synthesize diverse biaryls in good to excellent yields. The prepared catalyst was characterized by use of some different microscopic and spectroscopic techniques including elemental analysis, FT‐IR spectroscopy, diffuse reflectance UV–Vis spectrophotometery, scanning electron microscopy (SEM), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM) and X‐ray diffraction (XRD). The Pd‐NHC catalyst system is a magnetic reusable catalyst and it can be separated from the reaction mixture using an external magnetic field. The catalyst was reusable in the Suzuki‐Miyaura coupling reaction at least for 6 times without significant decreasing in its catalytic activity. 相似文献
14.
Hague C Patmore NJ Frost CG Mahon MF Weller AS 《Chemical communications (Cambridge, England)》2001,(21):2286-2287
The complex [(PPh3)Ag(CB11H6Br6)] 1 is an effective and selective catalyst (0.1 mol% loading) for a hetero-Diels-Alder reaction, which shows a marked dependence on the presence of trace amounts of water, while addition of Ag[Y] [Y = CB11H12, CB11H6Br6, O3SCF3] to a phosphine functionalized support gives an efficient and recyclable Lewis acid catalyst for this transformation. 相似文献
15.
Munetaka Ohkouchi Dai Masui Motowo Yamaguchi Takamichi Yamagishi 《Journal of molecular catalysis. A, Chemical》2001,170(1-2):1-16
Silver(I)-diphosphine complex is an effective catalyst for Mukaiyama Aldol reaction in polar solvents. AgPF6-(S)-BINAP cationic chiral complex indicated a good activity and could afford fairly high enantioselectivity in the reaction of aromatic aldehydes and silyl enol ethers. On the other hand, AgOAc-(S)-BINAP system afforded the aldol product of the absolute configuration opposite to that by AgPF6-(S)-BINAP and very high catalytic activity was shown. The structure and equilibrium state of Ag(I)-BINAP complexes in solution were examined to understand the reaction mechanism. In AgPF6 system [Ag((S)-BINAP)2]PF6 (1a), [Ag((S)-BINAP)]PF6 (1b), [Ag2((S)-BINAP)](PF6)2 (1c) and AgPF6 are present in solution. The active species of the aldol reaction in DMF is [Ag((S)-BINAP)]PF6 (1b), which exists as a minor species in solution. For this cationic Ag(I) catalyst, cyclic transition state containing substrate and silyl enol ether is assumed. In AgOAc-(S)-BINAP system, active species is also monomeric AgOAc((S)-BINAP) (2b) species which exists as a major component in solution and strong interaction was observed with a silyl enol ether. The reaction by AgOAc-(S)-BINAP catalyst is concluded to proceed as follows: nucleophile forms a complex with AgOAc-(S)-BINAP species and is activated. This complex attacks aldehydes to afford aldol adduct via acyclic transition state. 相似文献
16.
The regioselective ring-opening reactions of some epoxides with ammonium thiocyanate in the presence of a series of new phenol-containing macrocyclic diamides and also dibenzo-18-crown-6-, 18-crown-6-, benzo-15-crown-5-, and pyridine-containing macrocyclic diamide have been studied. The epoxides were subject to cleavage by NH(4)SCN in the presence of these catalysts under mild reaction conditions in various aprotic solvents. In this study, reagents and conditions have been discovered with which the individual beta-hydroxy thiocyanates can be synthesized in high yield and with more than 90% regioselectivity. The results can be discussed in terms of a four-step mechanism: (1) formation of complex between catalyst and NH(4)SCN, (2) release of SCN(-) nucleophile from the complex, (3) reaction of the active nucleophile at the less sterically hindered site in the epoxide, and (4) regeneration of catalyst. The major advantages of this method are as follows: (1) high regioselectivity, (2) simple regeneration of catalyst, (3) its reuse through several cycles without a decrease in activity, and (4) ease of workup of the reaction. 相似文献
17.
Ch. Syama Sundar N. Bakthavatchala Reddy S. Siva Prasad K. Uma Maheswara Rao S. H. Jaya Prakash C. Suresh Reddy 《Phosphorus, sulfur, and silicon and the related elements》2013,188(4):551-557
Abstract A new series of α-aminophosphonates have been synthesized by a one-pot three-component reaction of 2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde, various amines, and dimethyl phosphite by using nano-TiO2 as a catalyst under solvent-free conditions at 50°C. The major advantages of the present method are high yields, short reaction times, recyclable catalyst, and solvent-free reaction conditions. Among these new structurally diversified set of α-aminophosphonates, dimethyl (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(3-nitrophenylamino) methylphosphonate and dimethyl (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(4-fluoro-3-nitro-phenyl-amino) methylphosphonate have shown higher antioxidant activity in diphenyl picryl hydrazyl (DPPH) scavenging, reducing power assay, and lipid peroxidation methods. 相似文献
18.
The NiBr(2)(dppe)-Zn system effectively catalyzes the [2+2+2] cocyclotrimerization of arynes with allenes, leading to 10-methylene-9,10-dihydrophenanthrenes in moderate to good yields. The cocyclotrimerization is highly selective with only the internal double bond of the allenes being involved in the reaction. 相似文献
19.
The NiBr2(dppe)-Zn system effectively catalyzes the [2 + 2 + 2] cocyclotrimerization of arynes with diynes, leading to substituted naphthalene derivatives in moderate to good yields. This cocyclotrimerization reaction shows excellent tolerance of functional groups and leads to products of 5- to 7-membered fused-ring sizes. 相似文献