Boron Neutron Capture Therapy

Physics of Atomic Nuclei - Fundamentals of boron neutron capture therapy of malignant tumors are outlined, and the current status of the development of epithermal-neutron sources on the basis of...     

硼中子俘获治疗的蒙特卡罗方法模拟

用通用蒙特卡罗程序MCNP模拟了粒子在人脑中的输运过程. 吸收剂量率主要来自以下四个反应:¹⁰B(n,α)⁷Li,¹⁴N(n,p)¹⁴C,¹H(n,γ)²D,快中子弹性散射反应.对肿瘤区的贡献主要来自硼中子吸收反应.结果表明,超热中子比热中子适合于深肿瘤的治疗,而热中子对浅肿瘤的治疗有优越性,比如皮肤癌.同确定论方法的结果相比,蒙特卡罗方法不失为一种模拟中子俘获治疗的好工具.     

用于硼中子俘获治疗的FFAG加速器Lattice设计

研究设计了一种用于硼中子俘获治疗(BNCT)的紧凑型固定磁场交变梯度(FFAG)加速器。首先采用FFAG加速器磁铁的线性简化模型,计算确定了加速器的基本结构参数;再用WIN.AGILE程序进行了磁聚焦结构的设计和优化,得到了Beta函数、色散函数、包络函数及工作点等;采用MAD程序对设计结果进行了复算,并对两种程序的计算结果作了进一步的对比分析;最后采用ZGOUBI程序进行非线性磁场下粒子追踪。FFAG加速器的超周期为6,能量为11 MeV,场指数k为1.9,周长为11.1795 m,结构紧凑。分析结果表明,优化设计的FFAG加速器达到了预期的设计目标。     

Therapeutic Pretargeting with Gold Nanoparticles as Drug Candidates for Boron Neutron Capture Therapy

Boron neutron capture therapy (BNCT) is a binary approach for cancer treatment in which boron-10 atoms and thermal neutrons need to colocalize to become effective. Recent research in the development of BNCT drug candidates focuses increasingly on nanomaterials, with the advantages of high boron loadings and passive targeting due to the enhanced permeability and retention (EPR) effect. The use of small boron-rich gold nanoparticles (AuNPs) in combination with a pretargeting approach is proposed. Small sized polyethylene glycol–stabilized AuNPs (core size 4.1 ± 1.5 nm), are synthesized and functionalized with thiolated cobalt bis(dicarbollide) and tetrazine. To enable in vivo tracking of the AuNPs by positron emission tomography (PET), the core is doped with [⁶⁴Cu]CuCl₂. For the pretargeting approach, the monoclonal antibody Trastuzumab is functionalized with trans-cyclooctene-N-hydroxysuccinimide ester. After proving in vitro occurrence of the antibody conjugation onto the AuNPs by click reaction and the low toxicity of the AuNPs, the boron delivery system is evaluated in vivo using breast cancer xenograft bearing mice and PET imaging. Tumor uptake due to the EPR effect can be witnessed with ≈5% injected dose (ID) cm⁻³ at 24 h postinjection, but with slower clearance than expected. Therefore, no increased retention can be observed using the pretargeting strategy.     

一台用于空间状态模拟的紧凑型质子源

A compact proton beam source for space simulation has been developed.A compact structure was designed in order to meet the special requirements of miniaturization.Some particular means have been adopted for improving the proton portion and beam transmission at a long distance.The experimental results showed that 8mA/30keV proton beam can be successfully obtained from this source at about 700W input microwave power.     

贫金属星的中子俘获元素

利用分量系数公式并结合太阳系元素丰度的最新数据,计算了6?4颗贫金属星的中子俘获元素丰度.结果显示,快中子俘获过程(r过程)是贫金属星中子俘获元素的主要来源,且金属丰度小于–2.5的贫金属星的重中子俘获元素产量可能来自于纯r过程;重中子俘获元素与轻中子俘获元素来自于不同的天体物理场所     

一台2.45GHz强流中子源

A 2.45GHz microwave-driven ion source is being used to provide 40mA of deuterium ion beam (peak current) for an RFQ accelerator as part of a neutron source system.We have also designed a 60kV electrostatic LEBT using computer simulations.In our experiment,we measured the hydrogen and deuterium ion beam currents as functions of discharge power,gas flow,and magnetic field strength.The required beam current was obtained using leas than 700W of net microwave power with a gas flow of less than 1.5sccm.From the rise time data,it was determined that in order to obtain a high percentage of atomic ions in the beam, the beam extraction should start after 1ms of switching on the microwave power.At steady state,the proton fraction was above 90%.     

面向空间平台的小型化量子纠缠源

随着量子信息科学的迅速发展,以光子为物理载体的量子纠缠源已成为量子非定域性检验、量子通信、量子计算以及量子精密测量等领域必不可少的资源和重要技术手段。利用非线性介质中的自发参量下转换过程,从早期的β相偏硼酸钡晶体到后来的基于准相位匹配的周期性极化晶体等,双光子极化纠缠源凭借其在亮度和品质方面的优势得到了快速发展,这为基于卫星平台的广域量子通信和量子物理的基础检验提供了可能。从基本原理出发,系统介绍了近年来面向空间平台应用的量子纠缠源的发展和最新成果,特别是以“墨子号”量子科学实验卫星为代表的星载量子纠缠源载荷;此外,对国际上近几年关于星载量子纠缠源的进展以及未来发展趋势也进行了较为全面的介绍和分析。     

Fast Neutron Capture Cross Section of Natural Molybdenum

The radiative capture cross sections of natural Mo relative to the ¹⁹⁷Au (n,γ) were measured in the 0.7—1.4MeV neutron energy range,using a large liquid scintillator detector and the time-of-flight method.In the 0.01—2.0MeV neutron energy range,the theoretical calculation of (n,γ) reaction cross section for Mo was performed.The result of calculation is compared with the experimental data.     

Measuring Neutron Lifetime on an IBR-2 Pulsed Neutron Source

A new method of measuring neutron lifetimes on pulsed neutron sources based on changes in the neutron spectrum during the time of the neutron transit along a rather large path length due to their decay is proposed. The main advantage of this method is the use of relative measurements. Simulating the experiment made it possible to explore the influence of background and neutron losses caused by both the interaction with residual gas and the different level of detector efficiency on the systematic errors. All parameters can be measured experimentally.     

12C快中子辐射俘获反应中的共振现象

主要研究中子辐射俘获反应中的共振现象,利用DSD模型计算激发能量在5—25MeV能区的¹²C(n,γ0)反应截面与E_n=9MeV时的角分布.所考虑的反应机制包括复合核俘获、直接和半直接俘获、复弹性和非弹性散射道的辐射俘获.计算表明,矮共振的峰值在激发能量为13MeV处;巨共振的峰值位置在激发能量21MeV处.计算结果与实验符合较好.     

Proton-Accelerator Driven High-Flux Pulsed Neutron Source for Beam Research

Physics of Particles and Nuclei Letters - Parameters of the optimum alternative of a high-flux pulsed neutron source (fourth-generation neutron source in Dubna), which is foreseen to replace the...     

ADS中子源散裂靶物理研究

运用蒙卡程序DCM CEM对ADS标准散裂中子靶进行了计算研究.计算了在0.1~1.6GeV的质子轰击下,标准Pb靶发生散裂反应产生的泄漏中子产额及分布、中子能谱以及靶内能量沉积分布.计算结果与文献理论数据、实验数据进行了比较.     

1032－A型可控中子源

本文介绍一种适用快中子与介质发生非弹散射,同时产生非弹γ射线,以及用于测量非弹γ特征能量、检测炸药和其它物质成分而研制的脉冲中子源──１０３２－Ａ型可控中子源． The study on 1032-A type controllable neutron source is described in this paper. The source can meet with inelastic scattering of fast neutron and material, generate inelastic γ-ray and measured its characteristic energy, and examined explosive material andother substance component.     

中国散裂中子源小角中子散射谱仪探测器研制

中子小角散射探测器是小角散射（SANS）谱仪的关键设备之一,探测器要求有足够大的探测面积、较高的探测效率及较好的空间分辨率,能够在真空腔中稳定地工作并可在腔体内前后移动。综合考虑,SANS探测器采用120只8 mm直径位置灵敏3He管,组成有效面积1 000 mm（X）×1 020 mm（Y）的二维探测器阵列。探测器阵列分为10个模块,每一个模块功能完全独立,包括12只3He管及其对应的读出电子学和数据获取系统。读出电子学位于探测器背面的回字形密闭腔体内,由CSNS电子学组自主研发。SANS探测器从设计、选型、样机、调试到安装历时三年,中子束流实验结果显示探测器探测效率大于50%（@2Å）,空间分辨率好于10 mm（FWHM）,完全达到设计要求,目前正在中国散裂中子源小角散射谱仪运行使用。     

75As中子辐射俘获截面的实验测量及蒙特卡罗修正

在四川大学2.5 MV静电加速器上， 用活化法测量了29—1 100 keV 能区中子引起的75As(n， γ)76As反应截面， 并用MCNP 4C程序对实验中由中子的多次散射、 注量率衰减效应等引起的偏差进行了修正， 最后将所得结果与已有数据进行了比较。 We have measured the neutron radiative capture cross section of 75As in the energy range of En=29—1 100 keV using the activation technique at 2.5 MV electrostatic accelerator of Sichuan University. The experimental data were then corrected for multiple scattering and self shielding effects with MCNP 4C code. We also compared our results， with the existing measurement， calculation and evaluated data in ENDF/B Ⅵ.     

基于D-T紧凑型中子源的快中子照相准直屏蔽体设计及中子束特性模拟研究

中子照相是一种重要的无损检测技术,它能用于火工产品、毒品和核燃料元件等的检测。基于紧凑型D-T中子发生器,完成了一个用于快中子照相的准直屏蔽体系统（BSA）的物理设计。根据D-T中子源的能谱和角分布建立了中子源模型,采用MCNP4C蒙特卡罗程序,模拟了准直屏蔽体系统中中子和γ射线的输运,准直中子束相对于单位源中子的中子注量可以达到9.30×10-6 cm-2,准直中子束中主要是能量大于10 MeV的快中子;在设置的样品平面直径14 cm的照射视野范围,准直束中子注量的不均匀度为4.30%,准直束中中子注量与γ注量的比值为17.20,中子通量和中子注量比值J/Φ为0.992,说明准直中子束有好的平行性;准直屏蔽体外的泄露中子注量率与准直束中子注量率相比降低了2个量级。所设计的准直屏蔽体能满足快中子照相的要求。Neutron radiography is an important nondestructive testing technique. It can be used to detect the explosive devices, drug and the nuclear fuel element, etc. A beam-shaping-assembly (BSA) based on a compact D-T neutron generator is designed for fast neutron radiography in this paper. D-T neutron source model is constructed based on the neutron energy spectrum and angular distribution data. The transportation of neutron and γ-ray in the BSA is simulated using MCNP4C code. The neutron fluence of the collimated neutron beam with respect to the neutron source of the unit source is 9.30×10-6 cm-2. The collimated neutron beams is mainly fast neutrons with energies greater than 10 MeV. In the irradiation field range with a diameter of 14 cm, the neutron fluence uniformity of the collimated beam is 4.3%, the ratio of the neutron fluence to the gamma fluence in the collimated beam is 17.20, and the neutron flux and the neutron fluence ratio (J/Φ) is 0.992 which indicates that the collimated neutron beam has good parallelism. The leakage neutron fluence in outside of BSA is two orders of magnitude lower than that of the collimated neutron beam. The designed BSA can meet the need of fast neutron radiography.     

中国散裂中子源直线射频功率源系统的研制

中国散裂中子源加速器质子束流加速能量为1.6 GeV,重复频率为25 Hz,撞击固体金属靶产生散射中子,一期工程的打靶束流功率为100 kW。直线加速器的设计束流流强为15 mA,输出能量为81 MeV。射频加速和聚束系统包括一台射频四极场加速器、中能束流传输线的两个聚束器、四节漂移管直线加速器加速腔和直线-环束流传输线的一个散束器,与之相对应,共有8个单元在线运行的射频功率源为其提供所需的射频功率。目前,直线射频功率源系统预研项目已全部完成,各项性能参数均已达到设计指标,当前正处在批产安装调试阶段。151013     

中国散裂中子源直线射频功率源系统的研制

中国散裂中子源加速器质子束流加速能量为1.6 GeV,重复频率为25 Hz,撞击固体金属靶产生散射中子,一期工程的打靶束流功率为100 kW。直线加速器的设计束流流强为15 mA,输出能量为81 MeV。射频加速和聚束系统包括一台射频四极场加速器、中能束流传输线的两个聚束器、四节漂移管直线加速器加速腔和直线-环束流传输线的一个散束器,与之相对应,共有8个单元在线运行的射频功率源为其提供所需的射频功率。目前,直线射频功率源系统预研项目已全部完成,各项性能参数均已达到设计指标,当前正处在批产安装调试阶段。151013