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1.
《应用有机金属化学》2017,31(9)
Three water‐soluble complexes, [Cu2L2Cl2] ( 1 ), [CoL2(im)2] ( 2 ) and [ZnLClH2O] ( 3 ) (HL = 8‐hydroxyquinoline‐5‐sulphonic acid; im = N ‐methylimidazole), were prepared and characterized using various spectral techniques. The DNA binding behaviour of complexes 1 – 3 was studied using UV–visible and circular dichroism (CD) spectra and cyclic voltammetry. All three complexes exhibit hypochromism but complexes 1 and 3 alone give a red shift of 4 nm with a significant binding constant of K b = 2.1 × 104 and 1.0 × 104 M−1, respectively, but complex 2 shows no red shift with lower K b of 4.1 × 103 M−1. The voltammetric E 1/2 of complex 1 on interaction with herring sperm DNA shifts to a more positive potential, as expected, than complex 2 due to higher DNA affinity. Additionally, analysis of electrochemical data yields a value of K +/K 2+ greater than one suggesting that complex 1 binds to DNA through intercalation in the M(I) state. Evidently in CD spectral analysis, complex 1 exhibits a decrease in molar ellipticity with a red shift of 10 nm and a significant decrease in intensity compared to complexes 2 and 3 . This clearly indicates that complex 1 induces the B → A transition to a greater extent than 2 and 3 . Oxidative cleavage using circular plasmid pUC18 DNA with complex 1 was investigated using gel electrophoresis. Interestingly, complex 1 displays a strong DNA binding affinity and is efficient in cleaving DNA in the presence of H2O2 at pH = 8.0 at 37 °C. 相似文献
2.
Shuxiang Wang Wenhao Chu Yuechai Wang Siyuan Liu Jinchao Zhang Shenghui Li Haiying Wei Guoqiang Zhou Xinying Qin 《应用有机金属化学》2013,27(7):373-379
Eight novel Pt(II), Pd(II), Cu(II) and Zn(II) complexes with 4’‐substituted terpyridine were synthesized and characterized by elemental analysis, UV, IR, NMR, electron paramagnetic resonance, high‐resolution mass spectrometry and molar conductivity measurements. The cytotoxicity of these complexes against HL‐60, BGC‐823, KB and Bel‐7402 cell lines was evaluated by MTT assay. All the complexes displayed cytotoxicity with low IC50 values (<20 μm ) and showed selectivity. Complexes 3 , 5 , 7 and 8 exerted 9‐, 5‐, 12‐ and 7‐fold higher cytotoxicity than cisplatin against Bel‐7402 cell line. The cytotoxicity of complexes 3 , 5 , 6 , 7 and 8 was higher than that of cisplatin against BGC‐823 cell line. Complexes 3 , 7 and 8 showed similar cytotoxicity to cisplatin against KB cell line. Complex 7 exhibited higher cytotoxicity than cisplatin against HL‐60 cell line. Among these complexes, complex 7 demonstrated the highest in vitro cytotoxicity, with IC50 values of 1.62, 3.59, 2.28 and 0.63 μm against HL‐60, BGC‐823, Bel‐7402 and KB cells lines, respectively. The results suggest that the cytotoxicity of these complexes is related to the nature of the terminal group of the ligand, the metal center and the leaving groups. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
3.
《Journal of Coordination Chemistry》2012,65(4):699-714
(E)-2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (Hbid) was prepared by condensation of N-aminophthalimide and salicylaldehyde and characterized by elemental analysis, IR, 1H-NMR, and mass spectral studies. Mononuclear complexes [(phen)CuII(μ-Hbid)2H2O] (1), [(phen)CoII(Cl)2(μ-Hbid)]6H2O (2) (phen?=?1,10-phenanthroline) and binuclear complexes [CuII(μ-Hbid)]2 (3), and [CoII(μ-Hbid)]2 (4) with Hbid were prepared and characterized by elemental analysis, IR, UV-Vis, molar conductance, and thermogravimetric (TG) techniques. DNA-binding properties of 1–4 were investigated by UV spectroscopy, fluorescence spectroscopy, and viscosity measurements. The results suggest that 1 and 2 bind to DNA by partial intercalation, whereas 3 and 4 find different groove-binding sites. The cleavage of these complexes with super coiled pUC19 has been studied using gel electrophoresis; all the complexes displayed chemical nuclease activity in the absence and presence of H2O2 via an oxidative mechanism. Complexes 1–4 inhibit the growth of both Gram-positive and Gram-negative bacteria. 相似文献
4.
《应用有机金属化学》2017,31(12)
5‐phenylazo‐8‐hydroxyquinoline and its newly metal complexes with Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) metal ions have been prepared and characterized using different analytical techniques. The complexes are distorted octahedral binding via one oxygen and nitrogen atoms of the ligand; two/three coordinated water molecules. 1:1 complexes contain one chloride or OH− ion and some complexes have one or two water of hydration whereas 1:2 complexes contain only two coordinated water molecules in their coordination spheres. All complexes behave as neutral in dimethylformamide (DMF). The electronic structure and non‐linear optical parameters NLO of the complexes (ML and ML2) are investigated theoretically at the B3LYP/GEN level of theory. The geometries of the studied complexes are non‐planner. The calculated EHOMO and ELUMO energies of the studied complexes were used to calculate the global properties; hardness (η), global softness (S) and electronegativity (χ). The total dipole moment (μtot), static total and anisotropy of polarizability (α, Δα) and static first hyperpolarizability (β) values were calculated and compared with urea as a reference compound. The studied complexes show promising optical properties. 相似文献
5.
6.
Preparation and characterization of Cu (II) supported on poly(8‐hydroxyquinoline‐p‐styrene sulphonate) and its application as catalyst for the synthesis of hexahydroquinolines
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Ardeshir Khazaei Mahsa Tavasoli Vahid Jamshidi Fatemeh Gohari Ghalil Ahmad Reza Moosavi‐Zare 《应用有机金属化学》2018,32(7)
Cu ( II ) supported on poly(8‐hydroxyquinoline‐p‐styrenesulfonate) (Cu ( II )@PHQSS) was prepared and fully characterized by the different techniques including fourier transform infrared spectroscopy (FT‐IR), 1H NMR, 13C NMR, thermal gravimetric analysis (TGA), differential thermal gravimetric (DTG), differential thermal analysis (DTA), scanning electron microscope (SEM) and energy dispersive X‐ray analysis (EDS). Afterward, the Cu ( II )@PHQSS as nanostructured catalyst was used as catalyst for the synthesis of hexahydroquinolines. 相似文献
7.
Ritu B. Dixit Satish F. Vanparia Tarosh S. Patel Chandresh L. Jagani Hiren V. Doshi Bharat C. Dixit 《应用有机金属化学》2010,24(5):408-413
Looking at the pharmacological importance of 8‐hydroxyquinolines and sulfonamides, in the present study, a novel bi‐dentate ligand 4‐amino‐N′‐[(8‐hydroxyquinoline‐5‐yl)methyl] benzenesulfonohydrazide (AHQMBSH) having above both moieties within a single molecular framework was synthesized by the reaction of N‐acetamidobenzene sulfonohydrazide with 5‐chloromethyl‐8‐hydroxyquinoline hydrochloride. Its metal(II) oxinates were also prepared with Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) salts. All the above compounds were investigated by physicochemical analyses, thermogravimetric analysis and spectroscopic techniques. Antimicrobial activities for the above prepared compounds were carried out using the agar‐plate method against various strains of bacteria (Staphylococcus aureus, Bacillus subtillis, Pseudomonas aerugionsa, Escherichia coli) and fungi (Aspergillus niger and Aspergillus flavous). The results show a significant increase in antimicrobial and antifungal activities of AHQMBSH compared with the parent 8‐hydroxyquinoline and sulfonamides. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
8.
A set of four Cu(II) complexes, [Cu(cdnapen)], [Cu(cdnappd)], [Cu(cdMenappd)] and [Cu(cdMeMeOsalpd)], derived from Schiff base ligands with an asymmetric NN′OS coordination sphere have been synthesized. The molecular and the crystal structures have been determined by X-ray diffractometry. The structural results confirm that the complexes are tetra coordinated. The copper (II) ion coordinates to two nitrogen atoms from the imine moiety of the ligand, a sulfur atom from the methyl dithiocarboxylate moiety and a phenolic oxygen atom. The complexes show an unusual tetrahedral distortion to the square-planar geometry around the metal centre in spite of the pseudomacrocyclic skeleton of the ligand. The complexes were further characterized by cyclic voltammetry and electron paramagnetic resonance spectroscopy. The degree of tetrahedral distortion of the complexes appears to be dependent on the number of carbon atoms of the aliphatic bridge and the nature of the coordinating atoms. 相似文献
9.
《应用有机金属化学》2017,31(12)
A bioactive Schiff base HL i.e. 2‐hydroxy‐benzoic acid(3,4‐dihydro‐2H ‐naphthalen‐1‐ylidene)‐hydrazide was synthesized by reacting equimolar amount of salicylic acid hydrazide and 1‐tetralone. Co(II), Ni(II) and Zn(II) complexes of ligand HL was synthesized in 1:1 and 1:2 molar ratio of metal to ligand. The structure of the synthesized ligand and metal complexes was established by elemental analysis, molar conductance, magnetic susceptibility measurements, electronic, IR and EPR spectral techniques. For determining the thermal stability the TGA has been done. In DFT studies the geometries of Schiff bases and metal complexes were fully optimized with respect to the energy using the 6–31 + g(d,p) basis set. Spectral data reveal that ligand behave uninegative tridentate in ML complexes and uninegative bidentate in ML2 complexes. On the basis of characterization octahedral geometry has been assigned for Co(II) and Ni(II) complexes, while tetrahedral for Zn(II) complexes. Antibacterial activity of the synthesized compounds were evaluated against Staphylococcus aureus , Bacillus subtilis, Escherichia coli , Xanthomonas campestris and Pseudomonas aeruginosa and the results revealed that metal complexes show enhanced activity in comparison to free ligand. 相似文献
10.
《Journal of Coordination Chemistry》2012,65(1):147-155
Cu(II) complexes of three bis(pyrrol-2-yl-methyleneamine) ligands were synthesized and characterized by elemental analyses, mass spectra, and IR spectra. X-ray diffraction analysis shows that [CuL3]2 is a dinuclear complex with an extremely distorted square-planar geometry. Furthermore, the antioxidant activities of the compounds have been investigated. The electrochemical properties of the Cu(II) complexes have also been studied by cyclic voltammetry. The Cu(II) complexes show similar superoxide dismutase (SOD) activity compared with that of the native Cu, Zn-SOD. 相似文献
11.
Jun Xia Xiao‐Lin Gong Xing Fan 《Acta Crystallographica. Section C, Structural Chemistry》2015,71(10):878-882
Assemblies of pyrazine‐2,3‐dicarboxylic acid and CdII in the presence of bis(1,2,4‐triazol‐1‐yl)butane or bis(1,2,4‐triazol‐1‐yl)ethane under ambient conditions yielded two new coordination polymers, namely poly[[tetraaqua[μ2‐1,4‐bis(1,2,4‐triazol‐1‐yl)butane‐κ2N4:N4′]bis(μ2‐pyrazine‐2,3‐dicarboxylato‐κ3N1,O2:O3)dicadmium(II)] dihydrate], {[Cd2(C6H2N2O4)2(C8H12N6)(H2O)4]·2H2O}n, (I), and poly[[diaqua[μ2‐1,2‐bis(1,2,4‐triazol‐1‐yl)ethane‐κ2N4:N4′]bis(μ3‐pyrazine‐2,3‐dicarboxylato‐κ4N1,O2:O3:O3′)dicadmium(II)] dihydrate], {[Cd2(C6H2N2O4)2(C6H8N6)(H2O)2]·2H2O}n, (II). Complex (I) displays an interesting two‐dimensional wave‐like structure and forms a distinct extended three‐dimensional supramolecular structure with the help of O—H...N and O—H...O hydrogen bonds. Complex (II) has a three‐dimensional framework structure in which hydrogen bonds of the O—H...N and O—H...O types are found. 相似文献
12.
《应用有机金属化学》2017,31(10)
New Mn(II), Ni(II), Co(II) and Cu(II) complexes of an azo dye ligand based on p ‐phenylenediamine with 5‐nitro‐8‐hydroxyquinoline were synthesized and characterized using elemental analysis, inductive coupled plasma analysis, molar conductance, powder X‐ray diffraction, thermogravimetric analysis, magnetic moment measurements, and infrared, 1H NMR, electron ionization mass and UV–visible spectral studies. The spectral and analytical data reveal that the azo dye ligand acts as a monobasic bidentate ligand via deprotonated OH and nitrogen atom of the quinoline ring. The data support the formulation of all complexes with a 2:1 ligand‐to‐metal ratio, except the Mn(II) complex that has a mononuclear formula. All complexes have an octahedral structure. The molar conductance data reveal that all the metal complexes are non‐electrolytic in nature. From the X‐ray data, the average particle size of the ligand and its complexes is 0.32–0.64 nm. The colour fastness to light, washing, perspiration, sublimation and rubbing of the prepared ligand and its complexes on polyester fabrics and colorimetric properties were measured. The results reveal that the ligand and its complexes have a good to moderate affinity to polyester fibres. 相似文献
13.
Stable ruthenium(II) carbonyl complexes of the type [RuCl(CO)(EPh3)(B)(L)] (E = P or As; B = PPh3, AsPh3 or Py; L = 2′‐hydroxychalcones) were synthesized from the reaction of [RuHCl(CO)(EPh3)2(B)] (E = P or As; B = PPh3, AsPh3 or Py) with 2′‐hydroxychalcones in benzene under reflux. The new complexes were characterized by analytical and spectroscopic (IR, electronic 1H, 31P and 13C NMR) data. They were assigned an octahedral structure. The complexes exhibited catalytic activity for the oxidation of primary and secondary alcohols into their corresponding aldehydes and ketones in the presence of N‐methylmorpholine‐N‐oxide (NMO) as co‐oxidant and were also found to be efficient transfer hydrogenation catalysts. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
14.
Ruthenium(II) complexes of hybrid 8‐hydroxyquinoline–thiosemicarbazone ligands: synthesis,characterization and catalytic applications
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A series of new hexa‐coordinated ruthenium(II) hydroxyquinoline–thiosemicarbazone complexes of the type [Ru(CO)(EPh3)(B)(L)] (E = P or As; B = PPh3, AsPh3 or Py; L = hydroxyquinoline–thiosemicarbazone) were synthesized by reacting ruthenium precursor complexes [RuHCl(CO)(EPh3)2(B)] (E = P or As; B = PPh3, AsPh3 or Py) with hydroxyquinoline–thiosemicarbazone ligands in ethanol. The new complexes were characterized by analytical and spectroscopic (FT‐IR, UV–visible, NMR (1H, 13C and 31P) and fast atom bombardment (FAB)–mass spectrometric methods. Based on the spectral results, an octahedral geometry was assigned for all the complexes. The new complexes showed good catalytic activity for the conversion of aldehydes to amides in the presence of hydroxylamine hydrochloride–sodium bicarbonate and for the oxidation of alkanes into their corresponding alcohols and ketones in the presence of m‐chloroperbenzoic acid. The complexes also catalyzed the N‐alkylation of benzylamine in the presence of KOtBu in alcohol medium. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
15.
The 7‐allyl‐ and 7‐(2‐methylvinyl)‐functionalized derivatives of 8‐hydroquinoline are synthesized by Claisen rearrangement and double bond rearrangement respectively. Then 7‐allyl‐8‐hydroquinoline (C) and 7‐(2‐methylvinyl)‐8‐hydroquinoline (D) are reacted with aluminum chloride to afford the corresponding tris‐(7‐allyl‐8‐hydroxyquinoline) aluminum complex (F) and tris‐(7‐(2‐methylvinyl)‐8‐hydroxyquinoline) aluminum complex (G). The photoluminescence of complex (F) or (G), compared with that of tris‐(8‐hydroxyquinoline) aluminum complex (E), all showed a red shift in emission wavelengths in different solvents, such as chloroform, hexane and ethanol. For two substituents containing an external double bond, the 2‐methylvinyl group gives a larger red shift in the emission wavelength than the allyl group. The X‐ray crystal structure indicates that 7‐(2‐methylvinyl)‐8‐hydroxyquinoline (D) is a trans‐isomer. The styrene and 7‐allyl‐8‐hydroxyquinoline copolymer, and the styrene and 7‐(2‐methylvinyl)‐8‐hydroxyquinoline copolymer are also reported. Further reactions of the copolymer are then performed by adding aluminum(III) chloride and ligands 8‐hydroxyquinoline. The spectroscopic characteristics of these aluminum(III) polymeric complexes are discussed. Copyright © 2003 John Wiley & Sons, Ltd. 相似文献
16.
《Acta Crystallographica. Section C, Structural Chemistry》2017,73(11):1030-1037
The synthesis of potassium (η2‐4‐allyl‐2‐methoxyphenol)trichloridoplatinate(II), K[PtCl3(C10H12O2)], ( 1 ), starting from Zeise's salt and Ocimum sanctum L. oil has been optimized. Starting from ( 1 ), three new platinum(II) complexes, namely (η2‐4‐allyl‐2‐methoxyphenol)chlorido(2‐methylquinolin‐8‐olato‐κ2N ,O )platinum(II), ( 2 ), (η2‐4‐allyl‐2‐methoxyphenol)chlorido(5‐nitroquinolin‐8‐olato‐κ2N ,O )platinum(II), ( 3 ), and (η2‐4‐allyl‐2‐methoxyphenol)chlorido(5,7‐dichloroquinolin‐8‐olato‐κ2N ,O )platinum(II), [Pt(C9H4Cl2NO)Cl(C10H12O2)], ( 4 ), containing eugenol and a quinolin‐8‐ol derivative (R‐OQ), have been synthesized and characterized by elemental analyses, MS, IR, 1H NMR and NOESY spectra. For ( 1 ) and ( 4 ), single‐crystal X‐ray diffraction studies were also carried out. Complexes ( 2 )–( 4 ) show good inhibiting abilities on three human cancer cell lines, i.e. KB, Hep‐G2 and LU, with IC50 values of 1.42–17.8 µM . Complex ( 3 ) gives an impressively high activity against KB, Hep‐G2, LU and MCF‐7, with IC50 values of 1.42–4.91 µM , which are much lower than those of cisplatin and some other platinum(II) complexes. 相似文献
17.
A group of a diverse family of dinuclear copper(II) complexes derived from pyrazole‐containing tridentate N2O ligands, 1,3‐bis(3,5‐dimethylpyrazol‐1‐yl)propan‐2‐ol (Hdmpzpo), 1,3‐bis(3‐phenyl‐5‐methyl pyrazol‐1‐yl)propan‐2‐ol (Hpmpzpo) and 1,3‐bis(3‐cumyl‐5‐methylpyrazol‐1‐yl)propan‐2‐ol (Hcmpzpo), were synthesized and characterized by elemental analysis, IR spectroscopy and three of them also by single‐crystal X‐ray diffraction. Three complexes, [Cu2(pmpzpo)2](NO3)2·2CH3OH ( 3 ·2CH3OH), [Cu2(pmpzpo)2](ClO4)2 ( 4 ) and [Cu2(cmpzpo)2](ClO4)2·2DMF ( 7 ·2DMF), each exhibits a dimeric structure with a inversion center being located between the two copper atoms. The metal ion is coordinated in a distorted square planar environment by two pyrazole nitrogen atoms and two bridging alkoxo oxygen atoms. Both complexes 1 ·CH3OH·H2O and 3 ·2CH3OH were investigated in anaerobic conditions for the catalytic oxidation of 3,5‐di‐tert‐butylcatechol (3,5‐DTBC) to the corresponding quinone (3,5‐DTBQ), for modeling the functional properties of catechol oxidase. Copyright © 2007 John Wiley & Sons, Ltd. 相似文献
18.
A new series of six chromone‐derived compounds and their Cu(II) complexes was synthesized and characterized by their physical, spectral and analytical data The elemental analysis data of the complexes agree well with the proposed composition of the compounds, which were found to be dimeric in nature with two hydrazine molecules bridging the two copper atoms through coordination. The ligands and their Cu(II) complexes were screened for their in‐vitro antibacterial activity against four Gram‐negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Shigella flexneri) and two Gram‐positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains by the agar‐well diffusion method. The ligands were found to exhibit either no or low to moderate activities against one or more of the bacterial species, whereas all the metal complexes exhibited moderate to high activities against different bacterial species. The ligands which were inactive before complexation turned active and less active ones became more active upon coordination with copper ions. Overall, the complexes 7–12 showed comparatively much higher activities than the ligands. Copyright © 2009 John Wiley & Sons, Ltd. 相似文献
19.
Mirjana Antonijević Nikolić Jelena Antić Stanković Slađana B. Tanasković 《Journal of Coordination Chemistry》2018,71(10):1542-1559
New cationic tetranuclear Co(II) and neutral binuclear Cu(II) complexes with tpmc (N,N′,N″,N″′-tetrakis-(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane) and bridging pyromellitate ligand pma (tetraanion 1,2,4,5-benzenetetracarboxylic acid) were isolated. The composition of the compounds is proposed based on elemental analyses (C, H, N, M=Cu, Co), molar conductivity determination, UV-Vis, FTIR, EPR, LC-MS and reflectance spectroscopy, magnetic measurements, cyclic voltammetry, as well as TG and DTA. It is proposed that in [Co4(pma)(tpmc)2](ClO4)4·6H2O (1), cobalt(II) is six-coordinate out of cyclam rings and one OCO? from pma participates in coordination with one Co(II). In the case of [Cu2(pma)tpmc]?8H2O (2), one OCO? from pma bridges two Cu(II). The cytotoxic activity of 1 and 2 was tested against tumor cell lines human cervix adenocarcinoma (HeLa), estrogen-receptor-positive human breast cancer (MCF-7), human myelogenous leukemia (K562), and the human Caucasian Burkitt’s lymphoma (Ramos). The IC50 values for 1 and 2 were within the range 44.66 ± 2.39 to 152.40 ± 2.28 μM, and from 140.88 ± 3.51 to 192.05 ± 2.09 μM, respectively. Both 1 and 2 were tested for antimicrobial activity. We determined that minimal inhibitory concentration for 1 against Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumoniae was 25 mM. Complex 2 did not express activity against tested microbial strains. 相似文献
20.
A novel Schiff base derived from 2,4-dihydroxybenzaldehyde and tyrosine and its copper(Ⅱ)complex have been synthesized and characterized.The composition of the complex is K[CuL] H2O,where L=H11C16NO5.ESR spectra of the copper(Ⅱ)complex were investigated at different temperatures and in various solvents.The second order effect and the relaxation effect were observed in the solution spectrum at room temperature,which was satisfactorily explained by spin Hamiltonian.The bonding parameters of copper(Ⅱ)complex were calculated using spectral parameters from ESR spectra at low temperature.Its bonding characterization and stability were disscussed.The result shows that the in-plane a-bond and the in-plane π-bond in the complex all play an important role. 相似文献