展宽重离子束的Bragg峰

介绍了自行设计加工的用于对重离子束Bragg峰进行展宽的旋转式射程调制器. 实验上运用双电离室法测定了75MeV/u ¹²C离子束的Bragg曲线以及经该射程调制器调制的75MeV/u ¹⁶O及¹²C离子束的Bragg曲线,调制的离子束展示出明显展宽的Bragg峰,并将测量结果同计算结果进行了比较.     

重离子治癌中的三维剂量成形方式

介绍了重离子治癌装置ＨＩＭＡＣ和ＨＩＴＡＧ的三维剂量成形方式;对一种正在设计中的重离子对肿瘤的照射方式进行了分析,旨在为ＨＩＲＦＬ及ＨＩＲＦＬ－ＣＳＲ所提供的离子束设计三维剂量成形方案． Three dimensional dose shaping methods in heavy-ion therapy facilities,HI MAC and HITAG are introduced.A new tumor irradiation pattern with heavy ion beam which is being designed is analyzed.It aims at choosing suitable three dimensional dose shaping planning for heavy ion beam supplied by HIRFL and the proposed HIRFL-CSR.     

重离子放射治疗双微小展宽峰组合照射方法

在基于被动式束流配送系统的分层适形重离子治疗当中,需要利用微型脊形过滤器（mini ridge filter,mini-RF）将单能重离子束Bragg峰展宽为峰区近似高斯分布的微小展宽峰（mini spread-out Bragg peak,mini-SOBP）,从而达到减少照射分层数及照射时间的目的。采用较宽的mini-SOBP可以有效减少照射分层数,但会增大展宽Bragg峰（SOBP）远端剂量跌落距离,增加对靶区后方正常组织或危及器官的辐照剂量。这一问题可以通过双mini-SOBP的组合照射方法来解决。使用2种mini-RF对单能重离子束Bragg峰略微展宽得到2种半高宽（FWHM）且剂量分布近似高斯分布的mini-SOBP,通过基于放射生物学模型的剂量优化,证实了在SOBP平顶区按生物有效剂量均匀和物理吸收剂量均匀的展宽情况下,双mini-SOBP组合照射方法均可以在减少照射分层数的同时较大幅度地减小SOBP远端剂量跌落距离。In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.     

兰州重离子加速器及其应用前景

本文简要地介绍了兰州重离子加速器的结构和建造过程，并对它的应用前景作了简单的描述．     

重离子治疗计划的生物有效剂量及其验证

介绍了重离子治疗计划中的生物有效剂量，以及基于局部效应模型的相对生物学效应的计算. 报告了用生物测试系统测得的实验结果，并与治疗计划的计算结果做了比较. 靶子内外结果的一致性显示了重离子治疗计划的可靠性及保护紧挨着靶的重要器官的能力.     

200KV重离子加速器及其应用

本文介绍一台采用双潘宁型多电荷重离子源的200kV重离子加速器,简述它在GaP光探测器的研制、聚合物材料和金属材料的离子注入改性等方面的研究与应用。     

蛋白质组学及其在重离子治癌应用中的探讨

综述了蛋白质组学的主要方法和技术——双向凝胶电泳、生物质谱技术、蛋白质芯片技术，及其在肿瘤标志物的筛选和鉴定、肿瘤治疗效果的评价及肿瘤发生机制研究等方面的应用状况，并对蛋白质组学在重离子治疗中的应用进行了展望。With the accomplishment of the human genome project, proteomics becomes a new snbject on the buildup of the whole proteins and their dynamic changes in cell emerges. Cancer is a kind of complex disease involved in multi-genes and proteins. Heavy ion therapy is all arising and potential radiation treatment nowadays. This paper reviews on the main methods and technology in proteomics-- two-dimensional gel electrophoresis （2-DE）,biological mass spectrometry, protein biochips, bioinformatics and its application on identification of cancer biomarkers, evaluation of curative effect on tumour and the mechanisms of turnout formation. This paper also presents some prospects on the application of proteomics in heavv ion therapy.     

重离子辐照SiO2通过能量损失产生发光色心的研究

通过红外光谱和荧光发射光谱分别对600 keV、4 MeV和5 MeV Kr离子辐照的SiO2进行发光特性的研究。在低能量辐照体系中,简单色心(F2色心)的形成在损伤过程中占据主导地位,其主要诱发蓝光发射带;在高能离子辐照条件下,离子径迹上的能量密度较大,因此缺陷浓度的增大产生了一些缺陷团簇和离子径迹,形成了复杂的色心(F2+和F3+色心等)并诱发了强烈的绿光发射带和红光发射带。该实验结果与能量损失过程中统一热峰理论模型(一个综合的基于电子能损与核能损的非弹性碰撞模型和弹性碰撞模型)的模拟结果能够很好地吻合,表明在keV～MeV能区上存在电子能损过程与核能损过程的协同效应。     

重离子惯性聚变的研究

本文描述了重离子惯性聚变的研究现状和用于重离子惯性聚变的重离子加速器． The present researching status and the heavy ion accelerators used for inertial fusion of heavy ions are decribed in the paper.     

中国科学院近代物理研究所重离子辐照生物研究平台

介绍了中国科学院近代物理研究所和兰州重离子加速器国家实验室的重离子加速器辐照生物研究平台、 重离子辐照生物研究发展规划及在现代农业和生物产业方面取得的一些最新进展。 Heavy-ion accelerator facilities for the researches on biological effects induced by heavy ion at Institute of Modern Physics（IMP）, Chinese Academy of Sciences and National Laboratory of Heavy ion Accelerator in Lanzhou（HLHIAL） are introduced. New progresses in modern agriculture and biological industry are presented.     

重离子辐射植物的诱变效应研究及应用

重离子生物技术已引起人们的广泛关注, 植物育种是重离子生物技术研究和应用的热点之一。 简要介绍了重离子的基本特征和在育种应用中的优势, 综述了重离子辐射对植物分子、 细胞、 个体3个水平的诱变效应研究及重离子辐射育种取得的进展。 Heavy ion biotechnology has received much attention since the mid 1980s, when the first mutagenic effect of heavy ion beams was found in rice. Since then, plant breeding is one of the focuses in heavy ion biotechnology. In this paper we outlined the recent developments in plant breeding by heavy ion beams. We introduced briefly the essential characteristics and superiority of heavy ion beams applied in plant breeding, and reviewed further the mutagenic research in three levels(e.g., molecular, cell and individual) of plants. At last, we summarized artificial mutants obtained in plants irradiated by heavy ion beams.