2—甲基—3—芳基烯丙基三苯基溴化Lin的合成

取代苯甲本钱经醇醛缩合，硼氢化还原，溴化反应和成盐反应合成了２－甲基－３－间硝基苯基烯丙基三苯基溴化Ｌｉｎ和２－甲基－３０对硝基苯基烯丙基三苯基溴化Ｌｉｎ两个化合物，收率分别达８６．４％和６９．０％。结构经ＩＲ，＾１Ｈ ＮＭＲ确诊。     

3—嘧啶胺基或三嗪胺基甲酰基—4—羟基—2H—1,2—苯并噻…

通过３－乙氧甲酰基－４－羟基－２－氢（甲基）－２Ｈ－１，２－苯并噻嗪－１，１－二氧化物与取代嘧啶胺或均三嗪胺的胺解反应，合成了标题化合物。生物活性测定结果表明多数化合物具有较好的除草活性，部分化合物显示好的植物生长调节活性和抗炎免疫活性。     

2,6—二甲基—3—苯基—4α—对甲苯基—7—苯甲酰基—4α,5,6,12—四氢—1H,7H—1,3

通过２－甲基－４－对甲苯基－１－苯甲酰基－２，３－二氢－１Ｈ－１，５－苯并二氮杂Ｚｈｏｕ与由不对称１－苯基－２－偶氮－１，３－丁二酮热解产生的α－羰基烯酮的「２＋４」环加成反应制备了标题化合物（Ｃ３４Ｈ３０Ｎ２Ｏ３，Ｍｒ＝５１４．６２），用Ｘ射线衍射测定了其单晶结构。     

稠杂环化合物的研究（XV）：6—取代—3—（1H—苯并三唑—1—亚甲基）…

研究了３－（１Ｈ－苯并三唑－１－亚甲基）－４－氨基－５－巯基－１，２，４－三唑与取代苯甲酸在三氯氧磷催化下的反应，制得１０种新的３－（１Ｈ－苯并三唑－１－亚甲基）－１，２，４－三唑并［３，４－ｂ］－１，３，４噻二唑，通过元素分析，ＩＲ、＾１ＨＮＭＲ和ＭＳ确证了它们的结构并讨论了其波谱性质。     

5—甲基—2—巯基—1,3,4—噻二唑的合成

５－甲基－２－巯基－１，３，４－噻二唑的合成李占才李淑勉方少明侯守君聂晓兵林烨（郑州轻工业学院化工系郑州４５０００２）关键词５－甲基－２－巯基－１，３，４－噻二唑乙酰肼Ｎ－乙酰肼基二硫代甲酸钾中图分类号Ｏ６２６．２７５－甲基－２－巯基－１，３，４－噻...     

4—溴—5—甲基靛红的Baeyer—Villiger氧化物的波谱分析

４－溴－５－甲基靛红分别与单过邻苯二甲酸，过硫酸钾－硫酸两种氧化剂发生Ｂａｅｙｅｒ－Ｖｉｌｌｉｇｅｒ反应，生成两种同分异构体：５－溴－６－甲基－１Ｈ－苯并［１，３］恶嗪－２，４－二酮和新化合物５－溴－６－甲基－１Ｈ－苯并［１，４］恶嗪－２，３－二酮。利用ＭＳ、＾１３ＣＮＭＲ、＾１ＨＮＭＲ、ＩＲ反应，单过邻苯二甲醇，ＩＲ对产品结构进行了分析鉴定。     

1,9—二叠氮基—2,2,8,8—四硝基—4,6—二氧杂壬烷的合成及性能

１，９－二叠氮基－２，２，８，８－四硝基－４，６－二氧杂壬烷的合成及性能阎红＊管晓培（北京工业大学化学与环境工程学系北京１０００２２）（北京理工大学化工与材料学院北京）关键词叠氮化合物，含能增塑剂，合成，离去基团，性能评价１９９６－０９－２３收稿，１...     

3－嘧啶胺基或三嗪胺基甲酰基－4－羟基－2H－1，2－苯并噻嗪－1，1－二氧化物的合成及活性

通过３－乙氧甲酰基－４－羟基－２－氢（甲基）－２Ｈ－１，２－苯并噻嗪－１，１－二氧化物与取代嘧啶胺或均三嗪胺的胺解反应，合成了标题化合物。生物活性测定结果表明多数化合物具有较好的除草活性，部分化合物显示好的植物生长调节活性和抗炎免疫活性。     

5,6—二亚甲基双环[2.2.1]庚—2—醇及其衍生物的旋光与构型

从（－）－（１Ｓ，２Ｒ，４Ｓ）－５，６－二亚甲基双环［２．２．１］庚－２－醇（Ｉ）和（－）－（１Ｓ，２Ｓ，４Ｓ）－５，６－二亚甲基双环［２．２．１］庚－２－醇（Ⅱ）出发，合成了它们的醚类和取代苯甲酸酯类光学纯的衍生物。通过［α］Ｄ测定和构型分析，发现它们是含有３个手性碳（Ｃ１，Ｃ２和Ｃ４）的桥环化合物，其旋光性与构型的关系均符合可极化度多级圆球不对称性模型。     

2—芳基—5—巯基—1,3,4—三唑衍生物的合成

报道了７种双（２－芳基－１，３，４－三唑－５－基）二硫化物（２ａ￣２ｇ）和５种１－乙基－２－芳基－１，３，４－三唑－５－乙硫醚的合成。化合物结构经元素分析、红外光谱、核磁共振氢谱及质谱确证。生物活性测定结果表明，２ｂ和３ｂ具有较强的抗菌活性。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

Synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives

Different approaches for the synthesis of 1-benzyloxypyrazin-2(1H)-one derivatives from simple amino acids have been investigated. A library of 33 precursors for the preparation of N-hydroxy pyrazinones was obtained in moderate to good yields.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

Highly regioselective Buchwald–Hartwig amination at C-2 of 2,4-dichloropyridine enabling a novel approach to 2,4-bisanilinopyridine (BAPyd) libraries

The highly regioselective Buchwald–Hartwig amination at C-2 of the cheap and readily accessible reagent, 2,4-dichloropyridine with a range of anilines and heterocyclic amines is described. This new methodology is robust and provides a facile access to 4-chloro-N-phenylpyridin-2-amines on 0.25 mol scale. These intermediates undergo a further Buchwald–Hartwig amination at higher temperature to enable rapid exploration of the chemical space at C-4 and to provide a library of 2,4-bisaminopyridines.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.     

A general and convenient synthesis of 4-(tosylmethyl)semicarbazones and their use in amidoalkylation of hydrogen,heteroatom, and carbon nucleophiles

A general synthesis of previously unknown semicarbazone-based α-amidoalkylating reagents, 4-(tosylmethyl)semicarbazones, has been developed. The synthesis involved three-component condensation of semicarbazones of aliphatic or aromatic aldehydes with the same or other aldehydes and p-toluenesulfinic acid. The scope and limitations of this reaction were investigated. The compounds obtained were demonstrated to be an efficient α-(4-semicarbazono)alkylating agents. They were reacted with H- (sodium borohydride), O- (sodium methylate), S- (sodium phenylthiolate), N- (pyrrolidine, sodium succinimide), P- (trialkyl phosphites), and C-nucleophiles (sodium diethyl malonate) to give the corresponding products of the tosyl group substitution, 4-substituted semicarbazones, including analogues of nitrofurazone. Among the prepared compounds tested in vitro for antibacterial and antifungal activity, three nitrofuryl-containing semicarbazones exhibited high biological activities with minimum inhibitory concentration (MIC) values of 8–32 μg/mL.     

Sulfur-directed metal-free and regiospecific methyl C(sp3)–H imidation of thioanisoles

Regiospecific and direct imidation of the methyl C(sp³)–H bond of thioanisoles is realized under mild and metal-free conditions with N-fluorobis(benzenesulfonyl)imide as an oxidant and nitrogen source. Proposed mechanism suggests that thionium ion intermediates and a Pummerer-type reaction are involved. The imidation has advantages such as high step-economy, excellent functionality tolerance, and regiospecificity, giving structurally diverse imidation products.     

Synthesis of novel chiral bidentate hydroxyalkyl-N-heterocyclic carbene ligands and their application in palladium-catalyzed Mizoroki–Heck couplings and asymmetric addition of diethylzinc to benzaldehyde

A small library of new chiral bidentate hydroxyalkyl-imidazolium salts 1 is conveniently synthesized on multi-gram scale from inexpensive and commercially available chiral pool amino acids. The corresponding carbenes, generated by deprotonation of imidazolium salts 1, in combination with palladium(II) chloride were tested in the Mizoroki–Heck coupling reaction. The most significant results in terms of yields and reactivities were achieved with low catalyst loading. The catalytic activities of these imidazolium salts were also investigated in the asymmetric addition of diethylzinc to benzaldehyde. The use of MgO nanoparticles as an additive in conjunction with these ligands played a crucial role in increasing the efficiency of these reactions.