共查询到20条相似文献,搜索用时 15 毫秒
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V. A. Glushkov Yu. V. Shklyaev O. A. Maiorova G. A. Postanogova E. V. Feshina 《Chemistry of Heterocyclic Compounds》2000,36(3):319-325
Substituted 3-trifluoromethyl-5,6-dihydro-1,2,4-triazolo[3,4-a]isoquinolines were obtained by the reaction of substituted 1-methylthio-3,4-dihydroisoquinolines with hydrazine hydrate and trifluoroacetic acid. The corresponding 3-perfluoroalkyl derivatives are formed in the course of dehydration of 2-(3,3-dimethyl-3,4-dihydro-1-isoquinolyl)hydrazides of perfluorocarboxylic acids.Institute of Technical Chemistry, Ural Branch, Russian Academy of Sciences, Perm. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 3, pp. 380–386, March, 2000. 相似文献
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Branko Stanovnik Uroš Urleb Miha Tišler 《Monatshefte für Chemie / Chemical Monthly》1987,118(5):601-606
An unequivocal synthesis of 5-chloro-7-methyl- (8) and 7-methyl-1,2,4-triazolo[1,5-a]pyrimidine (10) from 2-amino-4-chloro-6-methylpyrimidine (5) through the corresponding amidine6 and formamide oxime7 was developed. It was unambigously shown by comparison of the chemical shifts and the magnitude of coupling constants that the compounds obtained by condensation of 3-amino-1,2,4-triazole (12) and ethyl acetoacetate (13) and some further transformations are isomeric 5-methyl substituted 1,2,4-triazolo[1,5-a]pyrimidines1,9, and11.
Eine eindeutige Synthese einiger substituierter 1,2,4-Triazolo[1,5-a]pyrimidine
Zusammenfassung Es wurde ein eindeutiger Syntheseweg für 5-Chlor-7-methyl- (8) und 7-Methyl-1,2,4-triazolo[1,5-a]pyrimidin (10) ausgehend von 2-Amino-4-chlor-6-methylpyrimidin (5) über das entsprechende Amidin6 und das Formamidoxim7 entwickelt. Durch Vergleich von chemischen Verschiebungen und Kopplungskonstanten konnte eindeutig gezeigt werden, daß die Verbindungen, die bei der Kondensation von 3-Amino-1,2,4-triazol (12) and Ethylacetoacetat (13), sowie einige weitere Transformationsprodukte, isomere 5-Methylsubstituierte 1,2,4-Triazolo[1,5-a]pyrimidine sind (1,9,11).相似文献
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A new convenient method is proposed for the preparation of 3-aryl- and 2-styrylimidazo[1,5-a]pyridines involving the cyclocondensation of 2-(acylaminobenzyl)pyridines in acetic anhydride with adding of p-toluenesulfonic acid.Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 252660 Kiev; e-mail: olga@elan-ua.net. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 5, pp. 640–642, May, 2000. 相似文献
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M. M. Vartanyan O. L. Eliseev T. Yu. Solov'eva V. A. Petukhov 《Russian Chemical Bulletin》1993,42(11):1921-1922
The reaction of 3-formyl-2-methoxy-1,6-dioxaspiro[4.4]nonanes with 3-amino-1,2,4-triazole gives 2-(1,2,4-triazolo[1,5-a]pyrimid-6-yl)methylenetetrahydrofurans in 51–65% yields.Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 11, pp. 2004–2005, November, 1993. 相似文献
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L. M. Mironovich M. A. Ivanov E. P. Koval'chuk 《Chemistry of Heterocyclic Compounds》2001,37(9):1150-1152
8-tert-Butyl-9-oxo-1,2,4-triazolo[4,5-b]-1,2,4-triazolo[3,4-c]-1,2,4-triazine has been synthesized by the interaction of 6-tert-butyl-3-hydrazino-1,2,4-triazolo[3,4-c]-1,2,4-triazin-5-one with formic acid. The conditions of carrying out the reaction are discussed. Spectral characteristics are given. 相似文献
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New dichloride platinum(II) complexes with 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one (HmtpO) have been synthesized and characterized by thermal analysis, infrared and 1H, 13C, 15N, 195Pt NMR spectroscopy. X-ray crystal structures of cis-PtCl2(NH3)(HmtpO) (1) and cis-PtCl2(HmtpO)2 · 4H2O (2b) were determined to R = 0.0332 and R = 0.0802, respectively. In both complexes the Pt(II) ions have a square-planar geometry with two adjacent corners being occupied by two nitrogens of HmtpO molecules for 2b or NH3 and HmtpO molecules for 1, whereas the remaining adjacent corners are occupied by two chloride anions. Spectroscopic data confirm the square planar geometry with N(3) bonded HmtpO, S-bonded dimethylsulfoxide and two trans chloride anions for trans-PtCl2(dmso) · 4H2O (3). 相似文献
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L. Kosychova Z. Stumbreviciute L. Pleckaitiene R. Janciene B. D. Puodziunaite 《Chemistry of Heterocyclic Compounds》2004,40(6):811-815
A one-pot synthetic approach to the novel 5,6-dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepines by thermal cyclization of 4-acylhydrazino-2,3-dihydro-1H-1,5-benzodiazepines is described. 相似文献
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以2-溴丙酸甲酯、α,α-二氯甲基甲醚和胍唑为原料, 经缩合以及环化反应制得2-氨基-6-甲基-5-氧代-4,5-二氢-1,2,4-三氮唑并[1,5-a]嘧啶. 为了提高其在有机溶剂中的溶解性, 该化合物再同1-溴丁烷发生亲核取代反应得到了2-氨基-6-甲基-5-氧代-4-正丁基-4,5-二氢-1,2,4-三氮唑并[1,5-a]嘧啶, 然后与芳基醛和叔丁基异氰发生Ugi多组分反应, 合成了一系列具有潜在催吐活性的2-取代氨基-6-甲基-5-氧代-4-正丁基-4,5-二氢-1,2,4-三氮唑并[1,5-a]嘧啶类衍生物, 产品结构经质谱、核磁共振谱及元素分析确认. 相似文献
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V. A. Mamedov A. A. Kalinin I. Kh. Rizvanov N. M. Azancheev Yu. Ya. Efremov Ya. A. Levin 《Chemistry of Heterocyclic Compounds》2002,38(9):1121-1129
When 3-(a-thiocyanobenzyl-2(1H)-one is heated, competing processes of [a]-annelation of the imidazole or thiazole rings occurs with formation of imidazo[1,5-a]- and thiazolo[3,4-a]quinoxalin-4(5H)-ones. 相似文献
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G. Kh. Khisamutdinov V. L. Korolev T. N. Parkhomenko V. M. Sharonova E. S. Artem'eva I. Sh. Abdrakhmanov S. P. Smirnov B. I. Ugrak 《Russian Chemical Bulletin》1993,42(10):1700-1702
New methods for the synthesis of 1,2,4-triazolo[4,3-d]-1,2,4-triazolo[3,4-f]furazano[3,4-b]pyrazines with functional substituents of various types are proposed and some properties of these compounds are studied.
Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 10, pp. 1776–1778, October, 1993. 相似文献
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The reaction between 5-amino-4-imino-1(2)-substituted-1(2)H-4,5-dihydropyrazolo[3,4-d]pyrimidines and several commercially available reactants afforded new heterocycles with a conserved pyrazolo[3,4-d]pyrimidine nucleus. The key intermediates employed proved to be suitable compounds by virtue of their two vicinal amino and imino groups that were used to obtain five, six and seven-membered rings. 相似文献
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Kh. S. Shikhaliev D. V. Krylski A. Yu. Potapov S. E. Nefedov O. E. Sidorenko 《Russian Chemical Bulletin》2008,57(6):1268-1272
Reactions of 5-R-3-amino-1,2,4-triazoles with ethoxymethylideneacetylacetone and ethyl ethoxymethylideneacetoacetate proceeded
regioselectively, giving 2-R-7-methyl[1,2,4]triazolo[2,3-a]-pyrimidines in good yields. The compounds obtained were characterized by elemental analysis, 1H NMR spectroscopy, and X-ray diffraction analysis (for ethyl 2-ethylthio-7-methyl[1,2,4]triazolo[2,3-a]pyrimidine-6-carboxylate). The frontier orbitals, the molecular electrostatic potential, and the geometries of the reagent
molecules were calculated by the DFT method (B3LYP/6-31G**).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1244–1248, June, 2008. 相似文献
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Igor A. Khalymbadzha Tatyana S. Shestakova Julia O. Subbotina Oleg S. Eltsov Alexandra A. Musikhina Vladimir L. Rusinov Oleg N. Chupakhin Inna L. Karpenko Maxim V. Jasko Marina K. Kukhanova Sergey L. Deev 《Tetrahedron》2014
New acyclovir analogues were obtained by reaction of 1,2,4-triazolo[1,5-a]pyrimidin-7-ones 4a–i with (2-acetoxyethoxy)methyl acetate 5 in the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) as catalyst (Vorbrüggen procedure). Coupling between compounds 4a–f and 5 led to a mixture of N3- and N4-isomers 6 and 7, respectively. On the contrary, the reaction of compounds 4g–i with 5 proceeded selectively with formation of N3-isomers only. It was found that the ratio of 6a–f and 7a–f depends on the presence or the absence of N,O-bis(trimethylsilyl)acetamide (BSA). Glycosylated products 6a–f and 7a–f underwent reversible isomerization under TMSOTf treatment. The ratio of glycosylated products of the coupling reaction between 4 and 5 was thermodynamically controlled. A similar reaction occurred if ZnCl2 was chosen as a catalyst, although lower yields of the acyclic analogues of nucleosides were observed. The glycosylation of other purines (adenine and guanine) can be achieved via the non-BSA modification of the Vorbrüggen procedure. 相似文献
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N. N. Polygalova A. G. Mikhailovskii E. V. Vikhareva M. I. Vakhrin 《Chemistry of Heterocyclic Compounds》2007,43(7):900-905
It has been shown that the Chichibabin reaction of enamines of the 1,2,3,4-tetrahydroisoquinoline series and 1,2,3,4-tetrahydrobenzo[f]isoquinoline
series with p-bromophenacyl bromide leads to pyrrolo[2,1-a]isoquinoline derivatives. The same heterocyclic system is obtained
on interaction of 1-alkyl-3,4-dihydroisoquinolines or their benzo[f]-analogs with oxalyl chloride. The obtained dioxopyrrolines
form derivatives of benzo[g]quinoxalino[2,3-b]indolizine on condensation with o-phenylenediamine.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 7, pp. 1068–1074, July, 2007. 相似文献