共查询到20条相似文献,搜索用时 15 毫秒
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Kevin G. Siver Kenneth B. Sloan Robert P. Waranis Akram Saab 《Journal of heterocyclic chemistry》1988,25(4):1077-1081
Labile aminomethyl and hydroxymethyl derivatives of 6-mercaptopurine (I) (6-MP) and S6-acyloxymethyl-6-MP have been converted to stable acetyloxymethyl derivatives by their reaction with acetic anhydride. Analysis of the reaction products and comparison of their 'H nmr spectra and hplc chromatograms with those of acetyloxymethyl derivatives of known structures suggested 1) that the aminomethyl derivatives of 6-MP were 7-substituted derivatives, 2) that the aminomethyl derivative of S6-acetyloxylmethyl-6-MP was a 9-derivative, 3) that the hydroxymethyl derivative of 6-MP was a mixture of 7-substituted and S6,3-disubstitu-ted derivatives, and 4) that the hydroxymethyl derivative of S6-pivaloyloxymethyl-6-MP was a 9-substituted derivative. In addition, a previously unreported dialkyl derivative of 6-MP VI was isolated from its reaction with aminomethylating agent and characterized. Analyses of the 'H nmr spectra and hplc chromatograms of the reaction of VI with acetic anhydride suggested that VI was a 1,7-disubstituted derivative. 相似文献
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A general method is described for the synthesis of 2-amino-3-carbethoxy-l-hydroxyindoles by the reductive cyclization of 2-nitrophenylcyanoacetates using zinc and acetic acid at temperatures of 15–28°. 相似文献
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L. M. Pevzner 《Russian Journal of General Chemistry》2006,76(7):1063-1068
Synthetic procedure for preparing 2-isobutyl-3-and 4-furancarboxylic acyl chlorides is developed. Reduction of these compounds with lithium alumohydride leads to corresponding alcohols which under treating with thionyl chloride in the presence of pyridine form chloromethyl derivatives. The latter compounds are phosphorylated with sodium diethyl phosphite under the Michaelis-Becker reaction conditions to give corresponding phosphonates. Reaction of compounds obtained with dimethyl(chloromethyl)amine proceeds at the free α-position of the furan ring and delivers aminophosphonates. These substances do not evolve dimethylamine even under the conditions of vacuum distillation (145–150°C, 1 mm Hg). 相似文献
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A general approach to the synthesis of new 3-acetyl-substituted pyrrolo[3,4-f]indole-5,7-diones, 3-[3-(dimethylamino)acryloyl]-1-methoxypyrrolo[3,4-f]indole-5,7-diones and similar indole-5,6-dicarbonitriles has been developed. Dimethylaminoacryloyl derivatives synthesized on their basis regioselectively reacted with hydrazine hydrochlorides and hydroxylamine with the formation of the corresponding 5-substituted azoles. 相似文献
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Reductive aromatization and demethylation of 1,3-disubstituted-2-amino-5-oxo-7a-methyl-5,7a-dihydroindoles with zinc, pyridine and a trace of water yields 1,3-disubstituted-2-amino-5-hydroxyindoles. Simple derivatives of the 5-hydroxy substituent are described. 相似文献
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DunWANG DeShengYU FangQIN LinFANG PingGONG 《中国化学快报》2004,15(1):19-22
Some new derivatives of 3-ethoxycarbonyl-6-bromo-5-hydroxyindoles were designedand prepared, their antiviral activity were determined in cell culture with virus cytopathic effect assay. The results showed compound Ⅶ b, Ⅶ h exhibited potential antiviral activity. 相似文献
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M. G. Shaibakova I. G. Titova G. A. Makhmudiyarov A. G. Ibragimov U. M. Dzhemilev 《Russian Journal of Organic Chemistry》2010,46(1):43-48
A general and effective procedure has been developed for the synthesis of symmetrical and unsym- metrical 2,3-acetylenic amines
by aminomethylation of terminal mono- and diacetylenes with geminal diamines in the presence of transition metal salts and
complexes. 相似文献
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Possibility of synthesizing sulfo- and aminomethyl derivatives of 4-isononylphenol (I) was examined and the anticorrosion activity of the compounds obtained was determined. 相似文献
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Bondarenko Svitlana P. Ishchenko Vera N. Frasinyuk Mykhaylo S. 《Chemistry of Heterocyclic Compounds》2018,54(11):1061-1064
Chemistry of Heterocyclic Compounds - Aminomethylation of harmol (7-hydroxy-1-methyl-β-carboline) was investigated. It was shown that the reaction proceeds chemoselectively to form... 相似文献
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S-Succinimidomethyl- and S-phthalimidomethyl xanthates are added efficiently to various alkenes resulting in an overall aminomethylation process. In contrast, under similar conditions, S-pyrrolidonyl xanthate gives rise mostly to oligomers. This unexpected difference in reactivity is attributed to the more important allylic character of the intermediate radical in the case of the imide derivative as compared to the lactam. 相似文献
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A. G. Korepin V. S. Malygina V. P. Kosilko N. M. Glyshakova G. V. Lagodzinskaya B. P. Lodygina 《Russian Chemical Bulletin》2016,65(2):479-484
Aminomethylation of 4,4-bis(nitrooxymethyl)oxazolidin-2-one and 4,4-bis(chloromethyl)-oxazolidin-2-one utilizing primary amines as the amino components yielded 6,7a-substituted tetrahydroimidazo[1,5-c]oxazol-3-ones. 相似文献