共查询到20条相似文献,搜索用时 31 毫秒
1.
Anhua Wang Xiaoxv Gao Xiaokui Huo Shanshan Huang Lei Feng Chengpeng Sun 《Natural product research》2018,32(18):2187-2192
A new acetophenone diglycoside, 2,4-dihydroxy-6-methoxy-3-methyl-acetophenone 4-O-gentiobioside (1), along with six know analogues (2–6), were isolated from the roots of Euphorbia ebracteolata. The structures of these isolates were determined by UV, HRESIMS, 1D and 2D NMR spectral analyses. In addition, all acetophenones showed moderate DPPH free radical scavenging capability, and no cytotoxicity against five human cancer cell lines. 相似文献
2.
Long-Xiao Xie Hao-Chao Zhang Hai-Yang Wang Yan Wang Feng-Ling Wang 《Natural product research》2016,30(9):1068-1074
Two new triterpenoids (1–2) were isolated and elucidated from the roots of Gypsophila oldhamiana, together with four known triterpenoids (3–6). Their structures were identified to be 3β-hydroxyolean-13(18)-ene-23, 28-dioic acid (1), 3β, 12α-dihydroxy-23-carboxyolean-28, 13β-olide (2), 3β, 16α-dihydroxy-23-oxoolean-13(18)-en-28-oic acid (3), gypsogenin (4), quillaic acid (5) and gypsogenic acid (6) by spectral methods. All compounds were tested for their cytotoxicities against human tumour cell lines (lung cancer H460 and gastric cancer SGC-7901) and for their antiangiogenic effects using a zebra fish model. All compounds showed interesting antiangiogenic activities and the significant cytotoxicities against H460. 相似文献
3.
Aluru Rammohan Rachakunta Munikishore Alexandre Deville Bernard Bodo 《Natural product research》2015,29(1):82-85
A new di-C-prenylated coumarin, 7-methoxy-6,8-bis-(2,3-dihydroxy-3-methylbutyl)-coumarin (1), together with seven known compounds, isopimpinellin (2), an arylbenzofuran (3), three flavonoids (4–6), (+)-maackianin (7) and echinoisoflavanone (8), were isolated from the leaves of Sophora interrupta Bedd. The structure of the new compound 1 as well as known compounds was elucidated by extensive 1D and 2D NMR spectral studies. 相似文献
4.
Three new anthraquinone secondary metabolites were isolated from Symplocos racemosa, a small tree of family symplocaceae. The structures of compounds (1–3) were elucidated to be 1,4-dihydroxy-6-(ethoxymethyl)-8-propylanthracene-9,10-dione (1), 1,4-dihydroxy-6-(hydroxymethyl)-8-butylanthracene-9,10-dione (2) and 1,4-dihydroxy-6-(hydroxymethyl)-8-propyl anthracene-9,10-dione (3) using their spectral data, i.e. through IR, UV, 1H NMR, 13C NMR and two-dimensional (2D) NMR techniques including heteronuclear multiple quantum coherence, heteronuclear multiple bond correlation and correlation spectroscopy. 相似文献
5.
In this work, six coumarins, including two new ones, 8-(3-hydroxy-2,2-dimethylpropyl)-7-methoxy-2H-chromen-2-one (2) and 5-[(7′,8′-dihydroxy-3′,8′-dimethyl-2-nonadienyl)oxy] psoralen (4), as well as four known ones, 5-[(6′,7′-dihydroxy-3′,7′-dimethyl-2-octenyl) oxy] psoralen (1), marmin (3), epoxybergamottin (5), and aurapten (6) were successfully separated from the crude extract of pummelo (Citrus maxima (Burm.) Merr. Cv. Shatian Yu) peel by high-speed countercurrent chromatography in a single run with petroleum-ether–ethyl acetate–methanol–water (4:6:6:4, v/v). The structures of these six coumarins were elucidated by ESI-MS, extensive 1D and 2D NMR spectroscopy. 相似文献
6.
A new flavone diglucoside named 7,3′-dihydroxy-4′-methoxyflavone-5-O-β-D-glucopyranosyl (6″ → 1‴)-β-D-glucopyranoside (1), along with four known flavonoids, luteolin (2), isoquercetin (3), catechin (4), and diosmetin (5), has been isolated and characterized from Salix denticulata. The structure of the new flavone diglucoside was characterized by means of high field 1D and 2D NMR and MS spectral analysis. 相似文献
7.
D. N. Pelageev M. N. Panchenko N. D. Pokhilo V. A. Denisenko V. F. Anufriev 《Chemistry of Natural Compounds》2008,44(6):719-723
5,8-Dihydroxy-2,3,6-trimethoxy-7-ethyl-1,4-naphthoquinone (1) was used to synthesize in high yield 5,8-dihydroxy-7(1′-hydroxyethyl)-2,3,6-trimethoxy-1,4-naphthoquinone (lomazarin, 3), a pigment from Lomandra hastilis. Alkaline hydrolysis of lomazarin produced mainly 5,6,8-trihydroxy-2,3-dimethoxy-1,4-naphthoquinone (9) through a retro-aldol decomposition of the 6-keto-form of 5,6,8-trihydroxy-7(1′-hydroxyethyl)-2,3-dimethoxy-1,4-naphthoquinone
(13b) formed during the reaction. 2,5,8-Trihydroxy-7(1′-hydroxyethyl)-3,6-dimethoxy-1,4-naphthoquinone (norlomazarin, 4a), a pigment of L. hastilis, and its 3,5,8-trihydroxy-7(1′-hydroxyethyl)-2,6-dimethoxy isomer 4b were formed as a difficultly separable mixture in addition to quinone 9.
Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 581–584, November–December, 2008. 相似文献
8.
Chemical constituents of crude ethyl acetate extract of roots of Akschindlium godefroyanum (Kuntze) H. Ohashi were investigated and seven flavonoids were isolated. Their structures were identified based on spectroscopic methods as well as by comparison with spectral data reported in the literature as six flavanonols and a flavonol including 7,4′-dihydroxy-5,3′-dimethoxyflavanonol (1), neophellamuretin (2), taxifolin (3), erycibenin D (4), geraldol (5), fustin (6) and garbanzol (7). Compounds 2, 4 and 7 were found in the genus Akschindlium for the first time. Compounds 3, 5 and 6 appeared to have free radical scavenging activities using DPPH assay with IC50 of 21, 40 and 15 μg/mL, respectively. 相似文献
9.
Zhongjing Huang Changlun Shao Yiguang Chen Zhigang She Yongcheng Lin Shining Zhou 《Chemistry of Natural Compounds》2007,43(6):655-658
A new isocoumarin, 3,4-dihydro-6-methoxy-8-hydroxy-3,4,5-trimethylisocoumarin-7-carboxylic acid methyl ester (1), together with three known compounds, 3,4-dihydro-4,8-dihydroxy-3,5-dimethylisocoumarin (2), 3,4-dihydro-8-hydroxy-3-methylisocoumarin-5-carboxylic acid (3), and Entinclole SB (4) were isolated from the mangrove endophytic fungus (No. dz17). The structure of the compound 1 was elucidated by analysis of spectroscopic data. Primary bioassays showed that 1 exhibited weak cytotoxicity against Hep-2 and HepG2 cells.
Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 543–545, November–December, 2007. 相似文献
10.
Nicole AmannHans-Achim Wagenknecht 《Tetrahedron letters》2003,44(8):1685-1690
The protected ethidium nucleosides 8-(3′,5′-di-O-benzoyl-2′-deoxy-d-ribofuranosyl)-3-acetamido-5-ethyl-6-phenyl-phenanthridinium (5), 8-(3′,5′-di-O-acetyl-2′-deoxy-d-ribofuranosyl)-3-acetamido-5-ethyl-6-phenyl-phenanthridinium (6), and the acyclic analog 8-[(3R)-1,3-dihydroxy-4-yl]-acetamido-3-amino-5-ethyl-6-phenyl-phenanthridinium (3) were prepared. Based on to their different stability, only the acyclic derivative 3 seems to be suitable for oligonucleotide synthesis. Furthermore, the acyclic ethidium nucleoside analog 3 exhibits comparable absorption and emission properties of the underivatized ethidium (1). 相似文献
11.
Jian Zhang Zhi-Qi Yin Peng Cao You-Bin Li Jin-Ao Duan 《Chemistry of Natural Compounds》2008,44(6):701-703
A new flavonol derivative 3, 8-dihydroxy-10-methoxy-5-H-isochromeno[4, 3-b]chromen-7-one (1) together with four known compounds, glutinone (2), luteolin (3), acacetin 7-O-α-L-rhamnopyranosyl- (1→6)-β-D-glucopyranoside (4), and rutin (5) were isolated from the dried roots of Fagopyrum dibotrys. Their structures were determined by UV, IR, MS, 1H, and 13C NMR spectroscopic analysis, including 2D NMR.
Published in Khimiya Prirodnykh Soedinenii, No. 6, pp. 567–568, November–December, 2008. 相似文献
12.
Salar Hafez Ghoran Soodabeh Saeidnia Esmaeil Babaei Fumiyuki Kiuchi Hidayat Hussain 《Natural product research》2016,30(11):1309-1314
The phytochemical investigation of Scilla persica HAUSSKN bulbs led to the isolation of a novel homoisoflavonoid that named Scillapersicene (1) and identified as 3-(3′,4′-dihydroxybenzylidene)-8-hydroxy-5,7-dimethoxychroman-4-one along with five known homoisoflavonoids 2–6, whose structures were elucidated using HRFAB-MS, 1D and 2D NMR spectroscopic data. The known compounds were identified as 3-(3′,4′-dihydroxybenzyl)-5,8-dihydroxy-7-methoxychroman-4-one (2), 3,9-dihydro-autumnalin (3), autumnalin (4), 3-(3′,4′-dihydroxybenzylidene)-5,8-dihydroxy-7-methoxychroman-4-one (5) and scillapersicone (6). All compounds obtained, expect 2 and 4, showed strong cytotoxic activity against AGS cell line. The toxicity on AGS cell line was measured by 1, 3, 5 and 6 with IC50 values of 8.4, 30.5, 10.7 and 24.2 μM, respectively. In addition, the physico-chemical properties of these natural compounds were optimised using density functional method (B3LYP) with standard 6-311+G* basis set. These natural products have low-energy gaps between the first ionisation potentials and highest occupied molecular orbital. In conclusion, the low-energy gap could cause reason for cytotoxic activity of homoisoflavonoids. 相似文献
13.
Ying Tang Chaomei Xiong Daonian Zhou Anhua Wei Wei Fu Yaling Cai Jinlan Ruan 《Chemistry of Natural Compounds》2010,46(2):209-211
A new flavonoid, 5,7-dihydroxy-2-(1-hydroxy-2,6-dimethoxy-4-oxo-cyclohex)-chromen-4-one (1), was isolated from the roots of Macrothelypteris torresiana (Gaud.) Ching. (Thelypteridaceae). The structure of the product was identified on the basis of detailed spectral analysis,
including X-ray structure analysis. 相似文献
14.
Ming Hu Xue-Qiong Yang Qing-Yan Zhou Shu-Quan Li Bang-Yan Wang Bao-Hui Ruan 《Natural product research》2019,33(10):1431-1435
Five new benzopyran derivatives (2–6) and a new natural product (1) were isolated from endophytic Daldinia eschscholzii in Dendrobium chrysotoxum and determined as (R)-2,3-dihydro-2,5-dihydroxy-2-methylchromen-4-one (1), (2R, 4S)-2,3-dihydro-2-methyl-benzopyran-4,5-diol (2), (R)-3-methoxyl-1-(2,6-dihydroxy phenyl)-butan-1-one (3), 7-O-α-d-ribosyl-5-hydroxy-2-methyl-4H-chromen-4-one (4), 7-O-α-d-ribosyl-2,3-dihydro-5-hydroxy-2-methyl-chromen-4-one (5), daldinium A (6). These compounds were evaluated for their antimicrobial activity, anti-acetylcholinesterase, nitric oxide inhibition, anticoagulant, photodynamic antimicrobial activities and glucose uptake of adipocytes. Some compounds showed photoactive antimicrobial activities and glucose uptake stimulating activities. 相似文献
15.
Mei Jin Shengbao Diao Changhao Zhang Shuo Cao Jinfeng Sun Ren Li 《Natural product research》2015,29(19):1839-1844
Two new diarylheptanoids, ( ? )-threo-3′,4″-epoxy-1-(4-hydroxyphenyl)-7-(3-methoxyphenyl)heptan-2,3-diol (1) and (1α,3β,5α,6α)-1,5-epoxy-3,6-dihydroxy-1,7-bis(3-methoxy-4-hydroxy-phenyl)-heptane (2), along with one known diarylheptanoid, rhoiptelol B (3), were isolated from the roots of Juglans mandshurica. The structures of compounds 1 and 2 were identified based on HR-ESI-MS, 1D and 2D NMR including 1H–1H COSY, HMQC, HMBC and NOESY spectroscopic methods. 相似文献
16.
Zhongjing Huang Ruiyun Yang Zhiyong Guo Zhigang She Yongcheng Lin 《Chemistry of Natural Compounds》2010,46(1):15-18
A new naphtho-γ-pyrone, 5-hydroxy-6,8-dimethoxy-2-benzyl-4H-naphtho[2,3-b]-pyran-4-one (1), together with three known compounds 5,7-dihydroxy-2-methylbenzopyran-4-one (2), 3,5-dihydroxy-2,7dimethylbenzopyran-4-one (3) and cyclo(Tyr-Tyr) (4) were isolated from the mangrove endophytic fungus Phomopsis sp. ZSU-H26 obtained from the South China Sea. Their structures were elucidated by spectroscopic methods, mainly 1D and 2D
NMR spectroscopic techniques. Primary bioassays showed that 1 exhibited cytotoxicity against HEp-2 and HepG2 cells with IC50 values of 10 and 8 μg/mL, respectively. 相似文献
17.
Priyapan Posri Jittra Suthiwong Pitchayakarn Takomthong Chatchawan Wongsa Chindawadee Chuenban Chantana Boonyarat 《Natural product research》2019,33(8):1115-1121
A new flavonoid, atalantraflavone (1) as well as eight known compounds including atalantoflavone (2), racemoflavone (3), 5,4′-dihydroxy-(3″,4″-dihydro-3″,4″-dihydroxy)-2″,2″-dimethylpyrano-(5″,6″:7,8)-flavone (4), lupalbigenin (5), anabellamide (6), citrusinine I (7), p-hydroxybenzaldehyde (8), and frideline (9), were isolated from the leaves of Atalantia monophylla (L.) DC. Focusing on Alzheimer’s disease, acetylcholine esterase (AChE) inhibition and antioxidant activity were evaluated using the modified Ellman’s method and the ABTS scavenging assay, respectively. It was found that isoflavonoid 5, lupalbigenin, showed 79% inhibition to AChE and was 1.4-fold stronger than the tacrine standard. In addition, acridone 7, citrusinine I, displayed 90.68% antioxidant activity. 相似文献
18.
《合成通讯》2013,43(20):3527-3536
Abstract The first total synthesis of (±)-7,3′-dihydroxy-4′-methoxyflavan (1) and (±)-7,4′-dihydroxy-3′-methoxyflavan (2), along with the synthesis of (±)-7,4′-dihydroxyflavan (3), three naturally occurring flavans, were described. The key step is the cyclization of 1,3-diaryl-1-propanol by BF3·Et2O. 相似文献
19.
Nargis Jamila Naeem Khan Imran Khan Amir Atlas Khan Sadiq Noor Khan 《Natural product research》2016,30(12):1388-1397
The dichloromethane bark extract of Garcinia hombroniana yielded one new cycloartane triterpene; (22Z,24E)-3β-hydroxycycloart-14,22,24-trien-26-oic acid (1) together with five known compounds: garcihombronane G (2), garcihombronane J (3), 3β acetoxy-9α-hydroxy-17,14-friedolanostan-14,24-dien-26-oic acid (4), (22Z, 24E)-3β, 9α-dihydroxy-17,14-friedolanostan-14,22,24-trien-26-oic acid (5) and 3β, 23α-dihydroxy-17,14-friedolanostan-8,14,24-trien-26-oic acid (6). Their structures were established by the spectral techniques of NMR and ESI-MS. These compounds together with some previously isolated compounds; garcihombronane B (7), garcihombronane D (8) 2,3’,4,5’-tetrahydroxy-6-methoxybenzophenone (9), volkensiflavone (10), 4’’-O-methyll-volkensiflavone (11), volkensiflavone-7-O-glucopyranoside (12), volkensiflavone-7-O-rhamnopyranoside (13), Morelloflavone (14), 3’’-O-methyl-morelloflavone (15) and morelloflavone-7-O-glucopyranoside (16) were evaluated for cholinesterase enzymes inhibitory activities using acetylcholinesterase and butyrylcholinesterase. In these activities, compounds 1–9 showed good dual inhibition on both the enzymes while compounds 10–16 did not reasonably contribute to both the cholinesterases inhibitory effects. 相似文献
20.
Jicheng Shu Linyu Li Meng Zhou Jiangli Yu Caiying Peng Feng Shao 《Natural product research》2018,32(15):1760-1768
Three new flavonoid glycosides, 2(S)-5-hydroxy-6,8-dimethoxyflavonone-7-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (1), 5-hydroxy-3,8-dimethoxyflavone-7-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (2) and 3,7-dihydroxy-8-methoxyflavone-6-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranoside (3), together with five known flavonoids (4–8) were isolated from the roots of Smilax glabra Roxb. Their structures were elucidated on the basis of chemical and spectral evidence, as well as by comparison with literature data. Three new flavonoids were subjected to evaluate anti-inflammatory activity. Compounds 1–3 inhibited the NF κB induction by 32.2, 55.8 and 61.7%, respectively. 相似文献