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1.
It is shown that the bases described in a number of papers and patents as 2,6-dimethyl-, 2,6-diamino-, and 2,6-dimercaptobenzo[1,2-d:4,3-d']bisthiazoles (isomers of linear structure) are actually 2,7-dimethyl-, 2,7-diamino-, and 2,7-dimercaptobenzo [1,2-d:6,5-d']bisthiazoles (isomers of angular structure). The synthesis of the hitherto unknown 2,6-dimethylbenzo[1,2-d:4,5-d'] bisthiazoles is described. 相似文献
2.
文献报道合成2,6-二芳基取代苯并[1,2-d;4,5-d']二(口恶)唑有两种方法,其一是2,5-二氨基对苯醌与芳香醛缩合,然后氧化,关环;其二是2,5-二氨基对苯二酚盐酸盐与酰氯缩合关环. 相似文献
3.
The structure and tautomerism of 2-amino-3, 6-dimethyl-, and 2-amino-3,6,7-trimethylbenzo[1,2-d: 3,4-d']diimidazoles were studied by means of IR and UV spectroscopy. It was found that they exist in the amino form in the crystalline state and in methanol solution.See [1] for communication III.Translated from Khimiya GeterotsiklicheskikhSoedinenii, No. 6, pp. 807–809, June, 1973 相似文献
4.
The bis(carbodiimides) 4, obtained from bis-aza-Wittig reactions of bis(iminophosphorane) 3 with 2 equiv of aromatic isocyanates, were reacted with secondary amine to give symmetrically substituted 2,7-diaminothieno[2,3-d:5,4-d']dipyrimidine-4,5(3H,6H)-dione 6 in the presence of a catalytic amount of EtO(-)Na(+). Reactions of 4 with phenols or ROH in the presence of a catalytic amount of potassium carbonate or RO(-)Na(+) gave symmetrically substituted 2,7-diaryl(alkyl)oxythieno[2,3-d:5,4-d']dipyrimidine-4,5(3H,6H)-diones 6 in satisfactory yields. However, iminophosphoranes 9 were obtained via reaction of bis(iminophosphorane) 3 with 1 equiv of aromatic isocyanate and subsequent reaction with an amine in the presence of a catalytic amount of EtO(-)Na(+). Further reaction of iminophosphoranes 9 with aromatic isocyanates and various nucleophile generated unsymmetrically substituted thieno[2,3-d:5,4-d']dipyrimidine-4,5(3H,6H)-diones 12 in good yields. 相似文献
5.
A. M. Simonov Yu. V. Koshchienko V. G. Poludnenko V. E. Khorunzhev 《Chemistry of Heterocyclic Compounds》1970,6(10):1313-1316
A new path for the synthesis of 3-monoalkyl- and 3,6-dialkyl-substituted benzo[1,2-d:3,4-d']-diimidazole is described: 5-tosylamino-1-alkylbenzimidazole is converted to the 4-nitro derivative by nitration in glacial acetic acid, and the imidazole ring is closed after alkylation and cleavage of the tosyl group.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1406–1409, October, 1970. 相似文献
6.
Fedorov Y Fedorova O Schepel N Alfimov M Turek AM Saltiel J 《Photochemistry and photobiology》2006,82(4):1108-1115
Irradiation of acetonitrile solutions of the bis-crown ether E,E-2,7-bis[2-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxabenzocyclopentadecen-2-yl)vinyl]-benzo[1,2-d;3,4-d']bisthiazole (hereafter, 1) gives efficient E --> Z photoisomerization (initial phi(trans --> cis) = 0.48), leading to lambda(exc)-dependent quasi-photostationary states composed primarily of E,Z and E,E isomer mixtures. Further irradiation gives [2 + 2]-cycloadducts of 1. In the presence of Ba2+ ions, essentially quantitative formation of 2:2 complexes, 1(2) x (Ba2+)2 controls the photochemical outcome. E --> Z photoisomerization of the ligand is entirely suppressed and efficient intramolecular [2 + 2]-photocycloaddition in the complexes leads to cyclobutane dimers of 1 (phiCB = 0.26). The reactivity of 1 in the presence of Mg2+ ions for which 1:2 complex formation dominates gives both cis-trans photoisomerization and enhanced photocycloaddition. 相似文献
7.
Two new triterpenoid saponins acylated with monoterpenic acid, 2β,23-dihydroxy-3-O-α-L-rhamnopyranosyl-21-O-{(6S)-2-trans-2,6-dimethyl-6-O-[3-O-(β-D-glucopyranosyl)-4-O-(2-methylbutanoyl)-β-L-arabinopyranosyl]-2,7-octadienoyl)-acacic acid 28-O-β-D-xylopyranosyl-(1?→?3)-β-D-xylopyranosyl-(1?→?4)-[β-D-glucopyranosyl-(1?→?3)]-α-L-rhamnopyranosyl-(1?→?2)-[α-L-rhamnopyranosyl-(1?→?6)]-β-D-glucopyranosyl ester and 2β,23-dihydroxy-3-O-α-L-rhamnopyranosyl-21-O-{(6S)-2-trans-2,6-dimethyl-6-O-[4-O-((6S)-2-trans-2,6-dimethyl-6-O-(β-L-arabinopyranosyl)-2,7-octadienoyl)]-β-L-arabinopyranosyl]-2,7-octadienoyl}-acacic acid 28-O-β-D-xylopyranosyl-(1?→?3)-β-D-xylopyranosyl-(1?→?4)-[β-D-glucopyranosyl-(1?→?3)]-α-L-rhamnopyranosyl-(1?→?2)-[α-L-rhamnopyranosyl-(1?→?6)]-β-D-glucopyranosyl ester were isolated from the fruit of Gymnocladus chinensis Baill. and the structural elucidation of both the compounds was accomplished by extensive studies of their spectroscopic (1D and 2D NMR, TOF-MS, QFT-MS) and chemical methods. 相似文献
8.
9.
10.
两个非对映异构三萜皂甙的结构鉴定 总被引:7,自引:0,他引:7
从合欢皮95%乙醇提取物中分得2个新三糖链九糖皂甙(1,2),经化学方法和光谱分析,将其结构分别鉴定为:3-O-[β-D-吡喃木糖基-(1→2)-β-D-吡喃阿拉伯糖基-(1→6)-β-D-葡萄糖基]-21-O-(6S)-2-反式-2,6-二甲基-6-O-[4-O-((6R)-2-反式-2,6-二甲基-6-O-β-D-吡喃鸡纳糖基-2,7-辛二烯酸基)-β-D-吡喃鸡纳糖基]-2,7-辛二烯酸基金合欢酸28-O-β-D-吡喃葡萄糖基-(1→3)-[α-L-呋喃阿拉伯糖基-(1→4)]-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖基酯(1)和3-O-[β-D-吡喃阿拉伯糖基-(1→2)-β-D-吡喃呋糖基-(1→6)-β-D-葡萄糖基]-21-O-(6S)-2-反式-2,6-二甲基-6-O-[4-O-((6S)-2-反式-2,6-二甲基-6-O-β-D-吡喃鸡纳糖基-2,7-辛二烯酸基)-β-D-吡喃鸡纳糖基]-2,7-辛二烯酸基金合欢酸28-O-β-D-吡喃葡萄糖基-(1→3)-[α-L-呋喃阿拉伯糖基-(1→4)]-α-L-吡喃鼠李糖基-(1→2)-β-D-吡喃葡萄糖基酯(2),分别命名为合欢皂甙J14(JulibrosideJ14)和合欢皂甙J15(JulibrosideJ15) 相似文献
11.
Fedorov YV Fedorova O Schepel N Alfimov M Turek AM Saltiel J 《The journal of physical chemistry. A》2005,109(38):8653-8660
2,7-Bis[2-(6,7,9,10,12,13,15,16-octahydro-5,8,11,14,17-pentaoxabenzocyclopentadecen-2-yl)vinyl]-benzo[1,2-d;3,4-d']bisthiazole, 2, with crown ether styryl moieties substituted on a heterocyclic core, was synthesized and its complex forming ability with several metal cations was evaluated in acetonitrile by absorption and fluorescence spectroscopy. The results are compared to those for the analogous ligand possessing a single crown ether styryl moiety. Selective binding of the metal cation at the heterocyclic core of both ligands was observed only for Hg2+. Alkali and alkaline earth cations bind selectively at the crown ether moieties. Stability constants and pure spectra of defined stoichiometry were determined with the use of HYPERQUAD, a least-squares fitting program, and the results were validated in one case by subjecting the titration spectral matrix to singular value decomposition with self-modeling (SVD-SM). The multitopic ligand 2 forms relatively strong 2:2 stoichiometric complexes with K+, among the alkali metal cations, and Ba2+, among the alkaline earth metal cations, and is a promising selective optical sensor for these ions. 相似文献
12.
The reaction of a mixture of 2-(1-naphthyl)benzothiazoline (HL1) and 2,6-diphenylbenzo[1,2-d:4,5-d']bisthiazoline (H3L2) with nickel(II) acetate tetrahydrate yielded three kinds of square-planar nickel(II) complexes: one nickel(II) complex with innocent ligands ([Ni(L1)2] (1c)) and two nickel(II) complexes with non-innocent ligands ([Ni(L1-L1)] (1a) and [Ni(L1-L2)] (1b)). The complex 1c has two bidentate-N,S ligands, which are formed via ring opening of HL1. On the other hand, the two complexes 1a and 1b contain a tetradentate-N2S2 ligand, which is created via ring opening of HL1 and H3L2, followed by bond formation between imino carbon atoms. Complexes 1a and 1b show very intense absorptions in the near-infrared (NIR) region, characteristic of square-planar complexes with non-innocent ligands. The third nickel(II) complex having a non-innocent tetradentate-N2S2 ligand ([Ni(L2-L2)] (2)) was prepared from H3L2 and nickel(II) acetate tetrahydrate. The electronic spectrum of 2 exhibits a very intense absorption at 981 nm (epsilon = 3.6 x 10(4) M-1 cm-1), which is significantly red-shifted compared with those of 1a (837 nm and 4.4 x 10(4) M-1 cm-1) and 1b (885 nm and 4.5 x 10(4) M-1 cm-1), indicating the presence of an extended pi delocalization. The reaction of 2,6-bis(3,5-dichlorophenyl)benzo[1,2-d:4,5-d']bisthiazoline (H3L3) with nickel(II) acetate tetrahydrate also led to the formation of a nickel(II) complex with a non-innocent ligand ([Ni(L3-L3)] (3)). While complex 3 is analogous to 2, its electrical conductivity is much higher than that of 2. The molecular structures of 1b, 1c, 2, and 3 were determined by X-ray crystallography. 相似文献
13.
The one-pot synthesis of 4,8-dibromobenzo[1,2-d;4,5-d']bistriazole, followed by alkylation and Stille coupling to yield three different isomeric derivatives with markedly different optoelectronic properties, is reported. These derivatives show potential as new units in organic oligomers and polymers for electronics applications. 相似文献
14.
Ricardo Bossio Stefano Marcaccini Valerio Parrini Roberto Pepino 《Journal of heterocyclic chemistry》1986,23(3):889-891
2-(2,6-Dimethylpyrimidin-4-ylaminobenzimidazole) (VIIa) and 2-(1,3,4-thiadiazol-2-ylamino)benzimidazole (VIIb) underwent a ring-closure reaction with phosgene giving 1,3-dimethyl-12H-benzirnidazo[1,2-a]pyrirnido[6,1][-d][1,3,5]triazin-12-one (IIa) and 5H-benzimidazo[1,2-a][1,3,4]thiadiazolo[2,3-d][1,3,5]triazin-5-one (IIb) two hitherto unknown heterocyclic systems. A convenient synthesis of 2,6-dimethyl-4-aminopyrimidine is described. 相似文献
15.
A new tridentate benzimidazole derivative, 2,6-bis (benzo[1,2-d:4,5-d′]diimidazole-2′-yl) -pyridine (Bzdiimpy),was prepared from o-phenylenediamine in five steps with improved methods according to the literature in good yield.The crystal structure was determined by X-ray diffraction analysis. It crystallized in monoclinic, space group P21/c,with a=1.1708(4) nm, b=2.4796(9) nm, c=1.215 9(4) nm,β=114.641(7)°, Z=1, R=0.035 0, wR2=0.0890. The bzdiimp molecule displayed an almost planar structure and formed a zig-zag chain through weak interactions between imidazole-N and [SnCl6]2--Cl. Its electronic absorption and emission spectra were measured and compared with the reported analogue 2,6-bis (benz[1,2-d:4,5-d′]imidazole-2′-yl)-pyridine (Bzp). 相似文献
16.
1,2-Diaminopyridinium iodide underwent reaction with ethyl acetoacetate to form 1,4-dihydro-2-methyl-4-oxopyrido[1,2-a]pyrimidin-1-ium iodide, and with acetyl acetone it gave 2,4-dimethylpyrido[1,2-a]pyrimidin-5-ium iodide. Though 2-acetylcyclohexanone gave the corresponding 5-methyl-1,2,3,4-tetrahydropyrido[1,2-a]quinazolin-11-ium iodide, no reaction was observed with 2,6-dimethyl-3,5-heptanedione, 1-benzoylacetone, 1,3-diphenyl-1,3-propanedione and its p-methoxyphenyl derivative. However, 1-aminopyridinium iodide and acetyl acetone in the presence of base gave 3-acetyl-2-methylpyrazolo[1,5-a]pyridine and 1-amino-2-methylpyridinium iodide yielded the corresponding 3-acetyl-2,7-dimethylpyrazolo[1,5-a]pyridine. With ethyl acetoacetate, the latter salt formed 3-ethoxycarbonyl-2,7-dimethylpyrazolo[1,5-a]pyridine but with 2,6-dimethyl substituents in the pyridine ring no condensation occurred. Reaction of 1-amino-2-methylpyridinium iodide with benzaldehyde gave N-benzalimino-2-methylpyridinium iodide which, on treatment with base, resulted in the formation of 2-picoline and benzonitrile, providing a convenient method of deamination. 相似文献
17.
Synthesis of benzo[1,2-d;3,4-d']diimidazole and 1H-pyrazolo[4,3-b]pyridine as putative A2A receptor antagonists 总被引:1,自引:0,他引:1
Piersanti G Giorgi L Bartoccini F Tarzia G Minetti P Gallo G Giorgi F Castorina M Ghirardi O Carminati P 《Organic & biomolecular chemistry》2007,5(16):2567-2571
The synthesis and the binding affinity for the putative adenosine receptor antagonist 6-methyl-7-[1,2,3]triazol-2-yl-1,6-dihydrobenzo[1,2-d;3,4-d']diimidazole (10) and 5-oxazol-2-yl-1H-pyrazolo[4,3-b]pyridin-3-ylamine (16) are reported. The title compounds were prepared from commercially available 1-chloro-2,4-dinitrobenzene (1) and 2-chloro-6-methoxy-3nitropyridine (11), respectively, but proved devoid of affinity for the adenosine A1 and A2A receptors. 相似文献
18.
Ihsan ali Ayen Yürüker Heinz Rüegger Anthony D. Wright Otto Sticher 《Helvetica chimica acta》1993,76(7):2563-2569
A new open-chain monoterpene glycoside, anatolioside E ( 1 ), was isolated from the leaves of Viburnum orientale in addition to three known acyclic monoterpene glycosides, betulalbusides A ( 2 ) and B ( 3 ), and 2(E)-2,6-dimethyl-2,7-octadien-1,6-diol-6-O-β-D -glucopyranoside( 4 ). The structure of anatolioside E ( 1 ) was elucidated on the basis of chemical and spectral data as 6-O-[β-D -glucopyransoyl-(1?? → 6?″)-2-(E), 6(R), 2,6-dimethyl-6-hydroxy-2,7-octadienoyl-(1?″ → 2″″)-β-D -glucopyranosyl-(1″″ → 6?)-2-(E), 6(R), 2,6-dimethyl-6-hydroxy-2,7-octadienoyl-(1? → 4″)-α-L -rhamnopyranosyl-(1″″ → 2′)-β-D -glucopyranosyl]linalool. 相似文献
19.
Long-term exposure of nifedipine to daylight in ethanol gives 2,2"-bis[3,5-bis(methoxycarbonyl)-2,6-dimethylpyridin-4-yl]azoxybenzene and 6-hydroxy-1-methoxycarbonyl-2,4-dimethyl-5-oxo-5,6-dihydrobenzo[c][2,7]naphthyridine as the major products. 相似文献
20.
In interactions of β-dicarbonyl compounds (2) with azodicarboxamidine (1), the primary reaction step consists of the addition of the active methylene group in 2 to the NN double bond in 1. Via the addition product 3 thus formed, 2,7-diamino-4,5-dialkyl-imidazo[5,1-f]-as-triazines (4) are produced through condensation. 3,5-Heptanedione (2a), 4,6-nonanedione (2b), and 2,6-dimethyl-3,5- heptanedione (2c) have been used as β-dicarbonyl compounds. 相似文献