Synthesis of new ether glycerophospholipids structurally related to modulator

A series of new glycerophospholipids, bearing a short-chain carboxylic acid in position sn-1 and phosphocholine or phosphoserine in postion sn-3 of glycerol, have been prepared in good overall yields. Compound 11, 1-0-(6-carboxyhexyl)-sn-glycero-3-phosphoserine, a strict analog of the structure proposed for modulator, has been synthesized in a stereoselective way from (R)-1,2-isopropylideneglycerol 1.     

两面针植物中的新生物碱7-去甲6-甲氧基-5,6-二氢白屈菜红碱的晶体结构

从两面针植物中分离得新生物碱7-去甲-6-甲氧基-5,6-二氢白屈菜红碱(C~2~1H~1~0O~5N的单晶结构已用直接法解出:空间群为P2t/c,晶能参数:a=14.213(7),b=17.347(3),c=7.513(9)A,β=101.40(13)°,z=4。对I≥3σ(I)的1876个独立反射, 用全矩阵最小二乘法修正到R=0.096和Rπ=0.077(单位权重)。     

Pegamine: A new alkaloid fromPeganum harmala

Chemistry of Natural Compounds - The structure of pegamine has been established from its UV, IR, NMR, and mass spectra. 2. A fragmentation scheme for pegamine on mass spectrometry has been proposed.     

Synthesis of aminopyrimidylindoles structurally related to meridianins

The synthesis of new meridianin derivatives substituted at the C-5′ position of the 2-aminopyrimidine ring by various aryl groups and substituted or not by a methyl group on the indole nitrogen is described. The 2-aminopyrimidine ring was obtained via a Bredereck synthesis. Aryl groups were introduced by Suzuki cross-coupling after bromination of the 2-aminopyrimidine ring at the C-5′ position.     

Syntheses of some indazoles structurally related to equilenin

This study reports the complete synthesis and characterization of the 15, 16-diazaequilenin derivative 10,11-dihydro-3H-naphth[1,2-g]indazol-7-ol ( 2b ) as well as the methyl ether 2a of the above compound and the novel “model” compound 4,5-dihydro-1H-benz[g]indazol-7-ol ( 3b ). Indazoles 2a and 3a have demonstrated in vitro activity against a variety of microorganisms.     

A new alkaloid from Lycoris aurea

A new alkaloid was isolated from the bulbs of Lycoris aurea(L'Herit.) Herb.Its structure was established as 3-o-ethyltazettinol through chemical and spectroscopic studies including 2D NMR.     

A new alkaloid from Lysimachia patungensis

A new pyridine alkaloid and six known compounds were isolated from the whole plant of Lysimachia patungensis Hand.-Mazz. The structure of the new alkaloid, named patungensin, was characterized as (17R, E)-2-hydroxy-4,6-dimethoxy-17-acetoxy-cyclopentadeca-1, 3-diene[1,2-b]pyridine, and the six known compounds were identified as octacosanoic acid (1), palmic acid (2), stigmasterol (3), ardisiacrispin A (5), isorhamnetin 3-β-D-galactopyranoside (6), and isorhamnetin 3-robinobioside (7), respectively. Published in Khimiya Prirodnykh Soedinenii, No. 2, pp. 141–142, March–April, 2007.     

A new bisbenzylisoquinoline alkaloid from Plumulanelumbinis

One new bisbenzylisoquinoline alkaloid, neferine N-oxide(1), along with three known compounds,neferine(2), liensinine(3), and isoliensinine(4), were isolated from Plumulanelumbinis – the embryo of the seed of Nelumbonucifera. Their structures were elucidated by extensive spectroscopic analysis(MS,UV, IR, NMR), and the absolute configurations were determined by experimental circulardichroism(CD)spectra. Compound 1 is a new naturally occurring bisbenzylisoquinoline alkaloid with an N-oxide functionality, and the CD spectrum of(1R, 1'R) neferine is first reported. The antioxidant activities of compounds 1–4 were evaluated using the ORAC assay, which illustrated that all these compounds showed the different levels of oxygen radical absorbance capacity.     

A new alkaloid from Stemona sessilifolia

A new alkaloid, named sessilistemonamine D, was isolated from the roots of Stemona sessilifolia and the structure and relative configuration were determined on the basis of NMR and MS spectrometric data analysis.     

A new alkaloid from Solanum cathayanum

A new alkaloid compound I was obtained from Solanum cathayanum, a folk medicine of Hubei Province, together with a known alkaloid, orotic acid ethyl ester. On the basis of spectroscopic data and chemical methods, I was identified as 8-hydroxy-3-methoxy- 5H-pyrido[2, 1-c]pyrazin-5-one. Compound I can inhibit the production of NO in peritoneal macrophage of mice induced with LPS. The content of NO was determined by enzyme methods. 2007 Jun Zhi Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.     

Enzymatic enantiomeric resolution of phenylethylamines structurally related to amphetamine

Both enantiomers of several phenylethylamines, structurally related to amphetamine, have been prepared in good yields and excellent enantiomeric purity by enzymatic kinetic resolution using CAL-B and ethyl methoxyacetate as the acyl donor. In the case of the 4-hydroxyderivative of amphetamine (compound 4i), the S enantiomer racemized possibly in a dynamic kinetic resolution (DKR) under the enzymatic conditions used.     

A concise route to the azaspirodecane moiety of halichlorine and structurally related alkaloids

[reaction: see text] A tandem Michael addition-enolate alkylation followed by Dieckmann cyclization and Beckmann rearrangement provided the corresponding [5.4.0] azaspirobicyclodecane, a key intermediate in our synthetic route to the marine alkaloid halichlorine (1).     

Synthesis of new indole derivatives structurally related to donepezil and their biological evaluation as acetylcholinesterase inhibitors

New series of indole derivatives analogous to donepezil, a well known anti-Alzheimer and acetylcholinesterase inhibitor drug, was synthesized. A full chemical characterization of the new compounds is provided. Biological evaluation of the new compounds as acetylcholinesterase inhibitors was performed. Most of the compounds were found to have potent acetylcholinesterase inhibitor activity compared to donepezil as standard. The compound 1-(2-(4-(2-fluorobenzyl) piperazin-1-yl)acetyl)indoline-2,3-dione (IIId) was found to be the most potent.     

O-methylcyclovirobuxine-D — A new alkaloid fromBuxus sempervirens

The amounts and compositions of the essential oils in the leaves and fruit of Meyer's lemon in the various vegetation periods have been studied. It has been established that as the fruit ripens the amount of essential oils and of monoterpene hydrocarbons in its peel and in the leaves increases.Institute of Plant Biochemistry, Academy of Sciences of the Georgian SSR. Sukhumi Zonal Experimental Station of Essential-Oil Crops. Sukhumi Experimental Station of Subtropical Crops, All-Union Institute of Plant Growing. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 784–787, November–December, 1985.