硒与癌症

硒是人体必需微量元素。流行病学调查表明。土壤硒含量，谷物硒含量。食物硒摄入量及人体血硒水平与多种癌症发病率（死亡率）呈负相关，动物实验证实，适量硒具有抑癌抗癌作用，硒抗癌机理研究及人体干预试验进一步说明硒与癌症关系密切。     

发硒血硒与人体疾病关系的探讨

为研究发硒，血硒与人体疾病的关系，对一些肝病及癌症患者的发硒，血硒进行了检测，获得了一些有价值的结果。     

硫代硫酸钠容量法测定电解锰厂废水中的微量硒

硒是人体必需的微量元素,对人体健康有着重要的影响,硒含量过高或过低都会引起疾病。同时,硒是多种人体酶中不可少的元素,流行病学研究表明,克山病、某些肿瘤的发病率与人体血硒水平呈显著负相关系,艾滋病(ADIS)患者血硒水平明显低于正常人群。湘西自治洲锰矿产量居全世界第二位,并且每生产1t电解锰,废渣为8～10t,污水为300t,未经任何处理直接排放于河中,为此,必须对废水中     

肝病患者血硒水平与甲胎蛋白浓度的相关性研究

硒是人体不可缺少的一种微量元素,其水平的高低影响着机体的肿瘤免疫反应,甲胎蛋白是癌胚蛋白,其浓度的高低反映了肝脏损害的程度（除胎儿期外）,本文血硒水平与甲胎蛋白浓度相关性研究结果表明,两者呈负相关（相关系数－0．627）,且血硒水平呈现慢乙肝＞肝硬化＞肝癌,提示硒对肝脏具有一定的潜在保护作用,补硒可以预防肝癌,在肝癌治疗中适量补硒,对增强患者免疫功能,延长生存期有着十分重要的临床意义。     

原子荧光法测定四城市成年男性全血、尿、膳食和粪便中硒含量

采用原子荧光法测定人血、尿、膳食及粪便中硒含量,并比较4个不同膳食类型的城市人体摄取硒的差异.分别在天津、成都、镇江、太原采集30名健康成年男性的全血、72hr尿、72hr膳食和72 hr粪便,在还原剂KBH4浓度为0.37 mol/L,HCl体积分数为5％的条件下采用原子荧光法测定硒含量,方法回收率为97.0％ ～ ...     

人体微量元素硒营养

硒是人体必需的微量元素。环境系统中的硒含量差异较大，缺硒现象普遍。利用天然食品摄取硒营养是安全，有效，可行的途径。     

天然产物中硒含量测定及形态分析

硒是人体必需微量元素之一，具有抗肿瘤、防衰老、防辐射和增强机体免疫力等多种功能。文章概述了国内近年来硒含量测定方法和国内外对硒形态分析的现状。     

土壤环境中的硒对人和动物健康的影响

硒是人和动物必需的微量元素之一。土壤中的硒含量过多或过低，人和 动物都会出现地方性疾病。土壤中硒的含量与土壤母质、地形、气候条件和土壤条件性质等有关，调节土壤性质可以改善作物的含硒量。防治硒缺额症和硒中毒症，每天必需摄入适量的硒，以100－200μg为宜，但人体对硒的需要量也与食物成分有关。     

54例白血病患者血清硒含量分析

以催化极谱法测定了５４例白血病患者血清硒含量。结果表明，急淋、急粒患者血清硒含量均低于正常对照组，慢粒及急、慢粒经治疗缓解者血清硒含量与正常对照组间均无显著性差异，提示低硒状态只存在于急性患者，且随病情缓解后血硒水平趋于正常，慢粒与血硒含量没有明显的相关关系。     

月亮女神与新冠肺炎

月亮女神——硒(Selenium)是人体不可或缺的微量元素之一，对生命的健康至关重要。然而，硒摄入量不足或过量对人体都是有害的。本文采用拟人化手法分别从硒的发现过程、存在形式和基本性质(特别是有趣的两面性)三个方面进行了简要概述，并对硒元素在新型冠状病毒肺炎(COVID-19)预防和治疗方面的最新研究进展与潜在应用前景进行了详细介绍。     

Selenium speciation from food source to metabolites: a critical review

Especially in the last decade, a vast number of papers on Se and its role in health issues have been published. This review gives a brief, critical overview of the main analytical findings reported in these papers. Of particular interest is the Se content in different food sources worldwide and the extent to which their consumption is reflected in the Se content of human tissues and body fluids. Several food sources, both natural (Brazil nuts, garlic, Brassica juncea) and Se-enriched (yeast-based supplements), are discussed as to origin, characteristics, Se metabolism and impact of their consumption on the human body. The continuous development of new and improvement of existing analytical techniques has provided different powerful tools to unravel the Se species and their function. An up-to-date literature study on Se speciation analysis is given, illustrating how analytical chemistry in its different facets aids in the identification of Se compounds and provides insight into the complete metabolic pathway of Se throughout the human body. This review includes a detailed image of the current state-of-the-art of Se speciation analysis in these food sources and in human tissues and body fluids.     

外源性加硒法增加枣中硒含量的研究

以不同深度硒溶液对枣树进行不同次数的叶面喷施,得到了不同硒含量的枣样品,用荧光光度法测定了样品中硒的含量。结果表明,与对照组相比,用外源性加硒法可明显提高枣中硒的含量;并且可通过调节喷施液浓度和喷施次数,得到硒含量适宜的成熟小枣。     

Variation of selenium concentration in toenails following long-term storage, washing and reactor irradiation

Summary Neutron activation analysis of toenails is often used to monitor body selenium in studies looking for an association between selenium deficiency and an increased cancer risk. In this study, 87 toenail samples were analyzed for Se four times, using neutron activation with 17.4-second ^77mSe, to determine the possible systematic effects of long-term storage, the washing procedure, and irradiation in a nuclear reactor. The mean Se concentration found was 0.92 mg/g, standard deviation 0.14 mg/g. The results showed that the Se concentrations are unaffected by washing and neutron irradiation, but the samples lost moisture during storage causing a 2% increase in the mean Se concentration.     

抗肿瘤中药微量元素硒的研究

与抗肿瘤作用关系密切的中药微量元素主要有Se、Ge、Zn、Cu、Fe、Mn、Mo、I、B、Si、Li等，本文介绍了近年来Se的研究。Se是人体健康必需的超微量元素．与某些地方病、癌的发生关系密切。是同时具备防癌和促免疫两种活性的理想防癌剂。大部分补气、补血、补肾、补阳等中药富含Se等微量元素，具有抗癌等药理作用．特别是人参等12种中药的抗癌作用尤明显。     

硒对癌症的预防和临床问题的研究现状

从流行病学、实验室和临床等的研究均表明微量元素硒具有化学防癌的潜力，特别是近来富硒酵母应用于肺癌、肠癌、前列腺癌和肝癌等临床干预试验，表现出硒具有强大的保护作用。本文着重论述了硒化合物发展成为化学防癌药物的作用机制问题，这些机制表现在硒具有抗致癌的生物活性。还讨论了对硒的化学预防试验人群的选择，硒的干预试验，临床应用结果和安全范围的指标等问题。     

Speciation of metabolites of selenate in rats by HPLC-ICP-MS

The metabolic pathway for and metabolites of selenium (Se) administered intravenously to rats in the form of selenate at a dose of 0.3 mg Se kg-1 body weight were studied by speciating Se in the bloodstream, liver and urine by HPLC-inductively coupled argon plasma mass spectrometry. Selenate was not taken up by red blood cells (RBCs) and disappeared from the bloodstream much faster than selenite, without any change in its chemical form before it disappeared from the plasma. Selenium excreted into the urine after the administration of selenate showed different patterns from those of selenite in both amounts and chemical forms. With the selenate group, the concentration of Se in urine was highest at 0-6 h and the chemical species of Se was selenate at 0-6 h; thereafter a monomethylselenol-related Se compound (MMSe*) and trimethylselenonium ions (TMSe) appeared, selenate not being excreted after 6 h. On the other hand, in the selenite group, the concentration of Se peaked at 6-12 h, and the chemical species of Se were MMSe* and TMSe. Selenate was reduced in vitro on incubation in either a liver homogenate or supernatant fraction, although much more slowly than in the whole body. Selenate was not reduced by glutathione or dithiothreitol. The results suggest that in contrast to selenite, which is taken up by and reduced in RBCs, and then transferred to the liver, approximately 20% of the selenate administered to rats was excreted into the urine without any change in its chemical form with the present dose, and the major portion of selenate was taken up by the liver, reduced and then utilized for the synthesis of selenoproteins or excreted into the urine after being methylated.     

大骨节病活跃严重病区和邻近非病区儿童尿硒与尿羟脯氨酸关系研究

通过测定尿硒、尿羟脯氨酸含量,研究了大骨节病活跃严重病区和邻近非病区儿童尿硒含量和尿羟脯氨酸含量的变化及其相关性.结果表明,大骨节病活跃严重病区组儿童尿硒含量和尿羟脯氨酸含量均明显低于邻近非病区组（P＜0.01）,处于病区中较低水平.两组的尿硒含量与尿羟脯氨酸含量均显著正相关（r=0.582,P＜0.01;r=0.383,P＜0.05）.这些结果提示,体硒水平是影响尿羟脯氨酸排泄量的原因之一,大骨节病活跃严重病区儿童的低硒状态,是导致其尿羟脯氨酸减少的一个重要因素.     

微量元素硒与生物体健康

从硒在生物体内的分布、存在形态及代谢,硒的生物学功能,硒缺乏及硒中毒,生物体日需要量等方面阐述了硒与生物体健康的关系。     

雷公藤的药效及毒性与微量元素的研究

雷公藤是一种药效大、毒性也大的中药。研究了雷公藤的28种无机元素，发现其有益元素铁、锰、锌、硒含量较高．其有害元素铅、砷、镉含量也较高，与其药效和毒性一一相对应。雷公藤对风湿性关节炎、肾病、肝脏病、皮肤病的疗效．与铁、锰、锌、硒在人体中生物学机理一致。雷公藤对消比道、心血管、肝脏、泌尿系统、造血系统的毒害作用，与铅、砷、镉在人体中的生物学效应一致。所以在使用雷公藤时，应考虑到微量元素作用．可提高雷公藤的疗效，降低其毒性。