共查询到20条相似文献,搜索用时 15 毫秒
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Yuan Huang Wei Chen Dan Zhao Chen Chen Huiqing Yin Likang Zheng Ming Jin Shiqing Han 《中国化学》2013,31(8):1007-1010
A concise route to access 5H‐imidazo[2,1‐a]isoindole heterofused compounds by copper(I)‐catalyzed intramolecular coupling of non‐activated aryl bromides with azoles is reported. With CuI as catalyst, 1,10‐phenanthroline as ligand, and K3PO4 as base, the reactions of 1‐(2‐bromobenzyl)‐1H‐imidazoles in DMF/o‐xylene (1:1, V:V) at 145°C afford the corresponding substituted 5H‐imidazo[2,1‐a]isoindoles in high yields via intramolecular C‐arylation. 相似文献
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Jian Jin David W. C. MacMillan 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(5):1585-1589
The direct α‐arylation of cyclic and acyclic ethers with heteroarenes has been accomplished through the design of a photoredox‐mediated C H functionalization pathway. Transiently generated α‐oxyalkyl radicals, produced from a variety of widely available ethers through hydrogen atom transfer (HAT), were coupled with a range of electron‐deficient heteroarenes in a Minisci‐type mechanism. This mild, visible‐light‐driven protocol allows direct access to medicinal pharmacophores of broad utility using feedstock substrates and a commercial photocatalyst. 相似文献
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