共查询到20条相似文献，搜索用时 0 毫秒
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Martin Wilming Kai Johnsson 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》1999,111(17):2724-2727
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(14):4095-4099
S‐Adenosylmethionine‐dependent methyltransferases are versatile tools for the specific alkylation of many compounds, such as pharmaceuticals, but their biocatalytic application is severely limited owing to the lack of a cofactor regeneration system. We report a biomimetic, polyphosphate‐based, cyclic cascade for methyltransferases. In addition to the substrate to be methylated, only methionine and polyphosphate have to be added in stoichiometric amounts. The system acts catalytically with respect to the cofactor precursor adenosine in methylation and ethylation reactions of selected substrates, as shown by HPLC analysis. Furthermore, 1H and 13C NMR measurements were performed to unequivocally identify methionine as the methyl donor and to gain insight into the selectivity of the reactions. This system constitutes a vital stage in the development of economical and environmentally friendly applications of methyltransferases. 相似文献
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David Schilter Thomas B. Rauchfuss 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2013,125(51):13760-13762
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Ching‐Chin Chen Peter P.‐Y. Chen 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2012,124(37):9459-9463
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Philipp Gotico Bernard Boitrel Rgis Guillot Marie Sircoglou Annamaria Quaranta Zakaria Halime Winfried Leibl Ally Aukauloo 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(14):4552-4557
Inspired by nature's orchestra of chemical subtleties to activate and reduce CO2, we have developed a family of iron porphyrin derivatives in to which we have introduced urea groups functioning as multipoint hydrogen‐bonding pillars on the periphery of the porphyrinic ring. This structure closely resembles the hydrogen‐bond stabilization scheme of the carbon dioxide (CO2) adduct in the carbon monoxide dehydrogenase (CODH). We found that such changes to the second coordination sphere significantly lowered the overpotential for CO2 reduction in this family of molecular catalysts and importantly increased the CO2 binding rate while maintaining high turnover frequency (TOF) and selectivity. Entrapped water molecules within the molecular clefts were found to be the source of protons for the CO2 reduction. 相似文献
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