共查询到20条相似文献,搜索用时 15 毫秒
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Florian Monnier Dr. Marc Taillefer Dr. 《Angewandte Chemie (International ed. in English)》2009,48(38):6954-6971
Copper‐catalyzed Ullmann condensations are key reactions for the formation of carbon–heteroatom and carbon–carbon bonds in organic synthesis. These reactions can lead to structural moieties that are prevalent in building blocks of active molecules in the life sciences and in many material precursors. An increasing number of publications have appeared concerning Ullmann‐type intermolecular reactions for the coupling of aryl and vinyl halides with N, O, and C nucleophiles, and this Minireview highlights recent and major developments in this topic since 2004. 相似文献
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Chris E. Houlden Marc Hutchby Chris D. Bailey J. Gair Ford Dr. Simon N. G. Tyler Dr. Michel R. Gagné Prof. Dr. Guy C. Lloyd‐Jones Prof. Dr. Kevin I. Booker‐Milburn Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(10):1830-1833
Pd and CO—ureally got me! The title reaction proceeds efficiently at 18 °C under CO (1 atm) with 5 % [Pd(OTs)2(MeCN)2] as precatalyst. Depending on the solvents used, either anthranilates or cyclic imides can be obtained in high yields (see picture, BQ=benzoquinone, Ts=4‐toluenesulfonyl).
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For organic chemists, the construction of C C bonds is the most essential aspect of the assembly of molecules. Transition‐metal‐catalyzed coupling reactions have evolved as one of the key tools for this task. Lately, gold has also emerged as a catalyst for this kind of transformation. Gold, with its special properties as a mild carbophilic π Lewis acid, its ability to insert into C H bonds, and, as discovered recently, its ability to undergo redox transformations, offers the opportunity to apply all this potent proficiency for the construction of compounds in an efficient and economical way. This Minireview critically presents the C C coupling reactions enabled by gold catalysts to encourage further research activities in this promising area of oxidation/reduction gold catalysts. 相似文献
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Cline Taglang Luis Miguel Martínez‐Prieto Iker delRosal Laurent Maron Romuald Poteau Karine Philippot Bruno Chaudret Serge Perato Anaïs SamLone Cline Puente Christophe Dugave Bernard Rousseau Grgory Pieters 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(36):10620-10623
The activation of C H bonds has revolutionized modern synthetic chemistry. However, no general strategy for enantiospecific C H activation has been developed to date. We herein report an enantiospecific C H activation reaction followed by deuterium incorporation at stereogenic centers. Mechanistic studies suggest that the selectivity for the α‐position of the directing heteroatom results from a four‐membered dimetallacycle as the key intermediate. This work paves the way to novel molecular chemistry on nanoparticles. 相似文献
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Nicolas Dietl Marianne Engeser Dr. Helmut Schwarz Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(26):4861-4863
No need for a metal : A combination of mass spectrometry and computational studies (density functional theory and coupled‐cluster methods) shows that [P4O10].+ is the first polynuclear nonmetal oxide cation that is capable of activating the C? H bond of methane at room temperature (see picture). This process represents a further example in the reactivity of oxygen‐centered radicals.
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Holger Helten Marianne Engeser Dr. Dietrich Gudat Prof. Dr. Reinhold Schilling Gregor Schnakenburg Martin Nieger Dr. Rainer Streubel Prof. Dr. 《Chemistry (Weinheim an der Bergstrasse, Germany)》2009,15(11):2602-2616
P? N bond activation of 2H‐azaphosphirene complexes 1 and 2 by using triflic acid led to ring expansion in the presence of nitriles. In the absence of nitriles, the reaction surprisingly afforded two haptomeric N‐protonated 1‐aza‐3‐phospha‐butadiene complexes in the case of complex 1 , whereas the N‐protonated 2H‐azaphosphirene complex [H‐ 2 ]+ was characterized by NMR spectroscopy.
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Shuo Guo Xiaofei Zhang Pingping Tang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2015,127(13):4137-4141
The first example of a practical and direct trifluoromethylthiolation reaction of unactivated aliphatic C H bonds employs a silver‐based reagent. The reaction is operationally simple, scalable, and proceeds under aqueous conditions in air. Furthermore, its broad scope and good functional‐group compatibility were demonstrated by applying this method to the selective trifluoromethylthiolation of natural products and natural‐product derivatives. 相似文献
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Xiao Chen Dr. Keary M. Engle Dong‐Hui Wang Jin‐Quan Yu Prof. Dr. 《Angewandte Chemie (International ed. in English)》2009,48(28):5094-5115
Pick your Pd partners : A number of catalytic systems have been developed for palladium‐catalyzed C? H activation/C? C bond formation. Recent studies concerning the palladium(II)‐catalyzed coupling of C? H bonds with organometallic reagents through a PdII/Pd0 catalytic cycle are discussed (see scheme), and the versatility and practicality of this new mode of catalysis are presented. Unaddressed questions and the potential for development in the field are also addressed.
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