共查询到20条相似文献,搜索用时 15 毫秒
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Highly Asymmetric Michael Addition to α,β‐Unsaturated Ketones Catalyzed by 9‐Amino‐9‐deoxyepiquinine
Jian‐Wu Xie Wei Chen Rui Li Mi Zeng Wei Du Lei Yue Ying‐Chun Chen Prof. Dr. Yong Wu Prof. Dr. Jin Zhu Prof. Jin‐Gen Deng Prof. Dr. 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2007,119(3):393-396
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Nis Halland Tore Hansen Karl Anker Jrgensen 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2003,115(40):5105-5107
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Samus H. McCooey Stephen J. Connon 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2005,117(39):6525-6528
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《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2017,129(12):3352-3356
A photochemical organocatalytic strategy for the direct enantioselective β‐benzylation of α,β‐unsaturated aldehydes is reported. The chemistry capitalizes upon the light‐triggered enolization of 2‐alkyl‐benzophenones to afford hydroxy‐o ‐quinodinomethanes. These fleeting intermediates are stereoselectively intercepted by chiral iminium ions, transiently formed upon condensation of a secondary amine catalyst with enals. Density functional theory (DFT) studies provided an explanation for why the reaction proceeds through an unconventional Michael‐type addition manifold, instead of a classical cycloaddition mechanism and subsequent ring‐opening. 相似文献
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Xuan Ding Chun‐Lin Dong Zhi Guan Yan‐Hong He 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2019,131(1):124-130
The combination of photoredox and enzymatic catalysis for the direct asymmetric one‐pot synthesis of 2,2‐disubstituted indol‐3‐ones from 2‐arylindoles through concurrent oxidization and alkylation reactions is described. 2‐Arylindoles can be photocatalytically oxidized to 2‐arylindol‐3‐one with subsequent enantioselective alkylation with ketones catalyzed by wheat germ lipase (WGL). The chiral quaternary carbon center at C2 of the indoles was directly constructed. This mode of concurrent photobiocatalysis provides a mild and powerful strategy for one‐pot enantioselective synthesis of complex compounds. The experiments proved that other lipases containing structurally analogous catalytic triad in the active site also can catalyze the reaction in the same way. This reaction is the first example of combining the non‐natural catalytic activity of hydrolases with visible‐light catalysis for enantioselective organic synthesis and it does not require any cofactors. 相似文献
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