共查询到20条相似文献,搜索用时 15 毫秒
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We achieved the total synthesis of the histone deacetylase inhibitor spiruchostatin A, as the prelude to the preparation of a combinatorial library of its analogues. Two key reactions were an asymmetric acetate aldol reaction using a Zr-enolate and macrolactonization using the Shiina method. 相似文献
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Joseph J. Romano 《Tetrahedron letters》2005,46(13):2323-2326
Advanced C-prenylated intermediates for three aromatase inhibitors, including morachalcone A, can be synthesized through a Claisen-Schmidt condensation followed by Florisil®-catalyzed [1,3]-sigmatropic rearrangement of a prenyl phenyl ether. 相似文献
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In this paper, we report a total synthesis of a naturally occurring pyrrolo[2,3-d]pyrimidine nucleoside, mycalisine A. Our synthetic strategy uses D-xylose as the startingmaterial and Vorbrüggen glycosylation as the key step. Mycalisine A was synthesized in 11 steps with a 15% overall yield. 相似文献
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A total synthesis of phomactin A (1) based on a Cr(II)/Ni(II) macrocyclisation from the aldehyde vinyl iodide 11, leading to 12, followed by elaboration of the epoxyketone 16, which then undergoes spontaneous pyran-hemiacetal formation on deprotection, is described. 相似文献
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Francisco A. Macías David Chinchilla Jose M.G. Molinillo Frank R. Fronczek Kozo Shishido 《Tetrahedron》2008,64(23):5502-5508
Both epimers of Heliannuol A, first heliannane reported in the literature, isolated from Heliannthus annuus, have been prepared individually in a stereoselective route using a ring closing metathesis (RCM) as a key step to obtain the eight-membered ring. Very good overall yield was obtained in both cases. 相似文献
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A total synthesis of millingtonine A, a diglycosylated alkaloid, has been accomplished. Millingtonine A possesses a unique racemic tricyclic core structure not known from any other natural or synthetic source until now. The synthesis features a key bond-forming radical Ueno-Stork cyclization to form the heterocyclic core. 相似文献
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The preparation of two new synthons, 2,5- and 2,6-dibromotryptophan esters, and their use in diastereoselective intramolecular N-acyliminium ion spirocyclization methodology for the rapid construction of spirotryprostatin A and analogues are described. 相似文献
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Jiaxiang Wang Jiahui Gao Tianyun Guo Prof. Dr. Xing Huo Prof. Dr. Wenhua Zhang Prof. Dr. Jian Liu Prof. Dr. Xiaolei Wang 《Angewandte Chemie (Weinheim an der Bergstrasse, Germany)》2023,135(3):e202213810
Herein, bioinspired total syntheses of A201A, A201D, and A201E based on a previously reported biosynthetic pathway are presented. The challenging 1,2-cis-furanoside, a core structure of the A201 family, was obtained by remote 2-quinolinecarbonyl-assisted glycosylation. We accomplished the total synthesis of A201A and A201E based on the critical 1,2-cis-furanoside moiety through late-stage glycosylation without any interference from basic dimethyl adenosine. We also confirmed the absolute configuration of A201E by total synthesis. This modular synthesis strategy enables efficient preparation of A201 family antibiotics, allowing the study of their structure–activity relationships and mode of action. This study satisfies the increasing demand for developing novel antibiotics inspired by the A201 family. 相似文献
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Jiaxiang Wang Jiahui Gao Tianyun Guo Prof. Dr. Xing Huo Prof. Dr. Wenhua Zhang Prof. Dr. Jian Liu Prof. Dr. Xiaolei Wang 《Angewandte Chemie (International ed. in English)》2023,62(3):e202213810
Herein, bioinspired total syntheses of A201A, A201D, and A201E based on a previously reported biosynthetic pathway are presented. The challenging 1,2-cis-furanoside, a core structure of the A201 family, was obtained by remote 2-quinolinecarbonyl-assisted glycosylation. We accomplished the total synthesis of A201A and A201E based on the critical 1,2-cis-furanoside moiety through late-stage glycosylation without any interference from basic dimethyl adenosine. We also confirmed the absolute configuration of A201E by total synthesis. This modular synthesis strategy enables efficient preparation of A201 family antibiotics, allowing the study of their structure–activity relationships and mode of action. This study satisfies the increasing demand for developing novel antibiotics inspired by the A201 family. 相似文献
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In continuation of our studies on the constituents of Clerodendrum serratum var.amplexghlium Moldenke'-"', a new triterpenoid saponin, sc-saponin A (l), was isolated.To the best of our knowledge, it is the second instance oftriterpenoid saponin from theClerodendrum genus. This paper deals with the structural elucidation of the newcompound.Se-saponin A (l) an amorphous powder, gave positive Liebermann-Burchardreaction. It was deduced to have a molecular formula of C58H,,O,, by high resoluti… 相似文献
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LiHongHU JingYuLIANG 《中国化学快报》2005,16(6):783-785
A novel compound, named fortunate A, was isolated from the ethanol extract of the stem bark of Cryptomerica fortunei. Its structure was established on the basis of the spectral evidences including 1D and 2D NMR spectrum. 相似文献
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《Liquid crystals》1998,25(4):459-465
The basic structural differences between three thermotropic liquid crystals TB4A, TB7A and TB10A have been interpreted by analysing their Raman spectra. Three spectral regions, 925-1025, 1275-1475 and 1525-1650 cm-1, have been chosen in this context to incorporate their structural dissimilarity. The induced planarity of the backbone, as an effect of increasing chain length, has been studied by observing the changes in the respective Raman spectra of the three compounds. A tentative assignment of all the modes observed in the region 400-1700cm-1 is made in this context. The molecular conformations of the three compounds have been predicted in their solution states, and are compared with the molecular environment that exists in their liquid crystalline states. Structural disorder at the solid-SmG transition is discussed and the changes are incorporated systematically. 相似文献
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