A New Diterpenoid and a New Diterpenoid Alkaloid from Aconitum coreanum

A new diterpenoid, guan fu diterpenoid A ( 1 ), and a new diterpenoid alkaloid, guan fu base S ( 2 ), were isolated from the Chinese medicinal herb Aconitum coreanum (Lèvl. ) Rapaics , together with five known diterpenoid alkaloids guan fu base P, guan fu base R, guan fu base G, guan fu base F, and guan fu base Z. The structures of the two new compounds were elucidated as ent‐kaurane‐16,20‐diol ( 1 ) and (11β,13S)‐2,3,15,16‐tetradehydro‐16,17‐dihydrohetisan‐11,13,14‐triol 11,13‐diacetate ( 2 ) on the basis of HR‐MS and 2D‐NMR analyses. This is the first report of an ent‐kaurane diterpenoid in Aconitum coreanum.     

A New Diterpenoid Alkaloid from Aconitum episcopale

A new diterpenoid alkaloid with an epoxy ring between C(3) and C(17) was isolated from Aconitum episcopale. The structure was elucidated on the basis of spectral and chemical evidence.     

A New Diterpenoid Alkaloid from the Roots of a White‐Flowering Aconitum orientale Sample

From the roots of a white‐flowering Aconitum orientale Miller sample, collected in Artvin‐?av?at, Turkey, a new diterpenoid alkaloid named aconitorientaline ( 1 ) was isolated, along with the known diterpenoid alkaloids septentiriodine, lappaconitine, finaconitine, ranaconitine, puberanidine and delstaphinine (Fig.). The structure of 1 was established on the basis of ¹H‐ and ¹³C‐NMR, DEPT, ¹H,¹H‐COSY, NOESY, HSQC, and HMBC studies. All the known compounds were identified by comparison of their ¹H‐ and ¹³C‐NMR data and co‐TLC behavior with those of authentic samples.     

Structure and Antiarhythmic Activity of 12-Acetyl-12-epinapelline, a New Diterpenoid Alkaloid from Aconitum soongoricum

The structure of the new diterpenoid alkaloid 12-acetyl-12-epinapelline that was isolated from the mother liquor of Aconitum soongoricum was established. The conformational state of ring A was analyzed. Spectral properties and data for the antiarhythmic activity were presented.     

Four New Nor‐Diterpenoid Alkaloids from Aconitum brachypodum

Four new C₁₉‐nor‐diterpenoid alkaloids, named brachyaconitines A–D ( 1 – 4 ), were isolated from the roots of Aconitum brachypodum Diels. Their structures were elucidated as 3‐O‐acetyl‐20‐deethyl‐20‐formylaconitine ( 1 ), 3‐O‐acetyl‐19,20‐didehydro‐20‐deethylaconitine ( 2 ), 3‐O‐acetyl‐8‐de(acetyloxy)‐7,8,17,20‐tetradehydro‐20‐deethyl‐7,17‐secoaconitine ( 3 ), and 1‐O‐methylflavaconitine ( 4 ) by means of MS, IR, 1D‐ and 2D‐NMR analyses. The structure of compound 1 was confirmed by an X‐ray diffraction experiment.     

New Diterpenoid Alkaloids from Aconitum liangshanicum

One new C₁₉‐diterpenoid alkaloid, named liangshantine ( 1 ), and three new C₂₀‐diterpenoid alkaloids, liangshansines A–C ( 2 – 4 , resp.), as well as eight known compounds, were isolated from the roots of Aconitum liangshanicum. The structures of these new alkaloids were elucidated by spectroscopic methods.     

Diterpenoid Alkaloids from Aconitum Nagarum var. Lasiandrum

Aconitum species have been used as a traditional chinese medicine having analgesic activity. Several groups 1-3 have studied the components of the roots of Aconitum nagarum var. lasiandrum W.T. Wang. Further chemical investigation of this plant led to isolate two new diterpenoid alkaloids, nagadine 1 and 14-benzoylsachaconitine 2. This type of norditerpenoid alkaloid has not been reported before.Nagadine 1, +43.0 (c, 0.00273, CHCl3), was isolated as white amorphous powder. The HREIMS of …     

New Diterpenoid Alkaloids from Spiraea japonica var. Ovalifolia

In the investigation of the chemical constituents of Spireae japonica L. f. var. ovalifolia (Rosaceae), a shrub originated in Songming, Yunnan, five new diterpenoid alkaloids, 19-O-deethylspiramine N (1), deacetylspiramine S (2), spiramidine A (3), spiramidine B (4) and deacetylspiramine F (5), were isolated from aerial parts of the plant and structurally elucidated. Compound 1, a white amorphous powder with [(]+17.99 (c, 0.26, MeOH ), was determined to have the molecular formula of C20H…     

A New Bislabdane-type Diterpenoid from Cunninghamia lanceolata

Cunninghmia lanceolata Hook. is a traditional Chinese medicine used for thetreatment of hernia, arthritis and strangury. its chemical constituents have beenexamined]' 2' 3' '. In a previous paper we reported a bislabdane-type diterpenoidlanceolatic acid from the roots of the plant 5. Further chemical studies on this plantled to the isolation of another new bislabdane-type diterpenoid, named lanceolatin(I ).Compound I was obtained as white amorphous powder. mp 232-234 'C, [a]."-24 (c 0. 10, C…     

藏药蓝翠雀花中的新二萜生物碱

蓝翠雀花(Delphinium caeruleum Jacq.ex Camb.)~[1]在甘肃西南部、西藏、青海等地分布较广,藏民常用其治疗牙痛、跌打损伤.其化学成分迄今未见报道.我们将其全草用乙醇浸泡,石油醚脱脂,乙醚除去色素,酸碱常法处理,氯仿萃取得总生物碱.用氧化铝、硅胶进行多次柱层析及硅胶薄层制备层析,分得碱(1)～(4).     

A New Abietane Diterpenoid from Orthosiphon wulfenioides

A new abietane diterpenoid,orthosiphonol (11-methoxy-12,14-dihydroxy-8,11,13-abieta trien-7-one)(1) together with known 11-hydroxysugiol (2) were isolated from Orthosiphon wulfenioides. Their structures were determined on the basis of spectroscopic evidence.     

A Novel 19,21‐Secohetisan Diterpenoid Alkaloid from Aconitum tanguticum

A novel 19,21‐secohetisan diterpenoid alkaloid, tangutisine A ( 1 ), was isolated from Aconitum tanguticum (Maxim .) Stapf . Its structure was determined by HR‐EI‐MS and 1D‐ and 2D‐NMR spectroscopy and by comparison with the data of known 19,21‐secohetisan derivatives.     

Diterpenoid alkaloids of Delphinium schmalhausenii

From the aerial parts of Delphinium schmalhausenii six norditerpenoid alkaloids gigactonine, lycoctonine, anthranoyllycoctonine, delsemine A, delsemine B, N-acetyldelectine and a diterpenoid alkaloid septatisine were isolated. Published in Khimiya Prirodnykh Soedinenii, No. 1, pp. 60–61, January–February, 2006.     

A New ent-Kaurane Diterpenoid from Isodon enanderianus

Isodon enanderianus (Hand. -Mazz.) H. W. Li, has been used in folk medicine as anti-inflammatory and detoxified agent1. The Isodon genus is known to be rich in ent-kaurane diterpenoids, a series of new ent-kaurane diterpenoids have been isolated from the dried leaves of I. enanderianus2-4. In order to find more biologically active substances, we have carefully investigated the chemical constituents of I. enanderianus collected in Shiping county of Yunnan province, and as a result, enanderi…     

A New Diterpenoid Glucoside from Aster smithianus

A new diterpenoid trisaccharide, smithoside A, was isolated from Aster smithianus. Its structure was identified as pimar- 15 (16)-β-en-3β, 8β, 11α-triol-3-O-β-D-glucopyranosyl ( 1→3)- [β-glucopyranosyl (1→2)]-β-D-glucopyranoside on the basis of the spectral and chemical methods.     

高乌头根中新的二萜生物碱

从高乌头根中分离得到3个新的冉乌头型的C₁₈-二萜生物碱高乌宁己(1)、高乌宁庚(3)、高乌宁辛(5)和一个新的牛扁碱型C₁₉-二萜生物碱高乌宁壬(7). 它们的结构通过IR, ¹H NMR, ¹³C NMR, MS予以确证.     

Diterpenoid Alkaloids Isolated from Delphinium brunonianum and Their Inhibitory Effects on Hepatocytes Lipid Accumulation

This research aimed to excavate compounds with activity reducing hepatocytes lipid accumulation from Delphinium brunonianum. Four novel diterpenoid alkaloids, brunodelphinine B–E, were isolated from D. brunonianum together with eleven known diterpenoid alkaloids through a phytochemical investigation. Their structures were elucidated by comprehensive spectroscopy methods including HR-ESI-MS, NMR, IR, UV, CD, and single-crystal X-ray diffraction analysis. The inhibitory effects of a total of 15 diterpenoid alkaloids on hepatocytes lipid accumulation were evaluated using 0.5 mM FFA (oleate/palmitate 2:1 ratio) to induce buffalo rat liver (BRL) cells by measuring the levels of triglyceride (TG), total cholesterol (TC), alanine transaminase (ALT), aspartate transaminase (AST), and the staining of oil red O. The results show that five diterpenoid alkaloids—brunodelphinine E (4), delbruline (5), lycoctonine (7), delbrunine (8), and sharwuphinine A (12)—exhibited significant inhibitory effects on lipid accumulation in a dose-dependent manner and without cytotoxicity. Among them, sharwuphinine A (12) displayed the strongest inhibition of hepatocytes lipid accumulation in vitro. Our research increased the understanding on the chemical composition of D. brunonianum and provided experimental and theoretical evidence for the active ingredients screened from this herbal medicine in the treatment of the diseases related to lipid accumulation, such as non-alcoholic fatty liver disease and hyperlipidemia.     

Piepunine,A Novel Bis‐diterpenoid Alkaloid from the Roots of Aconitum piepunense

Further investigation on the roots of Aconitum piepunense led to the isolation of a novel bis‐diterpenoid alkaloid designated as piepunine ( 1 ). Its structure was established by extensive interpretation of its 1D‐ and 2D‐NMR data, high‐resolution ESI‐MS, and IR spectra. Piepunine represents the first example of an atisine–denudatine‐type bis‐diterpenoid alkaloids.