共查询到20条相似文献,搜索用时 125 毫秒
1.
Zizhen Yin Dr. Hiroki Moriwaki Dr. Hidenori Abe Dr. Toshio Miwa Dr. Jianlin Han Prof. Dr. Vadim A. Soloshonok 《ChemistryOpen》2019,8(6):701-704
Here we report the first large-scale synthesis of Fmoc-(S)-2-amino-6,6,6-trifluorohexanoic acid via asymmetric alkylation of chiral Ni(II)-complex of glycine Schiff base with CF3(CH2)3I. The synthesis was performed on over 100 g scale and can be recommended as the most advanced procedure for reliable preparation of large amounts of enantiomerically pure Fmoc-(S)-2-amino-6,6,6-trifluorohexanoic acid for protein engineering and drug design. Chiral auxiliary used in this protocol can be >90 % recovered and reused. 相似文献
2.
Mansing M. Mane 《合成通讯》2013,43(7):868-876
A facile, ecofriendly procedure has been developed for the synthesis of substituted 5-deaza-10-oxaflavins by sulfamic acid–catalyzed two-component condensation of salicylaldehyde and barbituric acid at ambient temperature. Mild reaction conditions, short reaction time, ambient temperature, ecofriendly solvent system, wide substrate scope, simple workup procedure, no need for chromatographic separation, and good yields are auxiliary advantages of the present protocol. 相似文献
3.
Guang Dong LEI Li Xin LI Zhi Yun LU Ming Gui XIE 《中国化学快报》2005,16(8):1039-1042
An improved method for the large-scale preparation of 4,6-dihydroxyisophthalic acid and 2,3-dihydroxyterephthalic acid has been developed.Compared to the previous procedures,this new process-requires much lower CO2 pressure of 0.3 Mpa and shorter reaction time.thus providing a convenient access for large-scale synthesis.The yield is high (93% and 65%,respectively), and the oxidation of phenol is nearly inhibited,neither decolorization nor further chromatographic purification is required. 相似文献
4.
5.
6.
三氧化硫脲的合成 总被引:4,自引:1,他引:3
三氧化硫脲 (Aminoiminomethanesulfonicacid,简称 AIMSO3H)是十分有效的脒化试剂 ,它可在温和条件下将氨基转化成胍基 [1,2 ] . 1 965年Debowski[3] 报道了 AIMSO3H的合成 .此后 ,Miller[1] ,Kim等 [2 ]又相继报道了它的合成及物理常数 .他们多以硫脲或二氧化硫脲为原料 ,以过氧乙酸为氧化剂 .本文报道用 H2 O2 作氧化剂的合成方法 ,并对其热稳定性进行了研究 .二氧化硫脲 ,由烟台化工总厂提供 ,经重结晶提纯至 99.98% [5] ;市售 30 % H2 O2 试剂 .取 65m L H2 O2 于烧杯中 ,加入 1 .7m L浓硫酸 ,搅拌 ,配成 H2 O2 酸性溶液 .在… 相似文献
7.
Abstract An improved synthesis of ximenynic acid (1) starting from castor oil has been developed with the direct chlorination of ricinstearolic acid as the key step. By this modification, the synthetic route was more concise and economic. The separation of geometric somers was achieved by repeated urea fractionation. Supplemental materials are available for this article. Go the publisher's online edition of Synthetic Communications to view the free supplemental file. 相似文献
8.
Kaori Yagi 《Tetrahedron》2006,62(20):4933-4940
CuCN-catalyzed reaction of the (1R)-isomer of 4-cyclopentene-1,3-diol monoacetate with TBDPSO(CH2)6MgCl produced an SN2-type product regioselectively in high yield. Mitsunobu inversion of the product and subsequent Claisen rearrangement furnished aldehyde with the two side chains, from which the title compounds were synthesized efficiently. 相似文献
9.
10.
11.
12.
A simple, cost-effective method for synthesis of indoloquinoxalines from isatin and o-phenylenediamine employing a catalytic amount of sulfamic acid at ambient temperature is reported. Moreover, the method is applicable for a variety of isatins, ninhydrin, 4-hydroxynaphthaquinone, and 1,2-diketones. The key features of the protocol include rapid reactions with good yields, simple workup procedure, and easy isolation of products. 相似文献
13.
Kang Jin Jeong Soon Young Park Ji Hye Seo Kyung Bok Lee Wahn Soo Choi Jeung Whan Han Jae Ku Kang Chang Gyo Park Yong Kee Kim Hoi Young Lee 《Experimental & molecular medicine》2008,40(6):607-616
Lysophosphatidic acid (LPA) is a bioactive phospholipids and involves in various cellular events, including tumor cell migration. In the present study, we investigated LPA receptor and its transactivation to EGFR for cyclooxygenase-2 (COX-2) expression and cell migration in CAOV-3 ovarian cancer cells. LPA induced COX-2 expression in a dose-dependent manner, and pretreatment of the cells with pharmacological inhibitors of Gi (pertussis toxin), Src (PP2), EGF receptor (EGFR) (AG1478), ERK (PD98059) significantly inhibited LPA-induced COX-2 expression. Consistent to these results, transfection of the cells with selective Src siRNA attenuated COX-2 expression by LPA. LPA stimulated CAOV-3 cell migration that was abrogated by pharmacological inhibitors and antibody of EP2. Higher expression of LPA2 mRNA was observed in CAOV-3 cells, and transfection of the cells with a selective LPA2 siRNA significantly inhibited LPA-induced activation of EGFR and ERK, as well as COX-2 expression. Importantly, LPA2 siRNA also blocked LPA-induced ovarian cancer cell migration. Collectively, our results clearly show the significance of LPA2 and Gi/Src pathway for LPA-induced COX-2 expression and cell migration that could be a promising drug target for ovarian cancer cell metastasis. 相似文献
14.
15.
用三氧化硫脲合成氨基胍 总被引:3,自引:0,他引:3
氨基胍是重要的精细化工原料 ,广泛应用于医药、农药、发泡剂和染料等多种精细化学品的合成 ,近年来大量应用于阳离子染料合成 .由氨基氰与肼在水溶液中反应制备氨基胍已有报道 .但现行工业方法生产氨基胍收率和产品纯度均比较低 [1] .三氧化硫脲 ( Aminoiminomethanesulfonicacid,简称 AIMSO3H)自 1 965年问世以来研究很少 .本文讨论用三氧化硫脲与水合肼作用合成氨基胍 .合成手续简单 ,收率和产品纯度均较高 .仪器和试剂 :Nicolot公司 MAGAN- 5 5 0( series )型红外分光光度计 ,GRT- 1型差热分析仪 (上海天平仪器厂 ) ,p Hs- 2型酸… 相似文献
16.
Cembranoids, a large family of diterpenoid natural products characterized by the presence of fourteen-membered ring, have been isolated from various marine sources as well as some terrestrial organisms since the 1960's1. Crotocembraneic acid 1 and neocrotocembraneic acid 2 have been isolated from the stem bark of Croton oblongifolius Roxb. (Euphorbiaceae)2. In our studies on the total synthesis of 1 and 2, we find a novel perchloric acid-induced lactonization reaction of epoxy ester 9 (Scheme… 相似文献
17.
18.
Dicyclohexyldithiophosphinic acid was synthesized by a three-step strategy through the Grignard reaction of PSCl3 with cyclo-C6H11MgBr and the P-P bond-cleavage reaction of the intermediate. The 1H NMR data of ammonium dicyclohexyldithiophosphinate 4 and dicyclohexyldithiophosphinic acid 5 were characterized by 1H-1H correlation spectra. 相似文献
19.