Airlanggins A-B,two new isoprenylated benzofuran-3-ones from the stem bark of Calophyllum soulattri

Two new isoprenylated benzofuran 3-ones, airlanggin A (1) and B (2) along with two known xanthones, ananixanthone (3) and trapezifolixanthone (4) were isolated from the stem bark of Calophyllum soulattri. Structures of all the compounds were elucidated using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1–4 were evaluated for their cytotoxicity against P-388 cells, showing that compound 3 was the most active with IC₅₀ 0.68 μg/mL and compound 1 showed moderate activity with IC₅₀ 5.80 μg/mL.     

Object-oriented synthetic approach toward angular and linear fused pyrazoloquinolines of biological importance with InCl3 catalyst

A simple and short approach for the synthesis of pyrazolo[3,4-b]quinoline (3a–3p) and pyrazolo[4,3-c]quinoline (6a–6 h) using various Lewis acid catalysts was developed. InCl₃ was found to be more effective in providing greater yield of products compared to Yb(OTf)₃, Sc(OTf)₃, SnCl₄, AlCl₃, TiCl₄, ZnCl₂, FeCl₃, and BF₃ · Et₂O. Moreover, a comparison of conventional and microwave methods has revealed that the latter method is more efficient compared to former one. Structures were confirmed by Fourier transform infrared, mass spectrometry, ¹H and ¹³C NMR, X-ray crystallography, and elemental analyses. All of the synthesized compounds were evaluated for α-glucosidase inhibitory activity. Compounds 3a, 3p, 3i, 3 h, 3k, 3o, and 3 g exhibited anti α-glucosidase inhibitory activity with IC₅₀ values of 57.5, 60.3, 65.9, 71.9, 80.8, 123.7, and 126.4 µM, respectively, which is quite comparable to the standard drug acarbose (IC₅₀ = 115.8 µM).     

Tin-derivative sandwich-type polyoxometalates supported on Nd-doped TiO2 nanoparticles as efficient and reusable catalysts in the oxidation of sulfides and alcohols

New nanocomposites, including different loading levels of sandwich-type polyoxometalates [(HOSn^IVOH)₃(XW₉O₃₄)₂]^n? (X = As (1), P (2) n = 12 and Si (3) n = 14) on Nd-doped TiO₂ nanoparticles were prepared by a simple impregnation method. The nanocomposites were characterized by X-ray diffraction (XRD), scanning electron microscopy, transmission electron microscopy, Fourier transform infrared (FTIR), and energy-dispersive X-ray spectroscopy. Compounds 1–3 were successfully loaded on Nd-doped crystallized anatase-phase TiO₂ nanoparticles of 20–25 nm. Catalytic activities of nanocomposites were examined by carrying out the oxidation of sulfides and alcohols with H₂O₂. Simple synthesis method, reusability, and low amounts of the heterogeneous catalysts with a slight excess of H₂O₂ and mild reaction conditions make these oxidation reactions an environmentally benign chemical process.     

Synthesis,structure, and thermal decomposition of two copper coordination compounds [Cu(DAT)2(PA)2] and [Cu(DAT)2(HTNR)2] with nitrogen rich 1,5-diaminotetrazole (DAT)

Both [Cu(DAT)₂(PA)₂] (1) and [Cu(DAT)₂(HTNR)₂] (2) were prepared from 1,5-diaminotetrazole (DAT) and copper trinitrophenol, 1 for picrate (PA) and 2 for styphnate acid (2,4,6-trinitro resorcinol, TNR), and were characterized by elemental analysis, FT-IR spectroscopy, and single crystal X-ray diffraction. The space group of these compounds is P2₁/c (monoclinic). The lattice parameters are similar [a = 11.405(3) Å, b = 14.867(3) Å, c = 8.099(2) Å for 1 and a = 12.262(3) Å, b = 14.900(3) Å, c = 7.243(2) Å for 2], except the β = 106.257(3)° in 1 and β = 92.989(4)° in 2. Both have extended structures due to hydrogen bonds, but there are some differences because of the ligands induced effect. Differential scanning calorimetry analysis shows that two exothermic processes take place in both complexes, the first peak temperatures are 488.2 K for 1 and 519.2 K for 2. The kinetic parameters of the first exothermic process were studied by using Kissinger’s method and Ozawa’s method, in which the enthalpy of formation (?7346 and ?5706 kJ M^?1), critical temperature of thermal explosion (475.0 and 515.8 K), entropy of activation (ΔS^≠), enthalpy of activation (ΔH^≠), and free energy of activation (ΔG^≠) were calculated and obtained as ?117.25 J K^?1 M^?1, 140.64 kJ M^?1, 196.44 kJ M^?1 and ?219.1 J K^?1 M^?1, 383.56 kJ M^?1, 495.34 kJ M^?1 for 1 and 2, respectively. The sensitivity test results showed that both compounds were sensitive to impact (<5 J) and flame (>20 cm) rather than friction.     

Synthesis of new ruthenium(II) complexes derived from labile nitrile ligands: an alternative route to the preparation of trans-dichlorotetrakis(diphenylphosphine)ruthenium(II)

New ruthenium(II) complexes containing labile nitrile ligands have been prepared by treatment of either the polymer [{RuCl₂(COD)}_x] (COD = cycloocta-1,5-diene) (1) or its derivative [RuCl₂(COD)(NCCH₃)₂]·NCCH₃ (2) with the appropriate nitrile ligands in refluxing acetonitrile under argon. A new route to synthesis of trans-dichlorotetrakis(diphenylphosphine)ruthenium(II) (7) was also reported. A redetermination of the structure of 7 was undertaken and X-ray crystallographic data revealed that the complex crystallizes in the triclinic space group P-1 with unit cell dimensions a = 12.7016(9) Å, b = 13.0847(10) Å, c = 14.1498(10) Å, α = 101.46(3)°, V = 2080.6(3) Å³, Z = 2 and R = 0.0309. Its polymorph 7′ was also obtained. The crystal structure of 4 was also determined. This complex crystallizes in the monoclinic space group C2/c with unit cell dimensions a = 27.0510(3) Å, b = 11.0984(13) Å, c = 13.0450(16) Å, α = 90°, V = 3886.5(8) Å³, Z = 8 and R = 0.0282.     

Aqua substitution from mononuclear Pt(II) complexes with 2-(pyrazol-1-ylmethyl)quinoline non-leaving ligands

The rates of aqua substitution from [Pt{2-(pyrazol-1-ylmethyl)quinoline}(H₂O)₂](ClO₄)₂, [Pt(H₂Qn)], [Pt{2-(3,5-dimethylpyrazol-1-ylmethyl)quinoline}(H₂O)₂](ClO₄)₂, [Pt(dCH₃Qn)], [Pt{2-[(3,5-bis(trifluoromethyl)pyrazol-1-ylmethyl]quinoline}(H₂O)₂](ClO₄)₂, [Pt(dCF₃Qn)], and [Pt{2-[(3,5-bis(trifluoromethyl)pyrazol-1-ylmethyl]pyridine}(H₂O)₂](ClO₄)₂, [Pt(dCF₃Py)], with three sulfur donor nucleophiles were studied. The reactions were followed under pseudo-first-order conditions as a function of nucleophile concentration and temperature using a stopped-flow analyzer and UV/visible spectrophotometry. The substitution reactions proceeded sequentially. The second-order rate constants for substituting the aqua ligands in the first substitution step increased in the order Pt(dCH₃Qn) < Pt(dCF₃Qn) < Pt(H₂Qn) < Pt(dCF₃Py), while that of the second substitution step was Pt(dCH₃Qn) < Pt(dCF₃Qn) < Pt(dCF₃Py) < Pt(H₂Qn). The reactivity trends confirm that the quinoline substructure in the (pyrazolylmethyl)quinoline ligands acts as an apparent donor of electron density toward the metal center rather than being a π-acceptor. Measured pK_a values from spectrophotometric acid–base titrations were Pt(H₂Qn) (pK_a1 = 4.56; pK_a2 = 6.32), Pt(dCH₃Qn) (pK_a1 = 4.88; pK_a2 = 6.31), Pt(dCF₃Qn) (pK_a1 = 4.07; pK_a2 = 6.35), and Pt(dCF₃Py) (pK_a1 = 4.76; pK_a2 = 6.27). The activation parameters from the temperature dependence of the second-order rate constants support an associative mechanism of substitution.     

Synthesis,crystal structures,and magnetic properties of methoxido-bridged dinuclear MnIII complexes derived from tri-dentate chelating ligands

Two new doubly methoxido-bridged Mn^III dinuclear complexes, [Mn^III(mphp)(μ-OCH₃)(CH₃OH)]₂·2CH₃OH (1) and ([Mn^III(ahbz)(μ-OCH₃)(CH₃OH)]₂·2CH₃OH (2), have been synthesized by using the tridentate ligands H₂mphp (H₂mphp = 2-methyl-6-(pyrimidin-2-yl-hydrazonomethyl)-phenol) and H₂ahbz (H₂ahbz = N-(2-amino-propyl)-2-hydroxy-benzamide). The complexes have been characterized by single-crystal X-ray diffraction analysis and magnetic measurements. Complexes 1 and 2 have a similar dimeric molecular structure. Two [Mn(L)(CH₃OH)]⁺ moieties (L^2? = mphp^2? or ahbz^2?) are bridged by two μ-OCH₃^? groups in the axial-equatorial asymmetric manner. The coordination geometry of Mn^III is an axially elongated octahedron with two oxygens of a methanol ligand and a methoxido ligand situated at the axial positions. Magnetic measurements indicate that 1 and 2 exhibit antiferromagnetic behavior with the fitting parameter of J = ?1.49(3) cm^?1, D = ?1.3(1) cm^?1, g = 1.98(1) and zJ′ = ?0.18(4) cm^?1 for 1, and J = ?1.6(2) cm^?1, D = 4.5(3) cm^?1, g = 2.06(1) and zJ′ = 1.4(1) cm^?1 for 2 on the basis of the spin Hamiltonian ? = ?2J?_Mn1?_Mn2.     

Syntheses,structures and luminescent properties of a series of ladder-shaped [Ln2Sr3] heterometal-organic frameworks

A series of Ln^III–Sr^II heterometallic coordination polymers formulated as [Ln₂Sr₃(pda)₆(H₂O)₁₈]·nH₂O (Ln = Pr-1, n = 14; Nd-2, n = 12; Sm-3, n = 11; Eu-4, n = 11; Gd-5, n = 16; Tb-6, n = 13; Dy-7, n = 13) were synthesized via assembly of Ln(NO₃)₃·6H₂O, SrCl₂·6H₂O, pyridine-2,6-dicarboxylic acid (H₂pda) and imidazole (im) in H₂O/C₂H₅OH solution. Single crystal X-ray diffraction revealed that they are isostructural. All of these complexes possess ladder-shaped 1-D chain structures. The luminescent properties of Sm-3, Eu-4, Gd-5, Tb-6 and Dy-7 have been investigated. The solid-state quantum yields and the lifetimes of Eu-4 and Tb-6 are also studied.     

Two tetranuclear Ni(II) complexes from substituted imidazole dicarboxylates: syntheses,structures, thermal and magnetic properties

Two tetranuclear nickel(II) complexes, [Ni₄ (p-BrPhHIDC)₄(py)₄(H₂O)₄]·CH₃OH (p-BrPhH₃IDC = 2-(p-bromophenyl)-1H-imidazole-4,5-dicarboxylic acid) (1) and [Ni₄(p-ClPhHIDC)₄ (CH₃CN)₄(H₂O)₄]·4H₂O (p-ClPhH₃IDC = 2-(p-chlorophenyl)-1H-imidazole-4,5-dicarboxylic acid, py = pyridine) (2), have been solvothermally synthesised and structurally characterised. Both compounds consist of similar tetranuclear Ni(II) cores, in which the imidazole dicarboxylate ligands adopt the similar coordination mode. The thermal properties of 1 and 2 have been investigated. Also, it is discovered that there exists antiferromagnetic coupling between the Ni(II) ions in 1 and 2; the best fittings to the experimental magnetic susceptibilities gave J = ? 9.89 cm^? 1 and g = 2.18 for 1, and J = ? 10.54 cm^? 1 and g = 2.14 for 2.     

Reverse-Phase High-Performance Liquid-Chromotographic DAD Method for Simultaneous Determination of Five Isoflavones in Millettia nitida var. hirsutissima

Abstract

A reverse-phase high-performance liquid-chromatographic photodiode array detection (DAD) method has been developed and validated for the simultaneous determination of five isoflavones in Millettia nitida var. hirsutissima: hirsutissimiside B, sphaerobioside, lanceolarin, formononetin, and afromosin. The method utilized a C₁₈ column (4 µm, 250 × 4.6 mm) with an acetonitrile and aqueous H₃PO₄ gradient and ultraviolet detection at 259 nm. The recovery of the method is 94.1–105.9%, and linearity (r > 0.9996) is obtained for all the isoflavones.     

Antileishmanial diterpenoid alkaloids from Aconitum spicatum (Bruhl) Stapf

The crude extracts of tubers of Aconitum spicatum (Bruhl) Stapf were investigated for in vitro antileishmanial activity against Leishmania major. The dichloromethane extract at pH 2.5 showed antileishmanial activity with IC₅₀ value of 27.10 ± 0.0 μg/mL. Chromatographic purification of the dichloromethane extract led to isolation of three C-19 norditerpenoid alkaloids indaconitine (1), chasmaconitine (2) and ludaconitine (3). Compounds 3 and 2 showed antileishmanial activity with IC₅₀ = 36.10 ± 3.4 and 56.30 ± 2.1 μg/mL, respectively. Compound 1 was less effective (IC₅₀ > 100 μg/mL). The cytotoxicity of compounds 1, 2 and 3 studied against MCF7, HeLa and PC3 cancer cell lines and 3T3 normal fibroblast cell line did not show cytotoxicity at 30 μM.     

New complexes of Zn(II) with the anti-inflammatory non-steroidal drug,ibuprofen and nitrogen donor ligands. Synthesis,characterization and biological activity

Complexes of [Zn(ibup)₂(4,4′-bipy)]_n 1, [Zn(ibup)₂(phen)] 2, [Zn(ibup)₂(2,9-dmphen)] 3, [Zn(ibup)₂(1,2-dmimidazole)₂] 4, and [Zn(ibup)₂(2-am-6-picoline)₂] 5 (ibu = ibuprofen, 4,4′-bipy = 4,4′-bipypyridine, phen = 1,10-phenanthroline, 2,9-dmephen = 2,9-dimethyl-1,10-phenanthroline, 1,2-dmimidazole = 1,2-dimethylimidazole, and 2-am-6-picoline = 2-amino-6-picoline) were prepared and characterized. The crystal structure of 1 was determined by single-crystal X-ray diffraction. The in vitro anti-bacterial activities for the complexes against Gram-positive (Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli, Klebsiella pneumonia and Proteus mirabilis) bacteria were done using the agar well-diffusion method. Complexes 1–3 showed anti-bacterial activity against Gram-positive bacteria, while 4 and 5 did not exhibit anti-bacterial activity. Complexes 2 and 3 were selected for further studies. Complexation of zinc-ibuprofen with phen as in 2 decreased the anti-bacterial activity against most of the bacteria used. The complexation in 3 decreased the anti-bacterial activity in Gram-positive bacteria but for Gram-negative bacteria, the overall anti-bacterial activity of uncoordinated 2,9-dmphen was enhanced upon coordination with zinc ibuprofen.     

Structural diversity for three Zn(II) coordination polymers from 4-nitrobenzene-1,2-dicarboxylate and bispyridyl ligand

Three Zn(II) complexes, [Zn₂(bpp)₂(FNA)₂]·H₂O (1), [Zn(bpp)(FNA)]·H₂O (2), and Zn₂(bpp)₂(FNA)₂ (3) (bpp = 1,3-bi(4-pyridyl)propane, H₂FNA = 4-nitrobenzene-1,2-dicarboxylic acid), were synthesized and characterized by single-crystal and powder X-ray diffraction methods, IR spectroscopy, TG analyses, elemental analyses, and fluorescent analysis. In 1, the Zn(II) ions are linked by FNA anions and bpp into 2-D layers. The Zn(II) ions in 2 are bridged by FNA anions into chiral chains, which are interlinked by bpp into 3-D metal–organic framework with (6⁵·8) CdS topology. Complex 3 features 1-D zigzag chains, which are interconnected by bpp ligands to give a 3-D framework with (6·7⁴·8)(6⁴·7·8) topology. Complexes 2 and 3 exhibit significant ferroelectric behavior (for 2 remnant polarization Pr = 0.050 μC cm^?2, coercive field Ec = 1.13 kV cm^?1, saturation of the spontaneous polarization Ps = 0.239 μC cm^?2; for 3 Pr = 0.192 μC cm^?2, Ec = 4.64 kV cm^?1, Ps = 0.298 μC cm^?2).     

Conformational preferences of heteronuclear Fischer carbene complexes of cymantrene and cyclopentadienyl rhenium tricarbonyl

Homo- and heteronuclear bimetallic carbene complexes of group VII transition metals (Mn and Re), with cymantrene or cyclopentadienyl rhenium tricarbonyl as the starting synthon, have been synthesized according to classic Fischer methodology. Crystal structures of the carbene complexes with general formula [RC₅H₄ M'(CO)₂{C(OEt)(C₅H₄ M(CO)₃)}], where M = M′ = Mn, R = H (1), R = Me (2); M = Mn, M′ = Re, R = H (3); M = M′ = Re, R = H (4); and M = Re, M′ = Mn, R = H (5), are reported. A density functional theory (DFT) study was undertaken to determine natural bonding orbitals (NBOs) and conformational as well as isomeric aspects of the binuclear complexes. Application of second-order perturbation theory (SOPT) of the NBO method revealed stabilizing interactions between the methylene C–H bonds and the carbonyl ligands of the carbene metal moiety. Energy calculations in the gas phase of the cis and trans conformations of the Cp rings relative to one another are comparable, with the trans conformation slightly lower in energy. The theoretical findings have also been confirmed with single-crystal X-ray diffraction, and all solid-state structures are found in the trans geometry.     

Crystal structures,electrochemical properties,antioxidant screening and in vitro cytotoxic studies on four novel Cu(II) complexes of bidentate Schiff base ligands derived from 2-methoxyethylamine

Four novel Schiff base ligands and their copper(II) complexes, [Cu(L¹)₂] (1), [Cu(L²)₂] (2), [Cu(L³)₂] (3), and [Cu(L⁴)₂] (4), were synthesized and characterized by elemental analyses, FT-IR, and UV–Vis spectroscopy. The ligands were synthesized from the condensation of 2-methoxyethylamine with various salicylaldehyde derivatives (x-salicylaldehyde for HLⁿ, x = H (n = 1), 5-Br (n = 2), 3-OMe (n = 3), and 4-OMe (n = 4)). The molecular structures of 1, 2, and 3 were determined by the single crystal X-ray diffraction technique. The redox behavior studies of the complexes in acetonitrile display the electronic effects of the groups on the redox potential. The antioxidant activity of the Schiff base ligands and their Cu(II) complexes was evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method and FRAP assay. Furthermore, the in vitro anticancer activity of compounds was screened, including MTT and migration assays against gastric cancer cell line (MKN-45). The results show that all ligands and complexes have antioxidant and anticancer activity in a concentration-dependent way.     

New Zn(II) complexes based on biologically active substituted acetic acid and nitrogen donor ligands: synthesis,crystal structure and biological applications

The complexes [Zn(phenylacetato)₂(2-aminopyridin)₂] (3), [Zn(phenylacetato)₂(1,10-phenanthroline)]·H₂O (4), and [Zn(phenylacetato)₂(2,9-dimethyl-1,10-phenanthroline)]·0.5 H₂O (5) were prepared and characterized by IR-, UV–Visible, ¹H and ¹³C NMR spectroscopy, and single crystal X-ray diffraction. BNPP hydrolysis of the complexes and their parent nitrogen ligands showed that the hydrolysis rate of bis-(4-nitrophenyl) phosphate (BNPP) was 1.7 × 10⁵ L mol^?1 s^?1 for 3, 3.1 × 10⁵ L mol^?1 s^?1 for 4 and 4.3 × 10⁴ L mol^?1 s^?1 for 5. Antibacterial activities show the effect of complexation on activity against Gram-positive (S. epidermidis, S. aureus, E. faecalis, M. luteus and B. subtilis) and Gram-negative (K. pneumonia, E. coli, P. mirabilis and P. aeruginosa) bacteria using the agar well diffusion method. Complex 4 showed good activity against G? bacteria except P. aeruginosa, and against G+ bacteria except E. ferabis. Complex 5 showed no activity against G? bacteria, low activity against M. luteus and B. subtilis bacteria and high activity against S. epidemidis and S. aureus. Complex 3 did not show any activity against G? or G+ bacteria.     

Iron(II) complexes containing the 2,6-bis-iminopyridyl moiety. Synthesis,characterization, reactivity,and DNA binding

Two iron(II) complexes, [Fe^II(py^tBuN₃)₂](FeCl₄) (1) and [Fe^II(py^tBuMe₂N₃)Cl₂] (2), with sterically constrained py^tBuN₃ and py^tBuMe₂N₃ chelate ligands (py^tBuN₃ = 2,6-bis-(aldiimino)pyridyl; py^tBuMe₂N₃ = 2,6-bis-(ketimino)pyridyl), have been synthesized and characterized by elemental analysis, IR, UV–vis spectra, and preliminary X-ray single-crystal diffraction. The latter revealed that Fe(II) in 1 is six-coordinate by six nitrogen donors from two bisiminopyridines in a distorted octahedron. Complex 2 reacts with thiourea with a second-order rate constant k₂ = (2.50 ± 0.05) × 10^?3 M^?1 s^?1 at 296 K, and the reaction seemed to be slow. In a similar way, the interaction of 2 and DNA was studied by fluorescence and absorption spectroscopy. The results revealed that 2 caused fluorescence quenching of DNA through a dynamic quenching procedure. The binding constants K_A, K_app, and K_SV as well as the number of binding sites between 2 and DNA were determined.     

Synthesis,X-ray structural and DFT studies of n-membered ring P,C-chelated complexes of Pd(II) and Pt(II) derived from unsymmetrical phosphorus ylides and application of Pd(II) complexes as catalyst in Suzuki reaction

The phosphonium salts [Ph₂P(CH₂)_nPPh₂CH₂C(O)C₆H₄-m-OMe]Br (n = 1 (S₁) and n = 2 (S₂)) were synthesized in the reaction of bis(diphenylphosphino)methane (dppm) and bis(diphenylphosphino)ethane (dppe) with 2-bromo-3?-methoxy acetophenone, respectively. Further treatment with NEt₃ gave the phosphorus ylides Ph₂P(CH₂)_nPPh₂C(H)C(O)C₆H₄-m-OMe (n = 1 (Y₁) and n = 2 (Y₂)). These ligands were treated with [MCl₂(cod)] (M = Pd or Pt; cod = 1,5-cyclooctadiene) to give the P, C-chelated complexes, [MCl₂(Ph₂P(CH₂)_nPPh₂C(H)C(O)C₆H₄-m-OMe)] (n = 1, M = Pd (3), Pt (4), and n = 2, M = Pd (5), Pt (6)). These compounds were characterized by elemental analysis, spectroscopic methods, UV–visible, and fluorescence emission spectra. Further, the structures of complexes 3 and 6 were characterized crystallographically. The palladium complexes 3 and 5 proved to be excellent catalysts for the Suzuki reactions of various aryl chlorides. Also, a theoretical study on the structure of complexes 3–6 has been investigated at the BP86/def2-SVP level of theory. The strength and nature of donor?acceptor bonds between the phosphorus ylides (L) and MCl₂ fragment in the [LMCl₂] (M = Pd, Pt, L = Y₁, Y₂) were studied by NBO and energy decomposition analysis (EDA), as well as their natural orbitals for chemical valence variation (EDA-NOCV).     

Structure activity relationship of bergenin,p-hydroxybenzoyl bergenin, 11-O-galloylbergenin as potent antioxidant and urease inhibitor isolated from Bergenia ligulata

Ethanol extract of the aerial parts of Bergenia ligulata was subjected to solvent–solvent separation followed by various chromatographic techniques that lead to isolation of bergenine (1), p-hydroxybenzoyl bergenin (2), 11-O-galloylbergenin (3) and methyl gallate (4) as major constituents. Ethyl acetate fraction showed a dose-dependent urease inhibitory pattern with IC₅₀ value of 54μg/mL. Structures of compounds 1 and 3 were established by XRD and 2, 4 by NMR. All these compounds were subjected to DPPH scavenging activity, reducing power assay and urease inhibitory activity. The EC₅₀ 7.45 ± 0.2 μg/mL and 5.39 ± 0.28 μg/mL values in terms of antioxidant and reducing power, respectively, were less for 3. Compounds 1–3 showed moderate to significant urease inhibitory potential with IC₅₀ 57.1 ± 0.7, IC₅₀ 48.4 ± 0.3 and 38.6 ± 1.5. Antioxidant activities and urease inhibitory potential were investigated and compound 3 was found to be the most active.