[2+2] Cycloaddition of benzyne to cis,trans- and cis,cis-1,5-cyclooctadiene

The relative rates of formation of $\text{cis}$ and $\text{trans}$ [2+2]cycloadducts of benzyne to $\text{cis}$, $\text{trans}$- and $\text{cis}$, $\text{cis}$-1,5-cyclooctadiene, $\text{trans}$- and $\text{cis}$-cyclooctene are discussed and properties of the adducts (e.g., their unusual hydrogenation) are described.     

Empirical determination of medium effects on the equilibrium between transcis and transtrans 1,2-dibromo-4-t-butylcyclohexanes

Head space analysis, GLC retention time data, and solution calorimetry are used to determine the effect of medium on the thermodynamic parameters for the equilibrium (1) ? (2). It is shown that changes in ΔG° and ΔH° can be evaluated for the transfer of the equilibrium from a series of solvents to the gaseous phase which is used as the reference medium.     

Stereospecific synthesis of Z- and E-1 alkoxy-1,3-butadienes

A stereospecific, highly efficient, generally applicable synthesis of $\text{Z}$- and $\text{E}$-1-alkoxy-1,3-butadienes involving dehydrative decarboxylations of 4,5-unsaturated-2-alkoxy-3-hydroxy-carboxylic acids is described.     

Dichlorobis(organonitrile)palladium(II) catalysis of cis- to trans- isomerization of ethylchrysanthemate and chrysanthemic acid

Complexes of the type L₂PdCl₂ (L = CH₃,CN, CH₃CH₂CN, PhCN) in benzene or chloroform act as homogeneous catalysts in the room temperature $\text{cis}$ to $\text{trans}$ isomerization of ethylchrysanthemate and chrysanthemic acid.     

Total synthesis of 5-desoxyleukotriene D. A new and useful equivalent of the 4-formyl-trans, trans-1,3-butadienyl anion

The first total synthesis of 5-desoxyleukotriene D ($\text{14}$) is reported. The route of synthesis utilizes a novel method for five-carbon chain extension. The availability of $\text{14}$ allowed experimental demonstration that the 5-hydroxyl function is important for biological activity of the slow reacting substances.     

Stereospecific synthesis of trans-1,3-disubstituted-1,2,3,4-tetrahydro β-carbolines

The stereospecific synthesis of $\text{trans}$-1,3-disubstituted-1,2,3,4-tetrahydro β-carbolines has been accomplished in good yield by a two step sequence which involves Pictet-Spengler condensation of N_b-benzyltryptophan methyl ester with aldehydes, followed by removal of the 2-benzyl moiety from the corresponding tetrahydro β-carboline via catalytic hydrogenation.     

Synthesis of N-benzoyl L- and D-2,3,6-trideoxy-3-aminoxylo-hexose from non-carbohydrate precursors

The enantiomeric alcohols ($\text{2}$) and ($\text{11}$), obtained from (2$\text{R}$,3$\text{R}$) tartaric acid and, respectively, $\text{L}$-threonine, have been used to construct the C₆, enantiomeric deoxy amino sugar derivatives ($\text{7}$) and ($\text{12}$)     

Deoxygenation of Pyridine N-oxides with sulphur monoxide generated from trans-2,3-diphenylthiiran-1-oxide

Pyridine N-oxides are deoxygenated by sulphur monoxide. Electron withdrawing substituents lower drastically the yields of reduction.     

Reaction between N-acyl-2,3-dihydrobenzo-1,4-thiazine and N-acylphenothiazine with organometallic reagents

the title $\text{N}$-acyl-derivatives react with $\text{n}$-BuLi and Grignard reagents leading to products, which, formally, can be considered as derived from a Claisen-type condensation reaction.     

Stereoselective synthesis of 1,8- and 1,5-diketo-trans-syn-trans-perhydroanthracenes

A stereOselective conversion of 1,8- and 1,5-diethoxy-9,10-anthraquinone to 1,8- and 1,5-diketo-$\text{trans}$-$\text{syn}$-$\text{trans}$-perhydroanthracenes by successive sodium borohydride, metal-ammonia, and catalytic reductions is described.