DEA-based anti-HIV immunotherapy model

An application of Data Envelopment Analysis (DEA) to anti-HIV immunotherapy is first reported. DEA models are utilized to describe the drug treatment strategies. And the efficiency of the strategies is explored. Two prediction models are constructed respectively according to the given inputs and the given outputs. All models are solved numerically using the linear program (LP), which has the advantage over the differential equation models.     

Linguistic granular model: design and realization

A new linguistic granular model is proposed and the effect of its parameters on the output is analyzed. The design of the model consists of two stages: using conditional fuzzy clustering for information granular, and integrating all information granules to final output. The integrating tool is fuzzy integral based on fuzzy measure, and the generalization of fuzzy integral increases flexibility of the linguistic granular model greatly. A heuristic algorithm to determine the parameters in the fuzzy integral is used to realize the linguistic model. Two experiments verify the feasibility of the proposed model.     

An eSnake model for medical image segmentation

A novel scheme of external force for detecting the object boundary of medical image based on Snakes (active contours) is introduced in the paper. In our new method, an electrostatic field on a template plane above the original image plane is designed to form the map of the external force. Compared with the method of Gradient Vector Flow (GVF), our approach has clear physical meanings. It has stronger ability to conform to boundary concavities, is simple to implement, and reliable for shape segmenting. Additionally, our method has larger capture range for the external force and is useful for medical image preprocessing in various applications. Finally, by adding the balloon force to the electrostatic field model, our Snake is able to represent long tube-like shapes or shapes with significant protrusions or bifurcations, and it has the specialty to prevent Snake leaking from large gaps on image edge by using a two-stage segmentation technique introduced in this paper. The test of our models proves that our methods are robust, precise in medical image segmentation.     

Stochastic DEA model with undesirable outputs: An application to the prediction of anti-HIV therapy efficiency

This paper proposes a stochastic prediction DEA model with undesirable outputs and simplifies the process using chance-constrained techniques in order to obtain an equivalent linear programming formulation. The existence and stability of the optimal solutions have been proved. And the model is used to describe and predict the efficiency of anti-HIV therapy in AIDS patients.     

Improvement of different source function expressions in SWAN model for the Bohai Sea

The simulating wave nearshore (SWAN) wave model has been widely used in coastal areas, lakes and estuaries. However, we found a poor agreement between modeling results and measurements in analyzing the chosen four typical cases when we used the default parameters of the source function formulas of the SWAN to make wave simulation for the Bohai Sea. Also, it was found that at the same wind process the simulated results of two wind generation expressions (Komen, Janssen) demonstrated a large difference. Further study showed that the proportionality coefficient α in linear growth term of wave growth source function plays an unperceived role in the process of wave development. Based on experiments and analysis, we thought that the coefficient α should change rather than be a constant. Therefore, the coefficient α changing with the variation of friction velocity U* was introduced into the linear growth term of wave growth source function. Four weather processes were adopted to validate the improvement in the linear growth term. The results from the improved coefficient α agree much better with the measurements than those from the default constant coefficient α. Furthermore, the large differences of results between Komen wind generation expression and Janssen wind generation expression were eliminated. We also experimented with the four weather processes to test the new white-capping mechanisms based on the cumulative steepness method. It was found that the parameters of the new white-capping mechanisms are not suitable for the Bohai Sea, but Alkyon's white-capping mechanisms can be applicable to the Bohai Sea after amendments, demonstrating that this improvement of parameter α can improve the simulated results of the Bohai Sea.     

Diagnosis of prostate cancer by quantitative analysis of 3DMRSI data: A new model

Prostatecancer (PC)hasthehighestmorbidityrateinmaleurinarysystemdisordersinEuropeandAmerica ,anditisoneoftheprimaryreasonsofmaledeath[1] .InChina ,althoughtheattackofPCisrela tivelylow ,ithasa growingtrendinrecent 10years[2— 4 ] .Inclinicalpractice ,magneticresonanceimaging (MRI)could providehighresolutionmor phologicalstructureandhasthecapabilityofmulti parameterimaging ,butitcannotreliablydifferentiatePCfrombenignprostatehyperplasia (BPH)andnor maltissues ,particularlyforthepatientswi…     

有孔虫分子生物学研究进展

传统的微体古生物学研究中，有孔虫是生活于海洋环境中以具有膜状、胶结质或钙质壳为特征的丝网状肉足虫类原生动物．最近对底栖有孔虫rDNA序列的分析研究，揭示了有孔虫还有无壳(裸露)种类以及生活于陆地淡水环境的类型．同时分子系统学研究表明有孔虫位于真核生物系统树的基部，在双滴虫类与绿眼虫类之间．对浮游有孔虫大量基因型及其与环境关系的研究，揭示了传统研究低估了有孔虫的多样性．有孔虫基因型与生物地理分布、海洋环境有关研究表明利用rDNA序列分析识别出的同一物种的不同基因型可以为古环境研究提供更加精确的替代性指标．     

Modal extension rule

Modal logics are good candidates for a formal theory of agents. The efficiency of reasoning method in modal logics is very important, because it determines whether or not the reasoning method can be widely used in systems based on agent. In this paper, we modify the extension rule theorem proving method we presented before, and then apply it to P-logic that is translated from modal logic by functional transformation. At last, we give the proof of its soundness and completeness.     

A mathematical model for solid liquid and mass transfer coupling and numerical simulation for hydraulic fracture in rock salt

The hydraulic fracture in rock salt is a complicated solid fluid and mass transfer coupling process. Through theoretical analysis, a solid fluid and mass transfer coupling mathematical model of hydraulic fracture in rock salt is established in this work, and numerical simulations are carried out with the model. The simulation results indicate that rock salt cracks in the typical way of wing-crack(or tensile crack) during the fracture, and the relation of fracture aperture (w) with expanding distance (x) and fracture time (t) is w＝(0.0034＋0.0006t)e(0.0007+0.0018t)x. Furthermore, it has been found that both the water pressure in the crack and the expanding velocity of the crack decrease gradually as a result of the influence of salt dissolving during fracturing. These numerical simulations well illustrate the process of hydraulic fracture in rock salt and are significantly meaningful in engineering practice.     

素数幂分布定理

利用解析数论工具证明了算术级数数列中素数幂分布的若干结果，这些结果在提供ＲＢＩＢＤ设计与ＰＭＤ设计的渐近存在性定理的精确定界时具有重要作用．     

浅析大学生学习策略的培养

知识经济的到来使得大学生有限的学习年限与知识迅速老化之间的矛盾越来越突出,而解决这个问题的关键途径就是加强对大学生学习策略的研究,指导他们掌握适合自己的学习策略.     

电化学控制主客体相互作用研究进展

电化学控制主客体相互作用研究备受人们关注，近年来得到了迅速发展.文中按主体分子类别，从环糊精、杯芳烃、葫芦脲和环番等4个方面对电化学控制主客体相互作用研究进行了评述，展望了电化学控制主客体相互作用研究的发展趋势和潜在应用.     

一类新图族及其分类

本文按递归构造法给出了一类新图族,研究了其伴随多项式第四项系数的规律,由此得到了一种分类方法,其结果有助于我们进一步研究此类图族补图的色唯一性及色等价划分.     

化学研究中的光物理技术

概述了各种用于化学科学研究的光物理技术,并对用途极为广泛、公众了解较少的时间分辨荧光各向异性技术的基本测定原理和应用做了较为详细的论述.指出了光物理技术的最新发展以及国内光物理技术在化学科学研究中的应用现状.建议国家自然科学基金委员会发挥协调作用,促使合肥同步辐射国家实验室尽快建立时间分辨荧光各向异性测定的实验条件.     

Molecular biological research on Foraminifera

As one of the most important groups in micropaleontology, Foraminifera is traditionally described to have a membranous, agglutinated or carbonate shell according to its morphology, which resembles the marine granuloreticuloseans. However, recent molecular analyses on its ribosomal RNA gene have disclosed the existence of the naked, and also freshwater and terrestrial species. Foraminiferal SSU rDNA sequence suggests that this group is positioned at the base of the Eukaryotes phylogenetic trees, between Euglenoida and Diplomonadida. Existence of a large amount of genetic types in planktonic foraminifera suggests an underestimation of the biodiversity for the nearly 50 species in world oceans and their close relationship with the ocean environment, such as bio-geographic distribution and water currents. This provides a more reliable proxy for future paleoenvironmental study.     

组织工程血管研究现状

组织工程化血管的产生和发展使人类最终解决完善血管替代物的问题成为可能.随着干细胞功能研究的进步和材料及塑型科学的不断发展，血管组织工程进展迅速，备受瞩目.文中就血管组织工程中关键的3大要素：支架材料、种子细胞和共培养构建的研究进展作一综述.     

评 "双波理论"

对“双波理论”的立论出发点和逻辑性以及“双波理论”的四个基本假设中的三个作出了评述 .指出了双波函数假设的不合理性和假设的哈密顿量与实际采用的哈密顿量的不一致性 ;假设的力学量测量值的表达式不能代表力学量的测量值     

煤层气地球化学研究现状与发展趋势

概述了煤层气作为新资源的研究及开发状况，全面评述了煤层气地球化学研究的现状：其组分以CH4为主，δ13C1值约为－80‰—－10‰，有限的δD1值数据为－333‰—－117‰，CO2的δ13C值为－29.4‰—+18.6‰，其他组分的同位素则极少研究；煤层气目前仅主要识别出热成因气和次生生物气两种类型，还有其他划分标准；与常规天然气相比，煤层气CH4和CO2的δ13C值的分布范围很宽，尤其存在特高值．目前煤层气地球化学存在并需解决的主要问题为：甲烷碳、氢同位素组成变化的机理、影响因素及其应用；δ13C1值与Ro值的关系；煤层气成因类型的系统划分方案和指标以及煤层气地球化学在煤层气选区评价中的应用等．