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1.
Application of the exciton chirality rule has allowed assignment of absolute configuration to (+)--(4R,5R)-dihydroxy-4,5-dihydrobenzo[a]pyrene, a mammalian metabolite of the hydrocarbon. The cis 4,5-dlhydrodiol and 4,5-oxide are also assigned based on correlation with the trans dihydrodiol. 相似文献
2.
《Tetrahedron》1987,43(13):3021-3030
A new synthesis of 9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo aquinolizin-2-one ( and its 3-ethyl derivative via the corresponding 2-(3,4-dimethoxyphenyl)-4-piperidone ethylene acetals is reported. Alkylation of 2-arylpipendires with 2-bromoethanol followed by oxidation of the resulting amino alcohols with oxalyl chloride and dimethyl sulfoxide afforded the aldehydes , which were cyclized with hydrochloric acid to give 7-hydroxybenzo[α]quinolizidines . The reduction of with trinethylsilane and subsequent acid hydrolysis led to benzo aquinolizidin-2-ones . 相似文献
3.
Thermolysis of 4-azidotetrafluoropyridine in the presence of an excess of mesidine at 170 °C yields tetrafluoro-4-(2,4,6-trimethylphenylazo)- pyridine, which undergoes intramolecular dehydrofluorination to provide 1,3,4-trifluoro-7,9-dimethyl-11-pyrido[4,3-]benzo[1,2]diazepine. 相似文献
4.
The first syntheses of [1.1.1.1.1]paracyclophane () and [1.1.1.1.1.1]paracyclophane () are described, featuring a trifluoroacetic acid promoted Friedel-Crafts cycloalkylation as the final step. 相似文献
5.
Reaction of 1-(2-nitrophenoxy)naphthalene or its β-isomer with triethylphosphite produces benzo[a]phenoxazines and , through the intermediate . 相似文献
6.
Mikio Hori Kiyomi Tanaka Tadashi Kataoka Hiroshi Shimizu Eiji Imai Kazuhiko Kimura Yoshinobu Hashimoto 《Tetrahedron letters》1985,26(10):1321-1322
5,7-Dimethyl[1,2,4]triazolo[1,5-a]pyrimidinio-3-phenacylide () generated by the reaction of an iminium salt () with 1 eq. of triethylamine, underwent a new thermal ring cleavage of the triazole moiety to give the pyrimidine derivative. However reaction of with 2 eq. of triethylamine afforded the 2-iminooxazoline derivative. The iminooxazoline reacted with nucleophiles such as alcohols or amines to give imidazoles. 相似文献
7.
Anions of β,β-disubstituted acetyl acetates (, CH2COCR1R2COOR3; R1= R2 = Me2 R1 = Et, R2 = COOMe, R1 = Et, R2 = SPh) add to 1-tosyl-3,4,4-trimethyl-Δ -imidazolinium iodide () to give the corresponding imidazolines (), which are regarded as models of methylenetetrahydrofolate These models transfer C(2) of the imidazalodine -with its appended carbon fragment- to tryptamine and 2-(3,4-dimethoxybenzene)ethyl amine to yield enaminoketo ester intermediates which can be converted into benzo[a]quinolizine and indolo[2,3-a]quinolizine derivatives, respectively, in two cyclization steps. The intermediate derived from transfer of carbon fragment CH-CH2COC(SPh) (Et) COOMe to tryptamine exhibits reactions which involve nucleophilic displacement at a sulfur atom of a thio ether bond. 相似文献
8.
Cycl[4.2.2]azinium salts , and have been synthesized and shown to be diatropic. 相似文献
9.
Ernst-Ulrich Würthwein Jayaraman Chandrasekhar Eluvathingal D Jenmis Paul von Ragué Schleyer 《Tetrahedron letters》1981,22(9):843-846
Semi-empirical (MINDO/3 and UNDO) MO calculations on highly strained planar tetracoordinate carbon candidates indicate the central carbons in - [4.4.4.4] fenestrane () to have pyramidal () and in trans-[4.4.4.]fenestrane () to have distorted tetrahedral () geometries. In [2.2.2.2]paddlane (), the two central carbons are pentacoordinate. Each is nearly coplanar with four carbon neighbours; additionally, the two bridgehead carbons are connected by a single bond (). 相似文献
10.
The 185-nm denitrogenation of 2,3-diazabicyclo[2.2.1]heptene () afforded bicyclo[2.1.0]-pentane () and cyclopentene () presumably via a “hot” cyclopentane-1,3-diyl diradical (); 1,4-pentadiene () and methylenecyclobutane () were secondary products of the 185-nm photolysis of () and (). 相似文献
11.
Yoshito Tobe Yasuyoshi Ueda Masaharu Matsumoto Yasuo Sakai Yoshinobu Odaira 《Tetrahedron letters》1982,23(5):537-538
Bicyclo[6.2.2]dodecadienes (), (), and () having two bridgehead double bonds were synthesized by the pyrolysis of the acetate (). 相似文献
12.
The reaction of the halobicyclobutane derivatives and with LDA in the presence of isoindoles afforded the azapropellanes and via the bicyclobutene intermediates and , respectively. 相似文献
13.
L.A.M. Turkenburg P.M.L. Blok W.H. de Wolf F. Bickelhaupt 《Tetrahedron letters》1981,22(34):3317-3320
Base induced elimination of HCl from the dichloro[5.3.1]propellane gives a mixture of [5]metacyclophane () and tetrahydrocyclopentacyclooctenes (), while the stereoisomeric affords quantitatively. 相似文献
14.
Theodorus A Van Der Knaap Theodorus C Klebach Foppe Visser Rimmer Lourens Friedrich Bickelhaupt 《Tetrahedron》1984,40(6):991-997
Cycloaddition reactions of mesityl(diphenyliiifithylene)phosphine () were Investigated. With several dienes, no Diels-Alder reactions were oEserved. With azides, diphenyidiazomethane and 2,4,6-trimethylbenzonitrile oxide, the corresponding cycloadducts (were obtained. In the case of phenyl azide, a competing Staudinger reaction occurred leading to . 相似文献
15.
Syntheses for pyrazolo[3,4-g]quinazolin-8(7H)-one () and its [3,4-h]-analog 11 have been developed involving elaboration of aminoindazolcarboxylic acids and from correspondingly substituted methylnitroindazols, and subsequent anellation of the pyrimidine ring by v. Niementowski cyclization. 相似文献
16.
The vinylbromides and are allowed to react ith AgBF4 and AgPF6 in the presence of various olefins in CH2Cl2 as the solvent. Except for the reaction of cyclopentene with all other olefins used, react with vinyl cation to form the cycloaddition products , and in high yields. 相似文献
17.
The rearrangement of terminal allylic hexafluoroisopropyl sulfides to the internal olefinic sulfide occurs under either photochemical or thermal conditions. In the case of the formation of and isomers, the isomer was predominant. The rearrangement is suggested as a unimolecular, associative radical mechanism, kinetic studies, use of inhibitors, or radical initiator. 相似文献
18.
A short route to the 2-azabicyclo[3.3.1]nonan-7-one system is described. Condensation of 4-piperidones with diethyl 2-oxopropylphosphonate, followed by catalytic hydrogenation furnished the corresponding piperidylpropanones which were cyclized with mercuric acetate in acetic acid to the target target bicyclic ketones . The Fischer indole synthesis from afforded regioselectively the indole [3,2-f]morphan , a new heteromorphan type. 相似文献
19.
The two [2.2]metaparacyclophane quinhydrones and were synthesized. Structure, stereochemistry and charge-transfer absorptions are discussed. 相似文献
20.
Bruce E. Maryanoff Albert J. Molinari Gary P. Wooden R.A. Olofson 《Tetrahedron letters》1982,23(28):2829-2832
The free base of benzoquinolizidine undergoes a facile rearrangement to pyrimidoisoquinoline , the structure of which was confirmed by x-ray crystallography.The regiospecificity of this novel rearrangement is governed by stereoelectronic factors. 相似文献