构建“三三三”混合式课堂教学新模式——以“原子结构”类比模型的建构为例(Ⅰ)

基于在线开放课程和移动互联技术，探讨了医药类院校"无机化学"课堂教学的重构。实践中依托"一平台、一区域、六模块"，运用移动互联思维重构了三阶段、三环节、三分类的"三三三"教学新模式。进一步以"原子结构"为例介绍了课堂重构的教学设计。教学改革从学生问卷调查、考试成绩、能力培养以及学习心理等不同角度均得到非常积极的反馈，期望这一理念和实践能为新时期高校课堂教学和人才培养提供参考。     

高职有机化学抛锚式翻转课堂教学模式的构建和实践

以高职有机化学课程为例，探讨了抛锚式翻转课堂教学模式的构建和实践。主要包括：课前微课视频的制作、课堂组织、课后拓展、辅导和教学评价等环节。抛锚式教学模式和翻转课堂的结合，可以调动学生学习的主动性和积极性，使学生成为课程学习的主体，有利于有机化学课程的教学，有利于培养更多更好的新时代药学专业技术技能人才。     

化学社会课程资源开发及教学范例——水的净化与水资源保护

课程资源逐步走向开放化、共享化和社会化，社会已成为实施教育教学活动的重要场所。以"水的净化与水资源保护"主题内容为教学范例，提出了化学社会课程资源开发的思路和教学实施流程：在"前置学习"中通过社会课程资源的亲身实践，把化学的课堂延伸到社会领域；在"展示分享"中将获取的有效资源与课堂学习关联，实现知识与生活的有效链接；在"整理评价"中完成知识建构和巩固过程，让学生感受真实、有用的化学。     

以BOPPPS教学模式为途径深化仪器分析教学改革

在创新应用型人才培养目标的驱动下,结合仪器分析课堂教学的现状分析,把握教学重点,以BOPPPS教学模式为途径进行课堂设计,将课堂导入、学习目标、前测、参与式学习、后测、总结等6个部分深入课堂教学中,进而带动仪器分析课程教学的改革,重点关注学生的主动参与性与及时的效果反馈,让学生明白在未来将如何运用课堂内学到的内容,达到提高学生的应用技能的目的。     

雨课堂背景下巧用案例法提高现代分析测试技术教学效果*

现代分析测试技术是工程类相关专业硕士研究生的必选课程,该课程传统的教学模式往往以教师讲授为主,学生实际操作的机会少,造成了学生学习积极性不高。和传统的教学模式相比,雨课堂增加了教师和学生间的沟通互动和课堂趣味性,有利于提高学生的课堂积极性。基于雨课堂,将教师的科研作为案例融入课堂教学,同时采用“打卡通关”式的案例教学模式,通过案例模拟实际测试,提供真实情境教学,激发学生学习兴趣,提高学生的课堂参与度,明显提高了该课程的学习效果。     

“互联网+”时代下雨课堂在现代仪器分析课程教学中的实践与探索*

从课前预习、课上教学与管理和课后分析与总结等方面探讨了雨课堂在现代仪器分析课程教学中的实践探索。教学实践表明,采用基于“互联网+”的雨课堂混合式教学模式,学生的学习能力提高,教师的教学水平提高,课程评价模式提升。学生问卷调查结果表明,95%以上的学生认可雨课堂教学。同时,分析了目前雨课堂在实施过程中遇到的问题,并提出改进意见。旨在为高校进一步推进基于“互联网+”的雨课堂混合式教学模式提供参考。     

网络环境下生物化学理论课教学模式研究与实践

对网络环境下教学模式进行探讨,构建传统课堂教学与网络教学相结合的混合式教学模式,将信息化技术融入课堂,使教学手段更加高效,教学资源更加丰富,评价考核更加客观,学生学习更加主动,师生共建生物化学课程网络教学资源。实践证明,这种教学模式有效提升了教学效率和质量,提高了学生自主学习能力。     

混合式教学在“仪器分析”课堂教学中的应用探讨

针对农林类专业中“仪器分析”课堂教学效果实效性有待提高等问题，借鉴MOOC理念，通过网络平台开展SPOC课程建设，并对“仪器分析”课堂教学进行改革，重构教学理念和教学流程，“翻转”师生角色，课堂教学线上线下无缝对接，有效整合碎片化时间和信息，使学习成为自我持续性行为。同时进一步改革仪器分析教学模式与方法，建立多尺度教学考核体系，以期有效提升“仪器分析”课堂教学效果。     

混合式教学模式下仪器分析双语教学探究

探讨了混合式教学模式下仪器分析的双语教学情况,主要包括：教学设计、资源库建设、新型教学模式构建与教学方法实践、课堂教学考评、教学团队建设等。以期进一步拓宽学生的国际化视野,提升学生运用外语获取仪器分析前沿知识和自主综合学习能力,提高课堂教学效果和课程国际化水平。     

微视频技术在基础化学实验教学中的实践应用

以高校基础化学实验"从海带中提取碘""三草酸合铁（Ⅲ）酸钾的制备"为例，分别探讨了微视频技术在化学基本操作实验和综合设计型实验中的具体应用；此外，举例说明利用Flash软件制作的虚拟微视频可以在仪器分析实验中清晰地再现仪器真实操作中的每一个步骤，弥补了学生在实验前无法实际操作仪器的不足。实践证明，微视频技术的应用，丰富了基础化学实验教学模式，增强了学生自主学习的能力和动手能力，提高了实验成功率和实验教学效果。     

二氧化碳和丙烯直接合成甲基丙烯酸的NiPMo/TiO2催化剂的研究

用溶胶-凝胶法以磷钼酸(MPA)的镍盐溶液水解钛酸四丁酯制备了NiPMo/TiO2催化剂.使用ICP、 XRD、 TG-DTA、 IR、 TPD-MS和微反应技术研究了催化剂的化学组成、热稳定性、化学吸附性质和催化反应性能.杂多钼酸盐与TiO2通过O2-在TiO2表面发生了键合.在623 K下,杂多阴离子仍保持原有的Keggin结构.CO2在Lewis酸位Ni(Ⅱ)和Lewis碱位Ni-O-Mo的桥氧协同作用下生成CO2卧式吸附态Ni(Ⅱ)←O-(CO)←(O--Ni).丙烯有多种吸附态在催化剂上吸附.在563 K、 1 MPa和空速1500 h-1的反应条件下,丙烯的摩尔转化率为3.2%,产物MAA选择性为95%.     

α-Amino acid derived enaminones and their application in the synthesis of N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates and other heterocycles

A new and simple synthesis of novel N-protected methyl 5-substituted-4-hydroxypyrrole-3-carboxylates, which exist in equilibrium with their 4-oxo tautomers, has been developed in two steps starting from N-protected α-amino acids. The key intermediates are enaminones, which can also be isolated, characterized, and used for the construction of other functionalized heterocycles, before they spontaneously decompose to pyrrole products. 4-Hydroxypyrroles are prone to partial aerial oxidation but can be efficiently alkylated or reduced to stable polysubstituted pyrrolidine derivatives.     

Specific intramolecular aromatic CH insertion of diazosulfonamides

The chemoselectivity in the intramolecular CH insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp³)?H insertions of diazosulfonamides are not accessible, while the aromatic 1,5-C(sp²)?H insertion can be realized specifically by adjusting the diazo-adjacent group. In addition, the general chemoselectivities in the intramolecular CH insertions of diazosulfonyl compounds are summarized. Generally, diazosulfones undergo both aromatic 1,5-C(sp²)?H and aliphatic 1,5- and 1,6-C(sp³)?H insertions, while diazosulfonates undergo aliphatic 1,5- and 1,6-C(sp³)?H insertions. However, diazosulfonamides only undergo aromatic 1,5-C(sp²)?H insertion.     

Toward new camptothecins. Part 6: Synthesis of crucial ketones and their use in Friedländer reaction

In the context of the preparation of camptothecin and luotonin A analogs, the synthesis of some key keto-precursors and their use in Friedländer condensation are described. This paper also focuses on the stability of these keto intermediates and emphasizes the major differences between indolizinones and pyrroloquinazolinones series. Noteworthy is also the report of some original structures isolated as by-products of some experiments.     

N-Heterocyclic carbene-palladacyclic complexes: synthesis,characterization and their applications in the C-N coupling and α-arylation of ketones using aryl chlorides

N-Heterocyclic carbene-palladacyclic complexes 3 were successfully achieved in a one-pot procedure under mild conditions. The structure of 3a was unambiguously confirmed by X-ray single crystal diffraction and it was an active catalyst in the Buchwald-Hartwig amination and α-arylation of ketones even at very low catalyst loadings (0.01?mol%).     

Iodine-mediated oxidative Pictet-Spengler reaction using terminal alkyne as the 2-oxoaldehyde surrogate for the synthesis of 1-aroyl-β-carbolines and fused-nitrogen heterocycles

An efficient iodine-mediated oxidative Pictet-Spengler reaction in dimethyl sulphoxide (DMSO) using terminal alkynes as the 2-oxoaldehyde surrogate for the synthesis of aryl (9H-pyrido[3,4-b]indol-1-yl)methanones is described. The scope of the protocol includes the total synthesis of Fascaplysin, Eudistomins Y₁ and Y₂. The methodology is extended for preparing pyrrolo[1,2-a]-quinoxaline and indolo[1,5-a]quinoxaline derivatives. The utility of 1-aroyl-β-carbolines was demonstrated by performing palladium-catalyzed β-carboline directed ortho-C(sp2)-H functionalization of the phenyl ring with thiomethyl (SMe) group using DMSO as source and for accessing 4-aryl-canthin-6-ones.     

Facile synthesis of bicyclic 1-arylpyrazol-5-ones

In this Letter, we described a facile method for constructing fused bicyclic 1-arylpyrazol-5-one ring system. We employed various methylene-containing carboxylic acids as the substrates and proved that the pyrazolone ring closure requires activated methylene group in intermediate II. Accordingly, a series of structurally diversified, fused bicyclic 1-arylpyrazol-5-ones was prepared in moderate to high yields using the requisite substrates.     

CoFe2O4自形成磁性液体场致结构化对磁化的影响

The Langevin paramagnetic theory can’t describe the relation between magnetization of ferrofluids and applied magnetic field. The structuralization of ferrofluids, which is considered the main influence factor of the magnetization, is regarded. The part of magnetization works is deposited when the structure is forming. This action influences the magnetization of ferrofluids directly or indirectly. On the base of the “compressing” model, the Langevin function that usually describes the magnetization of ferrofluid is modified, and a well-fitted curve is obtained. An equation of the relation between the equivalent volume fraction after being “compressed” and the intensity of magnetic field is discovered, which approximately describes the process of magnetization. The relation between the approximate initial susceptibility and the volume fraction can be obtained from modified formula.     

KMnO4-mediated oxidative CN bond cleavage of tertiary amines: Synthesis of amides and sulfonamides

KMnO₄-mediated oxidative CN bond cleavage of tertiary amines producing secondary amine was introduced, which was trapped by electrophiles (acyl chloride and sulfonyl chloride) to form amides and sulfonamides. The reaction could take place at mild condition, tolerating a wide range of function groups and affording products in moderate to excellent yields.     

Chemistry of heterocyclic compounds at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, over 50 years (Review)

The review contains a concise historical account and information on the most significant researches undertaken by the staff at the A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences on the Chemistry of Heterocyclic Compounds. Dedicated to Academician of the Russian Academy of Sciences B. A. Trofimov on his 70th jubilee. Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1443–1502, October, 2008.