Theoretical analysis of a simple yet efficient portable magnetic separator design for separation of magnetic nano/micro-carriers from human blood flow

A technology that could physically remove substances from the blood such as biological, chemical, or radiological toxins could dramatically improve treatment of disease. One method in development proposes to use magnetic-polymer spheres to selectively bind toxins and remove them by magnetic filtration. Although magnetic filtration is a developed technology, the clinical boundary conditions described here require a new filter design. We investigated the removal of toxin-bound magnetic carriers from the blood stream using 2-D FEMLAB simulations. The magnetic separator consisted of a permanent magnet with parallel ferromagnetic prisms on the faces and in contact with a straight tube carrying the magnetic-polymer spheres in suspension. We varied the following parameters: blood flow velocity, the size, and number of ferromagnetic prisms, and the ferromagnetic material in both prisms and magnets. The capture efficiency reached maximum values when the depth of the prisms equaled the diameter of the tubing and the saturation magnetization of the prism material equaled twice that of the magnet. With this design a piece of 2 mm (diameter) tube carrying the fluid resulted in 95% capture of 2.0 μm magnetic-polymer spheres at 10 cm/s flow velocity.     

Scale separation for implicit large eddy simulation

With implicit large eddy simulation (ILES) the truncation error of the discretization scheme acts as subgrid-scale (SGS) model for the computation of turbulent flows. Although ILES is comparably simple, numerically robust and easy to implement, a considerable challenge is the design of numerical discretization schemes resulting in a physically consistent SGS model. In this work, we consider the implicit SGS modeling capacity of the adaptive central-upwind weighted-essentially-non-oscillatory scheme (WENO-CU6) [X.Y. Hu, Q. Wang, N.A. Adams, An adaptive central-upwind weighted essentially non-oscillatory scheme, J. Comput. Phys. 229 (2010) 8952–8965] by incorporating a physically-motivated scale-separation formulation. Scale separation is accomplished by a simple modification of the WENO weights. The resulting modified scheme maintains the shock-capturing capabilities of the original WENO-CU6 scheme while it is also able to reproduce the Kolmogorov range of the kinetic-energy spectrum for turbulence at the limit of infinite Reynolds number independently of grid resolution. For isentropic compressible turbulence the pseudo-sound regime of the dilatational kinetic-energy spectrum and the non-Gaussian probability-density function of the longitudinal velocity derivative are reproduced.     

Magnetic nanoparticles separation based on nanostructures

This study describes a magnetic array, which consists of depositing Fe nanowires on a porous alumina membrane. Such a device can be used as a planar magnetic separator. Its performance for the collection of Fe₃O₄ nanoparticles is experimentally shown. For magnetization of such iron nanowires in the vertical direction, we propose equations to calculate the theoretical absorption ratio.     

微通道冷却器的数值分析

微通道热沉是制作在硅芯片基底背面的微细通道,其水力直径范围为10～1 000 μm.微通道具有高表面积-体积比、低热阻、低流量等特点,是一种高效散热的解决方案.一个典型应用是激光二极管列阵的致冷.然而,微通道里流体的状态和传热与宏观状态相比有很大不同,有必要开展进一步研究.论文采用商业软件CoventorWareTM建立一个平板式微通道的有限元模型,据此对微通道中流体状态及传热进行了数值计算,获得了单个微通道中流场和温度的分布.结果表明,对于2 000 μm×50 μm×500 μm的微通道,能够对500 W/cm2的热通量快速散热,热阻仅有0.042 3 K/(W·cm-2).     

Multi-relaxation time lattice Boltzmann simulation of inertial secondary flow in a curved microchannel

The inertial secondary flow is particularly important for hydrodynamic focusing and particle manipulation in biomedical research.In this paper,the development of the inertial secondary flow structure in a curved microchannel was investigated by the multi relaxation time lattice Boltzmann equation model with a force term.The numerical results indicate that the viscous and inertial competition dominates the development of secondary flow structure development.The Reynolds number,Dean number,and the cross section aspect ratio influence significantly on the development of the secondary vortexes.Both the intensity of secondary flow and the distance between the normalized vortex centers are functions of Dean numbers but independent of channel curvature radius.In addition,the competition mechanism between the viscous and inertial effects were discussed by performing the particle focusing experiments.The present investigation provides an improved understanding of the development of inertial secondary flows in curved microchannels.     

Turbulent gas-dispersed flow in a pipe with sudden expansion: numerical simulation

A mathematical model was developed to simulate two-phase gas-dispersed flow moving through a pipe with axisymmetric sudden expansion. In the model, the two-fluid Euler approach was used. The model is based on solving Reynolds-averaged Navier — Stokes equations for a two-phase stream. In calculating the fluctuating characteristics of the dispersed phase, equations borrowed from the models by Simonin (1991), Zaichik et al. (1994), and Derevich (2002) were used. Results of a comparative analysis with previously reported experimental and numerical data on two-phase flows with separation past sudden expansion in a plane channel and in a pipe are given. This work was supported by the President of the Russian Federation through the Foundation for Young Candidates of Sciences under Grant MK-186.2007.8 and by the Russian Foundation for Basic Research (Grants Nos. 05-08-33586 and 06-08-00967).     

磁性核壳纳米粒子的制备及其在分离和光谱检测中的应用

磁性及其核壳复合纳米粒子由于在不同领域中具有广泛应用而受到研究者的极大关注,总结了磁性及磁性核壳纳米粒子常见的制备方法及各自的特点,并重点讨论了其在磁分离及光谱检测方面的应用,也介绍了本课题组在纳米粒子合成及应用方面所做的一部分工作。最后对磁性纳米粒子中存在的问题进行了探讨,并对其应用前景进行了展望。     

固体激光微通道冷却器内流动特性的数值模拟

建立了固体激光微通道冷却器数学模型,运用商业软件Fluent进行求解计算,并与文献中数据进行对比,验证了模型的可靠性。分析微通道尺寸及结构对转捩雷诺数影响,结果表明:微通道当量直径对于转捩雷诺数影响甚微,收缩比的大小是引起转捩雷诺数不同的关键因素,最终确定了不同收缩比下的转捩雷诺数。     

固体激光微通道冷却器内流动特性的数值模拟

建立了固体激光微通道冷却器数学模型,运用商业软件Fluent进行求解计算,并与文献中数据进行对比,验证了模型的可靠性。分析微通道尺寸及结构对转捩雷诺数影响,结果表明：微通道当量直径对于转捩雷诺数影响甚微,收缩比的大小是引起转捩雷诺数不同的关键因素,最终确定了不同收缩比下的转捩雷诺数。     

Numerical simulation of a tribo-aero-electrostatic separation of a ternary plastic granular mixture

Granular materials, when fluidized by air or other gaseous medium, acquire electrostatic charge by particle-particle and particle-wall collisions. The effectiveness of particle tribocharging achieved with such fluidization process is crucial for establishing the feasibility of electrostatic separation of mixed granular solid wastes in the recycling industry. The aim of the present work is to introduce a simple mathematical model for simulating the outcome of a novel tribo-aero-electrostatic separation process involving mixture of three granular materials. The process is characterized by the fact that the charging of the granules is produced in a fluidized bed device, in the presence of an electric field. The mathematical model in this case assumed that the probability of a granule to be separated can be expressed using the normal distribution law, as a function of the number of impacts with granules belonging to the other classes of materials. The effect of the presence of a third species of particles was taken into account. Thus, it was possible to calculate the evolution over time of the mass of granules separated at the electrodes for different compositions of the granular mixture. The calculated results are in good agreement with the experiments.     

Computer simulation study of phase separation in a binary mixture with a glass-forming component

We present a computer simulation study of spinodal decomposition with one of the two phases freezing in a glassy state during phase separation. As a model we used the Cahn-Hilliard equation with a concentration-dependent mobility coefficient which decreases rapidly with increasing concentration of the glass-forming component. We solved the Cahn-Hilliard equation numerically for two dimensions. The domain growth depends crucially on the volume fraction of the glassy phase. For high volume fractions, when the glassy phase forms a percolating matrix, a novel coarsening mechanism is discovered, which arises from the migration and coalescence of liquid droplets within the glassy matrix. Various quantities characterizing the time-dependent domain pattern, like droplet size distribution, one- and two-point distribution function and structure factor of the concentration field, are computed. We checked the validity of the dynamic scaling hypothesis.     

Experimental and numerical investigation of flow separation in a supersonic nozzle

The flow in a two-dimensional symmetric convergent-divergent supersonic nozzle with and without a deflector at the exit plane was tested experimentally and numerically. Combined optoelectronic devices were used to demonstrate the possibilities of the shadow and schlieren methods and holographic interferometry for the flow visualization especially in the separation region. A series of experiments was performed in a trisonic wind tunnel (VTI, Beograd). The experimental results obtained using optical methods are compared with the pressure measurements and numerical calculations. Numerical results were obtained using a code for solving the average Navier-Stokes equations. Five structured meshes with different resolutions and two turbulent models were employed. The coupled influence of the mesh resolution and the order of accuracy of the used numerical scheme is analyzed.     

Microfabricated magnetic sifter for high-throughput and high-gradient magnetic separation

A microfabricated magnetic sifter has been designed and fabricated for applications in biological sample preparation. The device enables high-throughput, high-gradient magnetic separation of magnetic nanoparticles by utilizing columnar fluid flow through a dense array (∼5000/mm²) of micropatterned slots in a magnetically soft membrane. The potential of the sifter for separation of magnetic nanoparticles conjugated with capture antibodies is demonstrated through quantitative separation experiments with CD138-labeled MACS nanoparticles. Capture efficiencies ranging from 28% to 37% and elution efficiencies greater than 73% were measured for a single pass through the sifter.     

电磁力控制湍流边界层分离圆柱绕流场特性数值分析

在亚临界区高雷诺数Re=1.4×105下,采用脱体涡模拟结合湍流分离的方法对弱电解质中电磁力作用下湍流边界层分离圆柱绕流场及其升(阻)力特性进行了数值模拟和分析.结果表明,电磁力可以提高圆柱体湍流边界层内的流体动能,延缓圆柱体湍流边界层的流动分离,减弱圆柱体湍流绕流场中在流向和展向上大尺度漩涡的强度,减小圆柱体阻力时均值及其升力脉动幅值.当电磁力作用参数大于某个临界值后,湍流边界层流动分离消失,在圆柱体尾部产生射流现象,从而电磁力对圆柱体产生净推力作用,出现负阻力现象,而且升力脉动幅值接近于零,出现圆柱体升力消失现象.     

带凹槽的微通道中液滴运动数值模拟

运用改进的耗散粒子动力学方法模拟了液滴在由凹槽所构成的粗糙表面微通道内的运动行为.改进的耗散粒子动力学方法采用新近提出的一种短程排斥、长程吸引相互作用势能函数,从而可以模拟带有自由面的流体,如液滴等.模拟了新势能函数下液滴与固体壁面的静态接触角,并用2次多项式拟合了"接触角-a_wf/a_f"变化曲线.研究了液滴在带凹槽的微通道中运动时,微通道壁面浸润性、外场力、液滴温度对液滴流动特性的影响.研究表明壁面浸润性和外场力对液滴流动特性的影响较大,液滴温度对液滴流动特性的影响较小.研究结果对运用耗散粒子动力学方法模拟并分析微流体在复杂微通道的流动有一定的参考价值.     

Flow separation behind a rib in a channel with laminar flow

Visualization data and results of combined measurements of flow quantities in flow with separation past a rib at nominally laminar regime of channel flow are reported. In the separation region, the flow is found to be essentially three-dimensional and unsteady, exhibiting a distinct cellular structure and flow zones with transverse motion. It is shown that the rib-induced flow separation gives rise to low-frequency fluctuations of flow velocity and initiates the turbulence transition in the channel flow. The critical Reynolds number at which flow instability starts developing in the channel is estimated. It is shown that at Reynolds numbers higher than the critical Reynolds number the linear integral scale of flow velocity fluctuations in the channel is defined by the duct size.     

Monte Carlo simulation of phase separation and clustering in the ABV model

As a model for a binary alloy undergoing an unmixing phase transition, we consider a square lattice where each site can be either taken by an A atom, a B atom, or a vacancy (V), and there exists a repulsive interaction between AB nearest neighbor pairs. Starting from a random initial configuration, unmixing proceeds via random jumps of A atoms or B atoms to nearest neighbor vacant sites. In the absence of any interaction, these jumps occur at jump rates _A and _B, respectively. For a small concentration of vacancies (c _v=0.04) the dynamics of the structure factorS(k,t) and its first two momentsk ₁(t),k ₂ ² (t) is studied during the early stages of phase separation, for several choices of concentrationc _B of B atoms. Forc _B=0.18 also the time evolution of the cluster size distribution is studied. Apart from very early times, the mean cluster sizel(t) as well as the moments of the structure function depend on timet and the ratio of the jump rates (= _B/ _A) only via a scaled timet/(). Qualitatively, the behavior is very similar to the direct exchange model containing no vacancies. Consequences for phase separation of real alloys are briefly discussed.     

Experimental investigation on laminar separation control for flow over a two-dimensional bump

The laminar boundary layer separation flow over a two-dimensional bump controlled by synthetic jets is experimentally investigated in a water channel with hydrogen-bubble visualisation and particle image velocimetry (PIV) techniques. The two-dimensional synthetic jet is applied near the separation point. Two Reynolds numbers (Re = 700 and 1120) based on the bump height and free-stream velocity are adopted in this experiment, and seven different excitation frequencies at each Reynolds number are considered, focusing on the separation control as well as the vortex dynamics. The experimental results show that the optimal control can only be achieved within some excitation frequencies at both Reynolds numbers. However, beyond this range, further increasing the excitation frequency leads to an increase in the separation region. The proper orthogonal decomposition (POD) technique and vortex identification by swirling strength (Λ_ci) are applied for the deeper analysis of the separated flow. The reconstructed Λ_ci field by the first four POD modes is used and vortex lock-on phenomenon is observed. It is found that the negative synthetic jet vortex with clockwise rotation draws the separated wake shear layer as it is convected downstream, and then they syncretise together. Thus, the new vortex is induced and shedding downstream periodically.     

Numerical simulation for separation of multi-phase immiscible fluids in porous media

Based on a lattice Boltzmann method and general principles of porous flow, a numerical technique is presented for analysing the separation of multi-phase immiscible fluids in porous media. The total body force acting on fluid particles is modified by axiding relative permeability in Nithiarasu＇s expression with an axiditional surface tension term. As a test of this model, we simulate the phase separation for the case of two immiscible fluids. The numerical results show that the two coupling relative permeability coefficients K12 and K21 have the same magnitude, so the linear flux-forcing relationships satisfy Onsager reciprocity. Phase separation phenomenon is shown with the time evolution of density distribution and bears a strong similarity to the results obtained from other numerical models and the flows in sands. At the same time, the dynamical rules in this model are local, therefore it can be run on massively parallel computers with well computational efficiency.     

Evaluation of Cyanex 923-coated magnetic particles for the extraction and separation of lanthanides and actinides from nuclear waste streams

In the magnetically assisted chemical separation (MACS) process, tiny ferromagnetic particles coated with solvent extractant are used to selectively separate radionuclides and hazardous metals from aqueous waste streams. The contaminant-loaded particles are then recovered from the waste solutions using a magnetic field. The contaminants attached to the magnetic particles are subsequently removed using a small volume of stripping agent. In the present study, Cyanex 923 (trialkylphosphine oxide) coated magnetic particles (cross-linked polyacrylamide and acrylic acid entrapping charcoal and iron oxide, 1:1:1, particle size=1–60 μm) are being evaluated for the possible application in the extraction and separation of lanthanides and actinides from nuclear waste streams. The uptake behaviour of Th(IV), U(VI), Am(III) and Eu(III) from nitric acid solutions was investigated by batch studies. The effects of sorption kinetics, extractant and nitric acid concentrations on the uptake behaviour of metal ions were systematically studied. The influence of fission products (Cs(I), Sr(II)) and interfering ions including Fe(III), Cr(VI), Mg(II), Mn(II), and Al(III) were investigated. The recycling capacity of the extractant-coated magnetic particles was also evaluated.